126 results on '"Shin-ichi Kikuchi"'
Search Results
2. Magnitude of Dural Tube Compression Still Does Not Show a Predictive Value for Symptomatic Lumbar Spinal Stenosis for Six-Year Follow-Up: A Longitudinal Observation Study in the Community
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Koji Otani, Shin-ichi Kikuchi, Takuya Nikaido, and Shin-ichi Konno
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lumbar spinal stenosis ,epidemiology ,natural history ,dural tube compression ,prognostic factors ,Medicine - Abstract
Background: Lumbar spinal stenosis (LSS) is a clinical syndrome based on anatomic narrowing of the spinal canal. It is well known that anatomic narrowing of the spinal canal is essential for manifestation, but not all of them cause symptoms. There are many studies assessing the relationship between dural tube compression on MRI and clinical symptoms; however, most of them are cross-sectional. The purpose of this study was to reveal the magnitude of dural tube compression’s influence on the presence or development of LSS symptoms at the six-year follow-up and the occurrence of surgery during the follow-up period or not in the community setting. Methods: This was a longitudinal observational study of 459 participants who were assessed for typical LSS symptoms, and whose Roland–Morris Disability Questionnaire and numerical rating scale of leg pain and numbness was recorded using a questionnaire and conventional MRI of the lumbar spine. Typical LSS symptoms were judged using an LSS diagnostic support tool, which was a self-administered, self-reported history questionnaire (LSS-SSHQ). After six years, 232 subjects (follow-up rate 50.5%) were followed-up with typical LSS symptoms using LSS-SSHQ by mail. The relationship between the magnitude of dural tube compression evaluated by dural tube cross-sectional area (DCSA) in the initial assessment and the time course of typical LSS symptoms for the six-year duration were analyzed. In addition, predictors of the presence of typical LSS symptoms at the six-year follow-up were assessed. Furthermore, we investigated the relationship between typical LSS symptoms and DCSA during the initial assessment of patients who underwent surgery during the follow-up period. A multivariate logistic regression analysis was performed for statistical analysis. Results: (1) Severe dural tube compression did not show that LSS symptoms continued after six years. (2) Severe dural tube compression could not detect development of LSS-symptoms and surgery during the six-year period. Conclusion: Severe dural tube compression could not detect typical LSS symptom development and occurrence of surgery during the six-year period.
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- 2022
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3. Relationship between spinal sagittal imbalance and neck symptoms - Locomotive syndrome and health outcome in AIZU cohort study (LOHAS)
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Kazuyuki Watanabe, Koji Otani, Miho Sekiguchi, Takuya Nikaido, Kinshi Kato, Hiroshi Kobayashi, Ryoji Tominaga, Junichi Handa, Shoji Yabuki, Shin-ichi Kikuchi, and Shin-ichi Konno
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Neurology. Diseases of the nervous system ,RC346-429 - Published
- 2021
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4. Epidemiological study of cervical cord compression and its clinical symptoms in community-dwelling residents.
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Toru Hirai, Koji Otani, Miho Sekiguchi, Shin-Ichi Kikuchi, and Shin-Ichi Konno
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Medicine ,Science - Abstract
BackgroundDegenerative compressive myelopathy (DCM) is caused by cervical cord compression. The relationship between the magnitude and clinical findings of cervical cord compression has been described in the literature, but the details remain unclear. This study aimed to clarify the relationship between the magnitude and clinical symptoms of cervical cord compression in community-dwelling residents.MethodsThe present study included 532 subjects. The subjective symptoms and the objective findings of one board-certified spine surgeon were assessed. The subjective symptoms were upper extremity pain and numbness, clumsy hand, fall in the past 1 year, and subjective gait disturbance. The objective findings were: Hoffmann, Trömner, and Wartenberg signs; Babinski's and Chaddock's signs; hyperreflexia of the patellar tendon and Achilles tendon reflexes; ankle clonus; Romberg and modified Romberg tests; grip and release test; finger escape sign; and grip strength. Using midsagittal T2-weighted magnetic resonance imaging, the anterior-posterior (AP) diameters (mm) of the spinal cord at the C2 midvertebral body level (DC2) and at each intervertebral disc level from C2/3 to C7/T1 (DC2/3-C7/T1) were measured. The spinal cord compression ratio (R) for each intervertebral disc level was defined and calculated as DC2/3-C7/T1 divided by DC2. The lowest R (LR) along C2/3 to C7/T1 of each individual was divided into 3 grades by the tertile method. The relationship between LR and clinical symptoms was investigated by trend analysis.ResultsThe prevalence of subjective gait disturbance increased significantly with the severity of spinal cord compression (p = 0.002812), whereas the other clinical symptoms were not significantly related with the severity of spinal cord compression.ConclusionsThe magnitude of cervical cord compression had no relationship with any of the neurologic findings. However, subjective gait disturbance might be a better indicator of the possibility of early stage cervical cord compression.
