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2. Effects of race and ethnicity on perinatal outcomes in high-income and upper-middle-income countries: an individual participant data meta-analysis of 2 198 655 pregnancies

Author

Abdollahain, Mali, Savitri, Ary I., Salvesen, Kjell Åsmund, Bhattacharya, Sohinee, Uiterwaal, Cuno S.P.M., Staff, Annetine C., Andersen, Louise Bjoerkholt, Olive, Elisa Llurba, Daskalakis, George, Macleod, Maureen, Thilaganathan, Baskaran, Ramírez, Javier Arenas, Massé, Jacques, Audibert, Francois, Magnus, Per Minor, Sletner, Line, Baschat, Ahmet, Ohkuchi, Akihide, McAuliffe, Fionnuala M., West, Jane, Askie, Lisa M., Mone, Fionnuala, Farrar, Diane, Zimmerman, Peter A., Smits, Luc J.M., Riddell, Catherine, Kingdom, John C., van de Post, Joris, Illanes, Sebastián E., Holzman, Claudia, van Kuijk, Sander M.J., Carbillon, Lionel, Villa, Pia M., Eskild, Anne, Chappell, Lucy, Prefumo, Federico, Velauthar, Luxmi, Seed, Paul, van Oostwaard, Miriam, Verlohren, Stefan, Poston, Lucilla, Ferrazzi, Enrico, Vinter, Christina A., Nagata, Chie, Brown, Mark, Vollebregt, Karlijn C., Takeda, Satoru, Langenveld, Josje, Widmer, Mariana, Saito, Shigeru, Haavaldsen, Camilla, Carroli, Guillermo, Olsen, Jørn, Wolf, Hans, Zavaleta, Nelly, Eisensee, Inge, Vergani, Patrizia, Lumbiganon, Pisake, Makrides, Maria, Facchinetti, Fabio, Sequeira, Evan, Gibson, Robert, Ferrazzani, Sergio, Frusca, Tiziana, Figueiró-Filho, Ernesto A., Lapaire, Olav, Laivuori, Hannele, Lykke, Jacob A., Conde-Agudelo, Agustin, Galindo, Alberto, Mbah, Alfred, Betran, Ana Pilar, Herraiz, Ignacio, Trogstad, Lill, Smith, Gordon G.S., Steegers, Eric A.P., Salim, Read, Huang, Tianhua, Adank, Annemarijne, Zhang, Jun, Meschino, Wendy S., Browne, Joyce L., Allen, Rebecca E., Da Silva Costa, Fabricio, Klipstein-Grobusch, Kerstin, Jørgensen, Jan Stener, Forest, Jean-Claude, Rumbold, Alice R., Mol, Ben W., Giguère, Yves, Ganzevoort, Wessel, Odibo, Anthony O., Myers, Jenny, Yeo, SeonAe, Teede, Helena J., Goffinet, Francois, McCowan, Lesley, Pajkrt, Eva, Haddad, Bassam G., Dekker, Gustaaf, Kleinrouweler, Emily C., LeCarpentier, Édouard, Roberts, Claire T., Groen, Henk, Skråstad, Ragnhild Bergene, Heinonen, Seppo, Eero, Kajantie, Kenny, Louise C., Anggraini, Dewi, Souka, Athena, Cecatti, Jose, Monterio, Ilza, Coomarasamy, Arri, Smuk, Melanie, Pillalis, Athanasios, Crovetto, Francesca, Souza, Renato, Ann Hawkins, Lee, Gabbay- Benziv, Rinat, Riley, Richard, Snell, Kym, Archer, Lucinda, Figuera, Francesc, van Gelder, Marleen, Sheikh, Jameela, Allotey, John, Kew, Tania, Fernández-Félix, Borja M, Zamora, Javier, Khalil, Asma, and Thangaratinam, Shakila

Published
2022
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5. Male patients with inflammatory joint diseases are less likely than controls to be childless: results from a Norwegian population-based cohort study of 10 865 patients

Author

Sigmo, Gudrun David, primary, Hauge, Solveig, additional, Hufthammer, Karl Ove, additional, Wallenius, Marianne, additional, Salvesen, Kjell Åsmund, additional, Daltveit, Anne Kjersti Nesje, additional, Bakland, Gunnstein, additional, and Fevang, Bjorg-Tilde Svanes, additional

