9 results on '"Recchia D"'
Search Results
2. Age‐related decline in murine heart and skeletal muscle performance is attenuated by reduced Ahnak1 expression
- Author
-
Mahmoodzadeh, S., Koch, K., Schriever, C., Xu, J., Steinecker, M., Leber, J., Dworatzek, E., Purfürst, B., Kunz, S., Recchia, D., Canepari, M., Heuser, A., Di Francescantonio, S., and Morano, I.
- Subjects
Male ,Mice, Knockout ,Age‐related mitochondrial dysfunction ,Ahnak1 ,QM1-695 ,Skeletal muscle ,Heart ,Original Articles ,Diseases of the musculoskeletal system ,Mitochondrial Dynamics ,Mitochondria ,Physical performance ,Mice ,RC925-935 ,Cardiovascular and Metabolic Diseases ,Human anatomy ,Animals ,Original Article ,Female ,Technology Platforms ,Function and Dysfunction of the Nervous System ,Muscle, Skeletal ,Muscle Contraction - Abstract
Background Aging is associated with a progressive reduction in cellular function leading to poor health and loss of physical performance. Mitochondrial dysfunction is one of the hallmarks of aging; hence, interventions targeting mitochondrial dysfunction have the potential to provide preventive and therapeutic benefits to elderly individuals. Meta‐analyses of age‐related gene expression profiles showed that the expression of Ahnak1, a protein regulating several signal‐transduction pathways including metabolic homeostasis, is increased with age, which is associated with low VO2MAX and poor muscle fitness. However, the role of Ahnak1 in the aging process remained unknown. Here, we investigated the age‐related role of Ahnak1 in murine exercise capacity, mitochondrial function, and contractile function of cardiac and skeletal muscles. Methods We employed 15‐ to 16‐month‐old female and male Ahnak1‐knockout (Ahnak1‐KO) and wild‐type (WT) mice and performed morphometric, biochemical, and bioenergetics assays to evaluate the effects of Ahnak1 on exercise capacity and mitochondrial morphology and function in cardiomyocytes and tibialis anterior (TA) muscle. A human left ventricular (LV) cardiomyocyte cell line (AC16) was used to investigate the direct role of Ahnak1 in cardiomyocytes. Results We found that the level of Ahnak1 protein is significantly up‐regulated with age in the murine LV (1.9‐fold) and TA (1.8‐fold) tissues. The suppression of Ahnak1 was associated with improved exercise tolerance, as all aged adult Ahnak1‐KO mice (100%) successfully completed the running programme, whereas approximately 31% male and 8% female WT mice could maintain the required running speed and distance. Transmission electron microscopic studies showed that LV and TA tissue specimens of aged adult Ahnak1‐KO of both sexes have significantly more enlarged/elongated mitochondria and less small mitochondria compared with WT littermates (P
- Published
- 2021
3. PARTICIPATORY IMAGE-BASED MODELS' ALIGNMENT FOR RECONSTRUCTING A LARGE-SCALE INDOOR MAPPING.
- Author
-
Baligh Jahromi, A., Sohn, G., Jung, J., Park, K., and Recchia, D.
- Subjects
AFFINE transformations ,CROWDSOURCING ,IMAGE registration ,INFORMATION modeling ,MODELS & modelmaking ,IMAGE reconstruction algorithms - Abstract
In this paper, we introduced a recently developed image-based model alignment technique for 3D reconstruction of large-scale indoor corridors. The proposed participatory model alignment technique enables crowd source single image-based modeling since it allows various participants to incorporate their images taken from different cameras for large-scale indoor mapping. This technique is robust against changes of camera orientation and prevents miss-association of a newly generated 3D model to the previously integrated models. To investigate the possibility of aligning two individual 3D models, their respective corridor topological graphs must match, and they need to geometrically transform into the same object space. Here 3D affine transformation is applied, and the transformation parameters are estimated through corresponding vertices of both 3D models. Having integrated two models in the same 3D space, they will be back projected into the image space for evaluation using Direct Linear Transformation. Note that the proposed method performs layout model matching in image space and considers information including layout topology and geometry as well as image information to address model alignment. The advantages of using layout information in the proposed alignment technique are twofold. First, a metric constraint is imposed to insure topological model consistency and balance 3D models scale issues. Second, it will reduce alignment ambiguity related to indoor corridor scenes, where the scene is enriched with multiple structural elements including various corridors junctions. To evaluate the performance of the proposed method, we have performed the experiments on a data set collected from Ross building corridors at York University. This dataset includes single images captured by a handheld wide-angle camera. The obtained results present the ability of the proposed method in alignment of single image-based 3D models while producing limited geometric errors. [ABSTRACT FROM AUTHOR]
- Published
- 2020
- Full Text
- View/download PDF
4. Beam and installation improvements of the NIO1 ion source.
- Author
-
Cavenago, M., Barbisan, M., Delogu, R., Pimazzoni, A., Poggi, C., Ugoletti, M., Agostini, M., Antoni, V., Baltador, C., Cervaro, V., De Muri, M., Giora, D., Jain, P., Laterza, B., Maero, G., Maniero, M., Martini, D., Minarello, A., Ravarotto, D., and Recchia, D.
