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6. Transmission characteristics in Tuberculosis by WGS: nationwide cross-sectional surveillance in China

Author

Liu, Dongxin, primary, Huang, Fei, additional, Li, Yaru, additional, Mao, Lingfeng, additional, He, Wencong, additional, Wu, Sihao, additional, Xia, Hui, additional, He, Ping, additional, Zheng, Huiwen, additional, Zhou, Yang, additional, Zhao, Bing, additional, Ou, Xichao, additional, Song, Yuanyuan, additional, Song, Zexuan, additional, Mei, Li, additional, Liu, Li, additional, Zhang, Guoliang, additional, Wei, Qiang, additional, and Zhao, Yanlin, additional

Published
2024
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7. Impact of MSMEG5257 Deletion on Mycolicibacterium smegmatis Growth

Author

He, Ping, primary, Zhao, Bing, additional, He, Wencong, additional, Song, Zexuan, additional, Pei, Shaojun, additional, Liu, Dongxin, additional, Xia, Hui, additional, Wang, Shengfen, additional, Ou, Xichao, additional, Zheng, Yang, additional, Zhou, Yang, additional, Song, Yuanyuan, additional, Wang, Yiting, additional, Cao, Xiaolong, additional, Xing, Ruida, additional, and Zhao, Yanlin, additional

Published
2024
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8. Association of lineage 4.2.2 of Mycobacterium tuberculosis with the 63-bp deletion variant of the mpt64 gene

Author

Song, Zexuan, primary, He, Wencong, additional, Pei, Shaojun, additional, Zhao, Bing, additional, Cao, Xiaolong, additional, Wang, Yiting, additional, He, Ping, additional, Liu, Dongxin, additional, Ma, Aijing, additional, Ou, Xichao, additional, Xia, Hui, additional, Wang, Shengfen, additional, Liu, Chunfa, additional, and Zhao, Yanlin, additional

Published
2023
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11. Insight into the drug-resistant characteristics and genetic diversity of multidrug-resistant Mycobacterium tuberculosis in China

Author

Song, Zexuan, primary, Liu, Chunfa, additional, He, Wencong, additional, Pei, Shaojun, additional, Liu, Dongxin, additional, Cao, Xiaolong, additional, Wang, Yiting, additional, He, Ping, additional, Zhao, Bing, additional, Ou, Xichao, additional, Xia, Hui, additional, Wang, Shengfen, additional, and Zhao, Yanlin, additional

Published
2023
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13. Proficiency testing for drug susceptibility testing of Mycobacterium tuberculosiscomplex using commercial broth microdilution plate in China in 2021

Author

Xia, Hui, Song, Yuanyuan, Zheng, Yang, Zhou, Yang, Ou, Xichao, Wang, Shengfen, Zhao, Bing, and Zhao, Yanlin

Abstract

•The drug layout and operation procedures varied between studied BMD plates.•Performance differed between types of plate and drugs.•Proficiency of laboratory staff may affect the performance.

Published
2024
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16. Endogenous relapse and exogenous reinfection in recurrent pulmonary tuberculosis: A retrospective study revealed by whole genome sequencing

Author

He, Wencong, primary, Tan, Yunhong, additional, Song, Zexuan, additional, Liu, Binbin, additional, Wang, Yiting, additional, He, Ping, additional, Xia, Hui, additional, Huang, Fei, additional, Liu, Chunfa, additional, Zheng, Huiwen, additional, Pei, Shaojun, additional, Liu, Dongxin, additional, Ma, Aijing, additional, Cao, Xiaolong, additional, Zhao, Bing, additional, Ou, Xichao, additional, Wang, Shengfen, additional, and Zhao, Yanlin, additional

Published
2023
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22. Whole-genome sequencing for surveillance of tuberculosis drug resistance and determination of resistance level in China

