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1. Effectiveness and Safety of Direct-acting Antivirals for Treatment of Adolescents With HCV/HIV Coinfection: Real-world Data From Europe

Author

Malik, Farihah, Crichton, Siobhan, Plotnikova, Yulia, Latysheva, Inga, Samarina, Anna, Pokorska-Śpiewak, Maria, Gomez, Marisa Navarro, Bailey, Heather, Thorne, Claire, Judd, Ali, Turkova, Anna, Collins, Intira Jeannie, Marczyńska, Magdalena, Popielska, Jolanta, Ołdakowska, Agnieszka, Zawadka, Konrad, Pluta, Magdalena, Doroba, Małgorzata, Okhonskaya, Liubov, Rozenberg, Vladimir, Voronin, Evgeny, Plynsky, Alexksey A., José Mellado, María, Escosa, Luis, García Hortelano, Milagros, Sainz, Talía, Grasa, Carlos, Rodríguez, Paula, Rojo, Pablo, Prieto-Tato, Luis, Epalza, Cristina, Tagarro, Alfredo, Domínguez, Sara, Ballesteros, Álvaro, Tomás Ramos, José, Illán, Marta, Berzosa, Arantxa, Guillén, Sara, Soto, Beatriz, Luisa Navarro, María, Saavedra, Jesús, Santos, Mar, Aguilera, David, Santiago, Begoña, Jimenez de Ory, Santiago, Bermejo, Amanda, Penín, María, Martínez, Jorge, Badillo, Katie, Belén Jiménez, Ana, Navas, Adriana, Oñate, Eider, Pocheville, Itziar, Garrote, Elisa, Colino, Elena, Afonso, Olga, Gómez Sirvent, Jorge, Garzón, Mónica, Román, Vicente, Angulo, Raquel, Neth, Olaf, Falcón, Lola, Terol, Pedro, Luis Santos, Juan, Vázquez, Álvaro, Carazo, Begoña, Medina, Antonio, Lendínez, Francisco, Ibáñez, Mercedes, Peromingo, Estrella, Isabel Sánchez, María, Ruiz, Beatriz, Grande, Ana, José Romero, Francisco, Pérez, Carlos, Calle, Laura, Pareja, Marta, Losada, Begoña, Herranz, Mercedes, Bustillo, Matilde, Collado, Pilar, Antonio Couceiro, José, Vila, Leticia, Calviño, Consuelo, Isabel Piqueras, Ana, Oltra, Manuel, Gavilán, César, Montesinos, Elena, Dapena, Marta, Jiménez, Beatriz, Gloria Andrés, Ana, Marugán, Víctor, Ochoa, Carlos, Isabel Menasalvas, Ana, Cervantes, Eloísa, Álvarez, Beatriz, Díez, Cristina, Bernardino, Ignacio, Luisa Montes, María, Valencia, Eulalia, Delgado, Ana, Rubio, Rafael, Pulido, Federico, Bisbal, Otilia, Monereo Alonso, Alfonso, Berenguer, Juan, Díez, Cristina, Aldamiz, Teresa, Tejerina, Francisco, Carlos Bernaldo de Quirós, Juan, Padilla, Belén, Carrillo, Raquel, Montilla, Pedro, Bermúdez, Elena, Valerio, Maricela, Sanz, Jose, Gimeno, Alejandra, Cervero, Miguel, Torres, Rafael, Moreno, Santiago, Jesús Perez, María, del Campo, Santos, Ryan, Pablo, Troya, Jesus, Sanz, Jesus, Losa, Juan, Gomez, Rafael, Górgolas, Miguel, Díaz, Alberto, de la Fuente, Sara, Antonio Iribarren, Jose, Jose Aramburu, Maria, Martinez, Lourdes, Josune Goikoetxea, Ane, Ibarra, Sofia, de la Peña, Mireia, Asensi, Víctor, Hernandez, Michele, Remedios Alemán, María, Pelazas, Ricardo, del Mar Alonso, María, María López, Ana, García, Dácil, Rodriguez, Jehovana, Angel Cardenes, Miguel, Castaño, Manuel A., Orihuela, Francisco, Pérez, Inés, Isabel Mayorga, Mª, Fernando Lopez-Cortes, Luis, Roca, Cristina, Llaves, Silvia, Jose Rios, Maria, Rodriguez, Jesus, Palomo, Virginia, Pasquau, Juan, Garcia, Coral, Hernandez, Jose, Martinez, Clara, Rivero, Antonio, Camacho, Angela, Merino, Dolores, Raffo, Miguel, Corpa, Laura, Martinez, Elisa, Mateos, Fernando, Javier Blanch, Jose, Torralba, Miguel, Arazo, Piedad, Samperiz, Gloria, Miralles, Celia, Ocampo, Antonio, Pousada, Guille, Mena, Alvaro, Montero, Marta, Salavert, Miguel, Jose Galindo, Maria, Pretel, Natalia, Portilla, Joaquín, Portilla, Irene, Gutierrez, Felix, Masia, Mar, Robledano, Cati, Adsuar, Araceli, Hinojosa, Carmen, Monteagudo, Begoña, Bachiller, Pablo, Abadía, Jesica, Galera, Carlos, Albendin, Helena, Fernandez, Marian, and Ramon Blanco, Jose

Published
2024
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2. The Value of the Second QuantiFERON-TB Gold-Plus Antigen Tube at Diagnosis and at Treatment Completion in Spanish Children With Tuberculosis

Author

Soler-Garcia, Aleix, Gamell, Anna, Monsonís, Manuel, Korta-Murua, José Javier, Espiau, María, Rincón-López, Elena, Rodríguez-Molino, Paula, Pérez-Porcuna, Tomàs, Bustillo-Alonso, Matilde, Santiago, Begoña, Tebruegge, Marc, Noguera-Julian, Antoni, AZURMENDI-GUNDÍN, Nerea, FORTUNY, Clàudia, COLINO, Elena, GÓMEZ-PASTRANA, David, MONTERO, María, PEROMINGO, Estrella, LAFUENTE-HIDALGO, Miguel, MOLINER, Elisenda, VALMANYA, Teresa, MINGUELL-DOMINGO, Laura, FENOY, Marina, VELÁZQUEZ, Marta, SOLER-CAMPINS, Maria Queralt, GARCIA, Lourdes, LAHOZ, Rebeca, CALAVIA, Olga, PASCUAL, María Teresa, RIUS, Neus, TÓRTOLA, Teresa, SORIANO-ARANDES, Antoni, MARTÍN-NALDA, Andrea, SOLER-PALACÍN, Pere, LILLO, Miguel, DAPENA, Marta, LÓPEZ-MEDINA, Eva María, PIQUERAS, Ana Isabel, RUIZ-JIMÉNEZ, Marta, SOTO-SÁNCHEZ, Beatriz, HERNÁNDEZ, Ángel, RUIZ-SERRANO, María Jesús, COBO-VÁZQUEZ, Elvira, SANTOS, María del Mar, HERNÁNDEZ-SAMPELAYO, Teresa, TAGARRO, Alfredo, MÉNDEZ-ECHEVARRÍA, Ana, MELLADO, María José, BAQUERO-ARTIGAO, Fernando, CALVO, Cristina, SAINZ, Talía, ÁLVAREZ, Javier, GARCÍA ASCASO, Marta Taida, VILLALOBOS, Enrique, PÉREZ-GORRICHO, Beatriz, GARCÍA-GARCÍA, María Luz, GARROTE-LLANOS, Maria Isabel, REMENTERÍA, Joseba, SÁNCHEZ-TORRENT, Laia, GARCÍA-HORTELANO, Milagros, and LOBATO, Zulema

