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Akshiv Malhotra,1 Arun Sendilnathan,1 Matthew O Old,2 Trisha M Wise-Draper11Division of Hematology-Oncology, Department of Internal Medicine, University of Cincinnati, Cincinnati, 2Department of Otolaryngology-Head and Neck Surgery, Ohio State University, Columbus, OH, USAAbstract: Head and neck cancer (HNC) is the sixth most common malignancy worldwide. Despite recent advancements in surgical, chemotherapy, and radiation treatments, HNC remains a highly morbid and fatal disease. Unlike many other cancers, local control rather than systemic control is important for HNC survival. Therefore, novel local therapy in addition to systemic therapy is urgently needed. Oncolytic virotherapy holds promise in this regard as viruses can be injected intratumorally as well as intravenously with excellent safety profiles. This review will discuss the recent advancements in oncolytic virotherapy, highlighting some of the most promising candidates and modifications to date.Keywords: head and neck cancer, virotherapy, oncolytic viruses