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Background: The aim of this study was to compare noise sensitivity (NS) in schizophrenic individuals with/without hallucinations and healthy individuals. Procedure: A retrospective (causal–comparative) study was conducted in three groups: (i) A group of individuals with schizophrenia and auditory hallucinations (14 participants), (ii) a group of schizophrenic individuals without auditory hallucinations (14 participants) selected by purposive sampling and (iii) a control group (19 participants) selected by convenience sampling. Schutte’s Noise Sensitivity Questionnaire was used to measure NS. Analysis of Variance and Kruskal–Wallis tests were applied to compare the three groups. All the analyses were done using SPSS-20. Results: ANOVA results indicated that the groups were significantly different in terms of NS (p

Some psychiatric disorders are mostly overlapping and measures for facilitating differential profiles play a key role in the identification of a disease, course, prognosis, and management. This systematic review and meta-analysis aimed to (i) explore the association between the components of temperament and character model and three overlap psychiatric diagnoses including avoidant personality disorder (APD), schizoid personality disorder (SPD), and social anxiety disorder (SAD) and (ii) provide differential profiles for each of these disorders. The literature search was performed on 7 international scientific databases for all articles published in English, January 1990-June 2019. The pooled effect sizes were obtained using the correlation coefficients or the standardized mean differences between cases with SAD and healthy controls by the random-effects method. Fifteen correlational studies for APD and SPD and eight case–control studies for SAD met the criteria for entering meta-analysis. All three disorders were positively associated with harm avoidance (HA) and negatively associated with novelty seeking (NS), self-directedness (SD), and cooperativeness. APD and SPD were also negatively associated with reward dependence (RD). The differential profiles are as follows: NS (APD < SAD), HA (APD > SPD, SAD), RD (SPD < APD < SAD), SD (APD < SPD, SAD), cooperativeness (APD, SPD < SAD), and self-transcendence (ST: APD > SPD, SAD). It seems that HA, SD, and cooperativeness are the common core of these three diagnostic categories. More extreme tendencies in NS and RD, along with ST with a lower possibility, are the main traits in the differential profiles.

Background and Objectives: Schizophrenia is one of the most severe psychiatric disorders that has a recurrent nature. Frequent relapses have destructive impacts on patient’s thoughts, behaviors and relationships. These can lead to disruption of personal and social performance of patient. The aim of this study was to identify risk factors for increasing the number of relapses. Methods: In this retrospective cohort study, data from medical records of individuals with SSD who were admitted at least once to Farabi Hospital between 2015 and 2019 years extracted. To determine factors related to recurrence of Schizophrenia, Univariate and multivariate analysis and multivariate Poisson Regression were performed respectively. Analysis was done using STATA 14.1. Results: Based on extracted data from 401 medical records, 255 (63.6%) were males and 146 (36.4%) were females. A total of 1105 relapse were observed in males with 683 cases, and females with 422 cases. 65 patient experienced relapse from 5 to 11 times. Among considered variables, Employment status (RR=0.85, P-value=0.043), age (RR=0.99, P-value=0.03), Mode of Onset (RR=0.78, P-value=0.027) and Medication Adherence (RR=1.67, P

Background and Objectives: Almost by default, people with major depression disorder (MDD) also report sexual health issues. This holds even more true when sexual dysfunctions are SSRI-induced. Herbal compounds may have the power to counterbalance such sexual dysfunctions, though research is still scarce. Therefore, we assessed females with diagnosed MDD treated with a standard SSRI (sertraline) and reporting SSRI-induced sexual dysfunctions, and we asked whether compared to placebo, Aphrodite (a blend of ginger, saffron, cinnamon, thistle, and Tribulus terrestris) may favorably impact on sexual dysfunctions, and on symptoms of depression, anxiety, and sleep disturbances. Materials and Methods: A total of 41 females (mean age: 35.05 years) with diagnosed MDD, treated with sertraline (a standard SSRI) at therapeutic dosages, and reporting SSRI-induced sexual dysfunction, were randomly assigned either to Aphrodite or to the placebo condition. At baseline and four and eight weeks later (study end), participants completed a series of self-rating questionnaires covering symptoms of sexual dysfunction, depression, anxiety, and sleep complaints. Results: Symptoms of sexual dysfunction, depression, and anxiety decreased over time, but more so in the Aphrodite condition, compared to the placebo condition (significant p-values and large effect sizes). Over time, sleep disturbances decreased irrespective of the study condition. Conclusions: The pattern of results suggests that compared to placebo, Aphrodite appeared to improve symptoms of sexual dysfunction, depression, and anxiety among females with diagnosed MDD and SSRI-induced sexual dysfunction. Further and similar studies should investigate the underlying psychophysiological mechanisms.

