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M.S. Selikhova1, E.S. Zvereva2 1Volgograd State Medical University, Volgograd, Russian Federation 2Emergency Clinical Hospital No. 7, Volgograd, Russian Federation Pubertal abnormal uterine bleeding (AUB) is the leading cause of visits to health care provider during adolescent period. The paper describes clinical course of pubertal AUB and the assessment of their severity and hemostasis. The importance of stress factors and somatic comorbidities is discussed. Data on anemia severity in girls with AUB to assess blood loss and treatment efficacy are addressed. Ultrasound reveals ovarian cysts in 10% and endometrial hyperplasia in 17% of these girls. In girls with comorbidities (including obesity), symptomatic hemostasis is associated with high risks of recurrent AUB. When selecting antianemia drugs, the lack of toxicity, good tolerability, and availability of both parenteral and peroral formulations used in various clinical situations should be considered. After homeostasis was achieved, hormonal and antianemic treatment is continued for 3 months. Keywords: abnormal uterine bleeding, pubertal period, hemostasis, anemia, iron deficiency, iron supplements. For citation: Selikhova M.S., Zvereva E.S. Abnormal uterine bleeding in girls: tips and tools. Russian Journal of Woman and Child Health. 2019;2(4):351–354.

A neurological syndrome characterized by levodopa unresponsive bradykinesia, retropulsion with falls backwards, dysarthria, gait disturbance, dystonia, and emotional lability was identified in 13 male opiate addicts following the prolonged intravenous use of ephedrone (methcathinone), a central nervous stimulant prepared from pseudoephedrine, potassium permanganate, and vinegar. The natural history, response to treatment, and clinical features has been studied, and MR and dopamine transporter SPECT brain imaging were carried out. Pubic hair was sampled for manganese. The clinical and radiological picture closely resembled previous reports of chronic manganese poisoning and increased mean manganese level in pubic hair observed for at least 1 year after cessation of ephedrone. Odor identification was intact. Cognitive assessment showed a mild executive dysfunction and a mild depression. DaTSCANs were all normal. The neurological syndrome bears some similarities to PSP but differs from Parkinson's disease. Delayed neurological progression despite discontinuation of ephedrone occurred in one-third of cases. Ephedrone poisoning should be considered as a possible cause of secondary Parkinsonism in young adults, particularly from Eastern Europe. [ABSTRACT FROM AUTHOR]

Hormonal contraception and its role for the maintenance of reproductive potential in women with pelvic inflammatory disease M.S. Selikhova, P.A. Soltys, A.A. Smol’yaninov Volgograd State Medical University, Volgograd, Russian Federation Aim: To study the effect of pelvic inflammatory disease (PID) on female reproductive functions and the importance of hormonal contraception for the rehabilitation of these women. Patients and Methods: The study included two steps. During step 1, 117 women with acute manifestations of PID were examined. These women were subdivided into 2 groups. Group 1 included 36 women (30.8%) with acute PID diagnosed for the first time. Group 2 included 81 women with exacerbations of chronic PID (69.2%). During step 2, the effects of combined oral contraceptive pills (COCPs) on the rehabilitation of 87 women were analyzed. Results: Our findings demonstrate that PID is diagnosed in the active reproductive age (29.4±4.9 years). In a half of these women, reproductive function was not realized. Adequate antibiotic therapy considering antibiotic susceptibility does not provide complete rehabilitation after the disease. In the second stage 87 women took part, 21 of them women received COCPs (Midiana®) for a year after PID, 47 — for 6 months, 8 — for 3 months, 11 — did not received COCs. In 3 women who did not received COCPs (27.3%), inflammation has exacerbated. Menstrual disorders were reported in 5 women (45.5%). Conclusions: Combined single-phase low-dose contraceptive containing 30 μg of ethinylestradiol and 3 mg of drospirenone (Midiana®) provides rehabilitation after PID thus preventing PID recurrences within a year, regaining regular menstrual cycle, and restoring reproductive potential. Keywords: active reproductive age, pelvic inflammatory disease, rehabilitation, single-phase low-dose contraceptive, decrease in recurrence rate, regaining menstrual cycle, contraception. For citation: Selikhova M.S., Soltys P.A., Smol’yaninov A.A. Hormonal contraception and its role for the maintenance of reproductive potential in women with pelvic inflammatory disease. Russian Journal of Woman and Child Health. 2019;2(2):102–106.