Published
2023
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3. Interferon-Gamma Release Assays Differentiate between Mycobacterium avium Complex and Tuberculous Lymphadenitis in Children

Author

Vallmanya, Teresa, Minguell, Laura, Martín-Nalda, Andrea, Soler-Palacín, Pere, Espiau, María, Lobato, Zulema, Garcia, Lourdes, Velázquez, Marta, Herranz, Mercedes, Arroyo, Mireia, Gutiérrez, Carmelo, Gavilán, César, Piqueras, Ana Isabel, Martinón-Torres, Federico, Villanueva, Isabel, Rueda, Santiago, Ramos, Marta Illán, Morales, Ana, ROA, Miguel, Pérez-Gorricho, Beatriz, Pinto, Enrique Villalobos, Sanz-Santaeufemia, Francisco José, Álvarez, Javier, Álvarez, Cristina, Guarch, Borja, Montero, María, Cilleruelo, María José, Otheo, Enrique, Calvo, Cristina, Korta Murua, José Javier, Mellado, María José, Rojo, Pablo, Moreno-Pérez, David, Neth, Olaf, Santos, Mar, Hernández, Teresa, Hidalgo, Miguel Lafuente, Antonio Cepillo, Martínez-Planas, Aina, Baquero-Artigao, Fernando, Santiago, Begoña, Fortuny, Clàudia, Méndez-Echevarría, Ana, Del Rosal, Teresa, Bustillo-Alonso, Matilde, Gale, Inés, Guerrero, Carmelo, Blázquez-Gamero, Daniel, Canet, Anna, Lillo, Miguel, Calavia, Olga, Núñez Cuadros, Esmeralda, Falcón-Neyra, Lola, Soriano-Arandes, Antoni, Van Ingen, Jakko, Tebruegge, Marc, and Noguera-Julian, Antoni

Published
2021
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4. Tuberculosis in Spain: An opinion paper

Author

Moreno Guillén, Santiago, primary, Rodríguez-Artalejo, Fernando, additional, Ruiz-Galiana, Julián, additional, Cantón, Rafael, additional, De Lucas Ramos, Pilar, additional, García-Botella, Alejandra, additional, García-Lledó, Alberto, additional, Hernández-Sampelayo, Teresa, additional, Gómez-Pavón, Javier, additional, González del Castillo, Juan, additional, Martín-Delgado, Mari Cruz, additional, Martín Sánchez, Francisco Javier, additional, Martínez-Sellés, Manuel, additional, Molero García, José María, additional, Santiago, Begoña, additional, Caminero, José Antonio, additional, Barros, Carlos, additional, García de Viedma, Darío, additional, Martín, Carlos, additional, and Bouza, Emilio, additional

Published
2023
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5. Evaluation of radiological capacity and usage in paediatric TB diagnosis: A mixed-method protocol of a comparative study in Mozambique, South Africa and Spain.

Author

Munyangaju, Isabelle, José, Benedita, Esmail, Ridwaan, Palmer, Megan, Santiago, Begoña, Hernanz-Lobo, Alicia, Mutemba, Crimenia, Perez, Patricia, Tlhapi, Liebe Hendrietta, Mudaly, Vanessa, Pitcher, Richard D., Jahnen, Andreas, Carruana, Eliseo Vañó, López-Varela, Elisa, and Thierry-Chef, Isabelle

Subjects
RADIATION protection, TUBERCULOSIS, SEX factors in disease, HEALTH facilities, COMPUTED tomography, DIAGNOSIS
Abstract

Introduction: Tuberculosis remains one of the top ten causes of mortality globally. Children accounted for 12% of all TB cases and 18% of all TB deaths in 2022. Paediatric TB is difficult to diagnose with conventional laboratory tests, and chest radiographs remain crucial. However, in low-and middle-income countries with high TB burden, the capacity for radiological diagnosis of paediatric TB is rarely documented and data on the associated radiation exposure limited. Methods: A multicentre, mixed-methods study is proposed in three countries, Mozambique, South Africa and Spain. At the national level, official registry databases will be utilised to retrospectively compile an inventory of licensed imaging resources (mainly X-ray and Computed Tomography (CT) scan equipment) for the year 2021. At the selected health facility level, three descriptive cross-sectional standardised surveys will be conducted to assess radiology capacity, radiological imaging diagnostic use for paediatric TB diagnosis, and radiation protection optimization: a site survey, a clinician-targeted survey, and a radiology staff-targeted survey, respectively. At the patient level, potential dose optimisation will be assessed for children under 16 years of age who were diagnosed and treated for TB in selected sites in each country. For this component, a retrospective analysis of dosimetry will be performed on TB and radiology data routinely collected at the respective sites. National inventory data will be presented as the number of units per million people by modality, region and country. Descriptive analyses will be conducted on survey data, including the demographic, clinical and programmatic characteristics of children treated for TB who had imaging examinations (chest X-ray (CXR) and/or CT scan). Dose exposure analysis will be performed by children's age, gender and disease spectrum. Discussion: As far as we know, this is the first multicentre and multi-national study to compare radiological capacity, radiation protection optimization and practices between high and low TB burden settings in the context of childhood TB management. The planned comparative analyses will inform policy-makers of existing radiological capacity and deficiencies, allowing better resource prioritisation. It will inform clinicians and radiologists on best practices and means to optimise the use of radiological technology in paediatric TB management. [ABSTRACT FROM AUTHOR]

Published
2024
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6. Advantages and disadvantages of maintaining the mandatory use of masks in health centers and nursing homes in Spain. How and when is it justified to maintain it?

