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4. National study of NAFLD management identifies variation in delivery of care in the UK between 2019 to 2022

Author

Abeysekera, Kush, Marjot, Tom, Brennan, Paul, Mahgoub, Sara, Cacciottolo, Tessa, Hydes, Theresa, Hardy, Tim, McGinty, Gio, Tavabie, Oliver, Cathcart, Jennifer, Premathilaka, Chirantha, Mukhopadhya, Ashis, Bhat, Arshiya, Begum, Shahnaz, Abushaban, Bashar, Bhuva, Meha, Sinclair, Sophie, Leith, Damien, McCulloch, Cullen, Leithead, Joanna, Fox, Richard, Shah, Muhammad Haris, Campbell, Eugene, Brown, Edward, Mansour, Dina, Shah, Fatma, Allison, Michael, Chan, Jonathan, Roberts, Victoria, Appanna, Gautham, Mandour, Mandour Omer, Slee, Georgina, Wong, Vicki, Kotha, Sreelakshmi, Pekarska, Katrina, Parker, Richard, Sieberhagen, Cyril, Ngan, Thomas, Asilmaz, Esra, Miller, Hamish, Cobbold, Jeremy, Crocombe, Dom, Tsochatzis, Manolis, Tanwar, Sudeep, Dias, Aruna, Singh, Gurmit, Agrawal, Swastik, Chhabra, Puneet, Gurung, Amrita, Veettil, Rajesh, Abeles, Robin Daniel, Chatterjee, Devnandan, Carbonell, Michael, Mohamed, Zameer, El-Sayed, Ahmed, Johnson, Amy, Barclay, Stephen, Kelly, Katherine, Munonye, Joshua, Coates, Dominic, Bamidele, Opeyemi, Johnston, Thomas, Samuel, David, Ball, Belinda, Arscott-Samuel, Rebecca, Hams, Pamela, Armstrong, Matthew, Elkhol, Ayman, Shailesh, Karanth, Bains, Vikram, Manousou, Pinelopi, Gupta, Tarun, Than, Sophia, Unitt, Esther, Gordon, Victoria, Wakefield, Alice, Gilchrist, Sian, Cozma, Ioana, Saeed, Sohaib, Umrani, Salman, Olsen, Kathryn, Li, Wenhao, Sheridan, David, McPherson, Stuart, and Alazawi, William

Published
2023
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5. Addressing the Pediatric Mental Health Crisis in Emergency Departments in the US: Findings of a National Pediatric Boarding Consensus Panel

Author

Aggarwal, Arpit, Behere, Aniruddh P., Brahmbhatt, Khyati, Burns, Beech, Carubia, Beau, Fabbro, Anilla Del, Dell, Mary Lynn, Donise, Kathleen, Duffy, Susan, Giles, Lisa, Johnson, Kyle, Kalapatapu, Raj K., Lardizabal, Marybeth, Moreno, Claudia, Pergjika, Alba, Pierce, Donald, Rogers, Steven, Schott, Meghan, Shaw, Richard J., Sheridan, David, Zablan, Kashmeer, Feuer, Vera, Mooneyham, GenaLynne C., and Malas, Nasuh M.

Published
2023
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9. The Role of Nonclassroom Spaces in Living-Learning Communities

Author

Altimare, Emily and Sheridan, David M.

Abstract

A body of research suggests that learning communities provide a range of academic benefits by increasing social connectedness. Researchers have also hypothesized that informal learning spaces--nonclassroom spaces (NCSs)--can facilitate learning by supporting social connectedness. This study uses qualitative methods to explore the way nonclassroom spaces facilitate learning-related activities within a recently established learning community at Michigan State University. Our findings suggest that NCSs function as social hubs, help make intellectual and creative work visible to the larger learning community, and provide access to important resources. More generally, NCSs help to facilitate community formation and identity.

