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To analyze the risk factors affecting prognosis of children with hemophagocytic lymphohistiocytosis (HLH).The clinical manifestations and laboratory data of 143 HLH children who met the HLH-2004 diagnostic criteria in Shenzhen Children's Hospital from January 2009 to May 2017 were retrospectively analyzed, and the independent factors affecting prognosis were also analyzed.The median age of 143 HLH children was 1.9 (0.1-14.3) years old, and the median follow-up time was 6.7 years (1 day - 11.9 years). The overall survival rate of 1 month, 1 year, and 10 years was (87.4±5.5)%, (81.1±6.5)%, and (81.1±6.5)%, respectively. The deaths occurred within 1 year after onset. Multivariate analysis showed that central nervous system (CNS) involvement (P=0.047), low hemoglobin (P=0.002), prolonged activated partial thromboplastin time (APTT) (P0.001), high triglyceride (P=0.005) were all the independent risk factors affecting survival of the children. Receiver operating characteristic curve indicated that APTT (AUC=0.753, P0.001) was more valuable than other risk factors in predicting death of the children. The cut-off value of APTT was 56.6 s, and the sensitivity and specificity of which was 55.6% and 89.7%, respectively.Hypohemoglobinemia, prolonged APTT, hypertriglyceridemia, and CNS involvement the risk factors affecting prognosis of HLH, and prolonged APTT shows a strong predictive value for death.儿童噬血细胞性淋巴组织细胞增生症预后相关因素分析.分析噬血细胞性淋巴组织细胞增生症（HLH）患儿的预后相关危险因素.回顾性分析深圳市儿童医院2009年1月至2017年5月143例符合HLH-2004诊断标准的HLH患儿临床表现及实验室检查，分析影响患儿预后的独立危险因素.患儿的中位年龄为1.9（0.1-14.3）岁，中位随访时间为6.7年（1天-11.9年）；1个月、1年和10年总生存率分别为（87.4±5.5）%、（81.1±6.5）%和（81.1±6.5）%，死亡集中发生在发病后1年内；多因素分析结果显示，中枢神经系统受累（P=0.047）、血红蛋白降低（P=0.002）、活化部分凝血活酶时间延长（P0.001）、高甘油三酯（P=0.005）均是影响患儿生存的独立危险因素；受试者工作特征曲线分析提示，活化部分凝血活酶时间（AUC=0.753，P0.001）较其他危险因素预测死亡的价值更大，其预测死亡的截断值为56.6 s，灵敏度和特异度分别为55.6%和89.7.血红蛋白降低、活化部分凝血活酶时间延长、高甘油三酯及中枢神经系统受累是影响HLH预后的危险因素，其中活化部分凝血活酶时间延长对死亡具有较强的预测价值.

Point set is a flexible and lightweight representation widely used for 3D deep learning. However, their discrete nature prevents them from representing continuous and fine geometry, posing a major issue for learning-based shape generation. In this work, we turn the discrete point sets into smooth surfaces by introducing the well-known implicit moving least-squares (IMLS) surface formulation, which naturally defines locally implicit functions on point sets. We incorporate IMLS surface generation into deep neural networks for inheriting both the flexibility of point sets and the high quality of implicit surfaces. Our IMLSNet predicts an octree structure as a scaffold for generating MLS points where needed and characterizes shape geometry with learned local priors. Furthermore, our implicit function evaluation is independent of the neural network once the MLS points are predicted, thus enabling fast runtime evaluation. Our experiments on 3D object reconstruction demonstrate that IMLSNets outperform state-of-the-art learning-based methods in terms of reconstruction quality and computational efficiency. Extensive ablation tests also validate our network design and loss functions., Accepted by CVPR 2021, Code: https://github.com/Andy97/DeepMLS