Abstract Introduction Depression is one of the most important psychiatric disorders, and the rate of recurrence is high. The heavy cost burden of depression is probably due to treatment-resistant depression. The purpose of this study was to determine the effectiveness of mindfulness-based cognitive therapy (MBCT) in patients with treatment-resistant depression (TRD). Method The present study was a quasi-experimental study conducted with twenty-four patients with treatment-resistant depression. Participants were selected by purposive sampling and randomly assigned to two groups, an experimental group and a control group. The experimental group received MBCT and antidepressants, while the control group received antidepressants only. The Hamilton and Beck Depression Inventory, Self-Compassion Scale, Thought Rumination Scale, and Mindfulness Scale were administered. The treatment program was conducted in eight sessions; with a follow-up period of one month subsequent to treatment termination. Data were analyzed using descriptive statistics (mean and standard deviation) and inferential statistics (analysis of variance for repeated measures and Bonferroni’s post-hoc test). Results The results showed that MBCT significantly reduced depression and ruminative thinking in the experimental group and also improved mediators such as mindfulness and self-compassion. Patients maintained gains over the one month follow-up period (p < 0.01). Conclusion The present study provides additional evidence for the effectiveness of MBCT for TRD.

Bipolar disorder (BD) is a severe psychiatric disorder and among the leading causes of disability worldwide that has a significant genetic component with high heritability. The prognosis for BD patients remains poor because of the lack of reliable biomarkers and also pathogenesis and diagnostic methods remain limited. The purpose of this study was the elucidation potential candidate hub miRNAs related to BD. We searched the gene and miRNA expression patterns of BD from five expression arrays (GSE74358, GSE69486, GSE12654, GSE46416 for gene expression, and GSE152267 for miRNA expression) from the Gene Expression Omnibus (GEO) database to recognize differentially expressed genes (DEGs) and differentially expressed miRNAs (DEMs) between normal and BD samples. Using limma package, 87 DEGs were identified and Enrichment analysis for identified genes was performed. Due to more validation of DEGs, their expression was evaluated by 8 independent expression arrays including GSE12649, GSE23848, GSE39653, GSE46449, GSE5388, GSE5389, GSE53987, and GSE62191. By merging DEMs and DEGs, miRNA-mRNA network was constructed. After elucidation of hub miRNAs, the ability of detected miRNAs to discriminate BD from healthy controls was assessed by area under the curve (AUC) using the ROC curve analysis. Furthermore, RT-qPCR on 50 BD samples and 50 healthy controls was performed to validate the in silico results. Our results showed that hsa-miR-19b-3p and hsa-miR-23b-3P could be potential biomarkers of BD.

According to Daniel McAdams’s (2004) modern developments in Erikson’s traditional standpoint, the Developmental Task of Middle Age is The Equilibrium between Generativity and Stagnation. In the current study, the relationship between the Big Five Personality Traits and Personality Development in Middle age (Generativity - Stagnation) has been investigated. It has also been attempted to study the contribution of these Big Five Personality Traits in the prediction of Generativity and Stagnation. The sample includes 300 people (include 150 male and 150 female) have been chosen from among Education Ministry Offices of Hamedan selected by multiple-stage Cluster Sampling method. Loyola Generativity Scale (LGS) (1992) and Bradley Based Stagnation Scale (BBS) (1997) and brief form of Neo Personality Inventory (NEO) (1992) were used for data gathering. For data analysis, Pearson correlation and Regression were used. The results of correlation analysis indicated that there was a negative relation between the personality trait of “Neuroticism” and “Generativity” (P

BACKGROUND: Irritable bowel syndrome (IBS) is one of the most common gastrointestinal diseases, and obsessive–compulsive disorder (OCD) is one of the main causes of this disease. The present study was aimed to investigate the prevalence of OCD in patients with IBS. MATERIALS AND METHODS: The present research is a cross-sectional survey study. The research sample included 120 patients with IBS who referred to Imam Reza Hospital and gastrointestinal clinics in Kermanshah (Iran) in the 3 months of April, May, July in 2019 that were selected using the census sampling method, and demographic information, clinical and medical records were collected. Data analysis was performed using frequency, percentage, and Chi-square. RESULTS: Among the patients who were studied, 58 of them (48.3%) were women and 62 (51.7%) were men, the results showed that the prevalence of OCD in patients with IBS was 14.96 and the symptoms of washing, checking, skepticism and slowness-repetition had the highest prevalence, respectively. These symptoms were more common in women than in men. There was also a significant relation between OCD prevalence in patients with IBS and with female gender, age-range 30–21 years, single, and history of OCD in the patient's immediate family and close relatives (P < 0.05), but there was no significant relationship between OCD prevalence in patients with IBS and level of education, occupation, income status, and place of residence CONCLUSION: Due to the high prevalence of OCD in patients with IBS, the interaction of gastroenterologists and psychiatrists to treat irritable bowel syndrome is very important.