Published
2024
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11. Effects of race and ethnicity on perinatal outcomes in high-income and upper-middle-income countries: an individual participant data meta-analysis of 2 198 655 pregnancies

Author

Sheikh, Jameela, primary, Allotey, John, additional, Kew, Tania, additional, Fernández-Félix, Borja M, additional, Zamora, Javier, additional, Khalil, Asma, additional, Thangaratinam, Shakila, additional, Abdollahain, Mali, additional, Savitri, Ary I., additional, Salvesen, Kjell Åsmund, additional, Bhattacharya, Sohinee, additional, Uiterwaal, Cuno S.P.M., additional, Staff, Annetine C., additional, Andersen, Louise Bjoerkholt, additional, Olive, Elisa Llurba, additional, Daskalakis, George, additional, Macleod, Maureen, additional, Thilaganathan, Baskaran, additional, Ramírez, Javier Arenas, additional, Massé, Jacques, additional, Audibert, Francois, additional, Magnus, Per Minor, additional, Sletner, Line, additional, Baschat, Ahmet, additional, Ohkuchi, Akihide, additional, McAuliffe, Fionnuala M., additional, West, Jane, additional, Askie, Lisa M., additional, Mone, Fionnuala, additional, Farrar, Diane, additional, Zimmerman, Peter A., additional, Smits, Luc J.M., additional, Riddell, Catherine, additional, Kingdom, John C., additional, van de Post, Joris, additional, Illanes, Sebastián E., additional, Holzman, Claudia, additional, van Kuijk, Sander M.J., additional, Carbillon, Lionel, additional, Villa, Pia M., additional, Eskild, Anne, additional, Chappell, Lucy, additional, Prefumo, Federico, additional, Velauthar, Luxmi, additional, Seed, Paul, additional, van Oostwaard, Miriam, additional, Verlohren, Stefan, additional, Poston, Lucilla, additional, Ferrazzi, Enrico, additional, Vinter, Christina A., additional, Nagata, Chie, additional, Brown, Mark;, additional, Vollebregt, Karlijn C., additional, Takeda, Satoru, additional, Langenveld, Josje, additional, Widmer, Mariana, additional, Saito, Shigeru, additional, Haavaldsen, Camilla, additional, Carroli, Guillermo, additional, Olsen, Jørn, additional, Wolf, Hans, additional, Zavaleta, Nelly, additional, Eisensee, Inge, additional, Vergani, Patrizia, additional, Lumbiganon, Pisake, additional, Makrides, Maria, additional, Facchinetti, Fabio, additional, Sequeira, Evan, additional, Gibson, Robert, additional, Ferrazzani, Sergio, additional, Frusca, Tiziana, additional, Figueiró-Filho, Ernesto A., additional, Lapaire, Olav, additional, Laivuori, Hannele, additional, Lykke, Jacob A., additional, Conde-Agudelo, Agustin, additional, Galindo, Alberto, additional, Mbah, Alfred, additional, Betran, Ana Pilar, additional, Herraiz, Ignacio, additional, Trogstad, Lill, additional, Smith, Gordon G.S., additional, Steegers, Eric A.P., additional, Salim, Read, additional, Huang, Tianhua, additional, Adank, Annemarijne, additional, Zhang, Jun, additional, Meschino, Wendy S., additional, Browne, Joyce L., additional, Allen, Rebecca E., additional, Da Silva Costa, Fabricio, additional, Klipstein-Grobusch, Kerstin, additional, Jørgensen, Jan Stener, additional, Forest, Jean-Claude, additional, Rumbold, Alice R., additional, Mol, Ben W., additional, Giguère, Yves, additional, Ganzevoort, Wessel, additional, Odibo, Anthony O., additional, Myers, Jenny, additional, Yeo, SeonAe, additional, Teede, Helena J., additional, Goffinet, Francois, additional, McCowan, Lesley, additional, Pajkrt, Eva, additional, Haddad, Bassam G., additional, Dekker, Gustaaf, additional, Kleinrouweler, Emily C., additional, LeCarpentier, Édouard, additional, Roberts, Claire T., additional, Groen, Henk, additional, Skråstad, Ragnhild Bergene, additional, Heinonen, Seppo, additional, Eero, Kajantie, additional, Kenny, Louise C., additional, Anggraini, Dewi, additional, Souka, Athena, additional, Cecatti, Jose, additional, Monterio, Ilza, additional, Coomarasamy, Arri, additional, Smuk, Melanie, additional, Pillalis, Athanasios, additional, Crovetto, Francesca, additional, Souza, Renato, additional, Ann Hawkins, Lee, additional, Gabbay- Benziv, Rinat, additional, Riley, Richard, additional, Snell, Kym, additional, Archer, Lucinda, additional, Figuera, Francesc, additional, and van Gelder, Marleen, additional