The performance of seed laser source will have a great impact on the output pulse quality of the master oscillator power amplifier (MOPA) system. Here, we report the influence of the soliton vector features on the pulse uniformity in an all-fiber MOPA configuration. We demonstrated that, although the intensity of the dissipative soliton seed source is uniform, the intensity of the output pulse train from the MOPA will show fluctuations if the soliton polarization state is not locked, i.e., polarization-rotating vector soliton. It is found that the appearance of non-uniform pulse intensity is caused by the combination of the polarization instability and the polarization dependent gain in the polarization maintaining fiber amplifier. The obtained results indicate that the polarization evolution of seed pulsed source is critical to generation of stable pulse train from the MOPA, and also might be useful to the communities dealing with solitons and high-power pulsed fiber lasers.

The effects of polymorphic form and particle size of SiO2 fillers on the dielectric, mechanical and thermal properties of SiO2–Polyetheretherketone (SiO2–PEEK) composites were investigated in this paper. Strong low frequency (2 fillers. All the composites obtained in this case demonstrate the dielectric permittivities of [Formula: see text] at high frequencies. The crystalline [Formula: see text]-cristobalite filled composite exhibits lower dielectric loss and mechanical strength, but larger thermal expansion coefficient and thermal conductivity, compared with the similar particle sized amorphous SiO2 filled one. The crystalline [Formula: see text]-quartz filled composite demonstrates the lowest mechanical strength and highest dielectric loss. An increase in particle size of the spherical fused silica fillers decreases the dielectric loss, while increases the thermal conductivity of the composite. The flexural strength of the composite reaches the maximum value of 113 MPa when the particle size of spherical SiO2 filler is [Formula: see text]m. Particle packing by combining optimal amounts of differently sized spherical fused silica fillers leads to a substantial improvement of mechanical strength (153MPa) coupled with reasonable dielectric and thermal properties due to the synergic effect (dielectric permittivity ([Formula: see text] = 3.35, dielectric loss (tan[Formula: see text] @10 GHz, thermal conductivity ([Formula: see text] = 0.74 W/m*k ([Formula: see text]C), coefficient of thermal expansion ([Formula: see text]C and relative density ([Formula: see text]) = 99.72%).

3D geometric features constitute rich details of polygonal meshes. Their analysis and editing can lead to vivid appearance of shapes and better understanding of the underlying geometry for shape processing and analysis. Traditional mesh smoothing techniques mainly focus on noise filtering and they cannot distinguish different scales of features well, even mixing them up. We present an efficient method to process different scale geometric features based on a novel rolling-guidance normal filter. Given a 3D mesh, our method iteratively applies a joint bilateral filter to face normals at a specified scale, which empirically smooths small-scale geometric features while preserving large-scale features. Our method recovers the mesh from the filtered face normals by a modified Poisson-based gradient deformation that yields better surface quality than existing methods. We demonstrate the effectiveness and superiority of our method on a series of geometry processing tasks, including geometry texture removal and enhancement, coating transfer, mesh segmentation and level-of-detail meshing.

Since the last decade the central government endeavors to promote large scale of urbanization in China. Lots of new urban towns and districts are taking shape. Outline of the 12th Five-year Plan released by the central government points out that the new towns and districts are to be regulated. But few researches are considering the new towns and districts especially in the spatial distributive pattern and status in China. Given this situation this paper, after sorting out the world-wide research and development of new urban towns and districts, gives definitions of broad and narrow meanings. Based on the broad meaning definition, the database of new towns and districts in China is established. This paper then conducts a preliminary analysis of the new towns and districts. Then the two-step work plan and the advices are also proposed to further improve the research and practice of its kind in China.