Author

Liu, Dongxin, primary, Huang, Fei, additional, Zhang, Guoliang, additional, He, Wencong, additional, Ou, Xichao, additional, He, Ping, additional, Zhao, Bing, additional, Zhu, Baoli, additional, Liu, Fei, additional, Li, Zhiyuan, additional, Liu, Chunfa, additional, Xia, Hui, additional, Wang, Shengfen, additional, Zhou, Yang, additional, Walker, Timothy M., additional, Liu, Lei, additional, Crook, Derrick W., additional, and Zhao, Yanlin, additional

Published
2022
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25. Drug-Resistant Characteristics, Genetic Diversity, and Transmission Dynamics of Rifampicin-Resistant Mycobacterium tuberculosis in Hunan, China, Revealed by Whole-Genome Sequencing

Author

He, Wencong, primary, Tan, Yunhong, additional, Liu, Chunfa, additional, Wang, Yiting, additional, He, Ping, additional, Song, Zexuan, additional, Liu, Dongxin, additional, Zheng, Huiwen, additional, Ma, Aijing, additional, Zhao, Bing, additional, Ou, Xichao, additional, Xia, Hui, additional, Wang, Shengfen, additional, and Zhao, Yanlin, additional

Published
2022
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26. Strong Increase in Moxifloxacin Resistance Rate among Multidrug-Resistant Mycobacterium tuberculosis Isolates in China, 2007 to 2013

Author

Xia, Hui, Zheng, Yang, Liu, Dongxin, Wang, Shengfen, He, WenCong, Zhao, Bing, Song, Yuanyuan, Ou, Xichao, Zhou, Yang, van den Hof, Susan, Cobelens, Frank, and Zhao, Yanlin

Subjects
resistance, moxifloxacin, multidrug-resistant tuberculosis
Abstract

We designed this study to determine the trend of moxifloxacin resistance among multidrug-resistant tuberculosis (MDR-TB) patients from 2007 to 2013 in China to inform the composition of multidrug-resistant/rifampicin-resistant tuberculosis (MDR/RR-TB) treatment regimens. We assessed moxifloxacin resistance among MDR-TB isolates collected in national drug resistance surveys in 2007 and 2013 that included 3,634 smear-positive and 7,206 culture-positive pulmonary tuberculosis patients, respectively. Moxifloxacin susceptibility was examined by a Mycobacterium growth indicator tube (MGIT) 960 for the 2007 isolates, and by the minimum inhibitory concentration (MIC) method for the 2013 isolates, at both breakpoints 0.5 and 2.0 μg/mL. Risk factors were explored through multivariable log-binominal regression analysis. Mutations in gyrA and gyrB for part of the isolates were also studied through sequencing. Of 401 MDR strains isolated in 2007, moxifiloxacin resistance could be determined for 319 (79.6%): 41 (12.9%) and 10 (3.1%) were resistant at 0.5 and 2.0 μg/mL, respectively. Of 365 MDR strains isolated in 2013, 338 (92.6%) could be analyzed: 140 (41.4%) and 79 (23.4%) were resistant at 0.5 and 2.0 μg/mL. For patients in 2007, no characteristics were significantly associated with moxifloxacin resistance. For patients in 2013, patients aged ≥60 years (adjusted prevalence ratio [aPR], 1.46; 95% confidence interval [CI], 1.10 to 1.93) were more likely to have resistance at 0.5 μg/mL, whereas those residing in eastern China compared to those in central China had an increased risk of resistance at both 0.5 (aPR, 1.85; 95% CI, 1.38 to 2.48) and 2.0 μg/mL (aPR, 2.14; 95% CI, 1.35 to 3.40). Sequencing results were obtained for 245 and 266 MDR-TB isolates in 2007 and 2013, respectively. In total, 34 of 38 (89.5%) and 89 of 104 (85.6%) of 2007 and 2013 moxifloxacin-resistant (0.5 μg/mL) MDR-TB strains had mutations in the gyrA and gyrB gene, respectively. Asp94Gly was the most common mutation among 2007 (11 of 38, 28.9%) and 2013 isolates (24 of 104, 23.1%) and conferred high-level moxifloxacin resistance. Moxifloxacin resistance among MDR-TB patients in China increased from modest to high from 2007 to 2013. Moxifloxacin should be used carefully as a potentially effective drug for composing MDR/RR-TB regimens especially for elderly patients in China. Individual susceptibility testing especially rapid molecular-based assays should be conducted to confirm the susceptibility to moxifloxacin. IMPORTANCE China is one of the high-burden countries for multidrug-resistant/rifampicin-resistant tuberculosis (MDR/RR-TB). Moxifloxacin is one of the critical antituberculosis drugs for MDR/RR-TB treatment. Susceptibility to moxifloxacin is therefore very important to compose effective regimens and to provide protection against development of resistance of companion drugs such as bedaquiline and linezolid. There are, however, no nationally representative data on moxifloxacin resistance among MDR/RR-TB cases in China. Therefore, we assessed the resistance prevalence for moxifloxacin among MDR-TB strains isolated in national drug resistance surveys in 2007 and 2013 that covered 72 sites around the country. We demonstrate that the prevalence of moxifloxacin resistance in MDR-TB isolates increased from modest to high, which should prompt the national tuberculosis program to use moxifloxacin cautiously in second-line regimens to treat MDR/RR-TB unless susceptibility can be laboratory-confirmed.

