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6. Reduction in Mortality after Umbilical Cord Blood Transplantation in Children Over a 20-Year Period (1995-2014)

Author

Spees, Lisa P., Martin, Paul L., Kurtzberg, Joanne, Stokhuyzen, Andre, McGill, Lauren, Prasad, Vinod K., Driscoll, Timothy A., Parikh, Suhag H., Page, Kristin M., Vinesett, Richard, Severyn, Christopher, Sung, Anthony D., Proia, Alan D., Jenkins, Kirsten, Arshad, Mehreen, Steinbach, William J., Seed, Patrick C., and Kelly, Matthew S.

Published
2019
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7. PRIMARY VITREORETINAL LYMPHOMA MASQUERADING AS POSTOPERATIVE ENDOPHTHALMITIS IN A PREGNANT PATIENT WITH LONG-STANDING IDIOPATHIC PANUVEITIS.

Author

Konda, Sri Meghana, Deaner, Jordan D., Proia, Alan D., and Jaffe, Glenn J.

Abstract

Purpose: To report primary vitreoretinal lymphoma after surgical 0.59 mg fluocinolone acetonide implant (FAi) exchange in a patient treated with adalimumab for idiopathic bilateral panuveitis. Methods: Retrospective case review. Results: A 37-year-old woman with bilateral idiopathic panuveitis, who had favorable responses to previous FAi surgical implants, presented with right eye recurrent intraocular inflammation and cystoid macular edema that partially responded to systemic adalimumab. Her FAi was replaced, given her previous favorable response. She developed postoperative ocular inflammation transiently responsive to two serial vitreous taps and injections of intravitreal antimicrobials and then worsening inflammation and new layered flocculant material. Diagnostic vitrectomy showed a few atypical lymphocytes and cultures were negative. At postdiagnostic vitrectomy Month 1, flocculant material recurred. Aqueous cytology and flow cytometry revealed large CD45-positive B cells suspicious for lymphoma. Postoperatively, she revealed that she was pregnant. She was treated with eight monthly intravitreal methotrexate injections and postpartum consolidation radiotherapy. Subsequent repeat cytology, flow cytometry, and corneal pathologic examination revealed large B cells that were CD20 positive, and next-generation sequencing detected a dominant monoclonal B-cell population, diagnostic of PVRL. Nineteen months after FAi exchange, she developed an area of enhancement in the lateral aspect of the right frontal lobe on brain MRI, consistent with central nervous system involvement. Conclusion: The authors present a unique case of PVRL masquerading as postoperative endophthalmitis after FAi exchange in an eye with chronic panuveitis treated with adalimumab immunosuppressive therapy. The authors hypothesize that there may be a causal relationship between adalimumab and PVRL. [ABSTRACT FROM AUTHOR]

Published
2024
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24. A CASE OF HIGH-RISK CILIARY BODY MELANOMA ARISING IN AN EYE AFTER RESECTION OF AN IRIDOCILIARY MELANOCYTOMA.

Author

Lee, Terry, Semenova, Ekaterina, Proia, Alan D., and Materin, Miguel A.

Abstract

We present a case of a 40-year-old woman with a ciliary body malignant melanoma of high metastatic potential that arose 5 years after excision of a benign iridociliary melanocytoma at the same site. Purpose: To report a case of a benign iridociliary melanocytoma recurring as malignant melanoma after excision. Methods: Observational case report with clinical data, slit-lamp examination findings, ultrasound biomicroscopy results, and histopathological and genetic analyses. Results: A 40-year-old African American woman initially presented with a superonasal iridociliary mass with a maximal thickness of 2.5 mm. Visual acuity of the involved eye was 20/25, intraocular pressure was 52 mmHg on maximal pressure-lowering medications, and Humphrey visual field testing revealed an inferior altitudinal defect. Fine-needle aspiration biopsy and incisional biopsy followed by tumor excision confirmed a benign melanocytoma. After 5 years of stability, possible recurrence was detected on ultrasound biomicroscopy as an increase in ciliary body thickness. The new lesion grew to a thickness of 5.1 mm over the next 18 months of observation. Fine-needle aspiration biopsy and gene expression profile of the recurrent lesion diagnosed a malignant melanoma with high metastatic potential (Class 2). The patient underwent plaque brachytherapy and has ongoing regression of the tumor. Conclusion: Transformation of benign iridociliary melanocytoma to melanoma is rare. To the best of the authors' knowledge, this is the first documented case of a melanoma arising in an eye after initial excision of a melanocytoma. Close monitoring of these patients is warranted even years after the initial excision. [ABSTRACT FROM AUTHOR]

Published
2023
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26. Comparative integrated molecular analysis of intraocular medulloepitheliomas and central nervous system embryonal tumors with multilayered rosettes confirms that they are distinct nosologic entities

Author

Korshunov, Andrey, Jakobiec, Frederick A., Eberhart, Charles G., Hovestadt, Volker, Capper, David, Jones, David T.W., Sturm, Dominik, Stagner, Anna M., Edward, Deepak P., Eagle, Ralph C., Proia, Alan D., Koch, Arend, Ryzhova, Marina, Ektova, Anastasia, Schüller, Ulrich, Zheludkova, Olga, Lichter, Peter, von Deimling, Andreas, Pfister, Stefan M., and Kool, Marcel

Published
2015
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47. Mönckeberg sclerosis with giant cells as a masquerade of giant cell arteritis.

Author

Johannemann, Andrew, Proia, Alan D., and Criscione-Schreiber, Lisa

Subjects
*GIANT cell arteritis, *MULTINUCLEATED giant cells, *TEMPORAL arteries, *PATHOLOGISTS, *MASQUERADES, *VASCULITIS
Abstract

Giant cell arteritis (GCA) is the most common type of vasculitis in adults, which is classified as a large/medium vessel vasculitis. It has a predilection for the ophthalmic circulation and extracranial carotid system. Temporal artery biopsy specimens can show the presence of inflammatory multinucleated giant cells. Here, we report just the third case of Mönckeberg sclerosis with multinucleated giant cells affecting the temporal artery and mimicking GCA. This rare finding in the evaluation of a common vasculitis is important for rheumatologists to be aware of and emphasizes close collaboration between clinicians and pathologists. [ABSTRACT FROM AUTHOR]

Published
2021
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