Published
2016

11. Assessment of hepatic steatosis by controlled attenuation parameter using the M and XL probes: an individual patient data meta-analysis

Author

Petroff, David, Blank, Valentin, Newsome, Philip N, Shalimar, Voican, Cosmin Sebastian, Thiele, Maja, de Lédinghen, Victor, Baumeler, Stephan, Chan, Wah Kheong, Perlemuter, Gabriel, Cardoso, Ana-Carolina, Aggarwal, Sandeep, Sasso, Magali, Eddowes, Peter J, Allison, Michael, Tsochatzis, Emmanuel, Anstee, Quentin M, Sheridan, David, Cobbold, Jeremy F, Naveau, Sylvie, Lupsor-Platon, Monica, Mueller, Sebastian, Krag, Aleksander, Irles-Depe, Marie, Semela, David, Wong, Grace Lai-Hung, Wong, Vincent Wai-Sun, Villela-Nogueira, Cristiane A, Garg, Harshit, Chazouillères, Olivier, Wiegand, Johannes, and Karlas, Thomas

Published
2021
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12. Willingness to Vaccinate Children against Influenza after the Coronavirus Disease 2019 Pandemic

Author

Ahmed, Sarah, Ali, Samina, Brown, Julie C., Craig, Simon, Davis, Adrienne L., Gaucher, Nathalie, Gianluca, Gualco, Goldman, Ran, Griffiths, Mark, Hall, Jeanine E., Hansen, Matt, Hurt, Thomas L., Kelly, Christopher, Klein, Eileen J., Kozer, Eran, Marneni, Shashidhar, Mater, Ahmed, Mistry, Rakesh, Parra, Cristina, Poonai, Naveen, Rao, Arjun, Sheridan, David, Shimizu, Naoki, Yue, Esther L., Goldman, Ran D., McGregor, Sophie, Marneni, Shashidhar R., Katsuta, Tomohiro, Griffiths, Mark A., Seiler, Michelle, Cotanda, Cristina Parra, Gelernter, Renana, Hoeffe, Julia, Gualco, Gianluca, Manzano, Sergio, Thompson, Graham C., and Ahmed, Sara

Published
2021
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13. Selonsertib for patients with bridging fibrosis or compensated cirrhosis due to NASH: Results from randomized phase III STELLAR trials

