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The article presents the results of a study that measured the attitudes of students of Education of the University of Barcelona to the Statistics, through scale EAE by Auzmendi (1992). Research has shown neutral-low level of general attitude towards the matter, but has also identified groups of students with different profiles: a group with an attitude unfavorably, but not especially anxious, just knowledge of statistics and very few numerical skills; another group is characterized by a positive attitude, who like statistics, but that worry and anxiety also shows; and a third group that stands out above all for anxiety before statistics. Given the potential relationship between academic achievement andattitude, the findings point to the need to explore strategies for Adaptive education for different groups.

The phase IIIb OPINION trial (NCT03402841) investigated olaparib maintenance monotherapy in patients without a deleterious or suspected deleterious germline BRCA1 / BRCA2 mutation (gBRCAm) who had platinum-sensitive relapsed ovarian cancer (PSROC) and had received ≥2 previous lines of platinum-based chemotherapy. In this single-arm, open-label, international study, patients who had responded to platinum-based chemotherapy received maintenance olaparib tablets (300 mg twice daily) until disease progression or unacceptable toxicity. The primary endpoint was investigator-assessed progression-free survival (PFS) (modified RECIST version 1.1). A key secondary endpoint was PFS by homologous recombination deficiency (HRD) and somatic BRCAm (sBRCAm) status. The primary analysis of PFS was planned for 18 months after the last patient received their first dose. Two hundred and seventy-nine patients were enrolled and received olaparib. At data cutoff (October 2, 2020), 210 PFS events had occurred (75.3% maturity) and median PFS was 9.2 months (95% confidence interval [CI], 7.6–10.9) in the overall population. At 12 and 18 months, 38.5% and 24.3% of patients were progression-free, respectively. In the predefined biomarker subgroups, median PFS was 16.4, 11.1, 9.7, and 7.3 months in sBRCAm, HRD-positive including sBRCAm, HRD-positive excluding sBRCAm, and HRD-negative patients, respectively. The most common treatment-emergent adverse events (TEAEs) were nausea (48.4%) and fatigue/asthenia (44.1%). TEAEs led to dose interruption, dose reduction, and treatment discontinuation in 47.0%, 22.6%, and 7.5% of patients, respectively. Maintenance olaparib demonstrated clinical benefit in patients without a gBRCAm, and across all subgroups, compared with historical placebo controls. There were no new safety signals. • OPINION investigated maintenance olaparib in platinum-sensitive relapsed ovarian cancer patients without a germline BRCAm. • In this primary analysis, median PFS was 9.2 months overall, demonstrating clinical benefit versus historical controls. • Median PFS was prolonged across predefined biomarker subgroups based on BRCAm and HRD status. • The safety profile of maintenance olaparib was generally consistent with previous reports. • Our findings support maintenance olaparib as a standard of care in PSROC, irrespective of BRCAm or HRD status. [ABSTRACT FROM AUTHOR]