Due to characteristics of random fluctuations and intermittence, large-scale wind power integration will worsen grid stability and power quality. According to grid code, a limit of ramp rate for both 1 minute and 10 minutes should be put on the interconnected power. Using energy storage system is an effective way to smooth the fluctuations of wind farm output. Due to the high cost of the energy storage system, an effective control of the energy state and the BESS charge and discharge rate acquiring a maximum utility of the limited energy storage to improve the output power quality becomes increasingly significant. A coordinated control method for BESS to smooth out wind power fluctuations and to limit wind power ramping rate as required by grid code is proposed, with the BESS energy state well controlled and the predicted wind power used to cope with emergent situation. The effictiveness of the control system is validated through real wind farm cases under MATLAB platform.

Mega-city region is the mainstream of global urban development and also the dominant model of the neo urbanization process in China. The Beijing-Tianjin-Hebei area, Yangtze River Delta area and Pearl River Delta area are China’s three largest and most mature mega-city regions, the status of which represents the general level of the urban and regional development in China. Based on entire-array-polygon method, this paper makes a comprehensive evolution assessment of the three mega-city regions in terms of urban population index, urban economy index, urban life index, urban culture index and urban primacy index. In terms of general developing level, the three mega-city regions have progressed to optimize the structure. With their respective advantages and disadvantages, the three mega-city regions initially realize a “diversified” regional layout. The difference and gap among the three mega-city regions are obviously decreasing, which contributes to the regional balance of China metropolitan development. The rankings of the three mega-city regions will be in a continuous adjustment. The Beijing-Tianjin-Hebei area is possible to catch up and take the lead.

The young-old concrete can work together as a whole is the key issue of structural strengthening. Aiming at the technical selection problem appeared frequently in the bridge strengthening about the young-old concrete interface treatments between bonded rebar and grooving, 12 specimens were designed to compare with the shear performance and failure modes of the young-old concrete interface. The test results show that the failure characteristics of specimens which embedded steel bars are ductile, but the failure characteristics of specimens which slotted are brittle and the new concrete in slot position were cut off. And the young-old concrete interface shear strength of the specimens which embedded steel bars was distinctly stronger than that of the slotted specimens. So, the treatment of bonded rebar is proposed during the structural strengthening design. At the same time, the depth and distance of the bonded rebar should be well controlled.

The preexisting strains of structures have some influence on the efficiency of CFRP Laminate. Based on the analysis of the abundant existing research productions, the calculation formulas of CFRP Laminate are proposed based on the supposition of plane section and balance of forces considering the preexisting strain. And the formulas are easy to understand and master for designers. By discussing the relation between the preexisting strain and relative depth of compression area, the essentials of the impact on reinforcement effect of residual strain are confirmed. The results can offer reference bases for strengthening engineering design with CFRP.

The main bridge of Zhengzhou Yellow River 2nd bridge is a concrete filled steel tubulur (CFST) arch bridge. Choosing the main bridge as the research object, the finite element procedure ANSYS was used to establish the 3D finite element dynamic model. In order to analyze the influence of structural Parameters variation on dynamic characteristic,17 different conditions were considered in the calculation and analysis process. The results show that the CFST arch bridge is a flexible structure. The vertical rigidity of the bridge is stronger than the lateral rigidity CFST arch rib. The changes of the transverse brace style have little effect on the vertical rigidity, but have great impacts on the lateral rigidity of the CFST arch rib. It is sensitive on the first step vibration if the bracing tube damage. But the bracing tube damage has little effect on the vertical rigidity. The damages of suspenders and bridge deck slabs influence weakly on the vibration modes.

Many factors need to be considered during the choice of strengthening scheme for arch bridges, and most factors are fuzzy. The reasonable and scientific strengthening scheme is an important precondition to ensure the effectiveness and quality of the strengthening engineering. The elementary objects of the bridges strengthening are effect reliability, economic reasonability, technological feasibility, and convenience of construction, which are used to appraise the strengthening scheme. Based on the basic objective of bridge strengthening, two levels fuzzy comprehensive appraisal index system of strengthening scheme are established, and the best scheme is chosen. Combining the idiographic example of arch bridge reinforcement, the process of fuzzy analytic hierarchy and optimum result is given. The result tests that fuzzy analytic hierarchy method is feasible during the preferred selection on strengthening schemes of arch bridge.

