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Skin cancer is the irregular growth of skin cells, which is most often termed as cancer, developed by exposure of ultraviolet rays from sun. In this research paper, deep learning enabled hybrid optimization is followed for skin cancer detection and lesion segmentation. Two optimization algorithms are followed for skin lesion segmentation and cancer detection. Here, pre-processing is done by anisotropic diffusion followed by skin lesion segmentation. Here, Multi-Scale Residual Fusion Network (MSRFNet) is utilized for skin lesion segmentation, which is trained by proposed Average Subtraction Student Psychology Based Optimization (ASSPBO). After skin lesion segmentation, necessary features are extracted, followed by skin cancer detection. Skin cancer is detected by Deep Residual Network (DRN) trained by proposed Fractional ASSPBO (FrASSPBO). Moreover, performance of proposed FrASSPBO-DRN is analysed by three performance metrics like testing accuracy, True Positive Rate (TPR), and False Positive Rate (FPR) with values of 93.4%, 94%, and 8.2%. [ABSTRACT FROM AUTHOR]