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- 2021
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5. Usefulness of the Brief Scale for Psychiatric Problems in Orthopaedic Patients (BS-POP) for Predicting Poor Outcomes in Patients Undergoing Lumbar Decompression Surgery
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Kazuyuki Watanabe, Koji Otani, Takuya Nikaido, Kinshi Kato, Hiroshi Kobayashi, Junichi Handa, Shoji Yabuki, Shin-Ichi Kikuchi, and Shin-Ichi Konno
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Medicine (General) ,R5-920 - Abstract
Background. The Brief Scale for Psychiatric Problems in Orthopaedic Patients (BS-POP) is an original questionnaire that evaluates psychosocial problems in orthopaedic patients. The purpose of this study was to clarify the relationship between BS-POP scores and surgical outcomes in patients with lumbar spinal stenosis (LSS). Methods. From our database, a total of 157 patients with LSS who had undergone decompression surgery and completed a 1-year follow-up were retrospectively observed. The primary outcome was the numerical rating scale (NRS) score for satisfaction with surgery (from 0: not satisfied to 10: completely satisfied). Patients with an NRS score ≥8 were classified into the satisfied group. The secondary outcomes were NRS scores for low back pain, leg pain, and leg numbness and scores on the Roland–Morris Disability Questionnaire (RDQ). BS-POP was used to detect psychiatric problems before surgery. A BS-POP score ≥11 on the physician version or a combination of 10 on the physician version and ≥15 on the patient version was considered to indicate the presence of psychiatric problems. The patients were classified into two groups and compared based on preoperative BS-POP scores at the 1-year follow-up. Results. Preoperatively, 22 and 135 patients showed high and low BS-POP scores, respectively. No significant differences in preoperative symptoms were found between the two groups. At 1 year after surgery, patients with high BS-POP scores showed significantly lower satisfaction with surgery, higher NRS scores for low back pain, leg pain, and leg numbness, and lower RDQ deviation scores than did the low BS-POP group (p
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- 2021
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6. The Change of Lumbar Spinal Stenosis Symptoms over a Six-Year Period in Community-Dwelling People
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Koji Otani, Shin-ichi Kikuchi, Shoji Yabuki, Takuya Nikaido, Kazuyuki Watanabe, Kinshi Kato, Hiroshi Kobayashi, and Shin-ichi Konno
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lumbar spinal stenosis ,epidemiology ,natural history ,quality of life ,predictive factors ,comorbidities ,Medicine (General) ,R5-920 - Abstract
Background and Objectives: The high prevalence of lumbar spinal stenosis (LSS) and its negative impact on quality of life in the elderly is well known. However, the longitudinal time course of LSS symptoms remains unclear. The purpose of this study was to clarify the longitudinal time course and associated factors of LSS symptoms over a period of six years in a community. Materials and Methods: This study was conducted with data prospectively collected in 2004 and 2010 under a retrospective design. In 2004, 1578 subjects (age range: 40 to 79 years) were interviewed on LSS symptoms using a specially designed and validated questionnaire. In 2010, a follow-up study was performed by mail, to which 789 subjects of the 2004 study population responded. Considering that the presence of osteoarthritis (OA) of the knee or hip may influence the participants’ answers in the questionnaire, analysis was performed in all 789 subjects with and 513 subjects without either knee or hip OA. Changes in LSS symptoms between the initial and the 6-year survey were investigated. Multiple logistic regression analysis was used for detecting the risk factors for LSS symptom presence at the six-year follow-up. Results: 1. At the six-year follow-up, more than half of the subjects who showed LSS symptoms at the initial analysis became LSS-negative, and 12–15% of those who were LSS-negative became LSS-positive. 2. From the multiple logistic regression analysis, a lower Roland-Morris Disability Questionnaire (RDQ) score and a positive LSS symptom at the initial analysis were detected as predictive factors of the presence of LSS symptoms at the six-year follow-up in the total number of subjects, as well as just in those who did not have either knee or hip OA. Conclusions: More than half of the subjects who were LSS-positive at their initial assessment still experienced improvement in their symptoms even after 6 years. This means that both LSS symptoms and their time course vary from person to person. Predictive factors for the presence of LSS symptoms during the six-year follow-up period were RDQ score and positive LSS symptoms.
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- 2021
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7. Surgical Outcomes of Cervical Myelopathy in Patients with Athetoid Cerebral Palsy: A 5-Year Follow-Up
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Kazuyuki Watanabe, Koji Otani, Takuya Nikaido, Kinshi Kato, Hiroshi Kobayashi, Shoji Yabuki, Shin-ichi Kikuchi, and Shin-ichi Konno
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Spine ,Myelopathy ,Cerebral palsy ,Surgery ,Medicine - Abstract
Study DesignObservational cohort study.PurposeTo assess the surgical outcomes of posterior decompression and fusion for cervical myelopathy in patients with athetoid cerebral palsy.Overview of LiteraturePatients with athetoid cerebral palsy demonstrate involuntary movements and develop severe cervical spondylosis with kyphosis. In these patients, surgery is often performed at an early age because of myelopathy. A few studies have reported about the long-term outcomes of surgical treatment; however, they contain insufficient information.MethodsFrom 2003 to 2008, 13 patients with cervical myelopathy due to athetoid cerebral palsy underwent posterior fusion surgery and were included in this study. The Japanese Orthopaedic Association (JOA) score, neck disability index (NDI), C2–7 angle on radiography, and need for additional surgical treatment were examined at 1 and 5 years postoperatively.ResultsThe mean C2–7 angle was −10.5°±21.1° preoperatively and was corrected to −2.9°±13.5° immediately postoperatively. This improvement was maintained for 5 years. The JOA score was 9.5±2.5 preoperatively and 12.2±1.7 at the 5-year follow-up. NDI was 17±6.9 preoperatively and 16±7.5 at the 5-year follow-up. Patient satisfaction with surgery on a 100-point scale was 62.2±22.5 at the 5-year follow-up. Three patients needed additional surgery for loosening of screws. These results demonstrate good surgical outcomes for posterior fusion at 5 years.ConclusionsPosterior decompression and fusion should be considered a viable option for cervical myelopathy in patients with athetoid cerebral palsy.