Published
2022
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16. Do Sexually Abstinent Women have more pelvic floor Disorders?A cross sectional, population based study

Author

Volløyhaug, Ingrid, Lonnée-Hoffmann, Risa Anna Margaretha, Salvesen, Kjell Åsmund Blix, and Guzman-Rojas, Rodrigo

Abstract

Introduction and hypothesis: The aims were to establish the prevalence of sexually abstinent women because of Pelvic Floor Disorders (PFDs) in parous women, and to examine if abstinence was associated with symptoms of PFDs or functional anatomy of the pelvic floor. Methods: Cross-sectional study of parous women responding to a questionnaire and undergoing pelvic floor examination. Distress for Urinary (UDI), Colorectal-Anal (CRADI), and Pelvic Organ Prolapse (POPDI) symptoms, Prevalence of Prolapse (POP-Q) ≥ grade 2, pelvic floor muscle injury on ultrasound and contraction (Modified Oxford Scale) were compared between sexually active women and abstinent women using Mann-Whitney U, logistic regression and Fisher’s exact tests. Results: 1625 of 3115 women responded to the questionnaire, and 604 were examined. 1379 (85%) were sexually active, 22 (1.4%) were sexually abstinent because of PFDs and 224 (14%) for other reasons. Abstinent women because of PFDs had higher mean (SD) symptom scores [UDI 38.8 (16.8), CRADI 36.6 (21.8), POPDI 10.9 (10.4)] than sexually active women [UDI 9.8 (14.1), CRADI 11.1 (14.4), POPDI 2.3(5.5)] p0.05. Conclusion: Symptoms of PFDs were more important than objective measures of prolapse, muscle injury and contraction for sexual activity in parous women.

Published
2022

22. Safety Aspects of Perinatal Ultrasound

Author

Sande, Ragnar, additional, Jenderka, Klaus-Vitold, additional, Moran, Carmel M., additional, Marques, Susana, additional, Jimenez Diaz, J. F., additional, ter Haar, Gail, additional, Marsal, Karel, additional, Lees, Christoph, additional, Abramowicz, Jacques S., additional, Salvesen, Kjell Åsmund, additional, Miloro, Piero, additional, Dall’Asta, Andrea, additional, Brezinka, Christoph, additional, and Kollmann, Christian, additional

Published
2021
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24. Controversies in implementing non‐invasive prenatal testing in a public antenatal care program.

Author

Salvesen, Kjell Åsmund Blix, Glad, Ragnhild, and Sitras, Vasilis

Abstract

Women's autonomy and an inclusive society for all individuals are highly valued in Norway. The Norwegian Biotechnology Act changed in 2020 allowing first‐trimester screening and cell‐free DNA for common trisomies to all pregnant women. However, implementing non‐invasive prenatal testing (NIPT) in a public antenatal care program is difficult, because many patients, politicians, and medical professionals do not consider trisomy 21 a severe medical disease. Screening for trisomies at an early gestation might inevitably lead to an increase in pregnancy terminations and making cost–benefit calculations is ethically challenging. Moreover, offering NIPT to all pregnant women is debatable because of the lower prevalence of fetal trisomies in younger women. Therefore, appropriate genetic pre‐test counseling is essential. Furthermore, organizing the service between private institutions and public hospitals poses another debate and challenges both quality and equal access to health services for women across the country. [ABSTRACT FROM AUTHOR]

Published
2022
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25. External validation of prognostic models to predict stillbirth using International Prediction of Pregnancy Complications (IPPIC) Network database: individual participant data meta-analysis.

