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4. Low-energy radioisotope beam separator CRIB

Author

Yanagisawa, Y., Kubono, S., Teranishi, T., Ue, K., Michimasa, S., Notani, M., He, J.J., Ohshiro, Y., Shimoura, S., Watanabe, S., Yamazaki, N., Iwasaki, H., Kato, S., Kishida, T., Morikawa, T., and Mizoi, Y.

Published
2005
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9. Activation of vascular protein kinase C-beta inhibits Akt-dependent endothelial nitric oxide synthase function in obesity-associated insulin resistance.

Author

Naruse K, Rask-Madsen C, Takahara N, Ha S, Suzuma K, Way KJ, Jacobs JRC, Clermont AC, Ueki K, Ohshiro Y, Zhang J, Goldfine AB, King GL, Naruse, Keiko, Rask-Madsen, Christian, Takahara, Noriko, Ha, Sung-woo, Suzuma, Kiyoshi, Way, Kerrie J, and Jacobs, Judith R C

Abstract

Activation of protein kinase C (PKC) in vascular tissue is associated with endothelial dysfunction and insulin resistance. However, the effect of vascular PKC activation on insulin-stimulated endothelial nitric oxide (NO) synthase (eNOS) regulation has not been characterized in obesity-associated insulin resistance. Diacylglycerol (DAG) concentration and PKC activity were increased in the aorta of Zucker fatty compared with Zucker lean rats. Insulin-stimulated increases in Akt phosphorylation and cGMP concentration (a measure of NO bioavailability) after euglycemic-hyperinsulinemic clamp were blunted in the aorta of fatty compared with lean rats but were partly normalized after 2 weeks of treatment with the PKCbeta inhibitor ruboxistaurin (LY333531). In endothelial cell culture, overexpression of PKCbeta1 and -beta2, but not PKCalpha, -delta, or -zeta, decreased insulin-stimulated Akt phosphorylation and eNOS expression. Overexpression of PKCbeta1 and -beta2, but not PKCalpha or -delta, also decreased Akt phosphorylation stimulated by vascular endothelial growth factor (VEGF). In microvessels isolated from transgenic mice overexpressing PKCbeta2 only in vascular cells, Akt phosphorylation stimulated by insulin was decreased compared with wild-type mice. Thus, activation of PKCbeta in endothelial cells and vascular tissue inhibits Akt activation by insulin and VEGF, inhibits Akt-dependent eNOS regulation by insulin, and causes endothelial dysfunction in obesity-associated insulin resistance. [ABSTRACT FROM AUTHOR]

Published
2006
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14. Production of beams from solid materials at Center for Nuclear Study electron cyclotron resonance ion source.

Author

Ohshiro, Y., Yamaka, S., Watanabe, S., Kobayashi, K., Kotaka, Y., Nishimura, M., Kase, M., Muto, H., Yamaguchi, H., and Shimoura, S.

Subjects
ION sources, NUCLEAR physics instruments, HEAVY ions, ION beams, CYCLOTRONS
Abstract

Two methods for the feed of vapor from solid materials in the Center for Nuclear Study ECR ion source are described. A rod placed near the wall of the plasma chamber, operating up to a melting point of 2600 °C, has been used for CaO, SiO2, and FeO. An oven with a number of openings, operating up to 800 °C, has been used for P2O5, Li, and S. Typical ion beam intensities of 7Li2+, 6Li3+, 40Ca12+, and 56Fe15+ are achieved 280, 75, 28, and 7 eμA, respectively. High intensity heavy ion beams are stably supplied into the azimuthally varying field cyclotron. [ABSTRACT FROM AUTHOR]

Published
2014
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15. Manufacture of a compact Ku-band electron cyclotron resonance ion source with two resonance zones and variable frequency.

Author

Tojyo, E., Ohshiro, Y., Jeong, S. C., Kawakami, H., Niki, K., Hattori, T., Shirakabe, Y., Imanishi, A., and Oyaizu, M.

Subjects
ELECTRON cyclotron resonance sources, PLASMA confinement, MICROWAVES
Abstract

Describes the manufacture of a compact Ku-band electron cyclotron resonance ion source with resonance zones and variable frequency. Use of permanent magnets for Bernstein minimum field configuration; Formation of a second Bernstein zone in the plasma chamber; Injection of the microwave power from axial and radial ports.

Published
1998
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16. Development of the National Institute of Radiological Sciences electron cyclotron resonance ion source for the heavy ion medical accelerator in Chiba.

Author

Kitagawa, A., Yamada, S., Kohno, T., Murakami, T., Muramatsu, M., Noda, K., Ogawa, H., Sato, Y., Yamada, T., Yoshizawa, J., Fu, S., Sekiguchi, M., Ohshiro, Y., Hattori, T., Shibuya, S., Matsushita, H., Sawada, K., and Morishita, O.

Subjects
ELECTRON cyclotron resonance sources, ION sources, HEAVY ions
Abstract

The development of an electron cyclotron resonance ion source for the heavy ion medical accelerator in Chiba (HIMAC) injector is reported. The HIMAC is a heavy ion medical accelerator for cancer therapy. The electron cyclotron resonance (ECR) ion source is expected to provide a long lifetime, easy operation, and easy maintenance for medical use. The NIRS-ECR ion source has a single closed ECR stage, and a microwave frequency of 10 GHz is applied. Under the present performance, the output electrical currents of the ions are 2500 eµA for He[sup 1+], 300 eµA for C[sup 2+], 480 eµA for Ne[sup 3+], and 110 eµA for Ar[sup 6+]. Stability of the intensity is better than 2%. The transmission efficiency through a low-energy beam-transport line with an acceptance of 200 πmm mrad is more than 70%; the typical 50% and 90% emittances of the injection beam with 8 keV/u are 20 and 80 πmm mrad, respectively. These performances satisfy the requirements for radiotherapy. [ABSTRACT FROM AUTHOR]

Published
1994
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