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- 2017
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8. Generalization of a clinical diagnosis support tool for lumbar spinal stenosis: Can the ankle brachial pressure index be replaced by palpation of the posterior tibial artery in the lumbar spinal stenosis diagnostic support tool? (DISTO project)
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Takuya Nikaido, Miho Sekiguchi, Koji Yonemoto, Tatsuyuki Kakuma, Kazuyuki Watanabe, Kinshi Kato, Hiroshi Kobayashi, Ryoji Tominaga, Koji Otani, Shoji Yabuki, Shin-ichi Kikuchi, and Shin-ichi Konno
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Orthopedics and Sports Medicine ,Surgery - Abstract
The Japanese Society for Spine Surgery and Related Research previously developed a diagnostic support tool for lumbar spinal stenosis (LSS-DST). Using the LSS-DST, general physicians can identify potential cases of LSS. However, in the LSS-DST, measurement of the ankle brachial pressure index (ABI) is required to exclude peripheral artery lesions in the lower limbs. We can expect further application of the LSS-DST if we can identify a simpler and easier method than ABI measurement. Therefore, in this large-scale, multicenter, cross-sectional study, we verified whether palpation of the posterior tibial (PT) artery could be used instead of ABI in the LSS-DST.This survey was conducted at 2177 hospitals and included 28,883 participants. The sensitivity and specificity of the original LSS-DST method using the ABI and that of the LSS-DST ver2.0 with PT artery palpation were assessed to screen their ability for diagnosing LSS, using the physicians' final diagnosis based on the patients' history, physical examination and radiographic findings as the gold standard.The sensitivity and specificity [95%CI] of the LSS-DST were 88.2% [87.5, 88.8] and 83.9% [83.4, 84.5], respectively, whereas the sensitivity and specificity of the LSS-DST ver2.0 were 87.7% [87.0, 88.3] and 78.3% [77.7, 78.9], respectively, indicating that LSS-DST ver2.0 is a useful screening tool for LSS with good sensitivity.When the item of ABI in the LSS-DST is replaced by palpation of the PT artery (LSS-DST ver2.0), its sensitivity is maintained as a screening tool for LSS.Level 3.
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- 2023
9. Nocturnal Leg Cramps and Lumbar Spinal Stenosis: A Cross-Sectional Study in the Community
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Junichi Handa, Koji Otani, Takuya Nikaido, Shin-ichi Kikuchi, and Shin-ichi Konno
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International Journal of General Medicine ,General Medicine - Abstract
Junichi Handa, Koji Otani, Takuya Nikaido, Shin-ichi Kikuchi ,â Shin-ichi Konno Department of Orthopaedic Surgery, Fukushima Medical University School of Medicine, Fukushima, Japanâ Shin-ichi Kikuchi passed away on February 22th, 2022Correspondence: Junichi Handa, Tel +81-24-547-1276, Fax +81-24-548-5505, Email hanhan@fmu.ac.jpPurpose: Nocturnal leg cramps are considered to be a symptom of lumbar spinal stenosis (LSS). However, the relationship between LSS and nocturnal leg cramps in the general population remains unclear. The purpose of this study was to investigate the prevalence and characteristics of nocturnal leg cramps in LSS in the community.Patients and Methods: 328 voluntary participants were enrolled in this study. The presence of LSS was assessed by a validated and self-administered diagnostic support tool. The presence of nocturnal leg cramps and neurological findings were evaluated by one experienced spine surgeon. To investigate the relationship between leg cramps and anatomical factors, the participants underwent an MRI scan, and the dural sac cross-sectional area (DCSA) at each lumbar intervertebral disc level was measured.Results: A total of 214 participants (65.2%) had nocturnal leg cramps, and 94 of 328 participants (28.7%) showed typical LSS symptoms. In the typical LSS symptom group, 31 participants (33.0%) had nocturnal leg cramps. In the atypical LSS symptom group, 83 participants (35.5%) had nocturnal leg cramps. There was no statistically significant difference in the prevalence of nocturnal leg cramps between the two groups. The narrowest DCSA (< 25 mm2 and 25â 49.4mm2) was statistically related to the presence of nocturnal leg cramp. Statistically significant differences in sensory disturbance and motor weakness were not observed between the subjects with and those without nocturnal leg cramps. Moreover, impaired PTR was statistically related to the presence of nocturnal leg cramp.Conclusion: The prevalence of nocturnal leg cramps did not differ with or without typical LSS symptoms in the community. The degree of dural tube compression that is determined by DCSA had a direct effect on the presence of nocturnal leg cramps. Neurological impairment, such as PTR abnormalities, was associated with the presence of nocturnal leg cramps.Keywords: nocturnal leg cramps, lumbar spinal stenosis, general population, magnetic resonance imaging, sensory disturbance, motor weakness
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- 2022
10. High Attention-Deficit/Hyperactivity Disorder Scale Scores Among Patients with Persistent Chronic Nonspecific Low Back Pain
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Satoshi, Kasahara, Shin-Ichi, Niwa, Ko, Matsudaira, Naoko, Sato, Hiroyuki, Oka, Tomoko, Fujii, Shin-Ichi, Konno, Shin-Ichi, Kikuchi, and Yoshitsugu, Yamada
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Adult ,Male ,Psychiatric Status Rating Scales ,Cross-Sectional Studies ,Attention Deficit Disorder with Hyperactivity ,Surveys and Questionnaires ,Humans ,Female ,Self Report ,Low Back Pain - Abstract
Associations between attention-deficit/hyperactivity disorder (ADHD) and chronic pain disorders, such as fibromyalgia, have been reported. However, associations between persistent chronic nonspecific low back pain (CNLBP) and ADHD have not yet been investigated.This study aimed to investigate the positive rates of possible ADHD, as assessed by self-reported ADHD scales, in patients with persistent CNLBP, using data from self-reported questionnaires completed by patients and their families. This study also aimed to compare the self-reported scores obtained from existing standardized data for healthy individuals, and to examine whether the ADHD scale scores of patients with persistent CNLBP are associated with pain variables.Cross-sectional study.The specialized pain clinic at our university hospital.This cross-sectional study included 60 consecutive patients with persistent CNLBP who were diagnosed with a possible somatic symptom disorder and were referred to a psychiatrist in our pain clinic. The Conners' Adult ADHD Rating Scales (CAARS) self-report (CAARS-S) and observer-rated (CAARS-O) questionnaires were utilized. We investigated the CAARS scores, and the association between the CAARS subscale scores and pain variables (pain duration and pain Numeric Rating Scale) in patients with persistent CNLBP.Of the 60 patients, 19 (31.7%) were positive on both CAARS-S and CAARS-O questionnaires (T-score65). The ADHD indices, which comprised subscales of the CAARS estimating the necessity of treatment for ADHD, were significantly higher in both male and female patients with persistent CNLBP than in the Japanese standardized sample (P0.005). CAARS-S hyperactivity/restlessness, CAARS-O hyperactivity/restlessness, and the Diagnostic and Statistical Manual of Mental Disorders, fourth edition hyperactive-impulsive symptom subscale scores also correlated with the pain intensity (P0.05).In this study, ADHD tendency was evaluated using only a self-reported questionnaire. Hence in the future, accurate and precise assessments of ADHD symptoms using structured clinical interviews conducted by ADHD experts are warranted. Additionally, the study only included patients with persistent CNLBP. Therefore in the future, it will be valuable to investigate ADHD scale scores (e.g., CAARS) among patients with CNLBP and nonspecific low back pain with larger sample sizes.Our findings revealed that the subscale scores on an ADHD scale were considerably high in patients with persistent CNLBP. As a previous study of our clinical experience indicates that persistent CNLBP can be substantially relieved by administering ADHD medications, ADHD screening is warranted in the treatment of persistent CNLBP.