An improved project based on decision trees in noisy environments is proposed for robust endpoints detection. Firstly, the noise level of the environment is estimated by wavelet decomposition, and then whether the denoising process is done according to the noise level is determined. Next, the thresholds are obtained by decision trees for the signal. Finally, endpoints are detected by the double thresholds on different importance of the energy and zero-crossing rate (ZCR) in the corresponding situation. The simulation results indicate that the proposed method based on noise estimation can obtain the same accurate data by computing less than the one with decision trees.

设 $U_q(\mathrm{osp}(1|2n))$是对应Lie超代数$\mathrm{osp}(1|2n)$的量子包络超代数. 利用满足一定条件的半标准Young表, 给出有限维既约$U_q(\mathrm{osp}(1|2n))$模晶体图的实现 . 建立晶体图张量积分解的广义Littlewood-Richardson法则.

Major, trace and rare earth elements of 37 sandstones of the Middle Oligocene-Pliocene from the Nanpu Sag, Bohai Bay Basin were analyzed to evaluate their provenance, weathering, tectonic setting. Low-intermediate values of the Chemical Index of Alteration (CIA) reveal that these sandstones experienced relatively weak chemical weathering. Trace element ratios and REE characteristics show that the source rocks mainly consisted of felsic magmatic rocks that formed in the Yanshan Fold Belt during Mesozoic Yanshanian period. Tectonic setting discrimination diagrams show that the sandstones were deposited in a reactivated inner-continental setting, supporting the origin of the Bohai Bay Basin as being related to subduction of the Pacific plate towards the Eurasian plate.

The Xiangshan deposit in Jiangxi province is one of the most important uranium deposits in China. The aim of this study is to achieve a better understanding of mineralization in the Xiangshan deposit through numerical simulation. In order to find the most favorable locations of mineralization and to help further mineral exploration, a coupling deformation and fluid flow model has been established to describe the mineralization process. In this model, the simulation reconstructs the strata deformations under fields of compressive stress and thrust structure on the hanging wall of the Zou-Shi fault. Compared with practical information, the simulation results are consistent with the No. 51 exploration section of the western Xiangshan. In addition, on the basis of geological information provided by previous investigators, the model simulates the flow process of fluids under compressive stress fields. The result suggests that many tensional areas are formed, which can help the fluid flowing upward from deeper parts. The fluid is easy to concentrate on the breccia fractured zone between two volcanic layers, especially on the intersection parts with faults, resulting in the formation of favourable locations of mineralization. In addition, the model is significant in guiding the exploration of uranium deposits in the western Xiangshan and provides clues for further exploration of deposits.

Light absorption plays a key role in photovoltaic devices, especially in thin-film CdTe-based solar cells. Here we study the enhancement of optical absorption in a ultrathin CdTe layer by embedding it into optical magnetic metamaterials. In a periodic metal-CdS-CdTe-metal sandwiched structure, the absorption of transverse magnetic polarized light has been significantly enhanced. The maximum enhancement is around 3 times, which is attributed to the strong local field enhancement in the CdTe thin film. Importantly, due to the coexistence of large electric resonance and magnetic resonance in magnetic metamaterials, the enhancement of light absorption has been obtained in a broadband from 400 nm to 800 nm, which is almost 1.5 times of that of the conventional CdTe-based photovoltaic device and covers the strongest part of the solar spectrum. Moreover, such absorption enhancement is also valid for a wide range of incident angles. We believe that our finding can lead to a variety of important applications in ultrathin CdTe-based solar cell technology.