Author

Gadano, Adrian, Martins, Marcelo, Angus, Peter, Bate, John, Danta, Mark, George, Jacob, Hodge, Alexander, Kontorinis, Nickolas, Roberts, Stuart, Sanagapalli, Santosh, Skoien, Richard, Thompson, Alexander, Zekry, Amany, Stauber, Rudolf, Trauner, Michael, Moreno, Christophe, Reynaert, Hendrik, Verbeke, Len, Silva, Mario Reis Alvares da, Parise, Edison, Oliveira, Claudia Pinto Marques Souza de, Araujo, Roberta Chaves, Martinelli, Ana de Lourdes Candolo, Borman, Meredith, Chandok, Natasha, Elkhashab, Magdy, Fraser, Hughie, Kaita, Kelly, Ma, Mang, Marotta, Paul, Ramji, Alnoor, Tam, Edward, Yoshida, Eric, Swain, Mark, Sebastiani, Giada, Petrunia, Denis, Abergel, Armando, Anty, Rodolphe, Bourlière, Marc, Boursier, Jérôme, Bureau, Christophe, Castera, Laurent, Habersetzer, François, Hézode, Christophe, Ledinghen, Victor De, Leroy, Vincent, Loustaud-Ratti, Véronique, Mathurin, Philippe, Pol, Stanislas, Zoulim, Fabien, Hinrichsen, Holger, Ingiliz, Patrick, Lammert, Frank, Manns, Michael, Schattenberg, Jörn, Schiefke, Ingolf, Trautwein, Christian, Zeuzem, Stefan, Hui, Aric, Li, King-Kong, Wong, Vincent, Acharya, Subrat, Chowdhury, Abhijit, Duseja, Ajay, Kapoor, Dharmesh, Mukewar, Shrikant, Sarin, Shiv, Shah, Samir, Shalimar, Sood, Ajit, Tantry, BV, Ben-Ari, Ziv, Katchman, Helena, Safadi, Rifaat, Veitsman, Ella, Zuckerman, Eli, Brunetto, Maurizia, Lampertico, Pietro, Mangia, Alessandra, Akahane, Takemi, Akuta, Norio, Eguchi, Yuichiro, Fujiyama, Shigetoshi, Genda, Takuya, Hiasa, Yoichi, Ido, Akio, Ikeda, Fusao, Ikegami, Tadashi, Imajo, Kento, Itoh, Yoshito, Iwasa, Motoh, Karino, Yoshiyasu, Kato, Naoya, Kawaguchi, Takumi, Kawanaka, Miwa, Kido, Masahiro, Kobayashi, Tomoo, Kurosaki, Masayuki, Matsuzaki, Yasushi, Mita, Eiji, Mizukoshi, Eishiro, Nakahara, Takashi, Nomura, Hideyuki, Notsumata, Kazuo, Okanoue, Takeshi, Saito, Satoshi, Sakugawa, Hiroshi, Suzuki, Yoshiyuki, Takaguchi, Koichi, Takaki, Akinobu, Takashima, Tomoyuki, Tanaka, Saiyu, Tsuji, Keiji, Ueno, Yoshiyuki, Umemura, Takeji, Uto, Hirofumi, Yamashita, Nobuyuki, Yanase, Mikio, Yatsuhashi, Hiroshi, Yoneda, Masashi, Chan, Wah Kheong, Tan, Soek Siam, Garza, Laura Cisneros, Ladron De Guevara Cetina, Alma, Angeles, Rocio Guadalupe Vargas, Silva, Francisca Martinez, Van Erpecum, Karel, Orr, David, Jabłkowski, Maciej, Jaroszewicz, Jerzy, Ramos, Jose, Ahmed, Taufique, Ang, Tiing, Dan, Yock young, Goh, Boon Bee, Kaliyaperumal, Kalaiyarasi, Yip, Cherng Hann, Baik, Soon Koo, Jang, Byoung Kuk, Jun, Dae Won, Kim, Won, Kim, Hyung Joon, Kim, Ji Hoon, Lee, Kwan Sik, Lee, Chun Kyon, Lim, Young-Suk, Park, Jun Yong, Tak, Won Young, Augustin, Salvador, Perez, Salvador Benlloch, Caballeria, Juan, Luis, Jose, Panero, Calleja, Rodríguez, Jose Carrión, Garcia, Javier Crespo, Samaniego, Javier Garcia, Gibert, Pere Ginès, Prieto, Martin, Gomez, Manuel Romero, Turnes, Juan, Dufour, Jean-Francois, Moriggia, Alberto, Sheen, I-Shyan, Kao, Jia-Horng, Cheng, Pin-Nan, Huang, Jee-Fu, Yang, Sheng-Shun, Su, Wei-Wen, Chen, Chi-Yi, Chien, Rong-Nan, Lo, Gin-Ho, Chu, Chi-Jen, Wang, Horng-Yuan, Hu, Jui-Ting, Huang, Yi Wen, Agarwal, Kosh, Allison, Michael, Anstee, Quentin, Austin, Andrew, Fowell, Andrew, Ch'ng, Chin Lye, Manousou, Pinelopi, Newsome, Philip, Ryder, Stephen, Shankar, Arun, Abdelmalek, Manal, Abrams, Gary, Aguilar, Humberto, Alam, Imtiaz, Alba, Laura, Alkhouri, Naim, Allen, Alina, Aqel, Bashar, Balart, Luis, Barritt, A. Sidney, IV, Behari, Jaideep, Bennett, Michael, Bernstein, David, Bhandari, Bal