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Your search keyword '"Shimizu, Takayuki"' showing total 236 results
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236 results on '"Shimizu, Takayuki"'

2. Primary analysis of a prospective cohort study of Japanese patients with plasma cell neoplasms in the novel drug era (2016–2021)

Author

Shibayama, Hirohiko, Itagaki, Mitsuhiro, Handa, Hiroshi, Yokoyama, Akihiro, Saito, Akio, Kosugi, Satoru, Ota, Shuichi, Yoshimitsu, Makoto, Tanaka, Yasuhiro, Kurahashi, Shingo, Fuchida, Shin-ichi, Iino, Masaki, Shimizu, Takayuki, Moriuchi, Yukiyoshi, Toyama, Kohtaro, Mitani, Kinuko, Tsukune, Yutaka, Kada, Akiko, Tamura, Hideto, Abe, Masahiro, Iwasaki, Hiromi, Kuroda, Junya, Takamatsu, Hiroyuki, Sunami, Kazutaka, Kizaki, Masahiro, Ishida, Tadao, Saito, Toshiki, Matsumura, Itaru, Akashi, Koichi, and Iida, Shinsuke

Published
2024
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5. Clinical and pathological factors associated with survival in patients with pancreatic cancer who receive adjuvant therapy after neoadjuvant therapy: A retrospective multi-institutional analysis

Author

Shimizu, Takayuki, Maeda, Shimpei, Link, Jason, Deranteriassian, Aletta, Premji, Alykhan, Verma, Arjun, Chervu, Nikhil, Park, Joon, Girgis, Mark, Benharash, Peyman, Hines, Joe, Wainberg, Zev, Wolfgang, Christopher, Burns, William, Yu, Jun, Fernandez-Del Castillo, Carlos, Lillemoe, Keith, Ferrone, Cristina, and Donahue, Timothy

Published
2024
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7. Laparoscopic surgery reduced frequency of postoperative small bowel obstruction, and hospital stay compared with open surgery in a cohort of patients with colorectal cancer: a propensity score matching analysis

Author

Suda, Kotaro, Shimizu, Takayuki, Ishizuka, Mitsuru, Miyashita, Shotaro, Niki, Maiko, Shibuya, Norisuke, Hachiya, Hiroyuki, Matsumoto, Takatsugu, Shiraki, Takayuki, Sakuraoka, Yuhki, Mori, Shozo, Iso, Yukihiro, Takagi, Kazutoshi, Aoki, Taku, and Kubota, Keiichi

Published
2022
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15. Gilteritinib versus chemotherapy in Japanese patients with FLT3-mutated relapsed/refractory acute myeloid leukemia

Author

Hosono, Naoko, Yokoyama, Hisayuki, Aotsuka, Nobuyuki, Ando, Kiyoshi, Iida, Hiroatsu, Ishikawa, Takayuki, Usuki, Kensuke, Onozawa, Masahiro, Kizaki, Masahiro, Kubo, Kohmei, Kuroda, Junya, Kobayashi, Yukio, Shimizu, Takayuki, Chiba, Shigeru, Nara, Miho, Hata, Tomoko, Hidaka, Michihiro, Fujiwara, Shin-Ichiro, Maeda, Yoshinobu, Morita, Yasuyoshi, Kusano, Mikiko, Lu, Qiaoyang, Miyawaki, Shuichi, Berrak, Erhan, Hasabou, Nahla, and Naoe, Tomoki

Published
2021
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26. Total Steroid Intake is Associated With Hospital Mortality in Patients With Pan-Peritonitis due to Colorectal Perforation.

