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The Next Prison Cell: Five Figures Of The Time To Come This contribution takes the famous Prisoner's Dilemma as its starting point in order to think about generational responsibility to futures not yet present. The cell next door, a figure of otherness, is brought back to a temporal figure, defined as the unthought par excellence of the market economy. The movement to move from a thought of spatiality to a reflection on time, thus on duration and sustainability, is articulated in five moments (Marinetti's Manifesto, the Deleuzian reading of Nietzsche, Bergsonian indications of method, Musil's doubts, the action of Pussy Riot), whose role is to guide through the three syntheses of time. In order to move from the total war promoted by futurism to the need to build social horizons capable of duration (cfr. Braidotti, 2017), it is indeed necessary to move from the capitalist paradigm of accumulation to ethical thought, whose field of pertinence does not lay on a spatial perimeter, but is actually time. Only within this field in fact will the concept of vulnerability no longer lead to the paralysis of action, but rather to a thought of sustainability

Abstract Background Prostate stem cell antigen (PSCA) is a glycosylphosphatidylinositol (GPI) anchored protein expressed not only in prostate but also in pancreas and bladder cancer as shown by immunohistochemistry and mRNA analysis. It has been targeted by monoclonal antibodies in preclinical animal models and more recently in a clinical trial in prostate cancer patients. The biological role played in tumor growth is presently unknown. In this report we have characterized the contribution of PSCA expression to tumor growth. Methods A bladder cell line was engineered to express a doxycycline (dox) regulated shRNA against PSCA. To shed light on the PSCA biological role in tumor growth, microarray analysis was carried out as a function of PSCA expression. Expression of gene set of interest was further analyzed by qPCR Results Down regulation of the PSCA expression was associated with reduced cell proliferation in vitro and in vivo. Mice bearing subcutaneous tumors showed a reduced tumor growth upon treatment with dox, which effectively induced shRNA against PSCA as revealed by GFP expression. Pathway analysis of deregulated genes suggests a statistical significant association between PSCA downregulation and activation of genes downstream of the IFNα/β receptor. Conclusions These experiments established for the first time a correlation between the level of PSCA expression and tumor growth and suggest a role of PSCA in counteracting the natural immune response.