Here we demonstrate the control of magnetic dipole spontaneous emission at yellow light by polarization-independent hexagonally arrayed nanorods magnetic metamaterials. By embedding a magnetic dipole into a polarization-independent magnetic metamaterial consisting of hexagonal arrays of paired silver nanorods, the radiative emission enhancement and the Purcell factor around 590 nm have been dramatically increased 44 times for a significant general far-field emission enhancement and 57 times for a maximum general magnetic dipole near-field emission enhancement, respectively. Moreover, the polarization-independent enhancements are found to be a robust variation of the dipole’s positions and structure geometries, showing nice fabrication tolerance for practical applications.

Abnormal breathing during sleep included many patterns. In this study, we investigated paradoxical breathing patterns during sleep in children using standard polysomnography (PSG).Children who come to the ENT because of snoring were included into the study consecutively. Those who had craniofacial anomalies, diabetes, chronic lung diseases, and neuromuscular diseases were excluded. At the same time, no sleep snoring children were include as controls. Thirty-eight snoring children and twenty-six no snoring children were recruited. Polysomnography (PSG) was performed on all subjects. We determined the frequency of paradoxical breathing patterns during sleep through blind analysis of polysomnograms obtained in all subjects and compared the difference between children with snoring and normal controls.The appearance of paradoxical breathing was assessed in all subjects. Among children with snoring, the apparent amount of paradoxical breathing time and the percent of paradoxical breathing time spent in total sleep time (x(-) ± s) were (70.1 ± 40.4) min and 17.9% ± 11.0% respectively. Comparing with control group (28.2 ± 25.7) min and 7.3% ± 6.8%, there was obvious difference (paradoxical breathing time t = 5.060, percent of paradoxical breathing time t = 4.767, P0.05). Thirty-eight snoring children were divided into normal-mild group (eighteen children) and moderate-severe group (twenty children). The children whose PSG results were normal and mild had more paradoxical breathing time and the percent of paradoxical breathing time than moderate-severe group. The apparent amount of paradoxical breathing time of normal-mild group, moderate-severe group and control group were (85.9 ± 31.7) min, (55.8 ± 42.7) min and (28.2 ± 25.7) min. Among the three groups, there was obvious difference (F = 15.897, P0.05). The percent of paradoxical breathing time of the three groups were 22.0% ± 10.2%, 14.1% ± 10.5% and 7.3% ± 6.8% (F = 14.167, P0.05).Currently published polysomnographic scoring recommendations overlook some common breathing abnormalities during sleep that are associated with clinical complaints. Paradoxical breathing is abnormal breathing patterns during sleep and its appearance is used to aid in the identification of respiratory events.

To evaluate the fluid in middle ear of otitis media with effusion (OME) by tympanometry, hearing threshold and in order to an effective and promptly way for treatment.Forty Patients (75 ears) with OME were collected since January 2007 to June 2008. The history of hearing loss, hearing threshold, CT results and the final fluid in the middle ear during operation were analyzed.There were 28 males and 12 females enrolled in this study. The average age of the patients was 78 months. All the 75 ears were with type "B" according to tympanometry test. For all the patients myringotomy was performed and the ventilation tubes were placed in 23 ears. Among all the ears, there were fluid in 62 ears (82.7%) and no fluid in 13 ears (17.3%). There was correlation between the levels of hearing loss, CT results and the fluid in middle ear (P0.05).Tympanometry and hearing threshold results should have a better sensitivity and specificity rates for diagnosis of OME.