Author

Suda, Kotaro, Shimizu, Takayuki, Ishizuka, Mitsuru, Miyashita, Shotaro, Niki, Maiko, Shibuya, Norisuke, Hachiya, Hiroyuki, Shiraki, Takayuki, Matsumoto, Takatsugu, Sakuraoka, Yuhki, Mori, Shozo, Iso, Yukihiro, Takagi, Kazutoshi, Aoki, Taku, and Kubota, Keiichi

Subjects
*HOSPITAL patients, *RECEIVER operating characteristic curves, *HEMODIALYSIS, *HOSPITAL mortality, *SEPTIC shock
Abstract

Background: Patients with pan-peritonitis (PP) due to colorectal perforation have high mortality rate because colorectal perforation causes septic shock. The association between total steroid intake (TSI) and hospital mortality of such patients is not clear. Methods: One hundred forty-two patients who underwent surgery for PP due to colorectal perforation were reviewed. Patients were divided into two groups by 8000 mg of TSI. The cut-off value of TSI was determined using a receiver operating characteristic curve for hospital mortality. Results: The cut-off value of TSI for hospital mortality was 8000 mg. Patients with TSI>8000 mg had high rate of hemodialysis, hospital mortality, and elevated neutrophil ratio (>95%) compared with those with TSI≤8000 mg. Multivariate analyses revealed that TSI (>8000/≤8000, mg) (OR, 9.669; 95% CI, 1.011-92.49; P =.049) was significantly associated with hospital mortality as well as bleeding volume (>1000/≤1000, mL) (OR, 26.08; 95% CI, 3.566-190.4; P =.001), lymphocyte ratio (≤4/>4, %) (OR, 7.988; 95% CI, 1.498-42.58; P =.015) and C-reactive protein (≤7.5/>7.5, mg/dL) (OR, 41.66; 95% CI, 4.784-33.33; P =.001). Discussion: There was a significant association between TSI and hospital mortality in patients with PP due to colorectal perforation as well as intraoperative bleeding and systemic inflammatory markers. [ABSTRACT FROM AUTHOR]

Published
2023
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29. Translation Enhancement by a Short Nucleotide Insertion at 5′UTR: Application to an In Vitro Cell-Free System and a Photosynthetic Bacterium.

Author

Kondo, Tomo and Shimizu, Takayuki

Subjects
*NUCLEOTIDES, *DICTYOSTELIUM, *ESCHERICHIA coli, *GENE expression, *MESSENGER RNA
Abstract

We previously showed that insertion of Dictyostelium gene sequences, such as mlcR, upstream of the Shine–Dalgarno sequence, positively impacts downstream gene expression in Escherichia coli. However, the mechanism by which protein production is facilitated and its applicability to other bacteria remains unknown. In this study, a translation-enhancing effect, associated with this system, on the mRNA amount and property as well as the versatility of the method has been demonstrated. The insertion of mlcR-terminal 25 bp (mlcR25) stabilized the mRNAs and led to increased mRNA levels in E. coli. In the in vitro translation system, a four-fold enhancement was observed when DNA was used as the template, and a three-fold enhancement was observed when mRNA was used as the template. This suggests that mlcR25 has an effect on the facilitation of the interaction between mRNA and ribosome. Furthermore, when this enhancement system was adapted to the photosynthetic bacterium Rhodobacter capsulatus, a more than six-fold increase in translation was observed. Thus, we propose that enhanced translation by mlcR25 is mediated by mechanisms that help the translation machinery to work efficiently, and the system can be applied to bacteria other than E. coli. [ABSTRACT FROM AUTHOR]

Published
2023
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33. Battery-less optically-powered miniaturized glucose sensor with 12 mm diameter for continuous glucose measurement system.

Author

Shimizu, Takayuki, Miura, Ryo, Fukamachi, Masato, Yokoshiki, Yasufumi, Tokuda, Takashi, Shibahara, Takuya, Kawaura, Daigo, and Kudo, Hiroyuki

Abstract

Diabetes is a typical lifestyle-related disease and blood glucose measurement plays an important role in daily health management and appropriate treatment for patients. Continuous glucose monitoring system (CGMS) is becoming common for general patients. In this paper, an optically-powered battery-less glucose sensor device with a 12 mm diameter is presented. The sensor is expected to be used for next-generation CGMS. The sensor is equipped with series-connected ultra-small photovoltaic cells as the power source. Circuit design and characterization, fabrication, and evaluation of a wireless sensor device are presented to demonstrate the feasibility of the proposed sensor architecture. [ABSTRACT FROM AUTHOR]

Published
2023
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36. Incidence and risk factors of hepatitis B virus reactivation in patients with multiple myeloma in an era with novel agents: a nationwide retrospective study in Japan