Raj, Bonacini, Maurizio, Borg, Brian, Brown, Kimberly, Bzowej, Natalie, Caldwell, Stephen, Chami, Tawfik, Coates, Allan, Cueli, Adolfo, Davis, Mitchell, deLemos, Andrew, Desai, Archita, Dunn, Winston, Ferreira, Nelson, Fine, Michael, Firpi-Morell, Roberto, Freedland, Curtis, Freilich, Bradley, Fuchs, Michael, Galambos, Michael, Gallegos-Orozco, Juan, Galler, Greg, Ghali, Maged, Ghalib, Reem, Gill, Satinder, Gillis, Marcum, Gilroy, Richard, Gordon, Stuart, Gunn, Nadege, Halegoua-DeMarzio, Dina, Hassan, Mohamed, Hassanein, Tarek, Herring, Robert, Jr., Hong, John, Huang, Jonathan, Kabler, Heidi, Kayali, Zeid, Knapple, Whitfield, Kolli, Geetha, Kowdley, Kris, Krause, Richard, Lawitz, Eric, Lidofsky, Steven, Lim, Joseph, Lipkis, Donald, Loomba, Rohit, Mahgoub, Amar, Malespin, Miguel, Manch, Richard, Mannis, Steven, Manos, Paul, McDonald, Thomas, McKenzie, Mark, Mena, Edward, Merriman, Raphael, Moehlen, Martin William, Montgomery, Richard, Murphy, Robert, Natarajan, Yamini, Neff, Guy, Noureddin, Mazen, Ortiz-Lasanta, Grisell, Pagadala, Mangesh, Patel, Keyur, Patton, Heather, Peyton, Adam, Pimstone, Neville, Poulos, John, Pound, David, Pyrsopoulos, Nikolaos, Rafiq, Nila, Ravendhran, Natarajan, Ravinuthala, Ravi, Reddy, K. Rajendar, Reindollar, Robert, Reynolds, Justin, Rinella, Mary, Rizvi, Syed, Rockey, Don, Rodriguez-Perez, Federico, Ruane, Peter, Rubin, Raymond, Ryan, Michael, Saeian, Kia, Sanyal, Arun, Sarkar, Souvik, Scanga, Andrew, Schiff, Eugene, Schmidt, Warren, Schneider, Jeffrey, Sepe, Thomas, Shah, Dhiren, Shaikh, Obaid, Shankar, Uday, Sheikh, Aasim, Sheikh, Muhammad, Sherman, Kenneth, Shiffman, Mitchell, Siddique, Asma, Smith, Matthew, Suarez, Rosa, Talal, Andrew, Te, Helen, Tekola, Bezawit, Tetri, Brent, Thuluvath, Paul, Toro, Doris, Torres, Dawn, Trinh, Huy, Trotter, James, Vento, Angel, Vierling, John, Vuppalanchi, Raj, Waters, Michael, Weisberg, Ilan, Wieland, Amanda, Williams, Alonzo, Younes, Ziad, Adams, Leon, Harding, Damian, Hodge, Alex, Kontorinis, Nick, Strasser, Simone, Thompson, Alex, Horsmans, Yves, Steenkiste, Christophe Van, Bailey, Robert, Giard, Jeanne-Marie, Montano-Loza, Aldo, Puglia, Marco, Tsoi, Keith, Larrey, Dominique, Nguyen-Khac, Eric, Ratziu, Vlad, Spengler, Ulrich, Wiegand, Johannes, Hui, Aric Josun, Acharya, Subrat Kumar, Sarin, Shiv Kumar, Tantry, Vishwanath, Braun, Marius, Hazzan, Rawi, Lurie, Yoav, Colombo, Massimo, Fujii, Hideki, Hashimoto, Etsuko, Kato, Masaki, Ogawa, Koji, Takehara, Tetsuo, Tokushige, Katsutoshi, Garza, Laura Esthela Cisneros, Ladrón De Guevara, Alma Laura, Schultz, Michael, Janczewska, Ewa, Toro, Doris H., Jeong, Sook-Hyang, Kim, Yoon Jun, Lee, Jin-Woo, Ang, Tiing Leong, Bee, George Goh Boon, Benlloch, Salvador, Caballería, Juan, Calleja, José Luis, Rodríguez, Jose A. Carrión, Crespo, Javier, Diago, Moises, Fernandez-Rodriguez, Conrado, García-Samaniego, Javier, Ginès, Pere, Romero, Manuel, Dufour, Jean-François, Alazawi, William, Ch'ng, Chin-Lye, Forton, Daniel, Priest, Matthew, Sheridan, David, Ankoma-Sey, Victor, Balakrishnan, Maya, Bambha, Kiran, Barritt, A. Sidney, Bhandari, Bal, Brandman, Danielle, Chang, Charissa, Corey, Kathleen, Feldman, Michael, Gholam, Pierre, Goff, John, Marzio, Dina Halegoua-De, Harrison, Stephen, Hellstern, Paul, Jr., Herring, Robert, Iyer, Rajalakshmi, Jakiche, Antoine, Kohli, Anita, Krok, Karen, Kugelmas, Marcelo, Kumar, Sonal, Lai, Michelle, Mahmoud, Mitchell, Mantry, Parvez, Marsano, Luis, Nguyen, Tuan, Park, James, Patton, Heather M., Pockros, Paul, Reddy, Rajender, Rodriguez, Miguel, Sarles, Harry, Satapathy, Sanjaya, Sedghi, Shahriar, Shah, Nikunj, Sheikh, Muhammad Yasin, Sigal, Samuel, Stanca, Carmen, Steinbook, Michael, Szabo, Gyongyi, Terrault, Norah, Tong, Myron, Victor, David, Zervos, Xaralambos, Harrison, Stephen A., Wong, Vincent Wai-Sun, Caldwell, Stephen H., Shiffman, Mitchell L., Camargo, Marianne, Li, Georgia, Kersey, Kathryn, Jia, Catherine, Zhu, Yanni, Djedjos, C. Stephen, Subramanian, G. Mani, Myers, Robert P., Anstee, Quentin M., Romero-Gomez, Manuel, Goodman, Zachary, Lawitz, Eric J., and Younossi, Zobair

