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The purpose of this paper is to introduce Stancu variant of generalized Lupaş operators whose construction depends on a continuously differentiable, increasing and unbounded function ρ. Depending on the selection of γ and δ, these operators are more Ćexible than the generalized Lupaş operators while retaining their approximation properties. For these operators we give weighted approximation, Voronovskaya type theorem, quantitative estimates for the local approximation. Finally, we investigate the statistical approximation property of the new operators with the aid of a Korovkin type statistical approximation theorem. [ABSTRACT FROM AUTHOR]

The purpose of this paper is to introduce a Stancu type generalization of the Lupa¸s operators based on the q-integers. We investigate the rate of convergence of operators by mean of modulus of continuity and functions belonging to the Lipschitz class as well as Peetre’s K-functional. [ABSTRACT FROM AUTHOR]

The design and development of drug-delivery nanocarriers with high loading capacity, excellent biocompatibility, targeting ability and controllability have been the ultimate goal of the biomedical research community. In this work, we have reported the synthesis and characterization of novel and smart thermoresponsive polymer coated and Fe3O4 embedded hollow mesoporous silica (HmSiO2) based multifunctional superparamagnetic nanocarriers for the delivery of doxorubicin (Dox) for cancer treatment. P(NIPAM-MAm) coated and Fe3O4 nanoparticle (NP) embedded hollow mesoporous silica nanocomposite (HmSiO2-F-P(NIPAM-MAm)) was prepared by the in situ polymerization of NIPAM and MAm monomers on the surface of hollow mesoporous silica NPs (HmSiO2) in the presence of Fe3O4 NPs, oxidizer and crosslinker. TEM analysis showed nearly spherical morphology of HmSiO2-F-P(NIPAM-MAm) nanocarrier with a diameter in the range of 100–300 nm. The coating of P(NIPAM-MAm) layer and embedding of Fe3O4 NPs on the surface of the HmSiO2 NPs was revealed by HRTEM analysis. XRD and FTIR analysis also confirmed the presence of P(NIPAM-MAm) shells and Fe3O4 NPs on hollow mesoporous silica NPs. VSM analysis suggested the superparamagnetic nature of HmSiO2-F-P(NIPAM-MAm) nanocarrier. DSC analysis of HmSiO2-F-P(NIPAM-MAm) nanocarrier showed a phase transition at the temperature of ∼38 °C. The prepared HmSiO2-F-P(NIPAM-MAm) nanocarrier was investigated for its suitability for drug-delivery application using doxorubicin as the model drug by an in vitro method. The encapsulation efficiency and encapsulation capacity were found to be 95% and 6.8%, respectively. HmSiO2-F-P(NIPAM-MAm)-Dox has shown a pH and temperature-dependent Dox release profile. A relatively faster release of Dox from the nanocarrier was observed at temperature above the lower critical solution temperature (LCST) than below the LCST. HmSiO2-F-P(NIPAM-MAm) nanocarrier was found to be biocompatible in nature. In vitro cytotoxicity studies against Hela cells suggested that the HmSiO2-F-P(NIPAM-MAm)-Dox nanocomposite nanocarrier has good anticancer activity. In vitro cellular uptake study of HmSiO2-F-P(NIPAM-MAm)-Dox nanocomposite nanocarrier demonstrated its good internalisation ability into Hela cells. Thus, the prepared nanocomposites show potential as nanocarrier for targeted and controlled drug delivery for cancer treatment. [ABSTRACT FROM AUTHOR]

Abstract: In recent years, polyaniline/CoFe2O4 nanocomposites have gained attention because of their wide utilization in optoelectronics and biomedical studies. However, very limited research has been carried out on the anticandidal activity of polyaniline/CoFe2O4 nanocomposite against Candida spp. Thus, the study was designed to investigate the anticandidal potential of PANI/CoFe2O4 nanocomposite against Candida albicans 077. PANI/CoFe2O4 nanocomposite (denoted as “cfPNCs”) was synthesized by polymerization of aniline in the presence of CoFe2O4 nanoparticles. The structural and thermal properties of the synthesized PANI/CoFe2O4 nanocomposite were investigated. It was noteworthy that PANI/CoFe2O4 nanocomposite showed promising anticandidal activity in a dose-dependent manner. Results also showed that the protection of histidine (a ROS quencher) against ROS clearly suggested the implication of ROS in anticandidal activity of PANI/CoFe2O4 nanocomposite. It is encouraging to conclude that PANI/CoFe2O4 nanocomposite bears the potential of their applications in biomedicine, especially nanotherapy for diseases caused by C. albicans. [Copyright &y& Elsevier]

Highlights: [•] PANI/CoFe2O4 nanocomposites (PANI@CF-1:1 and 1:2) have been successfully synthesized. [•] Nanocomposites properties modified by the addition of varying amount of the CoFe2O4 NPs into the PANI. [•] Nanocomposite (PANI@CF-1:2) showed the photocatalysis of MO dye via production of ROS. [Copyright &y& Elsevier]

The purpose of this paper is to introduce a new modification of Lupas operators in the frame of post quantum setting and to investigate their approximation properties. First using the relations between q-calculus and post quantum calculus, the post quantum analogue of operators constructed will be linear and positive but will not follow Korovkin's theorem. Hence a new modification of q-Lupas operators is constructed which will preserve test functions. Based on these modification of operators, approximation properties have been investigated. Further, the rate of convergence of operators by mean of modulus of continuity and functions belonging to the Lipschitz class as well as Peetre's K-functional are studied. [ABSTRACT FROM AUTHOR]

In the present work, multifunctional Ni 0.5 Zn 0.5 Fe 2 O 4 @albumen (NZF@Alb) and doxorubicin-loaded Ni 0.5 Zn 0.5 Fe 2 O 4 @albumen (NZF@Alb-Dox) core-shell nanoparticles have been prepared by a green and simple method using inexpensive chicken egg albumen and have been characterized for different physiochemical properties. The structural, morphological, thermal, and magnetic properties of the prepared nanoparticles have been investigated by an x-ray diffractometer, high-resolution transmission electron microscopy (HRTEM), field emission scanning electron microscopy, Fourier-transformed infrared, thermogravimetric analysis, and vibrating sample magnetometer techniques. Superparamagnetic Ni 0.5 Zn 0.5 Fe 2 O 4 nanoparticles (NZF NPs) with the mean size ∼20 nm were coated with albumen matrix by an ultrasonication process. Inverse fast Fourier transform-assisted HRTEM micrographs and FTIR analysis revealed the coating of amorphous albumen on crystalline NZF NPs. NZF@Alb and NZF@Alb-Dox NPs have the mean size (D 50 ) of ∼100 nm, good stability, and magnetic controllability. Magnetic measurements (field (H)-dependent magnetization (M)) show all samples to be super-paramagnetic in nature. Biocompatibilities of the NZF and NZF@Alb NPs were confirmed by in vitro 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay against RAW 264.7 cells. NZF@Alb NPs have been found to be more biocompatible than bare NZF. In Vitro Dox release behavior from NZF@Alb-Dox NPs has been studied at pH 7.4 and 5, and a sustained and pH-dependent drug release profile were observed. In vitro cytotoxicity or anticancer activity of the blank NZF@Alb NPs, free Dox, and NZF@Alb-Dox NPs against HeLa cells (cancer cell line) were also examined by MTT assay. The obtained results suggest that this scalable egg-albumen-based magnetic nanoformulation is suitable for targeted drug delivery applications. Thus, the present study could be extremely useful for the advancement of albumin-based nanocarrier design and development for biomedical applications such as targeted and controlled delivery of anticancer drugs.