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12 results on '"Sarasquete, M. Eugenia"'

1. A New Next-Generation Sequencing Strategy for the Simultaneous Analysis of Mutations and Chromosomal Rearrangements at DNA Level in Acute Myeloid Leukemia Patients

Author

Prieto-Conde, M. Isabel, Corchete, Luis A., García-Álvarez, María, Jiménez, Cristina, Medina, Alejandro, Balanzategui, Ana, Hernández-Ruano, Montserrat, Maldonado, Rebeca, Sarasquete, M. Eugenia, Alcoceba, Miguel, Puig, Noemí, González-Calle, Verónica, García-Sanz, Ramón, Gutiérrez, Norma C., González-Díaz, Marcos, and Chillón, M. Carmen

Published
2020
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2. Comparison of next-generation sequencing (NGS) and next-generation flow (NGF) for minimal residual disease (MRD) assessment in multiple myeloma

Author

Medina, Alejandro, Puig, Noemi, Flores-Montero, Juan, Jimenez, Cristina, Sarasquete, M.-Eugenia, Garcia-Alvarez, María, Prieto-Conde, Isabel, Chillon, Carmen, Alcoceba, Miguel, Gutierrez, Norma C., Oriol, Albert, Rosinol, Laura, Bladè, Joan, Gironella, Mercedes, Hernandez, Miguel T., Gonzalez-Calle, Veronica, Cedena, Maria-Teresa, Paiva, Bruno, San-Miguel, Jesus F., Lahuerta, Juan-Jose, Mateos, Maria-Victoria, Martinez-Lopez, Joaquin, Orfao, Alberto, Gonzalez, Marcos, and Garcia-Sanz, Ramon

Published
2020
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3. Molecular profiling of immunoglobulin heavy-chain gene rearrangements unveils new potential prognostic markers for multiple myeloma patients

Author

Medina, Alejandro, Jiménez, Cristina, Sarasquete, M. Eugenia, González, Marcos, Chillón, M. Carmen, Balanzategui, Ana, Prieto-Conde, Isabel, García-Álvarez, María, Puig, Noemí, González-Calle, Verónica, Alcoceba, Miguel, Cuenca, Isabel, Barrio, Santiago, Escalante, Fernando, Gutiérrez, Norma C., Gironella, Mercedes, Hernández, Miguel T., Sureda, Anna, Oriol, Albert, Bladé, Joan, Lahuerta, Juan-José, San Miguel, Jesús F., Mateos, María-Victoria, Martínez-López, Joaquín, Calasanz, María-José, and García-Sanz, Ramón

Published
2020
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4. Immunoglobulin gene rearrangement IGHV3-48 is a predictive marker of histological transformation into aggressive lymphoma in follicular lymphomas

Author

García-Álvarez, María, Alonso-Álvarez, Sara, Prieto-Conde, Isabel, Jiménez, Cristina, Sarasquete, M. Eugenia, Chillón, M. Carmen, Medina, Alejandro, Balanzategui, Ana, Maldonado, Rebeca, Antón, Alicia, Puig, Noemí, Rodríguez, Marta, Blanco, Oscar, Tamayo, Pilar, González-Calle, Verónica, Martín, Alejandro, García-Sanz, Ramón, González, Marcos, Caballero, M. Dolores, and Alcoceba, Miguel

Published
2019
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5. HLA specificities are related to development and prognosis of diffuse large B-cell lymphoma

Author

Alcoceba, Miguel, Sebastián, Elena, Marín, Luis, Balanzategui, Ana, Sarasquete, M. Eugenia, Chillón, M. Carmen, Jiménez, Cristina, Puig, Noemí, Corral, Rocío, Pardal, Emilia, Grande, Carlos, Bello, José Luis, Albo, Carmen, de la Cruz, Fátima, Panizo, Carlos, Martín, Alejandro, González-Barca, Eva, Caballero, M. Dolores, San Miguel, Jesús F., García-Sanz, Ramón, and González, Marcos

Published
2013
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6. High-resolution copy number analysis of paired normal-tumor samples from diffuse large B cell lymphoma

Author

Sebastián, Elena, Alcoceba, Miguel, Martín-García, David, Blanco, Óscar, Sanchez-Barba, Mercedes, Balanzategui, Ana, Marín, Luis, Montes-Moreno, Santiago, González-Barca, Eva, Pardal, Emilia, Jiménez, Cristina, García-Álvarez, María, Clot, Guillem, Carracedo, Ángel, Gutiérrez, Norma C., Sarasquete, M. Eugenia, Chillón, Carmen, Corral, Rocío, Prieto-Conde, M. Isabel, Caballero, M. Dolores, Salaverria, Itziar, García-Sanz, Ramón, and González, Marcos

Published
2016
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7. Molecular Characterization of Immunoglobulin Gene Rearrangements in Diffuse Large B-Cell Lymphoma: Antigen-Driven Origin and IGHV4-34 as a Particular Subgroup of the Non-GCB Subtype

Author

Sebastián, Elena, Alcoceba, Miguel, Balanzategui, Ana, Marín, Luis, Montes-Moreno, Santiago, Flores, Teresa, González, David, Sarasquete, M. Eugenia, Chillón, M. Carmen, Puig, Noemí, Corral, Rocío, Pardal, Emilia, Martín, Alejandro, González-Barca, Eva, Caballero, M. Dolores, San Miguel, Jesús F., García-Sanz, Ramón, and González, Marcos

Published
2012
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9. Liquid biopsy: a non‐invasive approach for Hodgkin lymphoma genotyping.