Author

Martínez-Sellés, Manuel, primary, Martín Sánchez, Francisco Javier, additional, Moreno Guillén, Santiago, additional, Rodríguez-Artalejo, Fernando, additional, Ruiz-Galiana, Julián, additional, Cantón, Rafael, additional, De Lucas Ramos, Pilar, additional, García-Botella, Alejandra, additional, García-Lledó, Alberto, additional, Hernández-Sampelayo, Teresa, additional, Gómez-Pavón, Javier, additional, González del Castillo, Juan, additional, Martín-Delgado, Mari Cruz, additional, Molero García, José María, additional, Santiago, Begoña, additional, Caminero, José Antonio, additional, Barros, Carlos, additional, García de Viedma, Darío, additional, Martín, Carlos, additional, and Bouza, Emilio, additional

Published
2023
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7. A HEV-restricted sulfotransferase is expressed in rheumatoid arthritis synovium and is induced by lymphotoxin-α/β and TNF-α in cultured endothelial cells

Author

Pablos, José L, Santiago, Begoña, Tsay, Durwin, Singer, Mark S, Palao, Guillermo, Galindo, María, and Rosen, Steven D

Subjects
Biomedical and Clinical Sciences, Immunology, Autoimmune Disease, Arthritis, 2.1 Biological and endogenous factors, Aetiology, Inflammatory and immune system, Antigens, Surface, Arthritis, Rheumatoid, Cells, Cultured, Chemotaxis, Leukocyte, Endothelial Cells, Endothelium, Vascular, Humans, L-Selectin, Lymphotoxin-alpha, Lymphotoxin-beta, Membrane Proteins, Receptors, Lymphocyte Homing, Sulfotransferases, Synovial Membrane, Tumor Necrosis Factor-alpha, Venules
Abstract

BackgroundThe recruitment of lymphocytes to secondary lymphoid organs relies on interactions of circulating cells with high endothelial venules (HEV). HEV are exclusive to these organs under physiological conditions, but they can develop in chronically-inflamed tissues. The interaction of L-selectin on lymphocytes with sulfated glycoprotein ligands on HEV results in lymphocyte rolling, which represents the initial step in lymphocyte homing. HEV expression of GlcNAc6ST-2 (also known as HEC-GlcNAc6ST, GST-3, LSST or CHST4), an HEV-restricted sulfotransferase, is essential for the elaboration of L-selectin functional ligands as well as a critical epitope recognized by MECA-79 mAb.ResultsWe examined the expression of GlcNAc6ST-2 in relationship to the MECA-79 epitope in rheumatoid arthritis (RA) synovial vessels. Expression of GlcNAc6ST-2 was specific to RA synovial tissues as compared to osteoarthritis synovial tissues and localized to endothelial cells of HEV-like vessels and small flat-walled vessels. Double MECA-79 and GlcNAc6ST-2 staining showed colocalization of the MECA-79 epitope and GlcNAc6ST-2. We further found that both TNF-alpha and lymphotoxin-alphabeta induced GlcNAc6ST-2 mRNA and protein in cultured human umbilical vein endothelial cells.ConclusionThese observations demonstrate that GlcNAc6ST-2 is induced in RA vessels and provide potential cytokine pathways for its induction. GlcNAc6ST-2 is a novel marker of activated vessels within RA ectopic lymphoid aggregates. This enzyme represents a potential therapeutic target for RA.

Published
2005

8. A HEV-restricted sulfotransferase is expressed in rheumatoid arthritis synovium and is induced by lymphotoxin-alpha/beta and TNF-alpha in cultured endothelial cells.

Author

Pablos, José L, Santiago, Begoña, Tsay, Durwin, Singer, Mark S, Palao, Guillermo, Galindo, María, and Rosen, Steven D

Subjects
Synovial Membrane, Endothelium, Vascular, Venules, Cells, Cultured, Endothelial Cells, Humans, Arthritis, Rheumatoid, Sulfotransferases, Tumor Necrosis Factor-alpha, Receptors, Lymphocyte Homing, L-Selectin, Membrane Proteins, Antigens, Surface, Chemotaxis, Leukocyte, Lymphotoxin-alpha, Lymphotoxin-beta, Endothelium, Vascular, Cells, Cultured, Arthritis, Rheumatoid, Receptors, Lymphocyte Homing, Antigens, Surface, Chemotaxis, Leukocyte, Immunology
Abstract

BackgroundThe recruitment of lymphocytes to secondary lymphoid organs relies on interactions of circulating cells with high endothelial venules (HEV). HEV are exclusive to these organs under physiological conditions, but they can develop in chronically-inflamed tissues. The interaction of L-selectin on lymphocytes with sulfated glycoprotein ligands on HEV results in lymphocyte rolling, which represents the initial step in lymphocyte homing. HEV expression of GlcNAc6ST-2 (also known as HEC-GlcNAc6ST, GST-3, LSST or CHST4), an HEV-restricted sulfotransferase, is essential for the elaboration of L-selectin functional ligands as well as a critical epitope recognized by MECA-79 mAb.ResultsWe examined the expression of GlcNAc6ST-2 in relationship to the MECA-79 epitope in rheumatoid arthritis (RA) synovial vessels. Expression of GlcNAc6ST-2 was specific to RA synovial tissues as compared to osteoarthritis synovial tissues and localized to endothelial cells of HEV-like vessels and small flat-walled vessels. Double MECA-79 and GlcNAc6ST-2 staining showed colocalization of the MECA-79 epitope and GlcNAc6ST-2. We further found that both TNF-alpha and lymphotoxin-alphabeta induced GlcNAc6ST-2 mRNA and protein in cultured human umbilical vein endothelial cells.ConclusionThese observations demonstrate that GlcNAc6ST-2 is induced in RA vessels and provide potential cytokine pathways for its induction. GlcNAc6ST-2 is a novel marker of activated vessels within RA ectopic lymphoid aggregates. This enzyme represents a potential therapeutic target for RA.