Published
2021

27. Strong Increase in Moxifloxacin Resistance Rate among Multidrug-Resistant Mycobacterium tuberculosis Isolates in China, 2007 to 2013

Author

Xia, Hui, primary, Zheng, Yang, additional, Liu, Dongxin, additional, Wang, Shengfen, additional, He, WenCong, additional, Zhao, Bing, additional, Song, Yuanyuan, additional, Ou, Xichao, additional, Zhou, Yang, additional, van den Hof, Susan, additional, Cobelens, Frank, additional, and Zhao, YanLin, additional

Published
2021
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31. Whole Genome Sequencing for Surveillance of Tuberculosis Drug Resistance in China: Based on a Cross-Sectional Surveillance Study

Author

Liu, Dongxin, primary, Huang, Fei, additional, Zhang, Guoliang, additional, He, Wencong, additional, Walker, Timothy M., additional, Ou, Xichao, additional, He, Ping, additional, Zhao, Bing, additional, Zhu, Baoli, additional, Liu, Fei, additional, Li, Zhiyuan, additional, Liu, Chunfa, additional, Xia, Hui, additional, Wang, Shengfen, additional, Zhou, Yang, additional, Liu, Lei, additional, Crook, Derrick W., additional, and Zhao, Yanlin, additional

Published
2021
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33. Non-Tuberculous Mycobacterial Pulmonary Disease Prevalence Status in China

Author

Liu, Chunfa, primary, Song, Yimeng, additional, He, Wencong, additional, Liu, Dongxin, additional, He, Ping, additional, Bao, Jingjing, additional, Wang, Xinyang, additional, Ou, Xichao, additional, Zhao, Bing, additional, Fan, Jiale, additional, Cheng, Qian, additional, Zhou, Yang, additional, Song, Yuanyuan, additional, Zheng, Yang, additional, Xia, Hui, additional, Wang, Shengfen, additional, Li, Yanming, additional, and Zhao, Yanlin, additional

Published
2020
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38. Association between genotype and drug resistance profiles of Mycobacterium tuberculosis strains circulating in China in a national drug resistance survey

Author

Zhou, Yang, primary, van den Hof, Susan, additional, Wang, Shengfen, additional, Pang, Yu, additional, Zhao, Bing, additional, Xia, Hui, additional, Anthony, Richard, additional, Ou, Xichao, additional, Li, Qiang, additional, Zheng, Yang, additional, Song, Yuanyuan, additional, Zhao, Yanlin, additional, and van Soolingen, Dick, additional

Published
2017
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40. Multicenter evaluation of a real-time loop-mediated isothermal amplification (RealAmp) test for rapid diagnosis of Mycobacterium tuberculosis

