1. Determining an infectious or autoimmune etiology in encephalitis
- Author
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Hai Ethan Hoang, Jessica Robinson‐Papp, Lan Mu, Kiran T. Thakur, Jacqueline Sarah Gofshteyn, Carla Kim, Vivian Ssonko, Rachelle Dugue, Eileen Harrigan, Brittany Glassberg, Michael Harmon, Allison Navis, Mu Ji Hwang, Kerry Gao, Helena Yan, Nathalie Jette, and Anusha K. Yeshokumar
- Subjects
Neurosciences. Biological psychiatry. Neuropsychiatry ,RC321-571 ,Neurology. Diseases of the nervous system ,RC346-429 - Abstract
Abstract Objectives Early presentation and workup for acute infectious (IE) and autoimmune encephalitis (AE) are similar. This study aims to identify routine laboratory markers at presentation that are associated with IE or AE. Methods This was a multi‐center retrospective study at three tertiary care hospitals in New York City analyzing demographic and clinical data from patients diagnosed with definitive encephalitis based on a confirmed pathogen and/or autoantibody and established criteria for clinical syndromes. Results Three hundred and thirty‐three individuals with confirmed acute meningoencephalitis were included. An infectious‐nonbacterial (NB) pathogen was identified in 151/333 (45.40%), bacterial pathogen in 95/333 (28.50%), and autoantibody in 87/333 (26.10%). NB encephalitis was differentiated from AE by the presence of fever (NB 62.25%, AE 24.10%; p 1:40; NB 11.54%, AE 32.73%; p
- Published
- 2022
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