12 results on '"Pavlinac Dodig, Ivana"'
Search Results
2. Salivary parameters and periodontal inflammation in obstructive sleep apnoea patients
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Tranfić Duplančić, Mia, Pecotić, Renata, Lušić Kalcina, Linda, Pavlinac Dodig, Ivana, Valić, Maja, Roguljić, Marija, Rogić, Dunja, Lapić, Ivana, Grdiša, Katarina, Peroš, Kristina, and Đogaš, Zoran
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- 2022
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3. Adherence to CPAP Therapy in Obstructive Sleep Apnea: A Prospective Study on Quality of Life and Determinants of Use.
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Milinovic, Karla, Pavlinac Dodig, Ivana, Lusic Kalcina, Linda, Pecotic, Renata, Ivkovic, Natalija, Valic, Maja, and Dogas, Zoran
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CONTINUOUS positive airway pressure , *SLEEP quality , *SLEEP apnea syndromes , *MULTIPLE regression analysis , *EPWORTH Sleepiness Scale - Abstract
Obstructive sleep apnea (OSA) often goes unrecognized despite common symptoms, such as excessive daytime sleepiness, fatigue, and impaired quality of life (QoL). Continuous positive airway pressure (CPAP) is the gold standard treatment for OSA, but optimal daily usage and time needed for observable effects remain unclear. This study aimed to investigate the short-term effects of CPAP on daytime sleepiness and QoL in patients with severe OSA. Medical records were collected from 87 patients with severe OSA who initiated CPAP therapy. Also, validated questionnaires were used before and after one month of CPAP to analyze QoL—the Calgary Sleep Apnea Quality of Life Index (SAQLI), the Cues to CPAP Use Questionnaire (CCUQ), and daytime sleepiness—the Epworth Sleepiness Scale (ESS). Multiple regression analysis was conducted to identify predictors of CPAP usage. Of the total participants aged 55.6 ± 12.5, 77% were males, and 62% were CPAP adherent. Reductions in daytime sleepiness (ESS) were noted, as well as improvements in both overall QoL (SAQLI) and specifically in the domains of daily functioning, social interactions, emotional well-being, and symptom perception. Important cues for CPAP usage recognized by patients were physicians' instructions and physicians' concern regarding their patients' condition. Furthermore, multiple regression revealed higher SAQLI scores and lower ESS scores as positive predictors of CPAP usage, along with lower AHI after one month of CPAP being associated with sufficient adherence. [ABSTRACT FROM AUTHOR]
- Published
- 2024
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4. Daytime Sleepiness from Preschool Children's and Parents' Perspectives: Is There a Difference?
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Marušić, Eugenija, Lušić Kalcina, Linda, Pavlinac Dodig, Ivana, Đogaš, Zoran, Valić, Maja, and Pecotić, Renata
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SELF-evaluation ,CROSS-sectional method ,LIFESTYLES ,T-test (Statistics) ,DATA analysis ,INTERVIEWING ,SEX distribution ,HYPERSOMNIA ,PARENT attitudes ,MANN Whitney U Test ,CELL phones ,TELEVISION ,SLEEP ,STATISTICAL reliability ,STATISTICS ,DATA analysis software ,DROWSINESS ,NONPARAMETRIC statistics ,VIDEO games ,EVALUATION ,CHILDREN - Abstract
This cross-sectional study investigated the level of daytime sleepiness and sleep-related behaviors in preschool children and compared their self-evaluations with the evaluations of their parents. It was conducted in Split-Dalmatian County, Croatia, among 196 preschool children aged 6–7 years seen at regular medical examinations, accompanied by their parents, using the Epworth sleepiness scale for children and parents/caregivers. Compared to their child's reports, parents tended to underestimate their child's sleepiness while sitting in a classroom at school (p = 0.001) and overestimate their child's sleepiness when lying down to rest or nap in the afternoon (p < 0.001). Boys were sleepier while sitting in a classroom at school during the morning than girls (p = 0.032). As much as 48.2% of preschool children had their own cellphones/tablets. Boys used video games (p < 0.001) and cellphones/tablets more than girls did (p = 0.064). Parental estimation of children playing video games at bedtime was lower than the child's report (p < 0.001). Children who had a TV in their bedroom reported more daytime sleepiness (p = 0.049), and those who played video games at bedtime went to sleep later during the weekend (p = 0.024). Also, children owning cellphone/tablets had longer sleep latency during the weekend compared to children not owning a cellphone (p = 0.015). This study confirmed that parents tend to underestimate children's habits of playing video games at bedtime and children's sleepiness during morning classes. Preschool children who use electronic devices at bedtime more frequently have prolonged sleep latency. These findings provide further evidence of the effects of electronic media devices on preschoolers' sleep patterns and daytime sleepiness. [ABSTRACT FROM AUTHOR]
- Published
- 2024
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5. Good and poor sleepers among OSA patients: sleep quality and overnight polysomnography findings
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Lusic Kalcina, Linda, Valic, Maja, Pecotic, Renata, Pavlinac Dodig, Ivana, and Dogas, Zoran
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- 2017
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6. Not-So-Sweet Dreams: Plasma and IgG N-Glycome in the Severe Form of the Obstructive Sleep Apnea.
