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(1) Background: This study aims to evaluate the efficacy and safety of non-thermal plasma (NTP) therapy in accelerating wound healing in patients who have undergone laparoscopic and open surgeries. (2) Methods: NTP was applied using a needle-type reactor with an irradiance of 0.5 W/cm2 on the surgical wounds of fifty patients after obtaining informed consent. Three NTP treatments, each lasting three minutes, were administered hourly. (3) Results: The pilot study showed that NTP-treated surgical wounds healed completely without any signs of infection, dehiscence, pain, or itching. Notably, patients reported minimal pain after the NTP treatment. Visual assessments conducted twenty-four hours after surgery revealed no redness or fluid discharge. Comparisons with traditionally sutured wounds indicated that NTP-treated wounds healed at a rate equivalent to seven days. (4) Conclusions: The application of NTP in laparoscopic and open wounds proved safe and effective, expediting the wound healing process and eliminating clinical risks post-surgery. Significantly, NTP facilitated a healing rate within twenty-four hours, equivalent to seven days for suture-treated wounds, significantly reducing the hospitalization time to a single day. These findings highlight the potential of NTP to be a transformative approach for promoting postoperative recovery.

Non-thermal plasmas (NTPs), known as cold atmospheric plasmas (CAPs), hold great potential for diverse medical applications, including dentistry. However, traditional linear and rigid dielectric barrier discharge reactors used for NTP generation encounter limitations in accessing oral cavities and root canals. To address this issue, we have developed an innovative NTP reactor featuring an angled end for improved accessibility. The central copper electrode, with a 0.59 mm diameter and adjustable length for desired angulation, is coated with zircon powder (ZrSiO4) to ensure stable NTP generation. This central electrode is housed within a stainless steel tube (3 mm internal diameter, 8 mm external diameter, and 100 mm length) with a 27° angle at one end, making it ergonomically suitable for oral applications. NTP generation involves polarizing the reactor electrodes with 13.56 MHz radio frequency signals, using helium gas as a working medium. We introduce plasma-treated water (PTW) as an adjunctive therapy to enhance biofilm eradication within root canals. A synergistic approach combining NTP and PTW is employed and compared to the gold standard (sodium hypochlorite, NaOCl), effectively neutralizing Enterococcus faecalis bacteria, even in scenarios involving biofilms. Moreover, applying NTP in both gaseous and liquid environments successfully achieves bacterial inactivation at varying treatment durations, demonstrating the device’s suitability for medical use in treating root canal biofilms. The proposed NTP reactor, characterized by its innovative design, offers a practical and specific approach to plasma treatment in dental applications. It holds promise in combatting bacterial infections in root canals and oral cavities.

Background: Infection by the human immunodeficiency virus (HIV) is associated with an increased risk of surgical wound infection. Non-thermal plasma (NTP) has multiple properties that help the healing process and deactivate pathogenic microorganisms. An HIV-positive patient was diagnosed with a neck tumour underwent excision of the neoplasm, and NTP therapy was applied as a coadjutant of wound closure. Methods: After the tumour's excision, the NTP therapy was applied to the surgical bed wound for 5 min. Subsequently, also spread the same therapy for 5 min more to the subcutaneous cellular tissue. Finally, a similar procedure was applied to the skin during 4 min. Results: With NTP's applications, wound closure was achieved without skin sutures in a short time, downgrading pain considerably, without the wound having any undesirable effect. Conclusions: Therapy using NTP can be an effective coadjutant procedure for wound closure and prevention of postoperative infection since it has been demonstrated to be effective and safe.

Recurrent aphthous stomatitis (RAS) is a common disease in the oral cavity characterized by recurrent ulcers (RU). Usually, these cause acute pain without definitive treatment. The present study determines the efficacy of non-thermal plasma (NTP) for treating RU. NTP is applied to the patient’s RU using a radiofrequency generator connected to a point reactor. The power density applied to the ulcer is 0.50 W/cm2, less than 4 W/cm2, which is the maximum value without biological risk. Each patient received two treatments of three minutes each and spaced 60 min apart at a distance of 5 mm from the RU. From a sample of 30 ulcers in patients treated for RU with an average age of 37 years, they stated that the pain decreased considerably and without the need for ingestion of analgesics and antibiotics. Regeneration took place in an average of three days. The NTP proved to be an excellent therapeutic alternative for the treatment of RU since it has a rapid effect of reducing pain and inflammation, as well as adequate tissue regeneration.

