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Se evaluaron 36 clones de papa por calidad para la industria, rendimiento, respuesta a gota y precocidad, utilizando como testigos las variedades cultivadas para procesamiento industrial, Diacol Capiro, Diacol Monserrate e lCA Unica. Las variables evaluadas fueron porcentaje de tiras y hojuelas no quemadas, gravedad específica, rendimiento procesable, peso tamaño 2, área bajo la curva de la severidad de gota y días después de la siembra a maduración. El experimento se realizó en la Estación Experimental San Jorge, municipio de Soacha (Cundinamarca), se analizó bajo una metodología estadística propuesta en el Programa de Fitomejoramiento dePapa de la Universidad Nacional, que utiliza la suma de rangos en el análisis de diseños incrementados bajo bloquescompletos al azar para seleccionar clones por varias variables y no por una como el análisis tradicional. Se seleccionaron 19 clones, de los cuales 7 son superiores para el conjunto de las variables: los clones 6.5 y 12.59 recomendables para procesamiento en forma de tiras; 2.14,6.8, 11.35, 12.62 y 12.71 para hojuelas. Entre los 7 clones se destacan el 6.8 y 2.14 por presentar menor susceptibilidad a gota y, el clon 6.5 por tener menor tiempo a maduración de tubérculo (15 días menos que Capiro). 36 clones ofpotato were evaluated for industrial quality, yield, late blight response and early ripen, using the varieties grew for industrial processing, Diacol Capiro, Diacol Monserrate and lCA Unica. Data consisted of the percentage of french fries and chips than did not burn, specific gravity, useful yield, weight of second tubers, area under the curve for the severity of late blight and days to ripen. The experiment was carried out at San Jorge Experiment Station, at Soacha municipality (Cundinamarca - Colombia), it was analyzed under a new statistic methodology proposed in the Breeding Program ofthe Universidad Nacional of Colombia that uses ranks sum on the augmented designs analysis in randomized bloc s, in order to choose the clones for several variables and not for one as the traditional analysis. With the macro in the analysis procedure, were found 19 clones, 7 are superior in the group of the evaluated variables: the clones 6.5 and 12.59 are recommended for processing in french fries, 2.14, 6.8, 11.35, 12.62 y 12.71 for chips. Between 7 clones mentioned stand out 6.8 and 2.14 for present an less susceptibility to late blight and, the clon 6.5 for having less time in the ripen of tuber (15 days less than Capiro).

Antiviral agents are needed for the treatment of SARS-CoV-2 infections and to control other coronavirus outbreaks that may occur in the future. Here we report the identification and characterization of RNA-binding compounds that inhibit SARS-CoV-2 replication. The compounds were detected by screening a small library of antiviral compounds previously shown to bind HIV-1 or HCV RNA elements with a live-virus cellular assay detecting inhibition of SARS-CoV-2 replication. These experiments allowed detection of eight compounds with promising anti-SARS-CoV-2 activity in the sub-micromolar to micromolar range and wide selectivity indexes. Examination of the mechanism of action of three selected hit compounds excluded action on the entry or egress stages of the virus replication cycle and confirmed recognition by two of the molecules of conserved RNA elements of the SARS-CoV-2 genome, including the highly conserved S2m hairpin located in the 3'-untranslated region of the virus. While further studies are needed to clarify the mechanism of action responsible for antiviral activity, these results facilitate the discovery of RNA-targeted antivirals and provide new chemical scaffolds for developing therapeutic agents against coronaviruses. [ABSTRACT FROM AUTHOR]

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