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1. A novel genotype encoding a single amino acid insertion and five other substitutions between residues 64 and 74 of the HIV-1 reverse transcriptase confers high-level cross-resistance to nucleoside transcriptase inhibitors

Author

Rakik, Abdelrahim, Ait-Khaled, Mounir, Griffin, Philip, Thomas, Deborah A., Tisdale, Margaret, and Kleim, Jorg-Peter

Subjects
Drug resistance in microorganisms -- Genetic aspects, Gene mutations -- Identification and classification, HIV (Viruses) -- Genetic aspects, Health
Abstract

A mutation consisting of an aspartate codon insertion between positions 69 and 70 in the beta3-beta4 connecting loop of the reverse transcriptase fingers subdomain leads to strong drug resistance by HIV. Resistance to nucleoside reverse transcriptase inhibitors is most likely but the mutation can co-exist with mutations conferring resistance to other AIDS drugs.

Published
1999

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