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Plećaš, Doris, Mraz, Nikol, Patanaude, Anne Marie, Pribić, Tea, Pavlinac Dodig, Ivana, Pecotić, Renata, Lauc, Gordan, Polašek, Ozren, and Đogaš, Zoran
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SLEEP apnea syndromes ,CAPILLARY electrophoresis ,DREAMS ,GLYCAN structure ,BODY mass index ,BISPECIFIC antibodies - Abstract
Obstructive sleep apnea (OSA) is a prevalent disease associated with increased risk for cardiovascular and metabolic diseases and shortened lifespan. The aim of this study was to explore the possibility of using N-glycome as a biomarker for the severe form of OSA. Seventy subjects who underwent a whole-night polysomnography/polygraphy and had apnea–hypopnea index (AHI) over 30 were compared to 23 controls (AHI under 5). Plasma samples were used to extract 39 glycan peaks using ultra-high-performance liquid chromatography (UPLC) and 27 IgG peaks using capillary gel electrophoresis (CGE). We also measured glycan age, a molecular proxy for biological aging. Three plasma and one IgG peaks were significant in a multivariate model controlling for the effects of age, sex, and body mass index. These included decreased GP24 (disialylated triantennary glycans as major structure) and GP28 (trigalactosylated, triantennary, disialylated, and trisialylated glycans), and increased GP32 (trisialylated triantennary glycan). Only one IgG glycan peak was significantly increased (P26), which contains biantennary digalactosylated glycans with core fucose. Patients with severe OSA exhibited accelerated biological aging, with a median of 6.9 years more than their chronological age (p < 0.001). Plasma N-glycome can be used as a biomarker for severe OSA. [ABSTRACT FROM AUTHOR]
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- 2023
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7. Sleep and Lifestyle Habits of Medical and Non-Medical Students during the COVID-19 Lockdown.
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Pavlinac Dodig, Ivana, Lusic Kalcina, Linda, Demirovic, Sijana, Pecotic, Renata, Valic, Maja, and Dogas, Zoran
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COVID-19 pandemic , *MEDICAL students , *STAY-at-home orders , *WELL-being , *SLEEP - Abstract
It has been shown that the measures of social distancing and lockdown might have had negative effects on the physical and mental health of the population. We aim to investigate the sleep and lifestyle habits as well as the mood of Croatian medical (MS) and non-medical students (NMS) during the COVID-19 lockdown. The cross-sectional study included 1163 students (21.6% male), whose lifestyle and sleep habits and mood before and during the lockdown were assessed with an online questionnaire. The shift towards later bedtimes was more pronounced among NMS (~65 min) compared to MS (~38 min), while the shift toward later wake-up times was similar in both MS (~111 min) and NMS (~112 min). All students reported more frequent difficulty in falling asleep, night-time awakenings and insomnia (p < 0.001) during lockdown. A higher proportion of MS reported being less tired and less anxious during lockdown compared to pre-lockdown (p < 0.001). Both student groups experienced unpleasant moods and were less content during lockdown compared to the pre-lockdown period (p < 0.001). Our results emphasize the need for the promotion of healthy habits in the youth population. However, the co-appearance of prolonged and delayed sleep times along with decreased tiredness and anxiety among MS during lockdown reveals their significant workload during pre-lockdown and that even subtle changes in their day schedule might contribute to the well-being of MS. [ABSTRACT FROM AUTHOR]
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- 2023
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8. The Associations between Results in Different Domains of Cognitive and Psychomotor Abilities Measured in Medical Students †.