- Subjects
ION sources ,MAGNETIC testing ,ANIONS ,CALORIMETERS ,CESIUM ,SPECTROMETERS - Abstract
The NIO1 (Negative Ion Optimization phase 1) source can provide continuous beam operation, which is convenient for systematic parameter and equipment studies. Even in the pure volume production regime, the source yield was found to depend on conditioning procedures. Magnetic configuration tests continued adding magnets to the existing setup; the filter field component B
x has been progressively extended to span the −12 to 5 mT range, and as a trend, source performances improved with |Bx |. The progress of camera beam diagnostics and of the quality of the volume-produced H− beam is also shown. The status, off-line results, and reliability of a first NIO1 cesium oven are discussed; other upgrades in preparation (cavity ring down spectrometer, the end calorimeter, and conceptual tests of the energy recovery system) are also listed. [ABSTRACT FROM AUTHOR]- Published
- 2020
- Full Text
- View/download PDF
5. Mechanism of the view-dependence of ultrasonic backscatter from normal myocardium.
- Author
-
Recchia, D., Hall, C.S., Shepard, R.K., Miller, J.G., and Wickline, S.A.
- Published
- 1995
- Full Text
- View/download PDF
6. Echocardiography in the evaluation of patients with syncope.
- Author
-
Recchia, Dino, Barzilai, Benico, Recchia, D, and Barzilai, B
- Subjects
ECHOCARDIOGRAPHY ,ELECTROCARDIOGRAPHY ,MEDICAL history taking ,PHYSICAL diagnosis ,SYNCOPE ,RETROSPECTIVE studies - Abstract
Objective: Echocardiography is frequently used as a screening test for cardiac disease in patients with syncope despite the lack of published data describing its utility in this regard. The goal of the study was to examine the frequency with which echocardiography was used in the evaluation of patients admitted to one medical center because of syncope and to examine the diagnostic information, over and above that provided by the initial history, physical examination, and electrocardiography, contributed by the echocardiogram.Design: A retrospective review was performed of all patients admitted to the study institution because of syncope over a seven-month period.Setting: University teaching hospital in an urban setting of 2.5 million population.Patients/participants: One hundred twenty-eight patients were identified: 47 men and 81 women (average age 67 +/- 17 years). Patients for whom syncope was of a known cause, those with near-syncope or vertigo, those with clinically obvious seizure, or those referred for electrophysiologic testing were excluded, leaving 128 patients for analysis. Details from the admission history, physical examination, and electrocardiography for each patient were recorded. The results of all other diagnostic tests ordered to evaluate syncope were recorded along with any consultations obtained. The cause of syncope was assigned by examining all physicians' notes and test results and with the use of previously published diagnostic criteria as guidelines.Measurements and Main Results: Ninety percent of the patients underwent cardiac testing other than routine electrocardiography and continuous telemetry monitoring while in the hospital. An echocardiogram was obtained for 64% of the patients and did not reveal an unsuspected cause for syncope in any case. The echocardiogram was normal for 52% of the patients undergoing the test. Echocardiograms of patients with syncope and no clinical evidence of heart disease by history, physical examination, or electrocardiography either were normal (63%) or provided no useful additional information for arriving at a diagnosis (37%). Nearly half (46%) of the patients undergoing echocardiography fit this clinical profile. Among the patients for whom cardiac disease was suspected after history, physical examination, or electrocardiography, the echocardiogram confirmed the suspected diagnosis for 48% and served to rule out a suspected diagnosis for the remaining 52%. In no instance did echocardiography provide an unsuspected cause for syncope. The history, physical examination, and initial electrocardiography provided sufficient information to permit a diagnosis to be made for 37 of the 48 patients (77%) for whom a cause of syncope was ultimately determined.Conclusion: Echocardiography was frequently used in the evaluation of patients admitted to the hospital because of syncope of unclear cause. For patients without suspected cardiac disease after history, physical examination, and electrocardiography, the echocardiogram did not appear to provide additional useful information, suggesting that syncope alone may not be an indication for echocardiography. For patients with suspected heart disease, echocardiography served to confirm or refute the suspicious in equal proportions. These data provide an objective basis to prospectively define the optimal role of echocardiography in the evaluation of patients with syncope. [ABSTRACT FROM AUTHOR]- Published
- 1995
- Full Text
- View/download PDF
7. Beyond intravascular imaging: quantitative ultrasonic tissue characterization of vascular pathology.
- Author
-
Wickline, S.A., Miller, J.G., Recchia, D., Sharkey, A.M., Bridal, S.L., and Christy, D.H.
- Published
- 1994
- Full Text
- View/download PDF
8. Quantification of ultrasonic anisotropy of scattering from myocardium in vitro and in vivo.
- Author
-
Wickline, S.A., Recchia, D., Shepard, R.K., Verdonk, E.D., and Miller, J.G.
- Published
- 1992
- Full Text
- View/download PDF
9. WS01.04 A new weapon against Mycobacterium abscessus.
- Author
-
Degiacomi, G., Chiarelli, L.R., Muñoz-Muñoz, L., Recchia, D., Stelitano, G., Riabova, O., Lorè, N.I., Monakhova, N., Saliu, F., Rossi, M., Ezquerra-Aznárez, J.M., Tortoli, E., Ramón-García, S., Cirillo, D., Makarov, V., and Pasca, M.R.
- Published
- 2022
- Full Text
- View/download PDF
Catalog
Discovery Service for Jio Institute Digital Library
For full access to our library's resources, please sign in.