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Although the evidence is not consistent, epidemiologic studies have suggested that taller adult height may be associated with an increased risk of some non-Hodgkin lymphoma (NHL) subtypes. Height is largely determined by genetic factors, but how these genetic factors may contribute to NHL risk is unknown. We investigated the relationship between genetic determinants of height and NHL risk using data from eight genome-wide association studies (GWAS) comprising 10,629 NHL cases, including 3,857 diffuse large B-cell lymphoma (DLBCL), 2,847 follicular lymphoma (FL), 3,100 chronic lymphocytic leukemia (CLL), and 825 marginal zone lymphoma (MZL) cases, and 9,505 controls of European ancestry. We evaluated genetically predicted height by constructing polygenic risk scores using 833 height-associated SNPs. We used logistic regression to estimate odds ratios (OR) and 95% confidence intervals (CI) for association between genetically determined height and the risk of four NHL subtypes in each GWAS and then used fixed-effect meta-analysis to combine subtype results across studies. We found suggestive evidence between taller genetically determined height and increased CLL risk (OR = 1.08, 95% CI = 1.00–1.17, p = 0.049), which was slightly stronger among women (OR = 1.15, 95% CI: 1.01–1.31, p = 0.036). No significant associations were observed with DLBCL, FL, or MZL. Our findings suggest that there may be some shared genetic factors between CLL and height, but other endogenous or environmental factors may underlie reported epidemiologic height associations with other subtypes.

The composition, morphology and crystal order of clay minerals in silt-sized sediments carried in suspensions from 25 major rivers across tropical southern Africa have been studied by X-ray diffractometry and scanning and transmission electron microscopy. Our goal was to determine the spatial variability of clay-mineral associations in diverse geological settings, and in climatic conditions ranging from humid Angola and Zambia to hyperarid Namibia and the Kalahari. Specific attention was paid to the micromorphology and chemical composition of smectite particles. The relative abundance of smectites, illite/mica, kaolinite and chlorite enabled identification of regions characterized by different physical and chemical processes: (1) negligible chemical weathering is documented in Namibia, where river muds mostly contain illite/mica or smectite derived from Damara metasedimentary or Etendeka volcanic rocks; (2) kaolinite documenting intense weathering, reaches a maximum in the Okavango, Kwando and Upper Zambezi, sourced in subequatorial Angola and Zambia; (3) suspended-load muds in the Limpopo and middle Zambezi catchments display intermediate features, with varied assemblages and smectite compositions reflecting diverse parent lithologies. Clay mineralogy and chemical composition are confirmed as a most effective tool to unravel present and past climatic conditions on a continental scale.

Located in the El Callao Mining District (Bolivar State), Choco 10 is one of the most important gold deposits in Venezuela. The deposit occurs in the greenstone belt of the Pastora Supergroup, a lithostratigraphic Province of the South American Guyana Shield.The Choco 10 lithostratigraphy is composed of two different formations. The lower El Callao Formation is composed of a Metabasalt Unit, mostly made of tholeiitic basalts, overlain by a Mafic Volcano-Sedimentary Unit, which represents its primary cover. The tholeiitic rocks show a flat, unfractionated REE pattern which is typical of greenstone belt basalts worldwide; the incompatible elements and REE distributions suggest a mid-ocean ridge or back-arc basin setting. Within the tholeiitic series, a transition to more evolved terms is suggested by the occurrence of rocks of andesitic composition mostly in the upper part of the same formation. The overlying Felsic Volcano-Sedimentary Unit, probably pertaining to the Cicapra Formation, is a relatively heterogeneous rock series largely composed of volcaniclastic rocks deriving from an acidic calc-alkaline source, as confirmed by the geochemical data. SHRIMP analyses on zircons from these rocks show consistent magmatic ages of 2143. ±. 6 to 2145. ±. 5. Ma. This unit contains a gabbroic sill-like body (Metagabbro Unit), composed of medium-grained amphibole gabbro, which yields an age (2142. ±. 2. Ma) that is undistinguishable from that of the main body.Both formations are affected by a greenschist-facies metamorphic overprint and different deformation phases. At 2117. ±. 3. Ma, the formations have been intruded by a trondhjemite that displays fractionated REE and incompatible elements patterns typical of calc-alkaline rocks.Gold has been introduced into the rock sequence in different stages; the main mineralization is related to highly focused flow of H2O-CO2, low salinity fluids to give quartz+ankerite±albite±pyrite veins, surrounded by strong sericite+carbonate+pyrite+quartz alteration. Gold concentrations are controlled by both structural setting and fluid-rock interaction processes.The gold metallogeny at El Callao is related to the world-scale metallogenic event of Paleoproterozoic age, which is responsible of important orogenic gold ores formation in the once adjacent Amazonian and West Africa cratons. Even in absence of direct dating of the hydrothermal phases, our precise geochronological dating - together with the geological and petrographic data - constrains the onset of deformation (i.e., the beginning of the Trans-Amazonian deformation) and the subsequent main mineralization phase to the time span comprised between 2142 and 2144. Ma (age of gabbro and calc-alkaline tuffs) and 2117. Ma (emplacement of the trondhjemite). On a regional scale these data suggest eastward younging of deformation and mineralization within the context of the Trans-Amazonian tectonism. © 2014 Elsevier B.V.

