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15. Respiratory viral infections in adults with hematologic malignancies and human stem cell transplantation recipients: a retrospective study at a major cancer center.

Author

Chemaly RF, Ghosh S, Bodey GP, Rohatgi N, Safdar A, Keating MJ, Champlin RE, Aguilera EA, Tarrand JJ, Raad II, Chemaly, Roy F, Ghosh, Shubhra, Bodey, Gerald P, Rohatgi, Nidhi, Safdar, Amar, Keating, Michael J, Champlin, Richard E, Aguilera, Elizabeth A, Tarrand, Jeffrey J, and Raad, Issam I

Published
2006
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19. The relationship between vitamin D and chemotherapy-induced toxicity - a pilot study.

Author

Kitchen, D, Hughes, B, Gill, I, O'Brien, M, Rumbles, S, Ellis, P, Harper, P, Stebbing, J, and Rohatgi, N

Subjects
CANCER chemotherapy, THERAPEUTIC use of vitamin D, COHORT analysis, DRUG side effects, ALBUMINS, C-reactive protein
Abstract

Background:There are anecdotal data that lower levels of vitamin D may be associated with increased levels of toxicity in individuals receiving chemotherapy; we therefore wished to investigate this further.Methods:From a cohort of over 11 000 individuals, we included those who had vitamin D levels (serum 1,25(OH)2D3) measured before and during chemotherapy. They were analysed for side effects correlating Chemotherapy Toxicity Criteria with vitamin D levels, normalising data for general markers of patient health including C-reactive protein and albumin.Results:A total of 241 (2% of the total cohort) individuals entered the toxicity analysis. We found no overall difference in toxicity effects experienced by patients depending on whether they were vitamin D depleted or had sufficient levels (P=0.78).Conclusion:This pilot study suggests routine vitamin D measurement during treatment does not appear to be necessary in the management of chemotherapy-induced toxicity. [ABSTRACT FROM AUTHOR]

Published
2012
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26. Planetary protection for Mars sample return

Author

Gershman, R., Adams, M., Mattingly, R., Rohatgi, N., Corliss, J., Dillman, R., Fragola, J., and Minarick, J.

Subjects
*MARS (Planet), *SPACE vehicles, *INNER planets, *ATMOSPHERE
Abstract

A Mars sample return (MSR) mission must deal with two new categories of planetary protection requirements: (1) assuring a very low probability of inadvertent release of the sample in order to provide extra protection against the extremely unlikely possibility of biological hazards in the returned material and (2) keeping the samples free of round-trip Earth organisms to facilitate confirmation of safety after return to Earth. This paper describes the planetary-protection-related technical challenges awaiting an MSR mission as well as the range of capabilities being developed to meet these challenges. Containment assurance requires breaking the chain of contact with Mars: the exterior of the sample container must not be contaminated with Mars material. The sample container and its seals must be designed to survive Earth impacts corresponding to the candidate mission profiles, and the Earth entry vehicle must be designed to withstand the thermal and structural rigors of Earth atmosphere entry (all with an unprecedented degree of confidence). Sample contamination must be avoided by sterilizing the entire spacecraft, a challenge with modern avionics, or by sterilizing the sample collection and containment gear and then isolating it from other parts of the spacecraft. [Copyright &y& Elsevier]

Published
2004
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