Author

Allotey, J., Whittle, R., Snell, K. I. E., Smuk, M., Townsend, R., von Dadelszen, P., Heazell, A. E. P., Magee, L., Smith, G. C. S., Sandall, J., Thilaganathan, B., Zamora, J., Riley, R. D., Khalil, A., Thangaratinam, S., Coomarasamy, Arri, Kwong, Alex, Savitri, Ary I., Salvesen, Kjell åsmund, and Bhattacharya, Sohinee

Subjects
PREGNANCY complications, PROGNOSTIC models, STILLBIRTH, FETAL death, PREGNANT women, FETAL monitoring
Abstract

Objective: Stillbirth is a potentially preventable complication of pregnancy. Identifying women at high risk of stillbirth can guide decisions on the need for closer surveillance and timing of delivery in order to prevent fetal death. Prognostic models have been developed to predict the risk of stillbirth, but none has yet been validated externally. In this study, we externally validated published prediction models for stillbirth using individual participant data (IPD) meta-analysis to assess their predictive performance.Methods: MEDLINE, EMBASE, DH-DATA and AMED databases were searched from inception to December 2020 to identify studies reporting stillbirth prediction models. Studies that developed or updated prediction models for stillbirth for use at any time during pregnancy were included. IPD from cohorts within the International Prediction of Pregnancy Complications (IPPIC) Network were used to validate externally the identified prediction models whose individual variables were available in the IPD. The risk of bias of the models and cohorts was assessed using the Prediction study Risk Of Bias ASsessment Tool (PROBAST). The discriminative performance of the models was evaluated using the C-statistic, and calibration was assessed using calibration plots, calibration slope and calibration-in-the-large. Performance measures were estimated separately in each cohort, as well as summarized across cohorts using random-effects meta-analysis. Clinical utility was assessed using net benefit.Results: Seventeen studies reporting the development of 40 prognostic models for stillbirth were identified. None of the models had been previously validated externally, and the full model equation was reported for only one-fifth (20%, 8/40) of the models. External validation was possible for three of these models, using IPD from 19 cohorts (491 201 pregnant women) within the IPPIC Network database. Based on evaluation of the model development studies, all three models had an overall high risk of bias, according to PROBAST. In the IPD meta-analysis, the models had summary C-statistics ranging from 0.53 to 0.65 and summary calibration slopes ranging from 0.40 to 0.88, with risk predictions that were generally too extreme compared with the observed risks. The models had little to no clinical utility, as assessed by net benefit. However, there remained uncertainty in the performance of some models due to small available sample sizes.Conclusions: The three validated stillbirth prediction models showed generally poor and uncertain predictive performance in new data, with limited evidence to support their clinical application. The findings suggest methodological shortcomings in their development, including overfitting. Further research is needed to further validate these and other models, identify stronger prognostic factors and develop more robust prediction models. © 2021 The Authors. Ultrasound in Obstetrics & Gynecology published by John Wiley & Sons Ltd on behalf of International Society of Ultrasound in Obstetrics and Gynecology. [ABSTRACT FROM AUTHOR]

Published
2022
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40. Erratum to Study protocol: Differential effects of diet and physical activity based interventions in pregnancy on maternal and fetal outcomes: Individual patient data (IPD) meta-analysis and health economic evaluation [Syst Rev., 3, 131, (2014)]

Author

Ruifrok, Anneloes E, Rogozinska, Ewelina, van Poppel, Mireille N M, Rayanagoudar, Girish, Kerry, Sally, de Groot, Christianne J M, Yeo, SeonAe, Molyneaux, Emma, Barakat Carballo, Ruben, Perales, Maria, Bogaerts, Annick, Cecatti, Jose G, Surita, Fernanda, Dodd, Jodie, Owens, Julie, El Beltagy, Nermeen, Devlieger, Roland, Teede, Helena, Harrison, Cheryce, Haakstad, Lene, Shen, Garry X, Shub, Alexis, Motahari, Narges, Khoury, Janette, Tonstad, Serena, Luoto, Riitta, Kinnunen, Tarja I, Guelfi, Kym, Facchinetti, Fabio, Petrella, Elisabetta, Phelan, Suzanne, Scudeller, Tânia T, Rauh, Kathrin, Hauner, Hans, Renault, Kristina, Sagedal, Linda Reme, Vistad, Ingvild, Stafne, Signe Nilssen, Mørkved, Siv, Salvesen, Kjell Åsmund, Vinter, Christina Anne, Vitolo, Marcia, Astrup, Arne, Geiker, Nina Rica Wium, McAuliffe, Fionnuala, Poston, Lucilla, Roberts, Tracy, Riley, Richard D, Coomarasamy, Arri, Khan, Khalid S, Mol, Ben Willem, Thangaratinam, Shakila, Obstetrics and gynaecology, Division 6, and ICaR - Ischemia and repair