INTRODUCTION: Given the close relationship between life style and mental health and the importance of students as valuable human resources, the present study aimed at determining the relationship between life style and mental health among medical students in Kermanshah. METHODS: This is a descriptive-correlational study that was conducted in 2018. The study involved 200 medical students. The sampling method was convenience sampling. Demographic questionnaire, general health questionnaire, and life style questionnaire were used for data collection. The data were analyzed Pearson's correlation test and regression analysis. The significance level was considered 0.05. RESULTS: The mean mental health score of the students was 25.43 ± 13.02 (2 points higher than the cutoff point of this test). The life style of 59.5 students was moderate. The results showed that all life style subscales had a negative significant relationship with the total mental health score and all its subscales (P < 0.05). Among the life style subscales, the highest relationship and predictive power to mental health were obtained for psychological health, social health, sport and fitness, and environmental health (R2 = 0.48, P < 0.001). CONCLUSION: According to the results, the life style of most medical students in the final year of Kermanshah University of Medical Sciences was moderate. Further, the students had a better life style, and they had higher mental health. Therefore, considering the vital role of medical students in providing and promoting community health, the need for more detailed planning and interventions to improve their life style and mental health is essential.

Objective: Risk of depression is particularly high for women during the prenatal period. Various investigators have attempted to establish a link between thyroid function and post partum depression. This study aimed to investigate whether thyroid function differs in women with postpartum depression compared to a control group.Methods: In this case-control study, subjects were selected from Obstetrics & Gynecology and Psychiatric clinics of Kermanshah University of Medical Sciences. Forty eight patients suffering from postpartum depression according to Diagnostic and Statistical Manual of Mental Disorders, fourth edition totally revised (DSM-IV-TR), and 65 normal controls underwent diagnostic evaluation by one trained psychiatrist using Structured Clinical Interview for DSM-IV-TR. Then, the demographic questionnaire and the Persian version of Edinburgh Postnatal Depression Scale (EPDS) were completed by the participants. Finally, their thyroid functions were assessed. Data analyses were done using the SPSS program 13.Results: No statistically significant differences were observed between thyroid function tests and postpartum depression. According to multiple regression analysis with stepwise method, subjects with lower serum TSH, T3RU, T3 levels, younger age and longer period after delivery tended to have higher EPDS scores (P-value=0.008). Conclusion:The present study reports that those women with postpartum depression had a no greater prevalence of thyroid dysfunction than the control subjects. It seems that thyroid dysfunction should be considered in women with postpartum depression individually, but the role of thyroid as an important cause of this condition is not yet established. This suggests that future studies should concentrate on this concept in postpartum depression.

Objective: Risk of depression is particularly high for women during the prenatal period. Various investigators have attempted to establish a link between thyroid function and post partum depression. This study aimed to investigate whether thyroid function differs in women with postpartum depression compared to a control group. Methods: In this case-control study, subjects were selected from Obstetrics & Gynecology and Psychiatric clinics of Kermanshah University of Medical Sciences. Forty eight patients suffering from postpartum depression according to Diagnostic and Statistical Manual of Mental Disorders, fourth edition totally revised (DSM-IV-TR), and 65 normal controls underwent diagnostic evaluation by one trained psychiatrist using Structured Clinical Interview for DSM-IV-TR. Then, the demographic questionnaire and the Persian version of Edinburgh Postnatal Depression Scale (EPDS) were completed by the participants. Finally, their thyroid functions were assessed. Data analyses were done using the SPSS pr gram 13. Results: No statistically significant differences were observed between thyroid function tests and postpartum depression. According to multiple regression analysis with stepwise method, subjects with lower serum TSH, T3RU, T3 levels, younger age and longer period after delivery tended to have higher EPDS scores (P-value=0.008). Conclusion:The present study reports that those women with postpartum depression had a no greater prevalence of thyroid dysfunction than the control subjects. It seems that thyroid dysfunction should be considered in women with postpartum depression individually, but the role of thyroid as an important cause of this condition is not yet established. This suggests that future studies should concentrate on this concept in postpartum depression.