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Your search keyword '"Moon JC"' showing total 18 results
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18 results on '"Moon JC"'

1. Myocardial T1 mapping: where are we now and where are we going?

Author

Abdel-Gadir A, Treibel TA, and Moon JC

Subjects
Diseases of the circulatory (Cardiovascular) system, RC666-701
Abstract

Amna Abdel-Gadir,1,2 Thomas A Treibel,1,2 James C Moon1,2 1The Heart Hospital Imaging Centre, University College London Hospitals, London, UK; 2Institute of Cardiovascular Science, University College London, London, UK Abstract: Cardiovascular magnetic resonance offers noninvasive myocardial tissue characterization as a key unique strength over other imaging techniques. In particular T1, a tissue property that alters with disease, has gained prominence as a diagnostic tool. Prior to the administration of contrast, the native T1 changes with a number of processes such as fibrosis, edema, and infiltration. If a post-contrast scan is also acquired, the post-contrast T1 and extracellular volume fraction can be measured. Detecting and quantifying early and established myocardial pathological processes permits better diagnosis, prognostication, and tracking of therapy. Keywords: extracellular volume fraction, diffuse fibrosis, interstitium, cardiac remodeling, myocardial intracellular volume

Published
2014

2. Characterising the myocardial interstitial space: the clinical relevance of non-invasive imaging.

Author

White SK, Sado DM, Flett AS, and Moon JC

Abstract

The myocardial interstitial or extracellular space exists as a complex and dynamic environment, vital for normal cardiac structure and function. The physiological pathways for normal control of collagen turnover, and the pathological development of fibrosis are beginning to be understood, as are their relationships to cardiac remodelling and adverse outcomes. Emerging non-invasive imaging techniques (echocardiography, cardiovascular magnetic resonance, positron emission tomography) may allow a clearer understanding and measurement of these processes in vivo. Preliminary results are exciting, spanning valvular and congenital heart disease, cardiomyopathy and rarer diseases such as amyloid. In this review, such developments and research directions are explored, including the rapid developments in cardiovascular magnetic resonance T1 mapping and its use with contrast to derive extracellular volume. The authors present a state-of-the-art assessment of the strengths and weaknesses of each modality, and distil a framework to equip the reader with an understanding of the technical issues useful for the interpretation of emerging clinical studies. [ABSTRACT FROM AUTHOR]

Published
2012

6. Cardiovascular magnetic resonance in cardiac amyloidosis.

Author

Maceira AM, Joshi J, Prasad SK, Moon JC, Perugini E, Harding I, Sheppard MN, Poole-Wilson PA, Hawkins PN, Pennell DJ, Maceira, Alicia Maria, Joshi, Jayshree, Prasad, Sanjay Kumar, Moon, James Charles, Perugini, Enrica, Harding, Idris, Sheppard, Mary Noelle, Poole-Wilson, Philip Alexander, Hawkins, Philip Nigel, and Pennell, Dudley John

Published
2005
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7. T1 Mapping for Myocardial Extracellular Volume Measurement by CMR Bolus Only Versus Primed Infusion Technique

Author

White, SK, Sado, DM, Fontana, M, Banypersad, SM, Maestrini, V, Flett, AS, Piechnik, SK, Robson, MD, Hausenloy, DJ, Sheikh, AM, Hawkins, PN, and Moon, JC

Subjects
bolus, cardiac imaging techniques, cardiac magnetic resonance, dynamic, ecv, eq-cmr, equilibrium, extracellular space, extracellular volume, fibrosis, infusion, t1 mapping, adult, aged, aged, 80 and over, biopsy, cardiomyopathy, hypertrophic, contrast media, extracellular matrix, female, gadolinium dtpa, humans, magnetic resonance imaging, cine, male, middle aged, myocardium, predictive value of tests, reproducibility of results, young adult, radiology, nuclear medicine and imaging, cardiology and cardiovascular medicine, EQ-CMR, ECV, T1 mapping
Abstract

Objectives: The aim of this study was to determine the accuracy of the contrast "bolus only" T1 mapping cardiac magnetic resonance (CMR) technique for measuring myocardial extracellular volume fraction (ECV). Background: Myocardial ECV can be measured with T1 mapping before and after contrast agent if the contrast agent distribution between blood/myocardium is at equilibrium. Equilibrium distribution can be achieved with a primed contrast infusion (equilibrium contrast-CMR [EQ-CMR]) or might be approximated by the dynamic equilibration achieved by delayed post-bolus measurement. This bolus only approach is highly attractive, but currently limited data support its use. We compared the bolus only technique with 2 independent standards: collagen volume fraction (CVF) from myocardial biopsy in aortic stenosis (AS); and the infusion technique in 5 representative conditions. Methods: One hundred forty-seven subjects were studied: healthy volunteers (n = 50); hypertrophic cardiomyopathy (n = 25); severe AS (n = 22); amyloid (n = 20); and chronic myocardial infarction (n = 30). Bolus only (at 15 min) and infusion ECV measurements were performed and compared. In 18 subjects with severe AS the results were compared with histological CVF. Results: The ECV by both techniques correlated with histological CVF (n = 18, r2 = 0.69, p < 0.01 vs. r2 = 0.71, p < 0.01, p = 0.42 for comparison). Across health and disease, there was strong correlation between the techniques (r2 = 0.97). However, in diseases of high ECV (amyloid, hypertrophic cardiomyopathy late gadolinium enhancement, and infarction), Bland-Altman analysis indicates the bolus only technique has a consistent and increasing offset, giving a higher value for ECVs above 0.4 (mean difference ± limit of agreement for ECV 0.4 = 0.040 ± 0.075, p < 0.001). Conclusions: Bolus only, T1 mapping-derived ECV measurement is sufficient for ECV measurement across a range of cardiac diseases, and this approach is histologically validated in AS. However, when ECV is >0.4, the bolus only technique consistently measures ECV higher compared with infusion. © 2013 American College of Cardiology Foundation. © 2013 By Theamerican College of Cardiology Foundation.

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