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- 2021
11. Bowel/bladder dysfunction and numbness in the sole of the both feet in lumbar spinal stenosis – A multicenter cross-sectional study
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Kazuyuki Watanabe, Miho Sekiguchi, Koji Yonemoto, Takuya Nikaido, Kinshi Kato, Koji Otani, Shoji Yabuki, Tatsuyuki Kakuma, Shin-ichi Kikuchi, Shin-ichi Konno, Kazuhisa Takahashi, Seiji Ohtori, Kazuo Yonenobu, Keisuke Takahashi, Hideki Iizuka, Toshihiko Taguchi, Tukasa Kanchiku, Katsushi Takeshita, Nobuhiro Hara, Toshikazu Tani, Ryuichi Takemasa, Kazuhiro Chiba, Naofumi Hozogane, Kensei Nagata, Kimiaki Sato, Yutaka Nohara, Hiroshi Teneichi, Yuichi Hoshino, Atsushi Seichi, Toshihiko Yamashita, Tsuneo Takebayashi, Munehito Yoshida, and Hiroshi Yamada
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Adult ,Male ,medicine.medical_specialty ,Cross-sectional study ,Rest ,Lumbar vertebrae ,Hypesthesia ,Young Adult ,03 medical and health sciences ,Spinal Stenosis ,0302 clinical medicine ,Quality of life ,Surveys and Questionnaires ,Back pain ,Humans ,Medicine ,Orthopedics and Sports Medicine ,Young adult ,Aged ,030222 orthopedics ,Lumbar Vertebrae ,Foot ,business.industry ,Urinary Bladder Diseases ,Cauda equina ,Lumbar spinal stenosis ,Middle Aged ,medicine.disease ,Low back pain ,Surgery ,Intestinal Diseases ,Cross-Sectional Studies ,medicine.anatomical_structure ,Quality of Life ,Female ,medicine.symptom ,business ,Low Back Pain ,030217 neurology & neurosurgery - Abstract
Background Numbness in the soles of both feet at rest or bowel/bladder dysfunction can occur in patients with lumbar spinal stenosis (LSS), especially in patients with cauda equina lesions. The purpose of this study was to clarify the relationship between cauda equina symptoms at rest and quality of life (QOL) in LSS patients using standardized questionnaires developed for the Japanese population. Methods A survey was conducted in 564 hospitals and general practice clinics nationwide from December 1, 2011 to December 31, 2012. All patients who visited hospital or clinic because of low back pain were included. Patients were diagnosed with LSS using the LSS-Diagnostic Support Tool (LSS-DST), and the severity of the disease was measured using the Japanese Orthopaedic Association Back Pain Evaluation Questionnaire (JOABPEQ) for quality of life. Presence of both sole numbness and/or bowel/bladder dysfunction were determined by medical interview. 3647 patients were diagnosed with LSS according to the results of the LSS-DST. 1294 of these patients (35.5%) had symptoms at rest. Of these patients, 359 patients with sole numbness, 135 patients with bowel/bladder dysfunction, and 52 patients with both numbness and bowel/bladder dysfunction were compared to the patients without rest symptoms (n = 2182). Comparisons between groups with or without sole numbness and bowel/bladder dysfunction were performed using statistical analysis of JOABPEQ responses in the categories of pain-related disorder, lumbar spine disorder, gait disturbance, social life disturbance, and psychological disorder. Results All groups with sole numbness and/or bowel/bladder dysfunction had statistically lower (worse) scores in all categories of the JOABPEQ compared to the group without these symptoms at rest. Conclusion LSS patients having numbness in the soles of both feet at rest or bowel/bladder dysfunction had lower measurements of QOL and activities of daily living than those patients without symptoms at rest. These symptoms appear to be related to QOL of LSS patients.
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- 2017
12. Relationship between spinal sagittal imbalance and neck symptoms - Locomotive syndrome and health outcome in AIZU cohort study (LOHAS)
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Kinshi Kato, Shoji Yabuki, Shin-ichi Kikuchi, Miho Sekiguchi, Koji Otani, Junichi Handa, Takuya Nikaido, Shin-ichi Konno, Hiroshi Kobayashi, Ryoji Tominaga, and Kazuyuki Watanabe
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medicine.medical_specialty ,medicine.anatomical_structure ,business.industry ,medicine ,Physical therapy ,Neurology. Diseases of the nervous system ,RC346-429 ,business ,Health outcomes ,Sagittal plane ,Cohort study ,LOHAS - Published
- 2021
13. What is the contribution that medical professionals can be to the people ?
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Shin-ichi Kikuchi
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Medical education ,business.industry ,Medicine ,business - Published
- 2015
14. Ossification of the ligamentum flavum in the thoracic spine mimicking sciatica in a young baseball pitcher: a case report.