Published
2005

9. The impact of Bacille Calmette-Guérin shortage on immunisation practice and policies in Europe – A Paediatric Tuberculosis Network European Trials Group (ptbnet) survey

Author

Blázquez, Daniel, Bogyi, Matthias, Buonsenso, Danilo, Dreesman, Alexandra, Krivec, Uros, Mouchet, Françoise, Nejat, Sahar, Neth, Olaf, Pavić, Ivan, Ruga, Ezia, Schlags, Rupert, Soriano-Arandes, Antoni, Thee, Steffi, Tsolia, Maria, Velizarova, Svetlana, Kontturi, Antti, Santiago, Begoña, Tebruegge, Marc, von Both, Ulrich, Salo, Eeva, and Ritz, Nicole

Published
2016
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10. Adequacy of the 10 mg/kg Daily Dose of Antituberculosis Drug Isoniazid in Infants under 6 Months of Age

Author

López-Ramos, Maria Goretti, primary, Vinent, Joan, additional, Aarnoutse, Rob, additional, Colbers, Angela, additional, Velasco-Arnaiz, Eneritz, additional, Martorell, Loreto, additional, Falcón-Neyra, Lola, additional, Neth, Olaf, additional, Prieto, Luis, additional, Guillén, Sara, additional, Baquero-Artigao, Fernando, additional, Méndez-Echevarría, Ana, additional, Gómez-Pastrana, David, additional, Jiménez, Ana Belén, additional, Lahoz, Rebeca, additional, Ramos-Amador, José Tomás, additional, Soriano-Arandes, Antoni, additional, Santiago, Begoña, additional, Farré, Rosa, additional, Fortuny, Clàudia, additional, Soy, Dolors, additional, and Noguera-Julian, Antoni, additional

Published
2023
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15. Dynamics of Reverse Transcription-Polymerase Chain Reaction and Serologic Test Results in Children with SARS-CoV-2 Infection

Author

Tagarro, Alfredo, primary, Sanz-Santaeufemia, Francisco José, additional, Grasa, Carlos, additional, Cobos, Elena, additional, Yebra, Julia, additional, Alonso-Cadenas, Jose Antonio, additional, Baquero-Artigao, Fernando, additional, Mesa-Guzmán, Juan Miguel, additional, Pérez-Seoane, Beatriz, additional, Calvo, Cristina, additional, Herreros, María Luisa, additional, Epalza, Cristina, additional, Melendo, Susana, additional, Dominguez-Rodriguez, Sara, additional, Vidal, Paula, additional, Pacheco, Mónica, additional, Ballesteros, Alvaro, additional, Bernardino, María, additional, Villanueva-Medina, Sara, additional, Rodríguez-Molino, Paula, additional, Miragaya Castro, Sandra, additional, Rivière, Jacques, additional, Garcés, Rosa, additional, Santiago, Begoña, additional, Fumadó, Victoria, additional, Urretavizcaya-Martínez, María, additional, García-García, María Luz, additional, Penín, María, additional, Cava, Fernando, additional, Sáez, Elena, additional, Iglesias-Bouzas, María Isabel, additional, Herrero, Blanca, additional, Reinoso, Teresa de Jesús, additional, and Moraleda, Cinta, additional

Published
2022
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16. Performance of QuantiFERON- Gold Plus assays in children and adolescents at risk of tuberculosis: a cross-sectional multicentre study.

Author

Soler-Garcia, Aleix, Gamell, Anna, Pérez-Porcuna, Tomàs, Soriano-Arandes, Antonio, Santiago, Begoña, Tórtola, Teresa, Jesús Ruiz-Serrano, María, Korta Murua, José Javier, Bustillo-Alonso, Matilde, Isabel Garrote-Llanos, María, Rodríguez-Molino, Paula, Isabel Piqueras, Ana, Tagarro, Alfredo, Monsonís, Manuel, Tebruegge, Marc, Noguera-Julian, Antoni, Ruiz-Serrano, María Jesús, Garrote-Llanos, María Isabel, Piqueras, Ana Isabel, and QFT-Plus Study Group of the Spanish Pediatric TB Research Network

Subjects
LATENT tuberculosis, LYMPHADENITIS, TUBERCULOSIS, NEUROBLASTOMA, MYCOBACTERIAL diseases, LATENT infection, TEENAGERS, TUBERCULOSIS diagnosis, CROSS-sectional method, INTERFERON gamma release tests, EVALUATION research, TUBERCULIN test, RESEARCH, COMPARATIVE studies, MYCOBACTERIUM tuberculosis
Abstract

Introduction: The QuantiFERON-TB Gold Plus (QFT-Plus) assay, which features two antigen-stimulated tubes (TB1 and TB2) instead of a single tube used in previous-generation interferon-gamma release assays (IGRAs), was launched in 2016. Despite this, data regarding the assay's performance in the paediatric setting remain scarce. This study aimed to determine the performance of QFT-Plus in a large cohort of children and adolescents at risk of tuberculosis (TB) in a low-burden setting.Methods: Cross-sectional, multicentre study at healthcare institutions participating in the Spanish Paediatric TB Research Network, including patients <18 years who had a QFT-Plus performed between September 2016 and June 2020.Results: Of 1726 patients (52.8% male, median age: 8.4 years), 260 (15.1%) underwent testing during contact tracing, 288 (16.7%) on clinical/radiological suspicion of tuberculosis disease (TBD), 649 (37.6%) during new-entrant migrant screening and 529 (30.6%) prior to initiation of immunosuppressive treatment. Overall, the sensitivity of QFT-Plus for TBD (n=189) and for latent tuberculosis infection (LTBI, n=195) was 83.6% and 68.2%, respectively. The agreement between QFT-Plus TB1 and TB2 antigen tubes was excellent (98.9%, κ=0.961). Only five (2.5%) patients with TBD had discordance between TB1 and TB2 results (TB1+/TB2-, n=2; TB1-/TB2+, n=3). Indeterminate assay results (n=54, 3.1%) were associated with young age, lymphopenia and elevated C reactive protein concentrations.Conclusions: Our non-comparative study indicates that QFT-Plus does not have greater sensitivity than previous-generation IGRAs in children in both TBD and LTBI. In TBD, the addition of the second antigen tube, TB2, does not enhance the assay's performance substantially. [ABSTRACT FROM AUTHOR]

Published
2022
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18. Performance of QuantiFERON-TB Gold Plus assays in children and adolescents at risk of tuberculosis: a cross-sectional multicentre study

Author

Soler-Garcia, Aleix, primary, Gamell, Anna, additional, Pérez-Porcuna, Tomàs, additional, Soriano-Arandes, Antonio, additional, Santiago, Begoña, additional, Tórtola, Teresa, additional, Ruiz-Serrano, María Jesús, additional, Korta Murua, José Javier, additional, Bustillo-Alonso, Matilde, additional, Garrote-Llanos, María Isabel, additional, Rodríguez-Molino, Paula, additional, Piqueras, Ana Isabel, additional, Tagarro, Alfredo, additional, Monsonís, Manuel, additional, Tebruegge, Marc, additional, and Noguera-Julian, Antoni, additional

