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The present study addresses the pattern distribution of recent landslides in Italy. The main objective is the detection and mapping of spatio-temporal clusters of landslides that occurred in the period 2010–2017 in the country. To this aim, a subdivision of the national area into 158 warning zones, as identified by the 21 civil protection regional centres to deal with weather-induced hydro-geological hazards, is adopted. Information on landslides comes from FraneItalia, a geo-referenced catalogue developed consulting online news sources. Analyses are performed both at national scale and at a regional scale, focusing on the Campania region. The space–time permutation scan statistics model is applied to detect statistically significant clustering, accounting for the geographical spatial dimension and for the temporal dimension. Two types of analyses are performed: annual, considering each single year; and multi-annual, encompassing the entire 8-year study period. In both cases, spatio-temporal cluster analyses are able to detect areas and frame-periods characterised by relevant and recurrent landslide activity. Finally, the obtained results are compared with a standard landslide density map, highlighting the complementarity of the two approaches. [ABSTRACT FROM AUTHOR]

Background: T-cell Acute Lymphoblastic Leukemia (ALL) represents about 10-15 % of pediatric ALL cases. EZH2, one of the components of Polycomb group proteins (PRC2) complex, catalyzes the trimethylation of histone H3 lysine 27 that is associated with transcriptional repression and tumor development. Methods: We examined the expression levels of PRC2 complex in primary samples of T cells ALL at diagnosis by western blotting and real time PCR. We evaluated the effect of 3-deazaneplanocin-A (DZNep), an EZH2 inhibitor, alone and in combination with Daunoblastine on cell viability, apoptotic death and cell cycle distribution of T cell established Jurkat cell line. Results: EZH2 was expressed in 75 % samples at different extents mainly with high expression level. SUZ12 was expressed in 60 % samples and EED in all samples, respectively. The Kaplan-Meier analysis shows that T-ALL expressing EZH2 had a lower probability of disease-free survival (DFS) compared to T-ALL negative for EZH2 (23 % vs 100 %) (p = 0.01). The EZH2 inhibitor DZNep used in combination with Daunoblastine was synergistic in inducing growth inhibition and increasing the apoptosis in T-ALL Jurkat cells at 48 and 72 h paralleled by EZH2 decreased expression. Moreover, the combination decreased the activity of Erk-1/2 proliferation enzymes with no effects on Akt survival pathway. Conclusions: The evaluation of EZH2 expression in pediatric T-ALL can be useful in predict the clinical outcome of the patients and EZH2 can be a useful target to improve the efficacy of conventional chemotherapy in this subset of patients with bad prognosis. [ABSTRACT FROM AUTHOR]

OBJECTIVES. Our aim was to discover whether it is possible to eliminate retrograde phlebography in the treatment of varicocele by using Tauber procedure. METHODS. We treated 102 consecutive left varicocele patients between November 2003 and May 2007. In 72 patients (Group A) we used the Tauber procedure, without performing preliminary retrograde phlebography, and injecting saline solution instead of contrast medium; in 30 patients (Group B) we performed the standard Tauber procedure. We followed up with scrotal color Doppler Ultrasonography and spermo grams at 6 months. RESULTS. The patients who underwent the Tauber procedure without phlebography (Group A) obtained results similar to those treated with phlebography (Group B). With our technique, surgical time and costs are reduced and, most importantly, exposure to radiation is avoided. CONCLUSIONS. We believe that Tauber procedure for the treatment of varicocele can be performed without retrograde phlebography. [ABSTRACT FROM AUTHOR]

OBJECTIVES: Cytomegalovirus infection has been reported as a cause of refractory inflammatory bowel disease, but no data are available on its prevalence in severe colitis. The aim of this study was to evaluate the prevalence and outcome of cytomegalovirus infection in a consecutive series of patients with severe steroid refractory colitis admitted to our department from 1997 to 1999. METHODS: Among 62 patients with severe colitis, 55 with ulcerative colitis and seven with Crohn's disease, 19 (30%) were resistant to intravenous steroids and bowel rest. In all of them, rectal biopsies were examined for cytomegalovirus (the flexible proctoscopy being performed without air insufflation and limited to the first 10 cm). Buffy coat preparation on leukocytes was also performed to detect systemic infection. If cytomegalovirus was not detected, cyclosporine was started. RESULTS: In seven (five with ulcerative colitis and two with Crohn's disease) out of 19 (36%) patients with refractory disease, cytomegalovirus was diagnosed in the rectal specimens as well as by buffy coat preparation. Five patients went into remission after antiviral treatment (three with ganciclovir and two with foscarnet). One patient did not respond and was operated on. In one patient, cytomegalovirus was found in the surgical specimen. CONCLUSIONS: Cytomegalovirus infection is a frequent cause of severe refractory colitis. Rectal biopsy should always be performed in severe steroid-resistant colitis. [ABSTRACT FROM AUTHOR]

Presents information on a study that compared the prevalence of markers of delta infection in patients with hepatitis B surface antigen (HBsAg) hepatocellular carcinoma to that in patients with HBsAg-positive cirrhosis and in chronic healthy carriers of HBsAg. Research methods; Results and discussion on the study.