Search

In 1969 an apparently unique patient with myasthenia gravis alopecia and an associated wide-spread hair follicle hamartoma was reported by Brown, Crounse & Winkelmann (1969). We describe here a case which shows striking clinical and pathological similarities to that original patient. [ABSTRACT FROM AUTHOR]

Two dark-skinned patients presented with well-defined hypopigmented macules, a biopsy of which showed the characteristic features of mycosis fungoides. Immunohistochemical studies with UCHI1 antiserum (a pan T cell marker) confirmed the almost complete T lymphocyte nature of the infiltrate. UCHT4 antiserum (a suppressor/cytotoxic marker) showed that the epidermal infiltrate consisted predominantly of T suppressor/cytotoxic cells and Leu3a antiserum (a T helper cell marker) showed that the dermal infiltrate was composed of helper and suppressor/cytotoxic cells in approximately equal proportions. Ultrastructural studies identified normal melanocytes in the basal layer of the epidermis from both patients but mitochondrial vacuolation was seen occasionally in Case 2. We believe that this is the first report which documents T cell subsets in skin biopsies from patients with hypopigmented mycosis fungoides. Infiltrate of these two patients contrasts with the usual predominance of T helper lymphocytes in the more common forms of mycosis fungoides. [ABSTRACT FROM AUTHOR]

The clinical features and response to therapy of histologically confirmed lichen sclerosus et atrophicus affecting 25 males arc reported. The disease affected the penis alone in 22 patients and the trunk alone in the remaining 3 patients. Of those with penile lesions, the majority had involvement of both the glans penis and the prepuce. Circumcision proved to be an effective therapy in 8 out of the 11 patients in whom it was performed. [ABSTRACT FROM AUTHOR]

Focuses on lichen sclerosus et atrophicus. Appearance of lichen sclerosus on the skin; Causes of the disease; Management of lichen sclerosus et atrophicus.

A case of Stevens-Johnson syndrome precipitated by the sulphonamide-containing anti-malarial drug, Fansidar, is described. [ABSTRACT FROM PUBLISHER]