Published
2021
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20. The Worldwide Antibiotic Resistance and Prescribing in European Children (ARPEC) point prevalence survey: developing hospital-quality indicators of antibiotic prescribing for children

Author

Versporten, Ann, Bielicki, Julia, Drapier, Nico, Sharland, Mike, Goossens, Herman, Calle, Graciela Maria, Garrahan, Juan P., Clark, Julia, Cooper, Celia, Blyth, Christopher C., Francis, Joshua Reginald, Alsalman, Jameela, Jansens, Hilde, Mahieu, Ludo, Van Rossom, Paul, Vandewal, Wouter, Lepage, Philippe, Blumental, Sophie, Briquet, Caroline, de Louvain, Catholique, Robbrecht, Dirk, Maton, Pierre, Gabriels, Patrick, Rubic, Zana, Kovacevic, Tanja, Nielsen, Jens Peter, Petersen, Jes Reinholdt, Poorisrisak, Porntiva, Jensen, Lise Heilmann, Laan, Mari, Tamm, Eda, Matsinen, Maire, Rummukainen, Maija-Liisa, Gajdos, Vincent, Olivier, Romain, Le Maréchal, Flore, Martinot, Alain, Prot-Labarthe, Sonia, Lorrot, Mathie, Orbach, Daniel, Pagava, Karaman, Hufnagel, Markus, Knuf, Markus, Schlag, Stephanie A. A., Liese, Johannes, Renner, Lorna, Enimil, Anthony, Awunyo, Marah, Syridou, Garyfallia, Spyridis, Nikos, Critselis, Elena, Kouni, Sofia, Mougkou, Katerina, Ladomenou, Fani, Gkentzi, Despoina, Iosifidis, Elias, Roilides, Emmanuel, Sahu, Suneeta, Murki, Srinivas, Malviya, Manoj, Kalavalapalli, Durga Bhavani, Singh, Sanjeev, Singhal, Tanu, Garg, Garima, Garg, Pankaj, Kler, Neelam, Soltani, Jafar, Jafarpour, Zahra, Pouladfar, Gholamreza, Nicolini, Giangiacomo, Montagnani, Carlotta, Galli, Luisa, Esposito, Susanna, Donaʼ, Daniele, Giaquinto, Carlo, Borgia, Eleonora, DʼArgenio, Patrizia, De Luca, Maia, Centenari, Chiara, Raka, Lul, Omar, Abeer, Al-Mousa, Haifaa, Mozgis, Dzintars, Sviestina, Inese, Burokiene, Sigita, Usonis, Vytautas, Tavchioska, Gabriela, Hargadon-Lowe, Antonia, Zarb, Peter, Borg, Michael A., González Lozano, Carlos Agustín, Zárate Castañon, Patricia, Cancino, Martha E., McCullagh, Bernadette, McCorry, Ann, Gormley, Cairine, Al Maskari, Zaina, Al-Jardani, Amina, Pluta, Magdalena, Rodrigues, Fernanda, Brett, Ana, Esteves, Isabel, Marques, Laura, Ali AlAjmi, Jameela, Claudia Cambrea, Simona, Rashed, Asia N., Mubarak Al Azmi, Aeshah Abdu, Chan, Si Min, Isa, Mas Suhaila, Najdenov, Peter, Čižman, Milan, Unuk, Sibila, Finlayson, Heather, Dramowski, Angela, Maté-Cano, Irene, Soto, Beatriz, Calvo, Cristina, Santiago, Begoña, Saavedra-Lozano, Jesus, Bustinza, Amaya, Escosa-García, Luis, Ureta, Noelia, Tagarro, Alfredo, Barrero, Pedro Terol, Rincon-Lopez, Elena Maria, Abubakar, Ismaela, Aston, Jeff, Heginbothom, Maggie, Satodia, Prakash, Garbash, Mehdi, Johnson, Alison, Sharpe, David, Barton, Christopher, Menson, Esse, Arenas-Lopez, Sara, Luck, Suzanne, Doerholt, Katja, McMaster, Paddy, Caldwell, Neil A., Lunn, Andrew, Drysdale, Simon B., Howe, Rachel, Scorrer, Tim, Gahleitner, Florian, Gupta, Richa, Nash, Clare, Alexander, John, Raman, Mala, Bell, Emily, Rajagopal, Veena, Kohlhoff, Stephan, Cox, Elaine, and Zaoutis, Theoklis

Published
2016
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21. QuantiFERON-TB Gold Plus Assay Specificity in Children and Adolescents With Suspected Tuberculosis—A Multicenter Cross-sectional Study in Spain

Author

Soler-Garcia, Aleix, primary, Gamell, Anna, additional, Santiago, Begoña, additional, Monsonís, Manuel, additional, Cobo-Vázquez, Elvira, additional, Bustillo-Alonso, Matilde, additional, Tagarro, Alfredo, additional, Pérez-Gorricho, Beatriz, additional, Espiau, María, additional, Piqueras, Ana Isabel, additional, Korta-Murua, José Javier, additional, Rodríguez-Molino, Paula, additional, Lobato, Zulema, additional, Pérez-Porcuna, Tomàs, additional, Tebruegge, Marc, additional, and Noguera-Julian, Antoni, additional

Published
2021
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22. Diagnostic Accuracy of the Panbio Severe Acute Respiratory Syndrome Coronavirus 2 Antigen Rapid Test Compared with Reverse-Transcriptase Polymerase Chain Reaction Testing of Nasopharyngeal Samples in the Pediatric Population