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Pavlinac Dodig, Ivana, Qazzafi, Aisha, Lusic Kalcina, Linda, Demirovic, Sijana, Pecotic, Renata, Valic, Maja, and Dogas, Zoran
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MEDICAL students , *COGNITION , *COGNITIVE ability , *EXECUTIVE function , *INTELLIGENCE tests , *INTELLIGENCE levels - Abstract
We aimed to investigate the associations between intelligence quotient test scores obtained using the Raven's Advanced Progressive Matrices (APM) and psychomotor testing using the Complex Reactionmeter Drenovac (CRD) test battery, while taking into account previous theoretical approaches recognizing intelligent behavior as the cumulative result of a general biological speed factor reflected in the reaction time for perceptual detections and motor decisions. A total of 224 medical students at the University of Split School of Medicine were recruited. Their IQ scores were assessed using Raven's APM, while the computerized tests of CRD-series were used for testing the reaction time of perception to visual stimulus (CRD311), psychomotor limbs coordination task (CRD411), and solving simple arithmetic operations (CRD11). The total test-solving (TTST) and the minimum single-task-solving (MinT) times were analyzed. On the CRD11 test, task-solving times were shorter in students with higher APM scores (r = −0.48 for TTST and r = −0.44 for MinT; p < 0.001 for both). Negative associations between task-solving times and APM scores were reported on CRD311 (r = −0.30 for TTST and r = −0.33 for MinT, p < 0.001 for both). Negative associations between task-solving times in CRD411 and APM scores (r = −0.40 for TTST and r = −0.30 for MinT, p < 0.001 for both) were found. Faster reaction time in psychomotor limbs coordination tasks, the reaction time of perception to visual stimulus, and the reaction time of solving simple arithmetic operations were associated with a higher APM score in medical students, indicating the importance of mental speed in intelligence test performance. However, executive system functions, such as attention, planning, and goal weighting, might also impact cognitive abilities and should be considered in future research. [ABSTRACT FROM AUTHOR]
- Published
- 2023
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9. Blockade of α2-Adrenergic Receptors in the Caudal Raphe Region Enhances the Renal Sympathetic Nerve Activity Response to Acute Intermittent Hypercapnia in Rats.
- Author
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MADIRAZZA, Katarina, PECOTIC, Renata, PAVLINAC DODIG, Ivana, VALIC, Maja, and DOGAS, Zoran
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BRAIN stem physiology ,SYMPATHETIC nervous system physiology ,ADRENERGIC receptors ,SYMPATHOLYTIC agents ,BLOOD pressure ,CARDIOVASCULAR system physiology ,ANIMAL experimentation ,ARTERIES ,TIME ,RATS ,ARTIFICIAL respiration ,PATIENT monitoring ,HEART rate monitoring ,DESCRIPTIVE statistics ,HYPERCAPNIA ,PHYSIOLOGIC salines ,PHARMACODYNAMICS - Abstract
The study investigated the role of α2-adrenergic receptors of the caudal raphe region in the sympathetic and cardiovascular responses to the acute intermittent hypercapnia (AIHc). Urethane-anesthetized, vagotomized, mechanically ventilated Sprague-Dawley rats (n=38) were exposed to the AIHc protocol (5×3 min, 15 % CO
2 +50 % O2 ) in hyperoxic background (50 % O2 ). α2-adrenergic receptor antagonist-yohimbine was applied intravenously (1 mg/kg, n=9) or microinjected into the caudal raphe region (2 mM, n=12) prior to exposure to AIHc. Control groups of animals received saline intravenously (n=7) or into the caudal raphe region (n=10) prior to exposure to AIHc. Renal sympathetic nerve activity (RSNA), mean arterial pressure (MAP) and heart rate (HR) were monitored before exposure to the AIHc protocol (T0), during five hypercapnic episodes (THc1-5) and at 15 min following the end of the last hypercapnic episode (T15). Following intravenous administration