Author

Tsukune, Yutaka, Sasaki, Makoto, Odajima, Takeshi, Sunami, Kazutaka, Takei, Tomomi, Moriuchi, Yukiyoshi, Iino, Masaki, Isoda, Atsushi, Nakaya, Aya, Muta, Tsuyoshi, Miyake, Takaaki, Miyazaki, Koji, Shimizu, Takayuki, Nakajima, Kei, Igarashi, Aiko, Nagafuji, Koji, Kurihara, Taro, Aoyama, Tomonori, Sugimori, Hiroki, and Komatsu, Norio

Published
2017
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39. Thioredoxin-2 Regulates SqrR-Mediated Polysulfide-Responsive Transcription via Reduction of a Polysulfide Link in SqrR.

Author

Shimizu, Takayuki, Hashimoto, Masaru, and Masuda, Tatsuru

Subjects
ENZYME kinetics, POLYSULFIDES, GENETIC transcription regulation, SULFHYDRYL group, TRANSCRIPTION factors, TRANSGENIC organisms
Abstract

Polysulfide plays an essential role in controlling various physiological activities in almost all organisms. We recently investigated the impact of polysulfide metabolic enzymes on the temporal dynamics of cellular polysulfide speciation and transcriptional regulation by the polysulfide-responsive transcription factor SqrR in Rhodobacter capsulatus. However, how the polysulfidation of thiol groups in SqrR is reduced remains unclear. In the present study, we examined the reduction of polysulfidated thiol residues by the thioredoxin system. TrxC interacted with SqrR in vitro and reduced the polysulfide crosslink between two cysteine residues in SqrR. Furthermore, we found that exogenous sulfide-induced SqrR de-repression during longer culture times is maintained upon disruption of the trxC gene. These results establish a novel signaling pathway in SqrR-mediated polysulfide-induced transcription, by which thioredoxin-2 restores SqrR to a transcriptionally repressed state via the reduction of polysulfidated thiol residues. [ABSTRACT FROM AUTHOR]

Published
2023
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40. Acute limb ischemia due to severe heparin-included thrombocytopenia with thrombosis during puerperium.

Author

Noto, Tatsunori, Anzai, Hitoshi, Nemoto, Naohiko, Takenaka, Hiroki, Sahara, Naohiko, Shimizu, Takayuki, Yaguchi, Tomoyuki, Takaesu, Satoru, and Samejima, Yusuke

Abstract

We present the case of a 39-year-old pregnant woman who had intrauterine fetal death and imminent uterine rupture and underwent cesarean section. She also underwent catheter embolization for hemorrhagic shock due to bleeding from the uterine artery, and heparin-containing saline was used. On day 7 of hospitalization, she felt severe pain in her right lower leg, and computed tomography (CT) revealed focal nonocclusive thrombus formations in the right common and external iliac artery. After intravenous heparin administration, she suddenly developed dyspnea, her blood pressure dropped, and her platelet count decreased. We diagnosed her with heparin-induced thrombocytopenia (HIT). Although we discontinued heparin and switched to argatroban, CT after 5 days revealed subtotal occlusion of the right iliac artery by a massive thrombus. We performed surgical thrombectomy using a Fogarty catheter, but blood flow was not restored. Therefore, we administered urokinase continuously with catheter-directed thrombolysis (CDT). The thrombus in the iliac artery gradually cleared and was successfully eliminated. However, the patient developed gangrene in her right lower leg, and we decided to perform an above-knee amputation of the right leg. She was discharged with a prosthetic leg and prescribed 15 mg of rivaroxaban per day. HIT is a known serious side effect of heparin administration, and it can sometimes be fatal. HIT treatment using aggressive thrombectomy procedures may be ineffective since such procedures may accelerate thrombus formation when the coagulation cascade is highly activated. In this case, CDT may have to be considered as the first-line treatment before Fogarty thrombectomy when argatroban therapy fails. [ABSTRACT FROM AUTHOR]

Published
2023
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42. A phase II study of bendamustine plus rituximab in Japanese patients with relapsed or refractory indolent B-cell non-Hodgkin lymphoma and mantle cell lymphoma previously treated with rituximab: BRB study