Published
2015

46. Hemoglobin A1c as screening for gestational diabetes mellitus in Nordic Caucasian women.

Author

Hov Odsæter, Ingrid, Åsberg, Arne, Vanky, Eszter, Mørkved, Siv, Stafne, Signe Nilssen, Salvesen, Kjell Åsmund, and Carlsen, Sven Magnus

Subjects
RISK factors of preeclampsia, FETAL macrosomia, GESTATIONAL diabetes, CAUCASIAN race, LOGISTIC regression analysis, DISEASE prevalence, BIRTH weight, DISEASES
Abstract

Background: Gestational diabetes mellitus (GDM) increases the risk for preeclampsia and macrosomia. GDM is conventionally diagnosed by an oral glucose tolerance test (OGTT). Hemoglobin A1c (HbA1c) is a marker for the average glucose level the last 2-3 months. We aimed to study if HbA1c alone or in combination with patient characteristics can be used to screen for GDM and reduce the number of OGTTs, and whether it could predict preeclampsia or birth weight. Methods: 855 women from a previous study on the effect of exercise on GDM prevalence were eligible, whereof 677 were included. GDM was diagnosed by WHO 1999 criteria (GDM-WHO) and modified IADPSG criteria (GDM-IADPSG), at pregnancy weeks 18-22 and 32-36. HbA1c analyzed at pregnancy weeks 18-22 and 32-36, variables from patient history and clinical examination were considered for logistic regression models. The diagnostic accuracy was assessed by ROC curve analysis. Results: Accumulated GDM prevalence was 6.7% by WHO and 7.2% by modified IADPSG criteria. Nearly a third could potentially have avoided an OGTT by using HbA1c to exclude GDM-IADPSG with a sensitivity of 88% at week 18-22 and 97% at week 32-36. Further, 16% could have avoided an OGTT with a sensitivity of 96% using HbA1c at week 18-22 to exclude GDM-IADPSG throughout pregnancy. HbA1c was not accurate at diagnosing GDM-IADPSG, and it was inaccurate at screening for GDM-WHO at any time point. Adding other predictors did not increase the number of potentially avoidable OGTTs significantly. HbA1c was not significantly associated with preeclampsia or birth weight. Conclusions: HbA1c could potentially reduce the number of OGTTs. [ABSTRACT FROM AUTHOR]

Published
2016
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49. Dietary Intake in Early Pregnancy and Glycemia in Late Pregnancy among Women with Obesity.

Author

Garnæs, Kirsti Krohn, Elvebakk, Trude, Salvesen, Øyvind, Stafne, Signe Nilssen, Mørkved, Siv, Salvesen, Kjell Åsmund, and Moholdt, Trine

Abstract

Women with obesity have increased risk for hyperglycemia during pregnancy, with negative health consequences for mother and child. We aimed to investigate adherence to nutritional recommendations in early pregnancy and to examine associations between early pregnancy dietary intake and late pregnancy glycemia among women with obesity. We included 120 women with pre-pregnancy body mass index (BMI) ≥30 kg/m2 who participated in one of two randomized controlled trials. The participants completed a food frequency questionnaire in early pregnancy (gestational weeks 12–22). Fasting and 120 min glucose tolerance after ingestion of 75 g glucose were assessed in late pregnancy (gestational weeks 32–37). About 90% of the participants reported early pregnancy diary intake within the recommendations. Average intakes of vitamin D, iron, and folate were below recommended levels. High intakes of dairy products and protein in early pregnancy were associated with lower fasting glucose in late pregnancy, whereas high intake of bread was associated with lower 120 min glucose. There were no clear associations between single dietary variables and gestational diabetes mellitus (GDM) diagnosis in late pregnancy. In conclusion, some early pregnancy dietary variables were associated with late pregnancy glycemia. Potential causality of these findings should be investigated in future studies. [ABSTRACT FROM AUTHOR]

Published
2022
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