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[Objective] As a new type of economic form characterized by innovation, progress, and extension, digital economy is an important driving force to promote the high-quality development of the Yellow River Basin and create new advantages in regional competition. Exploring the evolution of the spatial pattern of digital economy enterprises in the Yellow River Basin and the influencing factors is of great significance for realizing the effect of digital economy reshaping the economic geographical pattern. [Methods] Based on the data of more than 130000 digital economy enterprises in the Yellow River Basin from 2002 to 2019, we used standard deviation ellipse, kernel density estimation, and the multi-scale geographically weighted regression model to explore the evolution of the spatial pattern of digital enterprises in the region. [Results] (1) The number of digital economy enterprises in the Yellow River Basin had increased significantly, showing the characteristics of downstream cities > midstream cities > upstream cities, with the overall spatial pattern of strong in the east and weak in the west and a trend of contraction, and the urban agglomerations showed significant differences in the development process. (2) The distribution of the digital industry manufacturing enterprises showed a trend of a single cluster of downstream cities and the orderly expansion of middle and upstream cities, while the digital technology application enterprises showed a trend of close connection between middle and downstream cities and multi-core clusters. (3) The location selection of digital industry manufacturing enterprises gives more consideration to location factors and has the characteristics of path dependence, while the location selection of digital technology application enterprises gives consideration to location and technology factors and has the characteristics of both path dependence and path creation. [Conclusion] Developing digital economy according to local conditions is an important means to achieve high-quality development of the Yellow River Basin, and we recommend to promote the digital economy industry to release its potential by improving its foundation, achieving precise layout, promoting innovation and optimizing the structure, and promoting innovation.

Semaumaq means "return home" in the Paiwanese language. This article explored and described the efficacy and journey of a research team in facilitating culturally appropriate family dyadic interactions in a Paiwanese community in Taiwan using a shared book-reading program. This program was implemented in a rural elementary-school-affiliated preschool in a Paiwanese village in southern Taiwan. Eight families participated. A naturalistic inquiry method using a feedback form, strategy checklist, observations, brief interviews, and video recording was used to collect the data. "Enjoyment and improving family relationships" was identified as the core theme of the parent-child interaction experiences elicited during the program. The results of this naturalistic inquiry support the efficacy and acceptability of using parent-child shared book-reading programs in indigenous communities. The elements of the program that may have contributed to its success are described. Future research may adopt an experimental design to further validate and clarify results.

Lysozyme, a common antimicrobial agent, is widely used in the food, biopharmaceutical, chemical, and medicine fields. Rapid and effective isolation of lysozymes is an everlasting topic. In this work, ethylene vinyl alcohol (EVOH) copolymer nanofibrous membranes with a gradient porous structure used for lysozyme adsorption were prepared through layer-by-layer nanofiber wet-laying and a cost-efficient ultraviolet (UV)-assisted graft-modification method, where benzophenone was used as an initiator and 2-acrylamide-2-methylpropanesulfonic acid as a modifying monomer. As indicated in the Fourier Transform Infrared (FTIR) and X-ray photoelectric energy spectrometer (XPS) investigation, sulfonic acid groups were introduced on the surface of the modified nanofibrous membrane, which possessed the ability to adsorb lysozyme. Compared with membranes with homogenous porous structures, membranes with a gradient porous structure present higher static (335 mg/g) and dynamic adsorption capacities (216.3 mg/g). Meanwhile, the adsorption capacity remained high after five cycles of the adsorption–desorption process. The results can be attributed to the gradient porous structure rather than the highest porosity and specific surface area. This suggests that the membrane with comprehensive separation performance can be designed from the view of the transmembrane porous structure, which is of significance for the development of next-generation advanced chromatographic membranes.

The purpose of this study was to increase the duration of treadmill walking to reach moderate exercise intensity level for a 26-year-old male diagnosed with moderate autism spectrum disorder (ASD) accompanying an intellectual disability. We used a structured system including token reward system of visual representation of progress. A changing criterion single case research design was used and was consisted of the baseline phase, three sub-criteria intervention phase, and follow-up phase. Results showed that a functional relationship was established by demonstrating and replicating effects throughout the three sub-intervention phases. In addition, there was an increase of 173% (>2 standard deviations) from the original base-line duration and 93% of duration were at the moderate exercise intensity. This study may be of importance that the intervention may built up the health behavior and lifestyle of the participant with ASD. Further replicating studies are suggested.