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Kinshi Kato, Shoji Yabuki, Koji Otani, Takuya Nikaido, Ken-ichi Otoshi, Kazuyuki Watanabe, Shin-ichi Kikuchi, and Shin-ichi Konno
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THORACIC vertebrae ,PITCHERS (Baseball) ,LEG pain ,COMPUTED tomography ,SPASTICITY - Abstract
Thoracic ossification of the ligamentum flavum (OLF) is a pathological condition that causes myelopathy, with unilateral lower extremity pain rarely a feature in the presenting complaint. Moreover, most symptomatic cases of thoracic OLF occur in middle-aged men, with younger individuals rarely affected. We present a rare case of severe and chronic unilateral buttock and leg pain mimicking sciatica due to thoracic OLF in a professional baseball pitcher. A 28-year-old, right-handed, Japanese professional baseball pitcher experienced intractable left leg pain with numbness and spasticity. After the initial presentation, extensive testing focusing on lumbar, hip, and pelvis lesions failed to identify a cause for the pain. One year after onset, careful neurological examination showed signs of upper motor neuron disturbance, and thoracic computed tomography and magnetic resonance imaging revealed thoracic OLF at the level of the thoracolumbar junction. After resection of the thoracic OLF, the pain, numbness, and spasticity completely resolved. He resumed full training and was pitching in top condition within four months after surgery. Though rare, thoracic OLF should be considered in the differential diagnosis of lower extremity pain in young athletes, especially amongst high-level baseball pitchers. [ABSTRACT FROM AUTHOR]
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- 2021
15. Locomotor dysfunction and risk of cardiovascular disease, quality of life, and medical costs: design of the Locomotive Syndrome and Health Outcome in Aizu Cohort Study (LOHAS) and baseline characteristics of the study population
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Koji Otani, Miho Sekiguchi, Kenichi Otoshi, Shin-ichi Kikuchi, Shin-ichi Konno, Misa Takegami, Norio Fukumori, Shin Yamazaki, Yasuaki Hayashino, Shunichi Fukuhara, Yoshihiro Onishi, Rei Ono, and null The LOHAS Research Group
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Adult ,Male ,medicine.medical_specialty ,Disease ,Health outcomes ,Cohort Studies ,Quality of life (healthcare) ,Risk Factors ,Activities of Daily Living ,Humans ,Medicine ,Orthopedics and Sports Medicine ,Prospective Studies ,Prospective cohort study ,Aged ,Aged, 80 and over ,business.industry ,Syndrome ,Middle Aged ,LOHAS ,Cardiovascular Diseases ,Geriatrics ,Baseline characteristics ,Costs and Cost Analysis ,Quality of Life ,Physical therapy ,Population study ,Female ,Surgery ,business ,Locomotion ,Cohort study - Abstract
There is little evidence regarding long-term outcomes of locomotor dysfunction such as cardiovascular events, quality of life, and death. We are conducting a prospective cohort study to evaluate risk of cardiovascular disease, quality of life, medical costs, and mortality attributable to locomotor dysfunction. The present study determined baseline characteristics of participants in the Locomotive Syndrome and Health Outcome in Aizu Cohort Study (LOHAS).Cohort participants were recruited from residents between 40 and 80 years old who received regular health check-ups conducted by local government each year between 2008 and 2010 in Minami-Aizu Town and Tadami Town in Fukushima Prefecture, Japan. Musculoskeletal examination included assessment of physical examination of the cervical and lumbar spine, and upper and lower extremities and of physical function, such as grasping power, one-leg standing time, and time for the 3-m timed up-and-go test. Cardiovascular risk factors, including blood pressure and biological parameters, were measured at annual health check-ups. We also conducted a self-administered questionnaire survey.LOHAS participants comprised 1,289 men (mean age 65.7 years) and 1,954 women (mean age 66.2 years) at the first year. The proportion of obese individuals (body mass index 25.0 kg/m(2)) was 31.9% in men and 34.3% in women, and 41.0% of participants reported being followed up for hypertension, 7.0% for diabetes, and 43.6% for hypercholesterolemia. Prevalence of lumbar spinal stenosis was 10.7% in men and 12.9% in women, while prevalence of low back pain was 15.8% in men and 17.6% in women.The LOHAS is a novel population-based prospective cohort study that will provide an opportunity to estimate the risk of cardiovascular disease, quality of life, medical costs, and mortality attributable to locomotor dysfunction, and to provide the epidemiological information required to develop policies for detection of locomotor dysfunction.
- Published
- 2012
16. Laves phases in RE(Mg,Cd)2 (RE = rare earth) pseudo-binary alloys
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Nobuhisa Fujita, Shin Ichi Kikuchi, and An Pang Tsai
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Materials science ,Rare-earth element ,Alloy ,Rare earth ,Binary number ,General Chemistry ,Crystal structure ,engineering.material ,Laves phase ,Condensed Matter Physics ,Atomic species ,Crystallography ,engineering ,General Materials Science ,Phase diagram - Abstract
Trends in the stability of Laves phases in the pseudo-binary alloy systems RE(Mg,Cd) 2 (RE: rare earth element) are studied experimentally. Alloys are synthesized with various compositional ratios between Mg and Cd and with different REs. For most REs except Yb, a Laves phase forms only in the Mg-rich part of the phase diagram including the binary limit REMg 2 , while for Yb a Laves phase is maintained throughout the whole compositional range between YbMg 2 and YbCd 2 . A thorough analysis on the compositions of the Laves phases in the Mg-rich part is performed, which reveals a systematic tendency towards off-stoichiometry with Mg-enrichment of about 5–10 atomic %. The phenomenon can be understood as a consequence of an unbalanced mixing of atomic species between two kinds of atomic sites. Rietveld refinements of the crystal structures reveal that a better fit is achieved by allowing the RE-positions to be replaced partially by Mg, which provides a supporting evidence for the atomistic model of off-stoichiometry.