Author

Villaverde, Serena, primary, Domínguez-Rodríguez, Sara, additional, Sabrido, Gema, additional, Pérez-Jorge, Conchita, additional, Plata, Marta, additional, Romero, María Pilar, additional, Grasa, Carlos Daniel, additional, Jiménez, Ana Belén, additional, Heras, Elena, additional, Broncano, Antonio, additional, Núñez, María del Mar, additional, Illán, Marta, additional, Merino, Paloma, additional, Soto, Beatriz, additional, Molina-Arana, David, additional, Bermejo, Amanda, additional, Mendoza, Pablo, additional, Gijón, Manuel, additional, Pérez-Moneo, Begoña, additional, Moraleda, Cinta, additional, Tagarro, Alfredo, additional, Calvo, Cristina, additional, Mellado, Ma José, additional, Rodríguez-Molino, Paula, additional, del Rosal, Teresa, additional, Santos, Mar, additional, Navarro, Marisa, additional, Rincón, Elena, additional, Santiago, Begoña, additional, Saavedra-Lozano, Jesús, additional, Aguilera-Alonso, David, additional, Epalza, Cristina, additional, Blázquez-Gamero, Daniel, additional, Villanueva, Sara, additional, Rojo, Pablo, additional, Calleja, Gero, additional, Alonso, J.A., additional, de la Torre, Mercedes, additional, Sanz-Santaeufemia, F.J., additional, Iglesias, M.I., additional, Herrero, B., additional, Alonso, M., additional, Soriano-Arandes, Toni, additional, Pujol, J.M., additional, Melendo, Susana, additional, Soler-Palacin, Pere, additional, Simó, Silvia, additional, Fumadó, Victoria, additional, Lanaspa, Miguel, additional, Urretavizcaya, M., additional, Herranz, Mercedes, additional, Pareja, Marta, additional, Ara, Fatima, additional, Cabañas, Santiago, additional, del Valle, Rut, additional, Barrios, Ana, additional, Otheo, Enrique, additional, Vázquez, José Luis, additional, Falcón, Lola, additional, Neth, Olaf, additional, Olbrich, Peter, additional, Goicoechea, Walter, additional, Martín, Laura, additional, Figueroa, Lucía, additional, Llorente, María, additional, Penin, María, additional, García, Claudia, additional, García, María, additional, Alvaredo, Teresa, additional, Olmedo, Ma Inmaculada, additional, López, Agustín, additional, Cobo, Elvira, additional, Tovizi, Mariam, additional, Galán, Pilar, additional, Guillén, Sara, additional, Navas, Adriana, additional, García, M. Luz, additional, Pérez, Sara, additional, Hernández, María José, additional, Berzosa, Arantxa, additional, Gallego, Nerea, additional, López, Ana, additional, Ruiz, Beatriz, additional, Alfayate, Santiago, additional, Menasalvas, Ana, additional, Cervantes, Eloísa, additional, Méndez, María, additional, Hurtado, Ángela, additional, Ruiz, Yolanda, additional, García, Cristina, additional, Amich, Inés, additional, Oltra, Manuel, additional, Villaroya, Álvaro, additional, Ocaña, Angustias, additional, Romero, Isabel, additional, Guzmán, María Fernanda, additional, Pascual, M.J., additional, Sánchez-Códez, María, additional, Montesinos, Elena, additional, Jensen, Julia, additional, Rodríguez, María, additional, Caro, Gloria, additional, Rius, Neus, additional, Gómez, Alba, additional, Bretón, Rafael, additional, Rodríguez, Margarita, additional, Romero, Julio, additional, Campos, Ana, additional, García, Mercedes, additional, Velasco, Rosa María, additional, Lobato, Zulema, additional, Centeno, Fernando, additional, Pérez, Elena, additional, Vidal, Paula, additional, Rey, Corsino, additional, Vivanco, Ana, additional, Alonso, Maruchi, additional, Alcalá, Pedro, additional, de Dios, Javier González, additional, Solé, Eduard, additional, Minguell, Laura, additional, Astigarraga, Itziar, additional, Vázquez, Ma Ángeles, additional, Sánchez, Miguel, additional, Díaz, Elena, additional, Consuegra, Eduardo, additional, Cabanillas, María, additional, Peña, Luis, additional, Garrote, Elisa, additional, Goicoechea, Maite, additional, Centelles, Irene, additional, Lapeña, Santiago, additional, Gutiérrez, Sara, additional, Gutiérrez, Soraya, additional, Cavalle, Amparo, additional, Olmos, José María, additional, Cobo, Alejandro, additional, Díaz, Sara, additional, Jiménez, Beatriz, additional, González, Raúl, additional, Lafuente, Miguel, additional, Bustillo, Matilde, additional, Pons, Natividad, additional, Morata, Julia, additional, and Segura, Elsa, additional

Published
2021
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24. The clinical relevance of the microbiome when managing paediatric infectious diseases—Narrative review

Author

Sainz, Talía, primary, Delgado, Jaime, additional, Mendez‐Echevarría, Ana, additional, Santiago, Begoña, additional, Lopez‐Varela, Elisa, additional, Aguilera‐Alonso, David, additional, Saavedra‐Lozano, Jesús, additional, Rodríguez‐Fernández, Rosa, additional, Holguín, África, additional, Navarro, Marisa L., additional, Muñoz‐Fernández, María Ángeles, additional, Rivero‐Calle, Irene, additional, Solana, María José, additional, López‐Herce, Jesús, additional, and Calvo, Cristina, additional

Published
2020
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25. Diagnostic Accuracy of QuantiFERON-TB Gold Plus Assays in Children and Adolescents with Tuberculosis Disease

Author

Soler-Garcia, Aleix, primary, Gamell, Anna, additional, Santiago, Begoña, additional, Monsonís, Manuel, additional, Calvo, Cristina, additional, Cobo, Elvira, additional, Colino, Elena, additional, Espiau, María, additional, Guerrero-Laleona, Carmelo, additional, Lobato, Zulema, additional, Martín-Nalda, Andrea, additional, Pérez-Gorricho, Beatriz, additional, Perez-Porcuna, Tomas M., additional, Piqueras, Ana Isabel, additional, Rodríguez-Molino, Paula, additional, Ruiz, Marta, additional, Soriano-Arandes, Antoni, additional, Valmanya, Teresa, additional, Tebruegge, Marc, additional, Noguera-Julian, Antoni, additional, Gómez-Pastrana, David, additional, Montero, Maria, additional, Peromingo, Estrella, additional, Bustillo, Matilde, additional, Moliner, Elisenda, additional, Fenoy, Marina, additional, Velásquez, Marta, additional, Soler, Maria Queralt, additional, GARCÍA, Lourdes, additional, Calavia, Olga, additional, Rius, Neus, additional, Pascual, Maria Teresa, additional, Soler-Palacín, Pere, additional, Tórtola, Teresa, additional, Lillo, Miguel, additional, Dapena, Marta, additional, López-Medina, Eva María, additional, Santos, Maria del Mar, additional, Hernández, Ángel, additional, Hernández-Sanpelayo, Teresa, additional, Tagarro, Alfredo, additional, Méndez, Ana, additional, Mellado, María José, additional, Baquero-Artigao, Fernando, additional, Sainz, Talía, additional, García-Hortelano, Miluca, additional, Álvarez, Javier, additional, Villalobos, Enrique, additional, García-García, María Luz, additional, Garrote, María Isabel, additional, Korta Murua, José Javier, additional, Gundín, Nerea Azurmendi, additional, Sánchez-Torrent, Laia, additional, Velasco-Arnaiz, Eneritz, additional, and Fortuny, Clàudia, additional