Published
2020
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14. FibroScan-AST (FAST) score for the non-invasive identification of patients with non-alcoholic steatohepatitis with significant activity and fibrosis: a prospective derivation and global validation study

Author

Newsome, Philip N, Sasso, Magali, Deeks, Jonathan J, Paredes, Angelo, Boursier, Jérôme, Chan, Wah-Kheong, Yilmaz, Yusuf, Czernichow, Sébastien, Zheng, Ming-Hua, Wong, Vincent Wai-Sun, Allison, Michael, Tsochatzis, Emmanuel, Anstee, Quentin M, Sheridan, David A, Eddowes, Peter J, Guha, Indra N, Cobbold, Jeremy F, Paradis, Valérie, Bedossa, Pierre, Miette, Véronique, Fournier-Poizat, Céline, Sandrin, Laurent, and Harrison, Stephen A

Published
2020
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15. (Re)Mediating (Un)Heard Resonances: Tracing the Rhythms of Aurality in a Residential College Community

Author

Brownell, Cassie J., Sheridan, David M., and Scales, Christopher A.

Abstract

Although other disciplines have explored sound as more than oral language, music, or noise, educational scholarship exploring everyday soundscapes still has room to grow. In this article, a team of transdisciplinary scholars from education, writing and rhetoric, and ethnomusicology explore new possibilities for sound in research and teaching by examining a cross-course assignment grounded in the sonic experiences of a residential, living-learning college community. Through examining student-produced compositions, we introduce a number of relevant insights into the relationships between space, community, and a pedagogy of aurality.

Published
2018
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19. Impact of social media "challenges" on poison center case volume for intentional ingestions among school-aged children: an observational study.

Author

Marshall, Rebecca D., Bailey, Jessica, Lin, Amber, Sheridan, David C., Hendrickson, Robert G., Hughes, Adrienne, and Horowitz, B. Zane

Subjects
POISON control centers, SOCIAL media, INGESTION, SCHOOL children, SCIENTIFIC observation, ATTEMPTED suicide, AT-risk youth
Abstract

Mental health problems among youth have escalated over the past decade, with increased rates of self-harm, including suicide attempts by ingestion. Social media use has been linked to youth mental health, including "challenges" urging youth to ingest substances for recreational and other purposes. We hypothesized that social media challenges for particular substances would temporally correspond with increased ingestions of these substances. We identified peak Google Trends search times for social media ingestion challenges involving diphenhydramine, laundry pods, nutmeg, and cinnamon, and used data from America's Poison Centers National Poison Data System to plot reported ingestions 3 months before and after peak searches in school-aged children. There were 2,169 individuals in the analysis. Diphenhydramine was the most frequently reported ingestion for misuse/abuse and suicidal purposes (n = 266 and 1,609, respectively). For all ingestions together, 45 percent (n = 979) had a moderate health effect, and 6.35 percent (n = 137) had a major health effect. Time of peak searches corresponded with increased ingestions for each substance. We found a temporal relationship between peak Google Trends searches for ingestion challenges and ingestions of that substance reported to United States poison centers. Compared to misuse/abuse ingestions, most suicidal ingestions peaked 1–2 months later, suggesting a public health opportunity for intervention. This retrospective observational study does not establish causal effect. All data are a result of self-reporting of the exposures, which may lead to a reporting bias. Google Trends is not the only search engine and likely underestimates the true incidence of social media posts. Additional research is needed on the relationship between social media and youth mental health, particularly around "challenges" that place youths' health at risk. There may be opportunities for intervention to decrease medical and mental health sequelae of these challenges. [ABSTRACT FROM AUTHOR]