Author

Ou, Xichao, primary, Wang, Shengfen, additional, Dong, Haiyan, additional, Pang, Yu, additional, Li, Qiang, additional, Xia, Hui, additional, Qu, Yan, additional, Zhang, Zhiying, additional, Li, Junchen, additional, Zhang, Jack, additional, Huan, Shitong, additional, Chin, Daniel P., additional, and Zhao, Yanlin, additional

Published
2016
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41. Rapid diagnosis of MDR and XDR tuberculosis with the MeltPro TB assay in China

Author

Pang, Yu, primary, Dong, Haiyan, additional, Tan, Yaoju, additional, Deng, Yunfeng, additional, Cai, Xingshan, additional, Jing, Hui, additional, Xia, Hui, additional, Li, Qiang, additional, Ou, Xichao, additional, Su, Biyi, additional, Li, Xuezheng, additional, Zhang, Zhiying, additional, Li, Junchen, additional, Zhang, Jiankang, additional, Huan, Shitong, additional, and Zhao, Yanlin, additional

Published
2016
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43. A feasibility study of the Xpert MTB/RIF test at the peripheral level laboratory in China

Author

Ou, Xichao, primary, Xia, Hui, additional, Li, Qiang, additional, Pang, Yu, additional, Wang, Shengfen, additional, Zhao, Bing, additional, Song, Yuanyuan, additional, Zhou, Yang, additional, Zheng, Yang, additional, Zhang, Zhijian, additional, Zhang, Zhiying, additional, Li, Junchen, additional, Dong, Haiyan, additional, Chi, Junying, additional, Zhang, Jack, additional, Kam, Kai Man, additional, Huan, Shitong, additional, Jun, Yue, additional, Chin, Daniel P., additional, and Zhao, Yanlin, additional

Published
2015
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45. Diagnostic Accuracy of the PURE-LAMP Test for Pulmonary Tuberculosis at the County-Level Laboratory in China

Author

Ou, Xichao, primary, Li, Qiang, additional, Xia, Hui, additional, Pang, Yu, additional, Wang, Shengfen, additional, Zhao, Bing, additional, Song, Yuanyuan, additional, Zhou, Yang, additional, Zheng, Yang, additional, Zhang, Zhijian, additional, Zhang, Zhiying, additional, Li, Junchen, additional, Dong, Haiyan, additional, Zhang, Jack, additional, Kam, Kai Man, additional, Chi, Junying, additional, Huan, Shitong, additional, Chin, Daniel P., additional, and Zhao, Yanlin, additional

Published
2014
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46. Cost-Effectiveness Comparison of Genechip and Conventional Drug Susceptibility Test for Detecting Multidrug-Resistant Tuberculosis in China

Author

Pang, Yu, primary, Li, Qiang, additional, Ou, Xichao, additional, Sohn, Hojoon, additional, Zhang, Zhiying, additional, Li, Junchen, additional, Xia, Hui, additional, Kam, Kai Man, additional, O’Brien, Richard J., additional, Chi, Junying, additional, Huan, Shitong, additional, Chin, Daniel P., additional, and Zhao, Yan-lin, additional

Published
2013
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47. Multicenter Evaluation of Genechip for Detection of Multidrug-Resistant Mycobacterium tuberculosis

Author

Pang, Yu, primary, Xia, Hui, additional, Zhang, Zhiying, additional, Li, Junchen, additional, Dong, Yi, additional, Li, Qiang, additional, Ou, Xichao, additional, Song, Yuanyuan, additional, Wang, Yufeng, additional, O'Brien, Richard, additional, Kam, Kai Man, additional, Chi, Junying, additional, Huan, Shitong, additional, Chin, Daniel P., additional, and Zhao, Yanlin, additional

Published
2013
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49. Genotyping and Prevalence of Pyrazinamide- and Moxifloxacin-Resistant Tuberculosis in China, 2000 to 2010

