1. Performance of Tablet Splitters, Crushers, and Grinders in Relation to Personalised Medication with Tablets
- Author
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Herman J. Woerdenbag, J. Carolina Visser, Marlyn P. A. M. Leferink op Reinink, Roël R. van Orsoy, Anko C. Eissens, Paul Hagedoorn, Hilda Dijkstra, Derk P. Allersma, Shi W. Ng, Oscar S. N. M. Smeets, and Henderik W. Frijlink
- Subjects
oral solid dosage forms ,tablet splitting ,tablet crushing ,tablet grinding ,personalised medicine ,swallowing problems ,Pharmacy and materia medica ,RS1-441 - Abstract
Swallowing problems and the required dose adaptations needed to obtain optimal pharmacotherapy may be a hurdle in the use of tablets in daily clinical practice. Tablet splitting, crushing, or grinding is often applied to personalise medication, especially for the elderly and children. In this study, the performance of different types of (commercially available) devices was studied. Included were splitters, screwcap crushers, manual grinders, and electric grinders. Unscored tablets without active ingredient were prepared, with a diameter of 9 and 13 mm and a hardness of 100–220 N. Tablets were split into two parts and the difference in weight was measured. The time needed to pulverise the tablets (crush time) was recorded. The residue remaining in the device (loss) was measured. The powder was sieved to obtain a particle fraction >600 µm and
- Published
- 2022
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