Published
2020
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32. Ectopic lymphoid neogenesis in psoriatic arthritis

Author

Cañete, Juan D, Santiago, Begoña, Cantaert, Tineke, Sanmartí, Raimon, Palacin, Antonio, Celis, Raquel, Graell, Eduard, Gil-Torregrosa, Beatriz, Baeten, Dominique, and Pablos, José L

Published
2007

39. Performance of QuantiFERON-TBGold Plus assays in children and adolescents at risk of tuberculosis: a cross-sectional multicentre study

Author

Soler-Garcia, Aleix, Gamell, Anna, Pérez-Porcuna, Tomàs, Soriano-Arandes, Antonio, Santiago, Begoña, Tórtola, Teresa, Ruiz-Serrano, María Jesús, Korta Murua, José Javier, Bustillo-Alonso, Matilde, Garrote-Llanos, María Isabel, Rodríguez-Molino, Paula, Piqueras, Ana Isabel, Tagarro, Alfredo, Monsonís, Manuel, Tebruegge, Marc, and Noguera-Julian, Antoni

Abstract

IntroductionThe QuantiFERON-TBGold Plus (QFT-Plus) assay, which features two antigen-stimulated tubes (TB1 and TB2) instead of a single tube used in previous-generation interferon-gamma release assays (IGRAs), was launched in 2016. Despite this, data regarding the assay’s performance in the paediatric setting remain scarce. This study aimed to determine the performance of QFT-Plus in a large cohort of children and adolescents at risk of tuberculosis (TB) in a low-burden setting.MethodsCross-sectional, multicentre study at healthcare institutions participating in the Spanish Paediatric TB Research Network, including patients <18 years who had a QFT-Plus performed between September 2016 and June 2020.ResultsOf 1726 patients (52.8% male, median age: 8.4 years), 260 (15.1%) underwent testing during contact tracing, 288 (16.7%) on clinical/radiological suspicion of tuberculosis disease (TBD), 649 (37.6%) during new-entrant migrant screening and 529 (30.6%) prior to initiation of immunosuppressive treatment. Overall, the sensitivity of QFT-Plus for TBD (n=189) and for latent tuberculosis infection (LTBI, n=195) was 83.6% and 68.2%, respectively. The agreement between QFT-Plus TB1 and TB2 antigen tubes was excellent (98.9%, κ=0.961). Only five (2.5%) patients with TBD had discordance between TB1 and TB2 results (TB1+/TB2−, n=2; TB1−/TB2+, n=3). Indeterminate assay results (n=54, 3.1%) were associated with young age, lymphopenia and elevated C reactive protein concentrations.ConclusionsOur non-comparative study indicates that QFT-Plus does not have greater sensitivity than previous-generation IGRAs in children in both TBD and LTBI. In TBD, the addition of the second antigen tube, TB2, does not enhance the assay’s performance substantially.

Published
2022
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42. The clinical relevance of the microbiome when managing paediatric infectious diseases—Narrative review.

Author

Sainz, Talía, Delgado, Jaime, Mendez‐Echevarría, Ana, Santiago, Begoña, Lopez‐Varela, Elisa, Aguilera‐Alonso, David, Saavedra‐Lozano, Jesús, Rodríguez‐Fernández, Rosa, Holguín, África, Navarro, Marisa L., Muñoz‐Fernández, María Ángeles, Rivero‐Calle, Irene, Solana, María José, López‐Herce, Jesús, and Calvo, Cristina

Subjects
COMMUNICABLE diseases, HUMAN microbiota, JUVENILE diseases, DIAGNOSIS, THERAPEUTICS, EMERGING infectious diseases
Abstract

In recent years, the field of infectious diseases has been hit by the overwhelming amount of information generated while the human microbiome is being disentangled. Based on the interaction between the microbiota and the immune system, the implications regarding infectious diseases are probably major and remain a challenge. Aims: This review was conceived as a comprehensive tool to provide an overview of the available evidence regarding the influence of the microbiome on infectious diseases in children. Methods: We present the main findings aroused from microbiome research in prevention, diagnosis and treatment of infectious disease under a paediatric perspective, to inform clinicians of the potential relevance of microbiome‐related knowledge for translation to clinical practice. Results and Conclusion: The evidence shown in this review highlights the numerous research gaps ahead and supports the need to move forward to integrating the so‐called microbiome thinking into our routine clinical practice. [ABSTRACT FROM AUTHOR]

Published
2021
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44. Diagnostic Accuracy of the Panbio Severe Acute Respiratory Syndrome Coronavirus 2 Antigen Rapid Test Compared with Reverse-Transcriptase Polymerase Chain Reaction Testing of Nasopharyngeal Samples in the Pediatric Population

Author

Calvo, Cristina, Mellado, M<ce:sup loc='post">a</ce:sup> José, Rodríguez-Molino, Paula, del Rosal, Teresa, Santos, Mar, Navarro, Marisa, Rincón, Elena, Santiago, Begoña, Saavedra-Lozano, Jesús, Aguilera-Alonso, David, Epalza, Cristina, Blázquez-Gamero, Daniel, Villanueva, Sara, Rojo, Pablo, Calleja, Gero, Alonso, J.A., de la Torre, Mercedes, Sanz-Santaeufemia, F.J., Iglesias, M.I., Herrero, B., Alonso, M., Soriano-Arandes, Toni, Pujol, J.M., Melendo, Susana, Soler-Palacin, Pere, Simó, Silvia, Fumadó, Victoria, Lanaspa, Miguel, Urretavizcaya, M., Herranz, Mercedes, Pareja, Marta, Ara, Fatima, Cabañas, Santiago, del Valle, Rut, Barrios, Ana, Otheo, Enrique, Vázquez, José Luis, Falcón, Lola, Neth, Olaf, Olbrich, Peter, Goicoechea, Walter, Martín, Laura, Figueroa, Lucía, Llorente, María, Penin, María, García, Claudia, García, María, Alvaredo, Teresa, Olmedo, M<ce:sup loc='post">a</ce:sup> Inmaculada, López, Agustín, Cobo, Elvira, Tovizi, Mariam, Galán, Pilar, Guillén, Sara, Navas, Adriana, García, M. Luz, Pérez, Sara, Hernández, María José, Berzosa, Arantxa, Gallego, Nerea, López, Ana, Ruiz, Beatriz, Alfayate, Santiago, Menasalvas, Ana, Cervantes, Eloísa, Méndez, María, Hurtado, Ángela, Ruiz, Yolanda, García, Cristina, Amich, Inés, Oltra, Manuel, Villaroya, Álvaro, Ocaña, Angustias, Romero, Isabel, Guzmán, María Fernanda, Pascual, M.J., Sánchez-Códez, María, Montesinos, Elena, Jensen, Julia, Rodríguez, María, Caro, Gloria, Rius, Neus, Gómez, Alba, Bretón, Rafael, Rodríguez, Margarita, Romero, Julio, Campos, Ana, García, Mercedes, Velasco, Rosa María, Lobato, Zulema, Centeno, Fernando, Pérez, Elena, Vidal, Paula, Rey, Corsino, Vivanco, Ana, Alonso, Maruchi, Alcalá, Pedro, de Dios, Javier González, Solé, Eduard, Minguell, Laura, Astigarraga, Itziar, Vázquez, M<ce:sup loc='post">a</ce:sup> Ángeles, Sánchez, Miguel, Díaz, Elena, Consuegra, Eduardo, Cabanillas, María, Peña, Luis, Garrote, Elisa, Goicoechea, Maite, Centelles, Irene, Lapeña, Santiago, Gutiérrez, Sara, Gutiérrez, Soraya, Cavalle, Amparo, Olmos, José María, Cobo, Alejandro, Díaz, Sara, Jiménez, Beatriz, González, Raúl, Lafuente, Miguel, Bustillo, Matilde, Pons, Natividad, Morata, Julia, Segura, Elsa, Villaverde, Serena, Domínguez-Rodríguez, Sara, Sabrido, Gema, Pérez-Jorge, Conchita, Plata, Marta, Romero, María Pilar, Grasa, Carlos Daniel, Jiménez, Ana Belén, Heras, Elena, Broncano, Antonio, Núñez, María del Mar, Illán, Marta, Merino, Paloma, Soto, Beatriz, Molina-Arana, David, Bermejo, Amanda, Mendoza, Pablo, Gijón, Manuel, Pérez-Moneo, Begoña, Moraleda, Cinta, and Tagarro, Alfredo

