Search

Your search keyword '"Marie-Helene Andre"' showing total 2 results
Start Over Author "Marie-Helene Andre" Search Limiters Peer Reviewed
2 results on '"Marie-Helene Andre"'

1. Real-world experience with CLAIRYG® 50 mg/mL (intravenous immunoglobulin) in children under 12 years with primary immunodeficiency or immmune thrombocytopenia: a post-approval safety study

Author

Nizar Mahlaoui, Fanny Fouyssac, Françoise Mazingue, Coralie Mallebranche, Malika Barthez-Toullec, Lamia Denti, Kalaivani Ruhier, Marie-Hélène André-Bonnet, Aude Marie-Cardine, Nathalie Aladjidi, and Jean-Louis Stephan

Subjects
immunoglobulin, primary immunodeficiency, Clairyg®, post-approval safety study, real-world experience, pediatrics, Pediatrics, RJ1-570
Abstract

IntroductionThis study presents the results of a real-life, multicenter, prospective, post-approval safety evaluation of Clairyg® 50 mg/mL, a 5% intravenous immunoglobulin (IVIg) liquid, in 59 children (aged

Published
2023
Full Text
View/download PDF

2. Comparison of the immunogenicity of different therapeutic preparations of human factor VIII in the murine model of hemophilia A

Author

Sandrine Delignat, Suryasarathi Dasgupta, Sébastien André, Ana-Maria Navarrete, Srinivas V. Kaveri, Jagadeesh Bayry, Marie-Hélène André, Sami Chtourou, Zéra Tellier, and Sébastien Lacroix-Desmazes

Subjects
Diseases of the blood and blood-forming organs, RC633-647.5
Abstract

Von Willebrand factor (VWF) has been proposed to reduce the immunogenicity of therapeutic factor VIII (FVIII) in patients with hemophilia A. Using FVIII-deficient mice, we compared the immunogenicity of different preparations of plasma-derived (pd) and recombinant (r) FVIII. Treatment of mice with pdFVIII induced significantly lower titers of FVIII inhibitors, as measured by ELISA and in vitro coagulation assays, compared with rFVIII. Furthermore, pre-incubation of rFVIII with excess VWF significantly reduced rFVIII immunogenicity. Our data confirm that pdFVIII induces lower levels of inhibitors than rFVIII, and that VWF is an immuno-chaperone molecule for FVIII.

Published
2007
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results