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This article discusses the laparoscopic resection of a retrorectal cystic tumor, which is a rare condition that primarily affects women between the ages of 40 and 50. The diagnosis of these tumors is often incidental, with many cases being asymptomatic. Surgical treatment is recommended due to the risk of malignant degeneration. The laparoscopic approach is preferred over robotics as it allows for shorter operating times. The article provides a case study of a 50-year-old woman who underwent laparoscopic excision of a retrorectal cyst, with successful results and no evidence of recurrence after 6 months. [Extracted from the article]

Abstract: Objectives: p53 Gene variants BstUI RFLP at codon 72 in exon 4, 16bp tandem repeat in intron 3 and MspI RFLP in intron 6, which code for two functionally different protein isoforms, have been shown to modulate susceptibility to different types of human neoplasms. Methods: p53 genotype was assessed in 90 CRC patients, 321 age-matched controls and 322 centenarians. Results: The p53 codon 72 arginine, the p53 16bp deletion, and the MspI RFLP were significantly more frequent in CRC patients in comparison to the controls and to the centenarians (odd ratio 1.44 and 1.93). In the CRC group, the BstUI RFLP polymorphism was the more frequent combination (62.2%), and it was significantly associated with highly infiltrating (p <0.01), poorly differentiated (p <0.01), and metastatic (p <0.05) tumours. Our findings indicate that the p53 codon 72 polymorphisms are associated with a higher risk of CRC and are associated with more advanced and undifferentiated tumours. [Copyright &y& Elsevier]

Abstract: Aims: To investigate the survival benefit of extended lymphadenectomy (D2) in EGC patients in one European Institution. Methods: A review was made of our prospective gastric database from January 1980 to December 2001. Of 527 patients with primary gastric adenocarcinoma, 119 with EGC underwent potentially curative resection (R0) with D2 lymphadenectomy. Results: There were two post-operative deaths. Of the 117 evaluable cases, 96 were classified as N0 and 21 as N+, with metastases in the perigastric lymph nodes (level 1) in 13, and beyond this site (level 2) in eight. Five-year survival was 85.9 and 83.0% in N0 and N+ patients, respectively. During a median follow-up of 90 months, five of the eight patients with level 2 metastases died of recurrent disease and three were alive. The estimated survival benefit for 119 patients with EGC was 2.5% (3/119 cases). Conclusions: In patients with EGC, metastases to level 2 are rare. Our results indicate that D2 lymphadenectomy has a limited survival benefit and that in these cases a less extensive lymphadenectomy (D1) could be performed. [Copyright &y& Elsevier]