To study the prophylactic effects of nasal tolerance with a dual analogue, Lys262-Ala207, on the mouse model of experimental autoimmune myasthenia gravis (EAMG) and the underlying mechanism.Mouse model of EAMG was induced by intraperitoneal injection of mAb35. Lys262-Ala207 or PBS was given nasally before 10 days (study group A and control group A) or on the day (study group B and control group B) of immunization for 10 days. Clinical syndromes were evaluated after immunization. Serum level of acetylcholine receptor antibody (AChR-Ab) IgG was detected using ELISA. The number of monouclear cells expressing CD4+ and CD4+ CD25+T from spleen was measured using flow cytometry.Compared with the corresponding control groups, the clinical syndromes were improved (P0.01) in mice from the study groups A and B. The positive rate of the repetitive nerve stimulation (RNS) test in the study groups A and B was significantly lower than that in the corresponding control groups (P0.01). The study group A showed lower positive rate of RNS than the study group B (P0.05). The serum levels of AChR-Ab IgG in the study groups A and B (15.01+/-1.09 and 19.23+/-1.31 microg/mL) decreased compared with that in the corresponding control groups (28.12+/-1.28 and 29.35+/-1.28 microg/mL) (P0.01). The study group A mice had lower serum AChR-Ab IgG levels than the study group B (P0.01). The number of CD4+ CD25+T cells in the study groups A (4.516+/-0.598%) and B (3.671+/-0.300%) increased significantly compared with that in the corresponding control groups (2.661+/-0.411% and 2.412+/-0.500%) (P0.01) and more CD4+ CD25+T cells were found in the study group A than in the study group B (P0.01).Nasal administration with dual analogues may ameliorate clinical syndromes in EAMG rats, which may be associated with decreased serum AChR-Ab IgG levels and increased number of CD4+ CD25+T cells from spleen.

To evaluate the effect of low frequency and high frequency tympanometry in the diagnosis of middle ear function of infants.Tympanometries with 226 Hz, 678 Hz and 1000 Hz probe tones were obtained from infants aged 5-25 weeks with normal ABR (15 infants, 30 ears) and those with prolonged Wave I latency suggesting middle ear dysfunction (17 infants, 20 ears) using GSI Tympstar middle ear analyzer.The type, peak pressure, peak compensated static acoustic admittance and gradient of 226 Hz tympanometry were of no significant differences between two groups. The pattern of 678 Hz tympanograms for admittance, susceptance and conductance included non-peaked, single-peaked, W-shaped and three-peaked type in both groups. The consistency between auditory brainstem response (ABR) and 678Hz tympanometry for admittance, susceptance and conductance were 70.0%, 58.0%, 64.0% (kappa = 0. 324,0. 234,0. 118) respectively. A single peaked tympanogram was typical in normal infants for 1000 Hz admittance, susceptance and conductance tympanograms and there were 28 ears (93.3%), 25 ears (83.3%) and 26 (86.7%) respectively. Tympanogram without any positive peak was the most characteristic for a probe frequency of 1000 Hz in infants with prolonged wave I latency and there were 15 ears (75%), 17 ears (85%) and 13 ears (65%) respectively. For admittance, susceptance and conductance, the consistency between 1000 Hz tympanometry and ABR were 90.0%, 92.0% and 86.0% and kappa were 0.783, 0.831 and 0.690, respectively.1000 Hz probe tone tympanometry was accurate diagnostic tests for middle ear function in infants younger than 25 weeks of age, while 226 Hz and 678 Hz probe tone tympanometries were not.

To analyze the effects of obstructive sleep apnea hypopnea syndrome on hearing among children.One hundred and forty three apnea children proved with overnight polysomnography received pure tone audiometry, acoustic impedance test, and lateral nasopharyngeal airway X-ray. Hearing threshold level and blood oxygen's saturation, apnea hypopnea index were analyzed.Among the 127 cases,63 cases had type C or B tympanograms, and 33 of them had lifted hearing threshold level. The remaining 64 cases had normal hearing and tympanograms. It was found correlation between the A/N ratio and blood oxygen's saturation, and no correlation between the A/N ratio and average of hearing threshold level. There was no correlation between AHI and average of hearing threshold level of each group. Hearing level can be improved after adenoidectomy or adenotonsillectomy.The upper airway obstruction due to adenotonsillar enlargement is common in children. It also affects the middle-ear impedance. Although short -term and mild degree of hypoxemia has few influence on hearing threshold level, it may affect cochlear function.

