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171 results on '"Najafian, Behzad"'

4. A Diverse Spectrum of Immune Complex– and Complement-Mediated Kidney Diseases Is Associated With Mantle Cell Lymphoma

Author

Andeen, Nicole K., Abdulameer, Shahad, Charu, Vivek, Zuckerman, Jonathan E., Troxell, Megan, Kambham, Neeraja, Alpers, Charles E., Najafian, Behzad, Nicosia, Roberto F., Smith, Kelly D., Kung, Vanderlene L., Avasare, Rupali S., Vallurupalli, Anusha, Jefferson, J. Ashley, Hecox, Douglas, Swetnam, Leah, Yamashita, Michifumi, Lin, Mercury, Bissonnette, Mei Lin, Akilesh, Shreeram, and Hou, Jean

Published
2022
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5. Anti-Tubular Basement Membrane Antibody Nephritis Manifesting in a Patient With Chronic Lymphocytic Leukemia: A Very Rare Case Report.

Author

Ebrahimi, Niloufar, Najafian, Behzad, Chen Wongworawat, Yan, Norouzi, Sayna, and Abdipour, Amir

Subjects
CHRONIC kidney failure, CHRONIC lymphocytic leukemia, KIDNEY failure, BASAL lamina, KIDNEY physiology
Abstract

Anti-tubular basement membrane (anti-TBM) antibody nephritis is a rare type of tubulointerstitial nephritis associated with progressive decline in kidney function. It is characterized histopathologically by tubular atrophy and dilation, interstitial fibrosis, lymphocyte and macrophage-predominant cellular infiltration, and linear deposition of IgG and complement along the tubular basement membrane. We herein present a case of a 69-year-old male who was recently diagnosed with chronic lymphocytic leukemia (CLL) and was referred for evaluation of kidney failure, ultimately diagnosed as anti-TBM antibody nephritis progressing into end-stage kidney disease (ESKD). This case report highlights the management challenges of anti-TBM antibody nephritis as a rare kidney disorder. [ABSTRACT FROM AUTHOR]

Published
2024
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12. Lack of IL7Rα expression in T cells is a hallmark of T-cell immunodeficiency in Schimke immuno-osseous dysplasia (SIOD)

Author

Sanyal, Mrinmoy, Morimoto, Marie, Baradaran-Heravi, Alireza, Choi, Kunho, Kambham, Neeraja, Jensen, Kent, Dutt, Suparna, Dionis-Petersen, Kira Y., Liu, Lan Xiang, Felix, Katie, Mayfield, Christy, Dekel, Benjamin, Bokenkamp, Arend, Fryssira, Helen, Guillen-Navarro, Encarna, Lama, Giuliana, Brugnara, Milena, Lücke, Thomas, Olney, Ann Haskins, Hunley, Tracy E., Polat, Ayse Ipek, Yis, Uluc, Bogdanovic, Radovan, Mitrovic, Katarina, Berry, Susan, Najera, Lydia, Najafian, Behzad, Gentile, Mattia, Nur Semerci, C., Tsimaratos, Michel, Lewis, David B., and Boerkoel, Cornelius F.

Published
2015
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49. Renal complications of Fabry disease in children

Author

Najafian, Behzad, Mauer, Michael, Hopkin, Robert J., and Svarstad, Einar

Subjects
Fabry's disease -- Complications and side effects -- Genetic aspects -- Research, Kidney diseases -- Risk factors -- Genetic aspects -- Diagnosis -- Research, Health
Abstract

Fabry disease is an X-linked α-galactosidase A deficiency, resulting in accumulation of glycosphingolipids, especially globotriaosylceramide, in cells in different organs in the body. Renal failure is a serious complication of this disease. Fabry nephropathy lesions are present and progress in childhood while the disease commonly remains silent by routine clinical measures. Early and timely diagnosis of Fabry nephropathy is crucial since late initiation of enzyme replacement therapy may not halt progressive renal dysfunction. This may be challenging due to difficulties in diagnosis of Fabry disease in children and absence of a sensitive noninvasive biomarker of early Fabry nephropathy. Accurate measurement of glomerular filtration rate and regular assessment for proteinuria and microalbuminuria are useful, though not sensitive enough to detect early lesions in the kidney. Recent studies support the value of renal biopsy in providing histological information relevant to kidney function and prognosis, and renal biopsy could potentially be used to guide treatment decisions in young Fabry patients. This review aims to provide an update of the current understanding, challenges, and needs to better approach renal complications of Fabry disease in children. Keywords Fabry * Fabry nephropathy * Pediatrics * Kidney biopsy * Enzyme replacement therapy, Introduction Fabry disease, first described by Johannes Fabry and William Anderson in 1898, is an X-linked α-galactosidase A deficiency which results in the failure to breakdown glycosphingolipids, particularly globotriaosylceramide (abbreviated [...]

Published
2013
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