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Endoscopic discectomy is a painful surgery yet preferably done under moderate sedation and analgesia as the surgeon requires cooperation and inputs from the patient during the procedure. While prone positioning poses a problem for airway management, light sedation poses a problem for securing the airway if the need arises. Therefore, adequate sedation and analgesia is a challenge for the anesthesiologist. Here, we report the management of four patients who successfully underwent endoscopic discectomy under single-shot lumbar epidural and mild-to-moderate sedation.