To study high altitude environment affecting on worker's healthUsing the cohort study, the altitude reaction was investigated and the WBC, RBC, Hb and oxygenation indexes were measured on workers in several periods, namely, acclimatization period, initially arrived high altitude and resident 90 days.The 83.3% of men had altitude reactions with different kinds at initially arrived high altitude. The headache was the most. The rate of abnormal blood pressure increased with altitude and resident time (P0.01). The rate of 90 day's group was 41.7%. The rise of diastole pressure was obvious (P0.01). As the beginning of arrived highland, the increase of WBC, RBC were significant (P0.01). The increase of Hb appeared only in 90 day's group. The level of malondialdehyde (MDA) obviously increased during acclimatization period and increased with altitude and resident time (P0.01). The activity of catalase (CAT), glutathione peroxidase (GSH-Px), superoxide dismutase (SOD) increased significantly in 90 day's group [(222.36 +/- 36.52) x 10(3) U/L, (158.49 +/- 14.42) U/L, (45.74 +/- 8.31) NU/ml respectively] (P0.01).The high altitude environment may result in the abnormal blood pressure, the rise of diastolic pressure was important. It lead to the increase of WBC, RBC, Hb. It initiated activity of oxygenation reaction. The symptoms of headache, dizziness, loss of appetite and insomnia appeared as working in high altitude environment.

Sea cucumber(Apostichopus japonicus) is one of the most important economic aquaculture spe-cies in China.The study on the genome size(C-value) is highly significant because it plays an important role in instructing the hybridization breeding and improved variety breeding program,as well as in esti-mating the cost of the whole genome sequencing project.Previous studies mainly focused on these re-search areas such as ecology,physiology,nutrition etc.However,it is relatively scarce for the accumulation of basic data related to the genome size and characteristics in A.japonipus.Therefore,the measure of ge-nome size for enriching cytogenetics data of this species is meaningful.In this paper,the genome size(C-value) of sea cucumber,A.japonicus was measured through flow cytometry in 52 individuals,which came from aestivation,normal and wild groups,using erythrocyte DNA content of chicken,Gallus domesticus(2.5pg/2C) as internal standard.The result indicates that the C-value of A.japonicus is(0.90± 0.06) pg,equivalent to(880.2±72.26) Mb.And,the C-values of aestivation,normal and wild are(0.93±0.05) pg,(0.90±0.05) pg and(0.84±0.02) pg,respectively.In addition,analyzed by Independent-Samples T Test,it shows that the C-values have no significant difference in aestivation and normal groups,whereas,the C-values of wild group and that reared in captivity group have significant difference.In other words,there is no correlation between genome size and the physiology factor-aestivation,while the stability of envi-ronment factors has certain influences on genome size variation.Moreover,the development of C-value measure method was elucidated in detail,in the meanwhile,the relationship between C-value and the evo-lution in Holothuroidea was discussed in combination with genome size of other types of sea cucumber.

This paper presents an empirical analysis of regional disparities from 2000 to 2012 based on a time series of data involving 74 cities within three mega-urban regions along Yangtze River in China. Differing from previous researches on inter-provincial and coastal/interior data, this paper provides a new perspective of mega-urban regions and their cities in China. By Coefficient of Variation and Analysis of Variance the selection of three mega-urban regions along Yangtze River reveals how the mega-urban regional disparities evolve among the east, middle and west up to date in China. In terms of general trend the mega-urban regional inequalities have been decreasing ever since the year around 2005. By traditional regression modeling this paper relates the mega-urban regional inequality and the alleviation to the urbanization and its focus on mega-urban regional development. The regression shows that the evolution of intra mega-urban regions disparities is negatively influenced by the urbanization with meaningful statistical significance from 2000 to 2012. The multilevel regression is further applied based on the nested hierarchical data structure. The results indicate a complicated relationship of the urban population density of the city level, the urbanization ratio of the mega-urban region level and the urban disparities in 2012. Finally limitations and further research advice are provided.