of yohimbine, RSNA was significantly greater during THc1-5 and at T15 than in the control group (P<0.05). When yohimbine was microinjected into the caudal raphe region, AIHc elicited greater increases in RSNA during THc1-5 when compared to the controls (THc1: 138.0±4.0 % vs. 123.7±4.8 %, P=0.032; THc2: 137.1±5.0 % vs. 124.1±4.5 %, P=0.071; THc3: 143.1±6.4 % vs. 122.0±4.8 %, P=0.020; THc4: 146.1±6.2 % vs. 120.7±5.7 %, P=0.007 and THc5: 143.2±7.7 % vs. 119.2±7.2 %, P=0.038). During THc1-5, significant decreases in HR from T0 were observed in all groups, while changes in MAP were observed in the group that received yohimbine intravenously. These findings suggest that blockade of the α2-adrenegic receptors in the caudal raphe region might have an important role in sympathetic responses to AIHc. [ABSTRACT FROM AUTHOR]- Published
- 2022
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10. Intermittent hypercapnia-induced phrenic long-term depression is revealed after serotonin receptor blockade with methysergide in anaesthetized rats.
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Valic, Maja, Pecotic, Renata, Pavlinac Dodig, Ivana, Valic, Zoran, Stipica, Ivona, and Dogas, Zoran
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SEROTONIN receptors ,HYPERCAPNIA ,PHRENIC nerve ,LABORATORY rats ,RESPIRATION ,ANESTHESIA ,ANATOMY - Abstract
New Findings What is the central question of this study? Intermittent hypercapnia is a concomitant feature of breathing disorders. Hypercapnic stimuli evoke a form of respiratory plasticity known as phrenic long-term depression in experimental animals. This study was performed to investigate the putative role of serotonin receptors in the initiation of phrenic long-term depression in anaesthetized rats., What is the main finding and its importance? Phrenic nerve long-term depression was revealed in animals pretreated with the serotonin broad-spectrum antagonist, methysergide. This study highlights that serotonin receptors modulate respiratory plasticity evoked by acute intermittent hypercapnia in anaesthetized rats., This study was performed to test the hypothesis that intermittent hypercapnia can evoke a form of respiratory plasticity known as long-term depression of the phrenic nerve (pLTD) and that 5-HT receptors play a role in the initiation of pLTD. Adult male urethane-anaesthetized, vagotomized, paralysed, mechanically ventilated Sprague-Dawley rats were exposed to an acute intermittent hypercapnia protocol. One group received i.v. injection of the non-selective 5-HT receptor antagonist methysergide and another group received i.v. injection of the selective 5-HT
1A receptor antagonist WAY-100635 20 min before exposure to intermittent hypercapnia. A control group received i.v. injection of saline. Peak phrenic nerve activity and respiratory rhythm parameters were analysed at baseline (T0), during each of five hypercapnic episodes, and 15, 30 and 60 min (T60) after the last hypercapnia. Intravenous injection of methysergide before exposure to acute intermittent hypercapnia induced development of amplitude pLTD at T60 (decreased by 46.1 ± 6.9%, P = 0.003). Conversely, in control and WAY-100635-pretreated animals, exposure to acute intermittent hypercapnia did not evoke amplitude pLTD. However, a long-term decrease in phrenic nerve frequency was evoked both in control (42 ± 4 breaths min−1 at T0 versus 32 ± 5 breaths min−1 at T60; P = 0.036) and in methysergide-pretreated animals (42 ± 2 breaths min−1 at T0 versus 32 ± 3 breaths min−1 at T60; P = 0.028). In WAY-100635 pretreated animals, frequency pLTD was prevented. These results suggest that 5-HT receptors modulate respiratory plasticity induced by acute intermittent hypercapnia in anaesthetized rats. [ABSTRACT FROM AUTHOR]- Published
- 2016
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11. Acute intermittent hypoxia induces phrenic long-term facilitation which is modulated by 5-HT1A receptor in the caudal raphe region of the rat.