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- 2011
17. Effect of acute nerve root compression on endoneurial fluid pressure and blood flow in rat dorsal root ganglia
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Shin-ichi Kikuchi, Tamaki Igarashi, Shoji Yabuki, and Robert R. Myers
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Nerve root ,Ischemia ,Lumbar spinal canal stenosis ,Rats, Sprague-Dawley ,Sciatica ,Spinal Stenosis ,Dorsal root ganglion ,Ganglia, Spinal ,Edema ,Peripheral Nervous System ,Pressure ,medicine ,Animals ,Orthopedics and Sports Medicine ,business.industry ,Nerve Compression Syndromes ,Blood flow ,Anatomy ,medicine.disease ,Rats ,medicine.anatomical_structure ,Regional Blood Flow ,Anesthesia ,Acute Disease ,Crush injury ,Female ,medicine.symptom ,Spinal Nerve Roots ,business ,Low Back Pain ,Intervertebral Disc Displacement - Abstract
The objective of the current study was to test the hypothesis that crush injury to nerve root increases endoneurial fluid pressure (EFP) and decreases blood flow in the associated dorsal root ganglion (DRG). A total of 21 adult, female Sprague-Dawley rats had their left L5 nerve root and DRG exposed. The L5 nerve root was clamped for 2 s with a vascular suture clip just proximal to the DRG (compression group). Sham-operated animals without compression were used for control (control group). EFP was recorded with a servo-null micropipette system using a glass micropipette with tip diameter of 4 mum before and after 3 h of treatment. After the final measurement of EFP, DRG was excised and processed for histology. Blood flow in the DRG was continuously monitored by laser Doppler flow meter for 3 h. Three hours after treatment, EFP was 4.7+/-2.7 cm H(2)O in the compression group and 2.2+/-1.2 cm H(2)O in the control group (P
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- 2005
18. Assessment of environmental radiation based on the geographical distributions of background γ-ray intensity and soil-type in Tokai-mura Village and Hitachinaka City, Ibaraki Prefecture, Japan
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Koji Kurita, Masaaki Ikeda, Shin-ichi Kikuchi, Sanae Kimura, Akiko Goto, and Michio Tagiri
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Tokai mura ,General Engineering ,Gamma ray ,General Earth and Planetary Sciences ,Physical geography ,Soil type ,Geology ,General Environmental Science - Abstract
原子力施設が集中する東海村とひたちなか市にまたがる那珂台地を中心に土壌の環境放射線測定と化学組成の検討を行って,那珂台地とその中に存在する原子力施設敷地の環境放射線の評価を行った.調査研究はJCO事故直後に始めた.γ線測定と土壌採取は500 mメッシュをきり,その交点を測定地点とした.那珂台地地域の土壌は主成分化学組成の特徴から3タイプに分類でき,このタイプ分けは地形地質区分に対応している.すべての測定地点で,日本の花崗岩の放射線平均値や一般公衆の年間の実効線量限度を越える地点はなかった.環境放射線の強度分布は土壌タイプの分布と相関がよい.また,K20含量およびRb含量とγ線強度によい相関がみられた.これらの結果はこの地域の環境放射線は主として自然放射線のものであることを示している.
- Published
- 2005
19. Synthesis and Reactions of Optically Active Secondary Dialkylphosphine-Boranes
- Author
-
Shin-ichi Kikuchi, Tsuneo Imamoto, Hironari Yamada, and Tomoya Miura
- Subjects
Chemistry ,Organic Chemistry ,Boranes ,Optically active ,Combinatorial chemistry - Published
- 2000
20. Soft tissue reinforcement with a Leeds-Keio artificial ligament in revision surgery for dislocated total hip arthroplasty.
- Author
-
Shigeo Aota, Shin-ichi Kikuchi, Hironori Ohashi, Naoko Kitano, Michiyuki Hakozaki, and Shin-ichi Konno
- Subjects
- *
HIP joint physiology , *CONNECTIVE tissues , *ACETABULUM (Anatomy) , *FEMUR head , *ARTIFICIAL joints , *HIP joint dislocation , *POSTOPERATIVE period , *COMPLICATIONS of prosthesis , *REOPERATION , *SURGICAL complications , *TOTAL hip replacement , *DISEASE relapse , *TREATMENT effectiveness , *PREOPERATIVE period , *PHYSIOLOGY , *SURGERY , *INJURY risk factors - Abstract
Introduction: Since dislocation after total hip arthroplasty (THA) greatly diminishes patient's quality of life, the THA frequently needs revision. However, it is common for the dislocation not to heal even after reconstruction, but rather to become intractable. Methods: The 17 patients with dislocated THA, mean age of 71 years (range 51-87 years), who underwent a revision THA together with soft tissue reinforcement with a Leeds-Keio (LK) ligament were enrolled. The purposes of reinforcement with LK ligament were to restrict the internal rotation of the hip joint, and to encourage the formation of fibrous tissue in the posterior acetabular wall to stabilise the femoral head. We determined the success rate of surgical treatment for dislocation, the Harris Hip Score (HHS), a factor of recurrent dislocation. Results: There was no recurrent dislocation in 82% of the cases (14 joints) during the mean postoperative followup period of 63.5 months (15-96 months). The HHS was 82 ± 18 points preoperatively and 82 ± 14 points postoperatively. Recurrent dislocation after this surgical procedure occurred in 2 hips with breakage of the LK ligaments, and intracapsular dislocation in 1 hip with loosening of the LK ligament. Conclusions: Although the risk of recurrent dislocation still exists with this procedure, when performed to provide reinforcement with an LK ligament for dislocated THA it may be useful in intractable cases with soft tissue defects around the hip joint. [ABSTRACT FROM AUTHOR]