Published
2024
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22. Seladelpar (MBX-8025), a selective PPAR-δ agonist, in patients with primary biliary cholangitis with an inadequate response to ursodeoxycholic acid: a double-blind, randomised, placebo-controlled, phase 2, proof-of-concept study

Author

Jones, David, Boudes, Pol F, Swain, Mark G, Bowlus, Christopher L, Galambos, Michael R, Bacon, Bruce R, Doerffel, Yvonne, Gitlin, Norman, Gordon, Stuart C, Odin, Joseph A, Sheridan, David, Wörns, Markus-Alexander, Clark, Virginia, Corless, Linsey, Hartmann, Heinz, Jonas, Mark E, Kremer, Andreas E, Mells, George F, Buggisch, Peter, Freilich, Bradley L, Levy, Cynthia, Vierling, John M, Bernstein, David E, Hartleb, Marek, Janczewska, Ewa, Rochling, Fedja, Shah, Hemant, Shiffman, Mitchell L, Smith, John H, Choi, Yun-Jung, Steinberg, Alexandra, Varga, Monika, Chera, Harinder, Martin, Robert, McWherter, Charles A, and Hirschfield, Gideon M

Published
2017
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25. A variant in the MICA gene is associated with liver fibrosis progression in chronic hepatitis C through TGF-β1 dependent mechanisms

Author

Sharkawy, Rasha El, Bayoumi, Ali, Metwally, Mayada, Mangia, Alessandra, Berg, Thomas, Romero-Gomez, Manuel, Abate, Maria Lorena, Irving, William L., Sheridan, David, Dore, Gregory J., Spengler, Ulrich, Lampertico, Pietro, Bugianesi, Elisabetta, Weltman, Martin, Mollison, Lindsay, Cheng, Wendy, Riordan, Stephen, Santoro, Rosanna, Gallego-Durán, Rocío, Fischer, Janett, Nattermann, Jacob, D’Ambrosio, Roberta, McLeod, Duncan, Powell, Elizabeth, latchoumanin, Olivier, Thabet, Khaled, Najim, Mustafa A. M., Douglas, Mark W., Liddle, Christopher, Qiao, Liang, George, Jacob, Eslam, Mohammed, and International Liver Disease Genetics Consortium (ILDGC)

Published
2019
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26. Open‐label, clinical trial extension: Two‐year safety and efficacy results of seladelpar in patients with primary biliary cholangitis.

Author

Mayo, Marlyn J., Vierling, John M., Bowlus, Christopher L., Levy, Cynthia, Hirschfield, Gideon M., Neff, Guy W., Galambos, Michael R., Gordon, Stuart C., Borg, Brian B., Harrison, Stephen A., Thuluvath, Paul J., Goel, Aparna, Shiffman, Mitchell L., Swain, Mark G., Jones, David E. J., Trivedi, Palak, Kremer, Andreas E., Aspinall, Richard J., Sheridan, David A., and Dörffel, Yvonne

Subjects
CHOLANGITIS, CLINICAL trials, ADVERSE health care events, NON-alcoholic fatty liver disease, BIOMARKERS
Abstract

Summary: Background: Seladelpar is a potent and selective peroxisome proliferator‐activated receptor‐δ agonist that targets multiple cell types involved in primary biliary cholangitis (PBC), leading to anti‐cholestatic, anti‐inflammatory and anti‐pruritic effects. Aims: To evaluate the long‐term safety and efficacy of seladelpar in patients with PBC. Methods: In an open‐label, international, long‐term extension study, patients with PBC completing seladelpar lead‐in studies continued treatment. Seladelpar was taken orally once daily at doses of 5 or 10 mg with dose adjustment permitted for safety or tolerability. The primary analysis was for safety and the secondary efficacy analysis examined biochemical markers of cholestasis and liver injury. The study was terminated early due to the unexpected histological findings in a concurrent study for non‐alcoholic steatohepatitis, which were subsequently found to predate treatment. Safety and efficacy data were analysed through 2 years. Results: There were no serious treatment‐related adverse events observed among 106 patients treated with seladelpar for up to 2 years. There were four discontinuations for safety, one possibly related to seladelpar. Among 53 patients who completed 2 years of seladelpar, response rates increased from years 1 to 2 for the composite endpoint (alkaline phosphatase [ALP] <1.67 × ULN, ≥15% decrease in ALP, and total bilirubin ≤ULN) and ALP normalisation from 66% to 79% and from 26% to 42%, respectively. In those with elevated bilirubin at baseline, 43% achieved normalisation at year 2. Conclusions: Seladelpar was safe, and markedly improved biochemical markers of cholestasis and liver injury in patients with PBC. These effects were maintained or improved throughout the second year. Clinicaltrials.gov: NCT03301506; Clinicaltrialsregister.eu: 2017‐003910‐16. [ABSTRACT FROM AUTHOR]