Author

Pang, Yu, Zhang, Zhijian, Wang, Yufeng, Wang, Shengfen, Song, Yuanyuan, Zhao, Bing, Zhou, Yang, Ou, Xichao, Li, Qiang, Xia, Hui, Zheng, Yang, Fang, Xiangqun, and Zhao, Yanlin

Abstract

ABSTRACTWe investigated the prevalence, trends, and risk factors for pyrazinamide (PZA) and moxifloxacin (MOX) resistance among tuberculosis (TB) cases in China and also analyzed the population structure of Mycobacterium tuberculosisstrains. All the M. tuberculosisstrains enrolled in this study were collected from the national TB prevalence surveys. Each strain was genotyped by analyzing the regions of RD105 and IS6110in the NTF region. The Bactec MGIT 960 system was used to detect the drug susceptibility of M. tuberculosisisolates to PZA and MOX. Based on the genotyping results, 241 (66.4%) strains were classified as Beijing genotype in 2000, which was significantly lower than in 2010 (76.2%, P< 0.01). The proportion of the modern Beijing genotype increased significantly from 49.6% in 2000 to 68.1% in 2010 (P< 0.01), while no significant difference was observed in the rate of ancient Beijing genotype between 2000 and 2010 (P= 0.676). In addition, we found that the proportion of PZA resistance in 2010 (15.0%) was significantly higher than that in 2000 (9.6%, P= 0.04). For MOX, there were more MOX-resistant isolates detected in 2010 (7.7%) than in 2000 (3.0%). In conclusion, our data demonstrate that the Beijing genotype was the predominant M. tuberculosislineage during the past decade. The proportion of Beijing genotype isolates significantly increased from 2000 to 2010, largely due to an increase in the modern Beijing sublineage. In addition, resistance to PZA and MOX increased significantly in China between 2000 and 2010.

Published
2016
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50. The Epidemiological Characteristics of Pulmonary Tuberculosis - Kashgar Prefecture, Xinjiang Uygur Autonomous Region, China, 2011-2020.

Author

Tusun D, Abulimiti M, Mamuti X, Liu Z, Xu D, Li G, Peng X, Abudureyimu T, Zhang L, Zhao Y, and Ou X

Abstract

Introduction: National Notifiable Disease Reporting System (NNDRS) plays an important role in the early detection and control of tuberculosis (TB) in China. This study analyzed the epidemiological characteristics of pulmonary tuberculosis (PTB) in Kashgar Prefecture, Xinjiang Uygur Autnomous Region, China from 2011 to 2020 to provide a scientific basis for developing TB control strategies and measures in Kashgar., Methods: The data were collected from the NNDRS, which included the geographical distribution, age, sex, occupation, and pathogenic classification of reported PTB cases in 12 counties/cities of Kashgar Prefecture from 2011 to 2020. Descriptive statistics were used to describe the characteristic of PTB epidemic in Kashgar., Results: There were 189,416 PTB cases reported during 2011-2020, with a mean annual PTB case notification rate (CNR) of 451.29/100,000. A rising trend in the rate of reported PTB between 2011 and 2017 ( χ 2 trend =26.09, P <0.01) and a declining trend between 2018 and 2020 ( χ 2 trend =314.44, P <0.01) were observed. The months with the highest reported number of PTB cases were March to May and November to December. The mean annual rate of reported PTB was 451.88/100,000 for males and 450.67/100,000 for females. In addition, 19.76% of patients were bacteriologically-confirmed (Bac+) cases (37,425/189,416), and the mean annual Bac+ CNR was 89.17/100,000, rising from 64.76/100,000 in 2011 to 139.12/100,000 in 2020 ( χ 2 trend =74.44, P <0.01)., Conclusions: The CNR of reported PTB in Kashgar showed a significant declining trend in the past three years. Males, elderly population, winter and spring, and farmers as an occupation were the main factors associated with high incidence of tuberculosis in Kashgar. Targeted prevention and treatment of TB should be strengthened in key groups in this region., (Copyright and License information: Editorial Office of CCDCW, Chinese Center for Disease Control and Prevention 2021.)

Published
2021
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