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Cardiac amyloidosis（CA） is a rare disease caused by the precipitation of insoluble amyloid proteins in the myocardial extracellular matrix, which can lead to progressive heart failure and various arrhythmias. In this article, the diagnosis and treatment of one case of CA were reported. The patient was mainly manifested as chest distress. After admission, imaging examination, electrocardiogram and echocardiography were highly indicative of CA, which was eventually confirmed by biopsy. This case prompts that clinicians should deepen the understanding of CA, aiming to lower the risk of missed diagnosis and misdiagnosis.

The guided bone regeneration (GBR) technique is the most common and durable approach to repairing bone defects in periodontal surgery. However, membrane exposure causes bacterial infiltration, which lowers the functional integrity of the barrier membrane and destroys bone repair. Here, an antibacterial peptide-modified small intestinal submucosa (SIS) membrane is used as a new GBR membrane for effective bone regeneration. The peptide JH8194 was placed into chitosan microspheres to preserve its stability and allow for sustained release, which realizes rapid and efficient functional modification of the SIS membrane. Biocompatibility and certain antibacterial activities were found in the modified SIS membrane (SIS@CS-JH8194). Additionally, in vitro experiments showed that SIS@CS-JH8194 promoted the expression of osteogenic-related factors and decreased the secretion of inflammatory factors in rat bone mesenchymal stem cells. In vivo experiments showed that SIS@CS-JH8194 could effectively promote bone regeneration in rat skull defects. In this work, we created a new antibacterial GBR membrane to help avoid postoperative infection and improve bone tissue regeneration. [ABSTRACT FROM AUTHOR]

(Background) Precipitation is closely related to human production, life and ecology. The change of precipitation is related to the sustainable utilization of regional water resources, the protection of ecological environment and the development of economy and society, The research on the variation characteristics and evolution trend of precipitation has become a hot topic in the field of climate and water resources. Scholars and researchers has paid much attention on the accurate prediction of precipitation. (Objective) The purpose of this paper is to improve the prediction accuracy of precipitation, and reflect the actual characteristics of precipitation. (Method) Based on the advantages of empirical mode decomposition in the analysis and processing of nonlinear time series and other fields, Empirical Mode Decomposition (EMD) was carried out for the monthly average precipitation data of the Yellow River Delta Meteorological Station from 1954 to 2018, and a series of eigenmode functions were obtained. Hilbert transform was performed on IMF, and on this basis, two multi-scale forecast models of precipitation in the Yellow River Delta were established. (Result) The results showed that there were periods of 9, 13, 23, 76 and 135 months in precipitation in the Yellow River Delta, and 9-month fluctuations were the main ones; The 65-year monthly average precipitation data was predicted. The relative error of the model 1 was between 0.9% and 9.8%, and the relative error of the model 2 was between 1.6% and 11.8%. When modeling, the average prediction error of model 1 without considering the initial phase was 2.70%, and the overall prediction accuracy was better than that of model 2 considering the initial phase. (Conclusion)The fitting accuracy and significance of the two models meet the requirements. [ABSTRACT FROM AUTHOR]

The guided bone regeneration (GBR) technique is the most common and durable approach to repairing bone defects in periodontal surgery. However, membrane exposure causes bacterial infiltration, which lowers the functional integrity of the barrier membrane and destroys bone repair. Here, an antibacterial peptide-modified small intestinal submucosa (SIS) membrane is used as a new GBR membrane for effective bone regeneration. The peptide JH8194 was placed into chitosan microspheres to preserve its stability and allow for sustained release, which realizes rapid and efficient functional modification of the SIS membrane. Biocompatibility and certain antibacterial activities were found in the modified SIS membrane (SIS@CS-JH8194). Additionally, in vitro experiments showed that SIS@CS-JH8194 promoted the expression of osteogenic-related factors and decreased the secretion of inflammatory factors in rat bone mesenchymal stem cells. In vivo experiments showed that SIS@CS-JH8194 could effectively promote bone regeneration in rat skull defects. In this work, we created a new antibacterial GBR membrane to help avoid postoperative infection and improve bone tissue regeneration.

Injectable thermo-sensitive hydrogels composed of small intestinal submucosa (SIS) with exosomes derived from bone marrow mesenchymal stem cells (BMSCs) are desired for bone regeneration. However, poor mechanical properties limit the clinical application of SIS hydrogels. Herein, the mechanical properties of SIS hydrogels incorporated with 3-(3,4-dihydroxyphenyl) propionic acid (CA) are assessed. The results show that the mechanical properties of SIS hydrogels are improved. In addition, the retention and stability of exosomes over time at the defect site are also challenges. Fusion peptides are designed by connecting collagen-binding domines (CBDs) of collagen type I/III with exosomal capture peptides CP05 (CRHSQMTVTSRL) directly or via rigid linkers (EAAAK). In vitro experiments demonstrate that fusion peptides are contribute to promoting the positive effect of exosomes on osteogenic differentiation of BMSCs. Meanwhile, the results of hydrogels combining exosomes and fusion peptides in the treatment of rat skull defect models reveal that fusion peptides could enhance the retention and stability of exosomes, thereby strengthen the therapeutic effect for skull defects. Therefore, SIS hydrogels with CA modified by fusion peptides and exosomes appear to be a promising strategy in bone regenerative medicine., Competing Interests: The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (© 2021 The Authors. Published by Elsevier Ltd.)