Author

Alcoceba, Miguel, García‐Álvarez, María, Chillón, M. Carmen, Jiménez, Cristina, Medina, Alejandro, Antón, Alicia, Blanco, Oscar, Díaz, Luis G., Tamayo, Pilar, González‐Calle, Verónica, Vidal, María Jesús, Cuello, Rebeca, Díaz Gálvez, Francisco Javier, Queizán, José Antonio, Martín, Alejandro, González, Marcos, García‐Sanz, Ramón, and Sarasquete, M. Eugenia

Subjects
HODGKIN'S disease, CIRCULATING tumor DNA, BIOPSY, SERUM albumin, LIQUIDS
Abstract

Summary: The Hodgkin lymphoma (HL) genomic landscape is hardly known due to the scarcity of tumour cells in the tissue. Liquid biopsy employing circulating tumour DNA (ctDNA) can emerge as an alternative tool for non‐invasive genotyping. By using a custom next generation sequencing (NGS) panel in combination with unique molecule identifiers, we aimed to identify somatic variants in the ctDNA of 60 HL at diagnosis. A total of 277 variants were detected in 36 of the 49 samples (73·5%) with a good quality ctDNA sample. The median number of variants detected per patient was five (range 1–23) with a median variant allele frequency of 4·2% (0·84–28%). Genotyping revealed somatic variants in the following genes: SOCS1 (28%), IGLL5 (26%), TNFAIP3 (23%), GNA13 (23%), STAT6 (21%) and B2M (19%). Moreover, several poor prognosis features (high LDH, low serum albumin, B‐symptoms, IPI ≥ 3 or at an advanced stage) were related to significantly higher amounts of ctDNA. Variant detection in ctDNA by NGS is a feasible approach to depict the genetic features of HL patients at diagnosis. Our data favour the implementation of liquid biopsy genotyping for the routine evaluation of HL patients. [ABSTRACT FROM AUTHOR]

Published
2021
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10. Genetic complexity impacts the clinical outcome of follicular lymphoma patients.

Author

García-Álvarez, María, Alonso-Álvarez, Sara, Prieto-Conde, Isabel, Jiménez, Cristina, Sarasquete, M. Eugenia, Chillón, M. Carmen, Medina, Alejandro, Balanzategui, Ana, Maldonado, Rebeca, Antón, Alicia, Rodríguez, Marta, Blanco, Oscar, Díaz, Luis G., Tamayo, Pilar, Blanco, Pedro, Esteban, Carmen, González-Calle, Verónica, Puig, Noemí, Gutiérrez, Norma, and Martín, Alejandro

Subjects
LYMPHOMA treatment, LYMPHOMA risk factors, LYMPHOMA diagnosis, RITUXIMAB, ANTINEOPLASTIC agents, B cell lymphoma, CANCER genetics, CHROMOSOME abnormalities
Published
2021
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11. Molecular Characterization of Chronic Lymphocytic Leukemia Patients with a High Number of Losses in 13q14.

Author

Rodríguez, Ana Eugenia, Hernández, Jose Ángel, Benito, Rocío, Gutié rrez, Norma C., García, Juan Luis, Hernández-Sánchez, María, Risueño, Alberto, Sarasquete, M. Eugenia, Fermiñán, Encarna, Fisac, Rosa, García de Coca, Alfonso, Martín-Núñez, Guillermo, de las Heras, Natalia, Recio, Isabel, Gutiérrez, Oliver, De Las Rivas, Javier, Gonzaźlez, Marcos, and Hernández-Rivas, Jesüs M.

Subjects
CROP genetics, SOYBEAN, GENOMES, GENE expression, MICROARRAY technology, DROUGHTS, GENES
Abstract

Background: Patients with chronic lymphocytic leukemia and 13q deletion as their only FISH abnormality could have a different outcome depending on the number of cells displaying this aberration. Thus, cases with a high number of 13q- cells (13q-H) had both shorter overall survival and time to first therapy. The goal of the study was to analyze the genetic profile of 13q-H patients. Design and Methods::A total of 102 samples were studied, 32 of which served as a validation cohort and five were healthy donors. Results: Chronic lymphocytic leukemia patients with higher percentages of 13q- cells (.80%) showed a different level of gene expression as compared to patients with lower percentages (,80%, 13q-L). This deregulation affected genes involved in apoptosis and proliferation (BCR and NFkB signaling), leading to increased proliferation and decreased apoptosis in 13q-H patients. Deregulation of several microRNAs, such as miR-15a, miR-155, miR-29a and miR-223, was also observed in these patients. In addition, our study also suggests that the gene expression pattern of 13q-H cases could be similar to the patients with 11q- or 17p-. Conclusions: This study provides new evidence regarding the heterogeneity of 13q deletion in chronic lymphocytic leukemia patients, showing that apoptosis, proliferation as well as miRNA regulation are involved in cases with higher percentages of 13q- cells. [ABSTRACT FROM AUTHOR]

Published
2012
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12. Prognostic implications of MRD assessment in multiple myeloma patients: comparison of Next-Generation Sequencing and Next-Generation Flow.

Author

Medina, Alejandro, Jiménez, Cristina, Puig, Noemi, Flores-Montero, Juan, Paiva, Bruno, Sarasquete, M Eugenia, Prieto-Conde, Isabel, Garcia-Alvarez, Maria, Chillon, Carmen, Alcoceba, Miguel, Gonzalez-Calle, Veronica, Gutierrez, Norma C., de Arriba, Felipe, Hernandez, Miguel T., Blade, Joan, Martinez-Lopez, Joaquin, Calasanz, Maria-Jose, Lahuerta, Juan-Jose, Mateos, Maria-Victoria, and San-Miguel, Jesus

Published
2019
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