(1) Background: This study aims to evaluate the efficacy and safety of non-thermal plasma (NTP) therapy in accelerating wound healing in patients who have undergone laparoscopic and open surgeries. (2) Methods: NTP was applied using a needle-type reactor with an irradiance of 0.5 W/cm2 on the surgical wounds of fifty patients after obtaining informed consent. Three NTP treatments, each lasting three minutes, were administered hourly. (3) Results: The pilot study showed that NTP-treated surgical wounds healed completely without any signs of infection, dehiscence, pain, or itching. Notably, patients reported minimal pain after the NTP treatment. Visual assessments conducted twenty-four hours after surgery revealed no redness or fluid discharge. Comparisons with traditionally sutured wounds indicated that NTP-treated wounds healed at a rate equivalent to seven days. (4) Conclusions: The application of NTP in laparoscopic and open wounds proved safe and effective, expediting the wound healing process and eliminating clinical risks post-surgery. Significantly, NTP facilitated a healing rate within twenty-four hours, equivalent to seven days for suture-treated wounds, significantly reducing the hospitalization time to a single day. These findings highlight the potential of NTP to be a transformative approach for promoting postoperative recovery. [ABSTRACT FROM AUTHOR]

This paper presents a model of the typical dielectric barrier plasma discharge at atmospheric pressure, structured as an equivalent electric circuit whose elements are identified with, and deducted from, the main influential variables of the process, namely, the applied gas, the geometry of the reactor, the breakdown parameters, as well as the power supply associated to the dielectric barrier discharge cell. Considering a parallel-plate reactor and a high-voltage sinusoidal power supply, an electrical comprehensive Simulink/MATLAB model has been developed in order to reveal the interaction between these two elements. The main components of this discharge model are as follows: 1) a double dielectric capacitance; 2) a voltage-controlled current source; and 3) a gas capacitance associated to the ionized gas. A sinusoidal voltage of up to 15 kV peak to peak at frequencies of 12.5 and 47 kHz has been applied to the discharge electrodes. The electrical model is based on the power law proposed by Roth, which defines the V-I behavior during the discharge startup. A series of simulations has been carried out in order to estimate the total current and voltage consumed during each discharge and to identify those parameters which are not measurable during the process. Finally, both the experimental and simulated voltage and current results in helium, argon, and nitrogen, as well as their Q-V graphics, are shown, and a comparison between them is discussed. Index Terms--Dielectric barrier discharge (DBD), voltage-controlled current source, voltage source inverter (VSI).

In this paper, we present a model (which is structured as an equivalent electric circuit whose elements are identified and deducted from the nature of the medium, the ionization and expansion process of the streamers that convey the pre-breakdown current, and the energy associated to the electric breakdown in water) and a simulation of a pulsed corona discharge (PCD). Considering this, a coaxial reactor and an inexpensive and compact high-voltage pulsed-power supply (PPS) system were designed and constructed with the purpose of carrying out the PCD experimentally. The simulation results enable the prediction of the behavior of the discharge. The coaxial reactor is constituted by a cylindrical chamber and a straight central rod. The PPS operates within the 100-2000-Hz repetition rate and 0-30-kV amplitude ranges. All the system has been tested, and the first electrical results, voltage, and current waveforms, are presented. Index Terms--Electric breakdown, plasma applications, plasma generation, power system simulation.

Using as target a CpTi disk in an atmosphere of argon/oxygen and by rf plasma. First titanium dioxide (TiO2) films were obtained on silicon substrates, and subsequently, these films were doped with nitrogen (N-TiO2). In both processes, along four hours at 390°C of temperature. X-Ray diffraction and Raman spectroscopy confirmed the presence of the nanostructured anatase phase. X-ray photoelectron spectroscopy analyzes indicate that the nitrogen atoms were incorporated into the TiO2 film with ~33.9 at%. The films reach a thickness of 1.25 μm and 40 nm the average uniformity determined by using an atomic force microscope. Finally, UV-Vis diffuse reflectance spectroscopy outcome evaluated ones an energy band gap reduction from 3.17 eV to 2.95 eV corresponding to TiO2 films and N-TiO2 films respectively.