Published
2024
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31. FibroGENE: A gene-based model for staging liver fibrosis

Author

Eslam, Mohammed, Hashem, Ahmed M., Romero-Gomez, Manuel, Berg, Thomas, Dore, Gregory J., Mangia, Alessandra, Chan, Henry Lik Yuen, Irving, William L., Sheridan, David, Abate, Maria Lorena, Adams, Leon A., Weltman, Martin, Bugianesi, Elisabetta, Spengler, Ulrich, Shaker, Olfat, Fischer, Janett, Mollison, Lindsay, Cheng, Wendy, Nattermann, Jacob, Riordan, Stephen, Miele, Luca, Kelaeng, Kebitsaone Simon, Ampuero, Javier, Ahlenstiel, Golo, McLeod, Duncan, Powell, Elizabeth, Liddle, Christopher, Douglas, Mark W., Booth, David R., and George, Jacob

Published
2016
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32. Pretty Knotte

Author

Sheridan, David M.

Subjects
Pretty Knotte (Short story), Literature/writing
Abstract

This evening I had a conversation with the editor--I will call her Jan--of a small but reasonably prestigious literary journal on the West Coast. At the time of this writing, [...]

Published
2021

35. The impact of a novel policy for pediatric mental health patients in the emergency department.

Author

Sheridan, David C., Burns, Beech, Chung, SunHee, Saladik, Monica, Marx, Elizabeth, and Marshall, Rebecca

Abstract

Pediatric mental health presentations continue to increase across the US. These patients often board for significant periods of time and may require more resources than other acute non-mental health patients. This has important implications for the overall function of the emergency department (ED) as well as care of all ED patients. This study evaluated a policy developed to allow for inpatient hospital admission when 30% of the ED was occupied by boarding patients at a tertiary care children's hospital. We found an increase in the number of patients for whom this policy applied, and increased days/month this policy was executed over time. There was an increase in the average ED LOS and left without being seen rate during this time which we hypothesize would have been higher without this policy. A hospital policy allowing mental health patients to be admitted to the inpatient hospital once stabilized has the potential to improve ED flow and functionality. [ABSTRACT FROM AUTHOR]

Published
2023
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43. Trends in intentional abuse and misuse ingestions in school-aged children and adolescents reported to US poison centers from 2000-2020.

Author

Hughes, Adrienne R., Grusing, Sara, Lin, Amber, Hendrickson, Robert G., Sheridan, David C., Marshall, Rebecca, and Zane Horowitz, B.

Subjects
POISON control centers, AGE differences, TEENAGERS, INGESTION, TEENAGE boys, AGE groups, SCHOOL children
Abstract

