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1. A randomized, double-blind trial to evaluate immunogenicity and safety of 13-valent pneumococcal conjugate vaccine given concomitantly with trivalent influenza vaccine in adults aged ≥65 years

Author

Schwarz, T.F., Flamaing, J., Rümke, H.C., Penzes, J., Juergens, C., Wenz, A., Jayawardene, D., Giardina, P., Emini, E.A., Gruber, W.C., and Schmoele-Thoma, B.

Subjects
*PNEUMOCOCCAL vaccines, *INFLUENZA vaccines, *POLYSACCHARIDES, *SEROTYPES, *IMMUNOGLOBULIN G, *VACCINE safety, *RANDOMIZED controlled trials
Abstract

Abstract: This randomized, double-blind study evaluated concomitant administration of 13-valent pneumococcal conjugate vaccine (PCV13) and trivalent inactivated influenza vaccine (TIV) in adults aged ≥65 years who were naïve to 23-valent pneumococcal polysaccharide vaccine. Patients (N =1160) were randomized 1:1 to receive PCV13+TIV followed by placebo, or Placebo+TIV followed by PCV13 at 0 and 1 months, with blood draws at 0, 1, and 2 months. Slightly lower pneumococcal serotype-specific anticapsular polysaccharide immunoglobulin G geometric mean concentrations were observed with PCV13+TIV relative to PCV13. Concomitant PCV13+TIV demonstrates acceptable immunogenicity and safety compared with either agent given alone. [Copyright &y& Elsevier]

Published
2011
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