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A fibrin-free intraocular lens (IOL) has been developed for hindering secondary cataract. Hydrophilic and hydrophobic micro-domains were alternately generated on the poly(methyl methacrylate) [PMMA] IOL surface with UV photon irradiation. The modified IOL was soaked in aqueous fibrin solution, and the fibrin adsorption was measured by infrared spectroscopy (FT-IR). The results show that the fibrin adsorption on the sample with hydrophilic groups increased, while that on the sample with hydrophobic groups decreased. Moreover, the fibrin adsorption on the sample surface with hydrophilic and hydrophobic micro-domains arranged alternately was reduced to one-fifth of that on the untreated sample. [ABSTRACT FROM AUTHOR]

Poly (tetrafluoroethylene) (PTFE) is a material that causes only a few rejections in a living body but has low tissue affinity. A soft tissue implant material that not only has high biocompatibility but also excellent bondability has been developed by photo-chemically incorporating OH functional groups on the PTFE surface with ArF excimer laser irradiation. Protein adsorption on untreated and treated samples was evaluated by scanning electron microscopy (SEM) and attenuated total reflection Fourier-transform infrared (ATR–FT-IR) spectroscopy, with bovine serum albumin (ALB) and fibrin (FIB) solutions. It has been found that protein adsorption increases with the increase in the OH group density on the PTFE surface. The maximum adsorption of both ALB and FIB was found on the PTFE sample treated with a laser fluence of 20 mJ/cm2 and a shot number of 2000, whose water contact angle was 28 degrees; the quantities of both ALB and FIB adsorbed increased by a factor 2 as compared with untreated sample. [ABSTRACT FROM AUTHOR]