- Published
- 2018
- Full Text
- View/download PDF
21. ChemInform Abstract: Synthesis and Reactions of Optically Active Secondary Dialkylphosphine-Boranes
- Author
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Tomoya Miura, Tsuneo Imamoto, Shin-ichi Kikuchi, and Hironari Yamada
- Subjects
Chemistry ,Organic chemistry ,Boranes ,General Medicine ,Optically active ,Photochemistry - Published
- 2010
22. Characteristics of the progression of squamation and the formation of ctenii in the Japanese flounder,Paralichthys olivaceus
- Author
-
Shin-Ichi Kikuchi and Naoshi Makino
- Subjects
Dorsum ,Blind side ,Paralichthys ,biology ,%22">Fish ,Animal Science and Zoology ,General Medicine ,Anatomy ,biology.organism_classification ,Olive flounder - Abstract
The progression of squamation and the formation of ctenii in developing juveniles of completely ambicolorate specimens of the Japanese flounder, Paralichthys olivaceus (Temmink et Schlegel), have been examined and compared with those of normally colored fish. The squamation developed with a similar pattern on both the ocular and blind sides of completely ambicolorate fish and of normal fish. In the normal fish, formation of ctenii occurred only on the ocular side and not on the blind side. In the completely ambicolorate fish, the formation of ctenii occurred on both the ocular and the blind side, but the formation of ctenii on the blind side differed from that on the ocular side in both normal and completely ambicolorate fish in terms of both mode and pattern. On the blind side of ambicolorate fish, the formation of ctenii progressed not from the lateral axis as is the case in the normal fish, but from the dorsal and ventral edges just after the formation of ctenii reached the edges on the ocular side, suggesting the diffusion of an unknown factor(s) through the dermal tissue.
- Published
- 1990
23. [Antinociceptive effect of calcitonin]
- Author
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Bunji, Takayama, Shin-ichi, Kikuchi, Shin-ichi, Konno, and Miho, Sekiguchi
- Subjects
Calcitonin ,Serotonin ,Bone Density Conservation Agents ,Ovariectomy ,Nociceptors ,Estrogens ,Immunohistochemistry ,Rats ,Disease Models, Animal ,Back Pain ,Receptors, Serotonin ,Animals ,Humans ,Osteoporosis ,Spinal Fractures ,Female ,Proto-Oncogene Proteins c-fos - Published
- 2007
24. Psychosocial Stress After a Disaster and Low Back Pain-Related Interference With Daily Living Among College Students: A Cohort Study in Fukushima.
- Author
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Kinshi Kato, Miho Sekiguchi, Takuya Nikaido, Ken-ichi Otoshi, Yohei Matsuo, Takahiro Igari, Yoshihiro Kobayashi, Misa Takegami, Norio Fukumor, Shingo Fukuma, Shin-ichi Kikuchi, Shun-ichi Fukuhara, Shin-ichi Konno, Kato, Kinshi, Sekiguchi, Miho, Nikaido, Takuya, Otoshi, Ken-Ichi, Matsuo, Yohei, Igari, Takahiro, and Kobayashi, Yoshihiro
- Published
- 2017
- Full Text
- View/download PDF
25. An experimental study on the therapeutic effect of consecutive low-dose cisplatin with caffeine in sarcoma-bearing mice
- Author
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Akira, Takeda, Hiroyuki, Tsuchiya, Takahiro, Tajino, and Shin-Ichi, Kikuchi
- Subjects
Male ,Mice, Inbred BALB C ,Lung Neoplasms ,Dose-Response Relationship, Drug ,Fibrosarcoma ,Mice, Nude ,Cell Growth Processes ,Xenograft Model Antitumor Assays ,Drug Administration Schedule ,Mice ,Caffeine ,Cell Line, Tumor ,Antineoplastic Combined Chemotherapy Protocols ,Animals ,Humans ,Cisplatin ,Lung - Abstract
The aims of this study were to investigate the anti-tumor effects of consecutive low-dose cisplatin (LD-CDDP) in comparison with single high-dose CDDP (HD-CDDP) in combination with caffeine.Human fibrosarcoma cells (HT-1080) were transplanted in BALB/C-nu mice. According to the administration of CDDP and caffeine, 5 groups were defined: HD-CDDP, LD-CDDP, HD-CDDP +caffeine, LD-CDDP +caffeine and control group. The total dose of CDDP was 3.5 or 6 mg/kg. CDDP was injected i.p. bolus (HD-CDDP) or divided into 5 days (LD-CDDP). Caffeine was injected i.p. at a dose of 60 mg/kg twice a day for 4 days.Significant inhibition of tumor growth and prolongation of survival time were recognized in the HD- and LD-CDDP groups with and without caffeine compared to the control group. The caffeine-assisted groups had no advantage compared to the CDDP alone groups.The effects of LD-CDDP were similar to the effect of HD-CDDP.
- Published
- 2005
26. [Block treatment for low back pain--technical note]
- Author
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Koji, Otani and Shin-ichi, Kikuchi
- Subjects
Humans ,Nerve Block ,Low Back Pain - Abstract
Many types of block are used for treatment of low back pain. In the current paper, trigger-point block, facet block, ilio-sacral joint block, epidural block and nerve root infiltration (nerve root block), quite common procedures for treatment of low back pain, are introduced and technical notes are described. There are two important points for block treatment, one is the knowledge of anatomy and another is the knowledge of side effects. We must remember to prepare everything for side effects when block treatment is done.
