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For the past 14 years the Social Ecological Responsibility in Science and Engineering Education (SERSEE) Network has discussed the challenging but necessary task of teaching social and ecological responsibility to science and engineering students. Identifying, sharing and developing best practices, pedagogical materials and tools as well as a strategy for promoting it at universities can aid and promote this endeavour. This paper presents the central concepts and pedagogical methods that have emerged during the informal network's meetings, and compares these concepts and methods to trends in the research literature.

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• Three commercial botanical feed additives did not show significant effects on the parameters studied. • Cohen's size effect indicated a strong response of all treatments on egg excretion. • Only mugwort treatment showed a high Cohen's d on larval development. • Anthelmintic efficacy of each treatments was less than 39 %. The increasing emergence of anthelmintic-resistant parasitic isolates prompts us to reassess the management of intestinal strongylosis in horses. Additionally, societal demand is shifting toward reducing the use of chemical treatments, aligning with environmentally-friendly practices and the exploration of natural alternatives. In this context, we provide an initial view of the antiparasitic activity and the effect on immune circulating blood cells of three commercialized plant-based feed additives in ponies. Three treatments, based either on mugwort (Artemisia vulgaris), echinacea (Echinacea purpurea) or curcumin (Curcuma longa) were administrated to 18 (six per treatment) Welsh female ponies naturally infected with cyathostomins to mimic their practical use in farming conditions. Another group of six untreated ponies was used as a control. Fecal egg count (FEC), the larval development percentage and the number of red blood cells, lymphocytes, monocytes, neutrophils, eosinophils and basophils were measured the first and the last day of each treatment, and compared with those characterizing the control group. None of the three treatments showed a significant effect on the studied parameters. Moreover, the efficacy of treatments, measured from the FEC reduction compared to the control group, was weak (≤ 38.6 %). Therefore, these results do not support the practical use of these additives in equine farming, even if the determination of Cohen's d values associated with the three treatments revealed some incidences on FEC and blood immune cell counts, as well as on larval development for mugwort. [ABSTRACT FROM AUTHOR]

Cyathostomins are the most prevalent parasitic nematodes of grazing horses. They are responsible for colic and diarrhea in their hosts. After several decades of exposure to synthetic anthelmintics, they have evolved to become resistant to most compounds. In addition, the drug-associated environmental side-effects question their use in the field. Alternative control strategies, like bioactive forages, are needed to face these challenges. Among these, chicory (Cichorium intybus, Puna II cultivar (cv.)) is known to convey anthelmintic compounds and may control cyathostomins in grazing horses. To challenge this hypothesis, we measured fecal egg counts and the rate of larval development in 20 naturally infected young saddle horses (2-year-old) grazing either (i) a pasture sown with chicory (n = 10) or (ii) a mesophile grassland (n = 10) at the same stocking rate (2.4 livestock unit (LU)/ha). The grazing period lasted 45 days to prevent horse reinfection. Horses in the chicory group mostly grazed chicory (89% of the bites), while those of the control group grazed mainly grasses (73%). Cyathostomins egg excretion decreased in both groups throughout the experiment. Accounting for this trajectory, the fecal egg count reduction (FECR) measured in individuals grazing chicory relative to control individuals increased from 72.9% at day 16 to 85.5% at the end of the study. In addition, larval development in feces from horses grazed on chicory was reduced by more than 60% from d31 compared to control individuals. Using a metabarcoding approach, we also evidenced a significant decrease in cyathostomin species abundance in horses grazing chicory. Chicory extract enriched in sesquiterpenes lactones was tested on two cyathostomins isolates. The estimated IC 50 was high (1 and 3.4 mg/ml) and varied according to the pyrantel sensitivity status of the worm isolate. We conclude that the grazing of chicory (cv. Puna II) by horses is a promising strategy for reducing cyathostomin egg excretion and larval development that may contribute to lower the reliance on synthetic anthelmintics. The underpinning modes of action remain to be explored further. [Display omitted] [ABSTRACT FROM AUTHOR]

Introduction: The circulating concentration of PlGF is reported to be lower in patients experiencing preeclampsia and patients delivering a small for gestational age (SGA) neonate. Objectives: To evaluate the predictive value of circulating PlGF for preeclampsia and adverse outcome in patients with suspected preeclampsia or fetal growth restriction. Methods: We prospectively enrolled 96 women who were included after 22 weeks gestation (WG) for suspected preeclampsia or suspected SGA, and measured plasma levels of PlGF (Triage® PLGF, Alere©) at enrollment. We studied outcome until delivery and one week postpartum, and defined adverse outcome as severe preeclampsia, SGA neonate (<10th centile) or elective delivery for maternal or fetal complication. Severe adverse outcome was studied among patients included <34WG and defined as eclampsia, HELLP syndrome, very SGA (<3rd centile) or elective delivery <34WG. Results: The mean logtransformed PlGF level was lower for women who experienced preeclampsia than for those who did not (2.9 vs 3.7, p =0.02), and was markedly lower for patients who experienced adverse outcome (2.9 vs 4.3, p <0.001). The odds of presenting an adverse outcome were higher for the lowest tertile of PlGF compared to the higher (OR=12 , 95% CI [3–46] ). Among patients included <34WG, the odds of experiencing a severe adverse outcome were, respectively, for the lowest and intermediate tertile as compared with the higher tertile: OR=132 , 95% CI [14–1273]; and OR=20, 95% CI [4–106] . When included <34 WG, patients with a PlGF level <12pg/ml experienced a severe adverse outcome in 96% of cases (24/25), and only 1 of 28 patients with a PlGF level >50pg/ml experienced a severe adverse outcome within 15 days (4%). Among women with suspected SGA who were enrolled <32WG and whose PlGF level was <12pg/ml, 89% had an elective delivery before 34 WG (17/19). Conclusion: Among women with suspected preeclampsia or SGA, PlGF circulating levels differ between women who will experience an adverse outcome and those who will not. It can therefore be of help in the management of these patients, especially for those for whom the diagnosis is suspected early in pregnancy. [Copyright &y& Elsevier]