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CD11b+ cells markedly express the itch cytokine interleukin-31 in polymorphic light eruption Interleukin (IL)-31 is a novel cytokine of the IL-6 family, also described as a "pruritogenic cytokine" owing to its link between the immune and neuronal systems to induce itch.[5] IL-31 is expressed by a variety of inflammatory cells.[5] It binds to the IL-31 receptor alpha complex (IL-31RA), and mediates inflammatory itch by forming a functional receptor through coupling to oncostatin M receptor (OSMR) .[6] In psoriatic skin, overall expression of IL-31 (48-0 ± 19-4 cells/mm SP 2 sp ) and OSMR (5-9 ± 3-9 cells/mm SP 2 sp ) was lower compared with PLE, while IL-31RA (36-9 ± 8-2 cells/mm SP 2 sp ) was expressed at similar levels. [Extracted from the article]