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Two new mixed-ligand-based compounds, namely [Co(1,3-pde)(4-bpmh)]n (1) and [Zn3(3,3’-bpdc)3(4-bpmh)1.5]n (2) (1,3-H2pde = 1,3-phenylenediacetic acid, 3,3’-H2bpdc = biphenyl-3,3'-dicarboxylic acid, 4-bpmh = N,N-bis-pyridin-4-ylmethylene-hydrazine) have been prepared under hydrothermal conditions. The obtained compounds were determined by singe crystalX-ray diffraction analyses, elemental analyses, powder X-ray diffraction analyses and thermogravimetric analyses. Moreover, the photocatalytic activity of 1 and luminescent property of 2 have also been investigated. This presented research estimate their treatment activity of the polycystic ovary syndrome, also the mechanism was measured as well. Firstly, a relative expression of the estrogen receptor on the ovarian epithelial cells was determined with real time RT-PCR. In addition, the amount of progesterone of the plasma was measured with ELISA detection kit after indicated treatment.

The reaction of dimethylamine, 18-crown-6, and perchloric acid in methanol yields the title compound, C2H8N+·ClO4−·C12H24O6·H2O. The dimethylammonium cation and the water molecule interact with the 18-crown-6 unit: N—H...O hydrogen bonds are formed between the ammonium NH2+ group and four O atoms of the crown ether, while the water molecule on the other side of 18-crown-6 ring forms O—H...O hydrogen bonds with two other O atoms of the crown ether. All conventional donors and acceptors in the cations are thus engaged in hydrogen bonding. The ClO4− anion is disordered over two sites, and occupancies for the disordered O atoms were fixed at 0.5. In the crystal, the cations and anions are arranged in alternating layers.

A new organic-inorganic hybrid switchable and tunable dielectric compound, [(CH3)4P]4[Mn(SCN)6] (1), exhibits three distinct dielectric states above room temperature and undergoes two reversible solid-state phase transitions, including a structural phase transition at 330 K and a ferroelastic phase transition with the Aizu notation of mmmF2/m at 352 K. The variable-temperature structural analyses disclose that the origin of the phase transitions and dielectric anomalies can be ascribed to the reorientation or motion of both the [(CH3)4P]+ cations and [Mn(SCN)6]4- anions in solid-state crystals. [ABSTRACT FROM AUTHOR]

Peroxisome proliferator-activated receptor γ (PPAR-γ) has a protective role in several neurological diseases. The present study investigated the effect of the PPAR-γ agonist, pioglitazone, on the mammalian target of rapamycin (mTOR) signaling pathway in a rat model of pentylenetetrazol (PTZ)-induced status epilepticus (SE). The investigation proceeded in two stages. First, the course of activation of the mTOR signaling pathway in PTZ-induced SE was examined to determine the time-point of peak activity, as reflected by phopshorylated (p)-mTOR/mTOR and p-S6/S6 ratios. Subsequently, pioglitazone was administrated intragastrically to investigate its effect on the mTOR signaling pathway, through western blot and immunochemical analyses. The levels of the interleukin (IL)-1β and IL-6 inflammatory cytokines were detected using ELISA, and neuronal loss was observed via Nissl staining. In the first stage of experimentation, the mTOR signaling pathway was activated, and the p-mTOR/mTOR and p-S6/S6 ratios peaked on the third day. Compared with the vehicle treated-SE group, pretreatment with pioglitazone was associated with the loss of fewer neurons, lower levels of IL-1β and IL-6, and inhibition of the activation of the mTOR signaling pathway. Therefore, the mTOR signaling pathway was activated in the PTZ-induced SE rat model, and the PPAR-γ agonist, pioglitazone, had a neuroprotective effect, by inhibiting activation of the mTOR pathway and preventing the increase in the levels of IL-1β and IL-6. [ABSTRACT FROM AUTHOR]

