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1. The chemokine receptor CCR4 in vascular recognition by cutaneous but not intestinal memory T cells

Author

Campbell, J.J., Haraldsen, G., Pan, J., Rottman, J., Qin, S., Ponath, P., Andrew, D.P., Warnke, R., Ruffing, N., Kassam, N., Wu, Lu, and Butcher, E.C.

Subjects
Cytokines -- Research, Lymphocytes -- Research, Environmental issues, Science and technology, Zoology and wildlife conservation
Abstract

Chemoattractant cytokine molecules, or chemokines, control lymphocyte traffic, partly by triggering arrest of lymphocytes rolling on endothelium. Many systemic memory T cells in blood are found to carry the chemokine receptor CCR4, responding to its ligands TARC and MDC. It is suggested that CCR4 and TARC are important in recognition of skin vasculature by circulating T cells.

Published
1999

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