Childhood and adolescent misuse and abuse exposures remain a serious public health challenge in the United States. This study aimed to describe recent trends and patterns of intentional substance misuse and abuse exposures among school-aged children and adolescents in the United States. This study was a retrospective cohort study of intentional misuse and abuse exposures in children 6 through 18 years reported to the National Poison Data System (NPDS) from January 1, 2000, through December 31, 2020. Demographic trends, reported clinical effects, treatments, management sites, and health outcomes were assessed overall and within four age categories: 6–9, 10–12, 13–15, and 16–18. Between 2000 and 2020, there were 338,727 cases regarding intentional misuse and abuse exposures for children ages 6 through 18 years old. Overall, misuse/abuse ingestions fluctuated over time, with a peak in 2011. The majority of intentional misuse/abuse ingestions occurred in males (58.3%), and more than 80% of all reported exposure cases occurred in youth aged 13 to 18. 32.6% of ingestions resulted in worse than minor clinical outcomes. Older age groups had a greater number of severe medical outcomes compared to younger age groups. Major or life-threatening exposures (including those resulting in death) were more common in males. Overall, deaths were rare (n = 450), 0.1%). Male sex, older age, abuse ingestions, exposure site of a public area or other residence, and multiple ingested substances were other factors associated with increased mortality. Marijuana exposure rates had the highest average monthly increase overall, with the most dramatic rise occurring from 2017 to 2020. Edible marijuana preparations accounted for the highest increase in call rates compared with all other forms of marijuana. With over 330,000 poison center cases reported during the 20-year study period, intentional substance misuse and abuse exposures substantially impact the pediatric population. The substances most commonly misused/abused are more widely available substances such as over-the-counter medications, household products and pharmaceuticals commonly prescribed to youth. Differences in age and sex were evident, with males and adolescents more likely to abuse and misuse substances. Our study describes an upward trend in marijuana misuse/abuse exposures among youth, especially those involving edible products. These findings highlight an ongoing concern about the impact of rapidly evolving cannabis legalization on this vulnerable population. [ABSTRACT FROM AUTHOR]

Published
2023
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46. A New Cell Topology for 4H-SiC Planar Power MOSFETs for High-Frequency Switching.

Author

Zhu, Shengnan, Liu, Tianshi, Fan, Junchong, Salemi, Arash, White, Marvin H., Sheridan, David, and Agarwal, Anant K.

Subjects
TOPOLOGY, ELECTRIC capacity, METAL oxide semiconductor field-effect transistors
Abstract

A new cell topology named the dodecagonal (a polygon with twelve sides, short for Dod) cell is proposed to optimize the gate-to-drain capacitance ( C gd ) and reduce the specific ON-resistance ( R on , sp ) of 4H-SiC planar power MOSFETs. The Dod and the octagonal (Oct) cells are used in the layout design of the 650 V SiC MOSFETs in this work. The experimental results confirm that the Dod-cell MOSFET achieves a 2.2× lower R on , sp , 2.1× smaller high-frequency figure of merit (HF-FOM), higher turn on/off dv/dt, and 29% less switching loss than the fabricated Oct-cell MOSFET. The results demonstrate that the Dod cell is an attractive candidate for high-frequency power applications. [ABSTRACT FROM AUTHOR]

Published
2022
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47. Capillary Refill Technology to Enhance the Accuracy of Peripheral Perfusion Evaluation in Sepsis.

Author

Gillespie, Jordan, Hansen, Matthew, Samatham, Ravi, Baker, Steven D., Filer, Scott, and Sheridan, David C.

Subjects
SEPSIS, POINT-of-care testing, MEDICAL equipment, RESUSCITATION
Abstract

Background: Monitoring of capillary refill time (CRT) is a common bedside assessment used to ascertain peripheral perfusion in a patient for a vast array of conditions. The literature has shown that a change in CRT can be used to recognize life-threatening conditions that cause decreased perfusion, such as sepsis, and aid in resuscitation. The current practice for calculating CRT invites subjectivity and produces a highly variable result. Innovative technology may be able to standardize this process and provide a reliable and accurate value for use in diagnostics and treatment. This study aimed to assess a new technology (DCR by ProMedix Inc.) for rapid, bedside, and noninvasive detection of CRT. Methods: This was a secondary analysis of a prospective observational study evaluating the accuracy of new technology towards CRT-guided diagnosis of sepsis. It was carried out in the adult emergency departments (ED) of an academic tertiary care medical center. Patients seeking care in the ED were determined eligible if they were > 18 years in age and exhibited chief complaints suggestive of possible sepsis. The CRT produced by the technology was compared to the gold standard manual waveform assessment. Results: 218 consecutive subject enrollments were included and multiple measurements were made on each patient. Data with irregular waveforms were excluded. A total of 692 waveforms were evaluated for CRT values by a pair of trained PhD biomedical engineers. The average age of the cohort was 50.62 and 51.4% female. Results showed a Pearson correlation coefficient of 0.91 for the device CRT compared to the CRT gold standard. The Pearson correlation coefficient for the two independent engineering review of the waveform data was 0.98. This device produces accurate, consistent results and eliminates the subjectivity of CRT measurements that is in practice currently. [ABSTRACT FROM AUTHOR]

Published
2022
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