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PAVLINAC DODIG, IVANA, PECOTIC, RENATA, VALIC, MAJA, and DOGAS, ZORAN
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SLEEP apnea syndromes , *HYPOXEMIA , *PHRENIC nerve , *SEROTONIN , *MICROINJECTIONS , *LABORATORY rats - Abstract
Summary Obstructive sleep apnoea (OSA) is characterized by periods of upper airway collapse accompanied by repeated episodes of hypoxia. In experimental animals repeated bouts of hypoxia may evoke sustained augmentation of phrenic nerve activity, known as phrenic long-term facilitation (pLTF). This form of physiological compensation might contribute to stable breathing, minimizing the occurrence of apnoeas and/or hypopnoeas during sleep in patients with OSA. Serotonin (5-HT) has been shown to modulate respiratory neuronal activity, possibly via projections originating in the raphe nuclei. Our model focuses on the effects of 5-HT1A receptors blockade by selective antagonist WAY-100635 into the caudal raphe region on phrenic long-term facilitation after exposure to acute intermittent hypoxia (AIH) episodes. Adult, male, urethane-anaesthetized, vagotomized, paralyzed and mechanically ventilated Sprague-Dawley rats were exposed to AIH protocol. Experimental group received microinjection of WAY-100635 into the caudal raphe nucleus, whereas the control group received saline into the same site. Peak phrenic nerve activity and respiratory rhythm parameters were analysed during five hypoxic episodes, as well as at 15, 30 and 60 min after the end of hypoxias. In the control group, 1 h post-hypoxia pLTF was developed. Microinjections of selective 5-HT1A receptor antagonist WAY-100635 into the raphe nuclei prior to the AIH protocol prevented induction of pLTF. These results suggest that 5-HT1A receptor activation at supraspinal level is important for induction of pLTF, which is suggested to be an important respiratory neuroplasticity model in animal studies that possibly correlates with OSA in humans. [ABSTRACT FROM AUTHOR]
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- 2012
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12. The effect of COVID-19 lockdown on lifestyle and mood in Croatian general population: a cross-sectional study.
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Đogaš, Zoran, Lušić Kalcina, Linda, Pavlinac Dodig, Ivana, Demirović, Sijana, Madirazza, Katarina, Valić, Maja, and Pecotić, Renata
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STAY-at-home orders , *COVID-19 , *WEIGHT gain , *BEHAVIOR , *CROSS-sectional method - Abstract
Aim To investigate the effect of the coronavirus 2019 (COVID-19) lockdown on lifestyle behaviors and mood changes in the Croatian general population. Methods During ten days of the COVID-19 lockdown in Croatia, 3027 respondents (70.3% female) from the general population completed an online, self-report questionnaire. Demographic data and data on lifestyle habits and mood changes before and during the COVID-19 lockdown were collected. Results A total of 95.64% of respondents reported to follow most or all restrictions, with female sex (P < 0.001) and higher education level (P < 0.001) being associated with higher restriction compliance. Women smoked an increased number of cigarettes (P < 0.001). The proportion of respondents of both sexes who did not drink or drank 7 drinks per week or more increased (P < 0.001). Women also reported lower frequency (P = 0.001) and duration of physical exercise (P < 0.001). In total, 30.7% of respondents gained weight, with female sex (OR, 2.726) and higher BMI (OR, 1.116; both P < 0.001) being associated with an increased likelihood of gaining weight. Both men and women felt more frequently afraid (P < 0.001), discouraged (P < 0.001), and sad (P < 0.001). Conclusion Public health authorities should promote the adoption of healthy lifestyles in order to reduce long-term negative effects of the lockdown. [ABSTRACT FROM AUTHOR]
- Published
- 2020
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