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Spinal deformity is a condition that has been recognized for many millennia. There have been major advances in the treatment of spinal deformity in recent years and studies outlining new ideas can inspire others to further advance the speciality. The number of citations a paper receives may indicate the influence of that paper. It is therefore important that we evaluate and analyze the most cited works in our field. The aim of this study is to identify the 100 most cited papers relevant to spinal deformity surgery in the literature. A search through the Thomson Reuters Web of ScienceTM for citations related to spinal deformity surgery was performed. The number of citations, mean citation number (total number citations/years since publication), journal, authors, year of publication and country of origin of the top 100 papers was recorded. The top 100 papers were cited a combined 17,646 times, ranging from 453 to 112. The majority of papers originated from the United States (71) and were published in 20 different journals. The decade 1990-1999 was the most prolific, with 36 of the 100 papers published during this time. Papers pertaining to the management of scoliosis (49) were the most common. This study identifies the top 100 most cited papers in the field of spinal deformity surgery. While citation is not a specific marker of the scientific quality of a paper, it is a surrogate for the influence a paper has had on the orthopedic community. This list of papers provides an invaluable resource for both those in training and those actively practicing and involved in the further development of spinal deformity surgery. [ABSTRACT FROM AUTHOR]

Differentiation of oligodendrocyte progenitor cells (OPCs) into mature oligodendrocytes is regulated by the interplay between extrinsic signals and intrinsic epigenetic determinants. In this study, we analyze the effect that the extracellular ligands sonic hedgehog (Shh) and bone morphogenetic protein 4 (BMP4), have on histone acetylation and gene expression in cultured OPCs. Shh treatment favored the progression toward oligodendrocytes by decreasing histone acetylation and inducing peripheral chromatin condensation. BMP4 treatment, in contrast, inhibited the progression toward oligodendrocytes and favored astrogliogenesis by favoring global histone acetylation and retaining euchromatin. Pharmacological treatment or silencing of histone deacetylase 1 (Hdac1) or histone deacetylase 2 (Hdac2) in OPCs did not affect BMP4-dependent astrogliogenesis, while it prevented Shh-induced oligodendrocyte differentiation and favored the expression of astrocytic genes. Transcriptional profiling of treated OPCs, revealed that BMP4-inhibition of oligodendrocyte differentiation was accompanied by increased levels of Wnt (Tbx3) and Notch-target genes (Jag1, Hes1, Hes5, Hey1, and Hey2), decreased recruitment of Hdac and increased histone acetylation at these loci. Similar upregulation of Notch-target genes and increased histone acetylation were observed in the corpus callosum of mice infused with BMP4 during cuprizone-induced demyelination. We conclude that Shh and Bmp4 differentially regulate histone acetylation and chromatin structure in OPCs and that BMP4 acts as a potent inducer of gene expression, including Notch and Wnt target genes, thereby enhancing the crosstalk among signaling pathways that are known to inhibit myelination and repair. [ABSTRACT FROM AUTHOR]

Abstract: The goal of this paper is to use accelerometers as an early detection of restenosis. Restenosis (re-narrowing of the blood vessel) typically occurs within 3-6 months after the implantation of a stent. Finite element modelling of an occluded blood vessel showed that eddies along with an increase in velocity occur around the occlusion. In this paper a wireless accelerometer device was used to detect an occlusion. A human phantom model was used to mimic the wireless transmission capabilities of the system through human muscle ex-vivo. Fast Fourier transform results from the accelerometer showed that a non-occluded blood vessel had significant peaks >15Hz, whereas an occluded blood vessel had peaks <15Hz, which provides a signature template for detecting restenosis. The results of the FEM and human phantom experiments show that an accelerometer sensor is capable of detecting restenosis. [Copyright &y& Elsevier]

The article recommends the actions to be taken in order to improve the terrorist sanctions process of the U.S. Department of Treasury's Office of Foreign Assets Control (OFAC). Under the sanctions regime, OFAC has the power to indefinitely freeze all of a legal person's assets and publicly list it as a financier of terrorism. According to the author, a three-tiered system should be adopted by the Office for sanctioning terrorist financiers. The state of the current terrorist sanctions regime in the country in 2010 is evaluated. The author also argues that the creation of a three-tiered designation system combined with a National Security Sanctions Court (NSSC) will greatly improve the terrorism sanctions program of OFAC.