This study investigates the petrographic, mineralogical, geochronological, and geochemical signatures of river sands across southern Africa. We single out the several factors that control sand generation, including weathering and recycling, and monitor the compositional changes caused by chemical and physical processes during fluvial transport from cratonic sources to passive-margin sinks. Passive-margin sands have two first-cycle sources. Quartz and feldspars with amphibole, epidote, garnet, staurolite, and kyanite are derived from crystalline basements exposed at the core of ancient orogens and cratonic blocks (dissected continental block provenance). Volcanic rock fragments, plagioclase, and clinopyroxene are derived from flood basalts erupted during the initial phases of rifting (volcanic rift provenance). First-cycle detritus mixes invariably with quartzose detritus recycled from ancient sedimentary successions (undis-sected continental block provenance) or recent siliciclastic deposits (e.g., Kalahari dune sands; recycled clastic provenance). U-Pb ages of detrital zircons mirror the orogenic events that affected southern Africa since the Archean. Damara (0.5-0.6 Ga) and Namaqua (1 Ga) age peaks are prominent throughout Namibia, from the Orange mouth to the Namib and Skeleton Coast Ergs, and also characterize Kalahari dunes and sands of the Congo, Okavango, and Zambezi Rivers. Instead, sharp old peaks at 2.1 Ga and 2.6 Ga characterize Limpopo and Olifants sands, matching the age of the Bushveld intrusion and the final assembly of the Zimbabwe and Kaapvaal Cratons, respectively; discordant ages indicate Pb loss during the Pan-African event. Chemical indices confirm that weathering is minor throughout the tropical belt from South Africa and Zimbabwe to Namibia and coastal Angola but major for quartzose sands of the Congo, Okavango, and upper Zambezi Rivers, largely produced in humid subequatorial regions. Recycling of quartzose sediments is extensive in all of these catchments. From Congo to Mozambique, along the >15000-km Atlantic and Indian Ocean rifted margins, polycyclic detritus reaches commonly 50% and locally up to 100%, in line with the estimated incidence of recycling worldwide. Quantitative information provided by provenance studies of modern sands helps us to better understand the relationships between sediment composition and plate-tectonic setting and to upgrade the overly simplified and often misleading current provenance models. This is a necessary step if we want to decipher the stratigraphic record of ancient passive margins and reconstruct their paleotectonic and paleo-climatic history with greater accuracy. © 2014 by The University of Chicago. All rights reserved.

This article investigates how, where, and to what extent the mineralogical and chemical composition of sand-sized sediments is modified by extreme weathering in modern equatorial settings, with the ultimate goal of learning to read climate from the sedimentary record. To single out the weathering effect, we studied the compositional trends of fluvial sands along the western branch of the East African Rift between 5°S and 5°N. The relative durability of different detrital components, as well as potential hydraulic-sorting and grain-size effects, were assessed by comparing samples with similar provenances in different climatic and environmental conditions or of different size classes within the same sample. Sands of equatorial central Africa at the headwaters of the Congo and Nile basins display the full spectrum of petrologic suites characterizing rift-shoulder and volcanic rift provenances. Unlike in arid Arabia, quartzose sands are not restricted to areas where detritus is recycled from prerift sedimentary covers. In a hot humid climate, weathering can effectively obliterate the fingerprint of parent rock lithology and produce a nearly pure quartz residue even where midcrustal basement rocks are being actively uplifted and widely unroofed. In such settings garnet is destroyed faster than hornblende, and zircon faster than quartz. Weathering control on detrital modes is minor only in the rain shadow of the highest mountains or volcanoes, where amphibole-dominated quartzofelicdspathic metamorphiclastic sands (Rwenzori Province) or clinopyroxene-dominated feldspatholithic volcaniclastic sands (Virunga Province) are generated. Our detailed study of the Kagera basin emphasizes the importance of weathering in soils at the source rather than of progressive maturation in temporary storage sites during stepwise transport and shows that the transformation of diverse parent rocks into a quartzose "white sand" may be completed in one sedimentary cycle in hydromorphic soils of subequatorial lowlands. Micas and heavy minerals, which are less effectively diluted by recycling than main framework components, offer the best key to identify the original source-rock imprint. The different behavior of chemical indexes such as the CIA (a truer indicator of weathering) and the WIP (markedly affected by quartz dilution) helps us to distinguish strongly weathered first-cycle versus polycyclic quartz sands.