Author

Matsumoto, Kimihiro, Takayama, Nobuyuki, Aisa, Yoshinobu, Ueno, Hironori, Hagihara, Masao, Watanabe, Kentaro, Nakaya, Aya, Chen, Kenko, Shimizu, Takayuki, Tsukada, Yuiko, Yamada, Yuji, Nakazato, Tomonori, Ishida, Akaru, Miyakawa, Yoshitaka, Yokoyama, Kenji, Nakajima, Hideaki, Masuda, Yoshihiro, Yano, Takahiro, and Okamoto, Shinichiro

Published
2015
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45. The Sulfide-Responsive SqrR/BigR Homologous Regulator YgaV of Escherichia coli Controls Expression of Anaerobic Respiratory Genes and Antibiotic Tolerance.

Author

Balasubramanian, Rajalakshmi, Hori, Koichi, Shimizu, Takayuki, Kasamatsu, Shingo, Okamura, Kae, Tanaka, Kan, Ihara, Hideshi, and Masuda, Shinji

Subjects
GENE expression, ESCHERICHIA coli, ANTIBIOTICS, ENTEROBACTERIACEAE, REACTIVE oxygen species
Abstract

Compositions and activities of bacterial flora in the gastrointestinal tract significantly influence the metabolism, health, and disease of host humans and animals. These enteric bacteria can switch between aerobic and anaerobic growth if oxygen tension becomes limited. Interestingly, the switching mechanism is important for preventing reactive oxygen species (ROS) production and antibiotic tolerance. Studies have also shown that intracellular and extracellular sulfide molecules are involved in this switching control, although the mechanism is not fully clarified. Here, we found that YgaV, a sulfide-responsive transcription factor SqrR/BigR homolog, responded to sulfide compounds in vivo and in vitro to control anaerobic respiratory gene expression. YgaV also responded to H2O2 scavenging in the enteric bacterium Escherichia coli. Although the wild-type (WT) showed increased antibiotic tolerance under H2S-atmospheric conditions, the ygaV mutant did not show such a phenotype. Additionally, antibiotic sensitivity was higher in the mutant than in the WT of both types in the presence and absence of exogenous H2S. These results, therefore, indicated that YgaV-dependent transcriptional regulation was responsible for maintaining redox homeostasis, ROS scavenging, and antibiotic tolerance. [ABSTRACT FROM AUTHOR]

Published
2022
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46. Sub-6 GHz V2X-Assisted Synchronous Millimeter Wave Scheduler for Vehicle-to-Vehicle Communications.

Author

He, Chenyuan, Wan, Yan, Zhao, Lu, Lu, Hongsheng, and Shimizu, Takayuki

Subjects
MILLIMETER waves, POLYNOMIAL time algorithms, FACE-to-face communication, NP-hard problems, LINEAR programming, MULTICASTING (Computer networks)
Abstract

As millimeter wave (mmWave) technology becomes more integrated into today's communication infrastructure, its application to mobile scenarios has attracted considerable interests. In particular, mmWave technology is one of the leading candidates in Vehicle-to-Everything (V2X) community to address the ever-rising data exchange demand from vehicles. However, the inherent directionality of the technology poses challenges to peer discovery and transmission scheduling in typical V2X scenarios, causing significant loss of network capacity. To mitigate this issue, we propose a novel sub-6 GHz V2X-assisted synchronous mmWave communication scheduler in this paper. The sub-6 GHz channel serves as control channel for mmWave scheduling. The scheduler carefully considers data importance and freshness in determining communication schedule, such that network utility across mmWave links is maximized. We formulate the scheduling problem into an integer linear programming (ILP) problem. However, ILP problem is NP-hard and has exponential computational complexity for the worst cases. We then develop a scheduling algorithm, maximum weight matching based iterative algorithm (MWMIA), that operates in polynomial time with performance guarantees for the NP-hard ILP, by leveraging structural properties of link conflicts. Comparative simulation studies verify the effectiveness of our scheduler against other solutions. [ABSTRACT FROM AUTHOR]

Published
2022
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