Recently, a plastic crystal of quinuclidinium perrhenate (HQReO4) was reported to have the feasibility of controlling the crystallographic orientation in the grown crystal, but the corresponding temperature window is only about 22 K (345-367 K). Such a narrow window and uncertain ferroelectricity at room temperature would extremely limit its application potential. In this report, we prepared a large area high-quality polycrystalline thin film of HQReO4 and for the first time observed ferroelectricity in the temperature range from 298 to 367 K. Density functional theory calculations revealed the origin of room-temperature ferroelectricity is ascribed to the collaborative flipping of HQ (protonated quinuclidine) and ReO-4, which is dynamically preferred in the presence of a N-H···O hydrogen bond. A local piezoresponse force microscopy measurement was also employed to study the mechanisms of multiaxial polarization rotation and domain dynamics. By extending the ferroelectric temperature window to room temperature and the extraordinary thin-film processability, HQReO4 would certainly become a suitable candidate for next generation ferroelectric materials. [ABSTRACT FROM AUTHOR]

The reaction of 1-bromomethyl-1,4-diazoniabicyclo[2.2.2]octane bromide, zinc chloride and hydrochloric acid in water yields the title compound, (C7H15BrN2)[ZnCl4]. In the crystal, the components are linked by N—H...Cl hydrogen bonds. The ZnII atom has an approximately tetrahedral coordination geometry.

The reaction of dimethylamine hydrochloride, 18-crown-6 and ferric chloride in ethanol yields the title compound, (C2H8N)[FeCl4]·C12H24O6, which exhibits an unusual supramolecular structure. The protonated dimethylamine contains one NH2+ group, resulting in a 1:1 supramolecular rotator–stator structure (CH3—NH2+—CH3)(18-crown-6), through N—H...O hydrogen-bonding interactions between the ammonium group of the cation and the O atoms of the crown ether. In the crystal, all three components lie on a common crystallographic mirror plane normal to [010].

There are two independent molecules in the asymmetric unit of the title compound, C21H21NO2, which was synthesized by the one-pot reaction of 2-naphthol, morpholine and benzaldehyde. The dihedral angles between the naphthalene ring systems and the benzene rings are 84.03 (7) and 75.76 (8)° in the two molecules and an intramolecular O—H...N hydrogen bond occurs in each independent molecule.

The crystal structure of the title compound, (C6H7FN)2[CuCl4], consists of parallel two-dimensional perovskite-type layers of corner-sharing CuCl6 octahedra. These are bonded together via N—H...Cl hydrogen bonds from the 4-fluoroanilinium chains, which are almost perpendicular to the layers. The CuCl4 dianions have two short Cu—Cl bonds [2.2657 (15) and 2.2884 (13) Å] and two longer bonds [2.8868 (15) Å], giving highly Jahn–Teller-distorted CuCl6 octahedra. The Cu atoms are situated on crystallographic centers of inversion.

In the title hydrated salt, 2,4,6-triamino-1,3,5-triazin-1-ium perchlorate monohydrate, C3H7N6+·ClO4−·H2O, the constituents are linked via hydrogen bonds of the O—H...O, N—H...O, N—H...N and N—H...Cl types. All the H atoms of the melaminium cation are involved in the hydrogen bonds. The melaminium residues are interconnected by four N—H...N hydrogen bonds, forming chains parallel to (111). The ribbons are interconnected by other hydrogen bonds as well as by π–π interactions [centroid–centroid distance = 3.8097 (7) Å].

In the title melaminium salt, 2,4,6-triamino-1,3,5-triazin-1-ium iodide monohydrate, C3H7N6+·I−·H2O, the components are linked via N—H...O, N—H...N, O—H...I and N—H...I hydrogen bonds. All of the H atoms of the melaminium cation are involved in hydrogen bonds. The melaminium cations are interconnected by four N—H...N hydrogen bonds, forming ribbons along [111]. The water molecules connected by N—H...O hydrogen bonds also form part of these ribbons. The ribbons are interconnected by other hydrogen bonds (O—H...I and N—H...I), as well as by π–π interactions [centroid–centroid distance = 3.6597 (17) Å].