A practical classification of surface textures observed on detrital grains in sands and sandstones is proposed, in order to enhance data reproducibility among operators and to implement the use of high-resolution heavy-mineral data in studies of sediment-generation, provenance, and diagenesis. Five stages of progressive weathering (unweathered, corroded, etched, deeply etched, skeletal) are recognized for diverse detrital minerals. Archetypal grains displaying increasing degrees of corrosion are illustrated in numerous color tables for visual comparison. This catalog, specifically devised to systematically collect valuable information for paleoclimatic or diagenetic interpretation during routine grain-counting under the microscope, is here shown to represent a useful subsidiary tool to reveal the different degrees of weathering for diverse minerals in modern sands of equatorial Africa, and to identify post-depositional modifications of detrital assemblages in buried orogenic sediments of the Bengal Basin. The data thus obtained need to be interpreted by carefully considering the concentration of heavy minerals in each sample, which provides the fundamental clue to quantify the degree of heavy-mineral depletion caused by either pre-depositional or post-depositional processes. The scrutiny of dissolution effects has applications in the study of the chemical properties of minerals and of diagenetic evolution, helping us to understand the development of secondary porosity and to assess the potential of water and hydrocarbon reservoirs.

Strontium and neodymium isotopes, measured on diverse mud and sand fractions of sediment in transit along all major Nile branches, identify detritus sourced from Precambrian basements, Mesozoic strata, and Tertiary volcanic rocks exposed along the shoulders of the East African rift and in Ethiopian highlands. Sr and Nd isotopic ratios reflect the weighted average of detrital components generated in different catchments, allowing us to discriminate provenance, calculate sediment budgets, and investigate grain-size and hydraulic-sorting effects. 87Sr/86Sr and 143Nd/144Nd range, respectively, from as high as 0.722 and as low as 0.5108 for sediment derived from Archean gneisses in northern Uganda, to 0.705 and 0.5127 for sediment derived from Neoproterozoic Ethiopian and Eritrean basements. 87Sr/86Sr and 143Nd/144Nd, ranging 0.705–0.709 and 0.5124–0.5130 for Blue Nile tributaries, are 0.704–0.705 and 0.5127–0.5128 for largely volcaniclastic sediments of River Tekeze–Atbara, and 0.705–0.706 and 0.5126–0.5127 for main Nile sediments upstream Lake Nasser. Model mantle derivation ages (tDM), oldest in Uganda where sediment is principally derived from the Congo Craton (3.4–3.0 Ga for Victoria and Albert Nile), progressively decrease northward across the Saharan Metacraton, from 2.6 Ga (Bahr el Jebel in South Sudan), to 2.4–2.2 Ga (Bahr ez Zeraf across the Sudd), and finally 1.6–1.3 Ga (White Nile upstream Khartoum). Instead, tDM ages of Sobat mud increase from 0.9 to 1.5 Ga across the Machar marshes. TDM ages are younger for sediments shed by Ethiopian (1.2–0.7 Ga) and Eritrean basements (1.5–1.2 Ga), and youngest for sediments shed from Ethiopian flood basalts (0.3–0.2 Ga). Integrated geochemical, mineralogical, and settling-equivalence analyses suggest influence on the Nd isotopic signal by volcanic lithic grains and titanite rather than by LREE-rich monazite or allanite. Because contributions by ultradense minerals is subordinate, intrasample variability of Sr and Nd ratios is minor. In Blue Nile, Atbara and main Nile sediments of mixed provenance, however, the Nd ratio tends to be higher and tDM ages lower in largely volcaniclastic mud than in mixed volcaniclastic/metamorphiclastic sand. The complete geochemical database presented here, coupled with high-resolution bulk-petrography and heavy-mineral data, provides a key to reconstructing erosion patterns and detrital fluxes across the whole Nile basin, and to investigate and understand how sources of sediment have changed in the historical and pre-historical past in relation to shifting climatic zones across arid northern Africa.