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2021
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45. A HEV-restricted sulfotransferase is expressed in rheumatoid arthritis synovium and is induced by lymphotoxin-α/β and TNF-α in cultured endothelial cells

Author

Palao Guillermo, Singer Mark S, Tsay Durwin, Santiago Begoña, Pablos José L, Galindo María, and Rosen Steven D

Subjects
Immunologic diseases. Allergy, RC581-607
Abstract

Abstract Background The recruitment of lymphocytes to secondary lymphoid organs relies on interactions of circulating cells with high endothelial venules (HEV). HEV are exclusive to these organs under physiological conditions, but they can develop in chronically-inflamed tissues. The interaction of L-selectin on lymphocytes with sulfated glycoprotein ligands on HEV results in lymphocyte rolling, which represents the initial step in lymphocyte homing. HEV expression of GlcNAc6ST-2 (also known as HEC-GlcNAc6ST, GST-3, LSST or CHST4), an HEV-restricted sulfotransferase, is essential for the elaboration of L-selectin functional ligands as well as a critical epitope recognized by MECA-79 mAb. Results We examined the expression of GlcNAc6ST-2 in relationship to the MECA-79 epitope in rheumatoid arthritis (RA) synovial vessels. Expression of GlcNAc6ST-2 was specific to RA synovial tissues as compared to osteoarthritis synovial tissues and localized to endothelial cells of HEV-like vessels and small flat-walled vessels. Double MECA-79 and GlcNAc6ST-2 staining showed colocalization of the MECA-79 epitope and GlcNAc6ST-2. We further found that both TNF-α and lymphotoxin-αβ induced GlcNAc6ST-2 mRNA and protein in cultured human umbilical vein endothelial cells. Conclusion These observations demonstrate that GlcNAc6ST-2 is induced in RA vessels and provide potential cytokine pathways for its induction. GlcNAc6ST-2 is a novel marker of activated vessels within RA ectopic lymphoid aggregates. This enzyme represents a potential therapeutic target for RA.

Published
2005
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47. Diagnostic Accuracy of QuantiFERON-TB Gold Plus Assays in Children and Adolescents with Tuberculosis Disease

Author

Colino, Elena, Gómez-Pastrana, David, Montero, Maria, Peromingo, Estrella, Bustillo, Matilde, Moliner, Elisenda, Fenoy, Marina, Velásquez, Marta, Soler, Maria Queralt, GARCÍA, Lourdes, Calavia, Olga, Rius, Neus, Pascual, Maria Teresa, Soler-Palacín, Pere, Tórtola, Teresa, Lillo, Miguel, Dapena, Marta, López-Medina, Eva María, Ruiz, Marta, Santos, Maria del Mar, Hernández, Ángel, Hernández-Sanpelayo, Teresa, Tagarro, Alfredo, Méndez, Ana, Mellado, María José, Baquero-Artigao, Fernando, Sainz, Talía, García-Hortelano, Miluca, Álvarez, Javier, Villalobos, Enrique, García-García, María Luz, Garrote, María Isabel, Korta Murua, José Javier, Gundín, Nerea Azurmendi, Sánchez-Torrent, Laia, Velasco-Arnaiz, Eneritz, Fortuny, Clàudia, Soler-Garcia, Aleix, Gamell, Anna, Santiago, Begoña, Monsonís, Manuel, Calvo, Cristina, Cobo, Elvira, Espiau, María, Guerrero-Laleona, Carmelo, Lobato, Zulema, Martín-Nalda, Andrea, Pérez-Gorricho, Beatriz, Perez-Porcuna, Tomas M., Piqueras, Ana Isabel, Rodríguez-Molino, Paula, Soriano-Arandes, Antoni, Valmanya, Teresa, Tebruegge, Marc, and Noguera-Julian, Antoni

Published
2020
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49. The impact of Bacille Calmette-Guérin shortage on immunisation practice and policies in Europe – A Paediatric Tuberculosis Network European Trials Group (ptbnet) survey

Author

Kontturi, Antti, primary, Santiago, Begoña, additional, Tebruegge, Marc, additional, von Both, Ulrich, additional, Salo, Eeva, additional, Ritz, Nicole, additional, Blázquez, Daniel, additional, Bogyi, Matthias, additional, Buonsenso, Danilo, additional, Dreesman, Alexandra, additional, Krivec, Uros, additional, Mouchet, Françoise, additional, Nejat, Sahar, additional, Neth, Olaf, additional, Pavić, Ivan, additional, Ruga, Ezia, additional, Schlags, Rupert, additional, Soriano-Arandes, Antoni, additional, Thee, Steffi, additional, Tsolia, Maria, additional, and Velizarova, Svetlana, additional

Published
2016
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