- Published
- 2005
27. [Therapeutic effects of calcitonin on back pain in the patients with osteoporosis]
- Author
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Shin-ichi, Konno and Shin-ichi, Kikuchi
- Subjects
Aged, 80 and over ,Calcitonin ,Treatment Outcome ,Humans ,Female ,Prospective Studies ,Middle Aged ,Low Back Pain ,Osteoporosis, Postmenopausal ,Aged - Abstract
A prospective study was performed to clarify the therapeutic effect on calcitonin in the patients with osteoporosis using patient-based outcome measures. A total of 67 patients with primary osteoporosis who complained back pain were included in this study. All patients were administered calcitonin 20 Unit/week intramuscularly. The therapeutic effects were assessed using various patient-based outcome measures before treatment, 2, 4 weeks and 3 months after treatment. We used Short form 12 for measuring general well-being, Roland Morris disability questionnaire for functional status associated with back pain, and visual analogue scale for pain intensity. Statistic analysis was performed using paired-t test. Pain intensity and functional status were significantly recovered at 2 weeks follow-up time and the effects were continued at 3 months follow-up time. Physical component summary (PCS) was recovered at 3 months follow-up tme, whereas mental component summary (MCS) was improved at 2 weeks follow-up time. These facts suggest that improvement of back pain using calcitonin correlates directly with recovery in functional status, indirectly with recovery in general well being.
- Published
- 2005
28. [Clinical anatomy of lumbar spine]
- Author
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Takatomo, Moro, Shin-ichi, Kikuchi, and Shin-ichi, Konno
- Subjects
Lumbar Vertebrae ,Humans ,Low Back Pain - Abstract
Three elements contribute to the neurologic symptoms of the lumbar spine or its multiplicity from an anatomical viewpoint. The first element is the problem of neural tissue. The second element is the bone or the soft tissue existing around the circumference of the neural tissue. The third element is the correlation of the above two. In other words, the neural tissue as content is too large or the adjacent tissue as container is too narrow or else an aberration in the correlation of the aforesaid is involved. Therefore, it is necessary to study those three elements to comprehend the neurologic symptoms of the lumbar spine.
- Published
- 2005
29. [Experimental studies of lumbar spinal stenosis]
- Author
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Miho, Sekiguchi and Shin-ichi, Kikuchi
- Subjects
Dogs ,Lumbar Vertebrae ,Spinal Stenosis ,Cauda Equina ,Receptors, Serotonin ,Animals ,Serotonin Antagonists ,Epoprostenol ,Rats - Abstract
Neurophysiologic function and ischemia causes neurogenic symptoms in lumbar spinal stenosis. Neurophysiologic function and potential therapeutic agents were investigated using a chronic cauda equina compression model that was developed according to a clinical pathogenesis. In the chronic cauda equina compression model, nerve conduction velocity and blood flow in spinal nerves decreased but mechanical allodynia was not induced. Prostaglandins and 5-HT receptor antagonist effected to improve blood flow in nerve roots after cauda equina compression;therefore, they might be potential agents for lumbar spinal stenosis.
- Published
- 2005
30. Stereospecific reduction of phosphine oxides to phosphines by the use of a methylation reagent and lithium aluminum hydride
- Author
-
Tsuneo Imamoto, Yoshiyuki Wada, Shin-ichi Kikuchi, and Tomoya Miura
- Subjects
Methyl triflate ,Chemistry ,Organic Chemistry ,ALUMINUM HYDRIDE ,Inorganic chemistry ,Methylation ,Optically active ,Biochemistry ,chemistry.chemical_compound ,Stereospecificity ,Reagent ,Phosphorus atom ,Polymer chemistry ,Physical and Theoretical Chemistry ,Phosphine - Abstract
[figure: see text] Various phosphine oxides are efficiently reduced by the use of a methylation reagent and lithium aluminum hydride. Optically active P-chirogenic phosphine oxides are also reduced with inversion of configuration at phosphorus atom by treatment with methyl triflate, followed by reaction with LiAlH4.
- Published
- 2001
31. ChemInform Abstract: Stereospecific Reduction of Phosphine Oxides to Phosphines by the Use of a Methylation Reagent and Lithium Aluminum Hydride
- Author
-
Yoshiyuki Wada, Tsuneo Imamoto, Tomoya Miura, and Shin-ichi Kikuchi
- Subjects
chemistry.chemical_compound ,Stereospecificity ,Chemistry ,Reagent ,Phosphorus atom ,ALUMINUM HYDRIDE ,Polymer chemistry ,chemistry.chemical_element ,Lithium ,General Medicine ,Methylation ,Optically active ,Phosphine - Abstract
[figure: see text] Various phosphine oxides are efficiently reduced by the use of a methylation reagent and lithium aluminum hydride. Optically active P-chirogenic phosphine oxides are also reduced with inversion of configuration at phosphorus atom by treatment with methyl triflate, followed by reaction with LiAlH4.
- Published
- 2001
32. Erratum to: Prevalence of lumbar spinal stenosis, using the diagnostic support tool, and correlated factors in Japan: a population-based study
- Author
-
Shoji Yabuki, Koji Otani, Miho Sekiguchi, Shin-ichi Kikuchi, Shin-ichi Konno, Norio Fukumori, Misa Takegami, Shunichi Fukuhara, Yoshihiro Onishi, and Takafumi Wakita
- Subjects
Orthopedics and Sports Medicine ,Surgery ,Erratum - Published
- 2013
33. Prevalence and Location of Neuropathic Pain in Lumbar Spinal Disorders: Analysis of 1804 Consecutive Patients With Primary Lower Back Pain.
- Author
-
Sumihisa Orita, Toshihiko Yamashita, Seiji Ohtori, Kazuo Yonenobu, Mamoru Kawakami, Toshihiko Taguchi, Shin-ichi Kikuchi, Takahiro Ushida, Shin-ichi Konno, Masaya Nakamura, Keiji Fujino, Shuichi Matsuda, Kazunori Yone, Kazuhisa Takahashi, Orita, Sumihisa, Yamashita, Toshihiko, Ohtori, Seiji, Yonenobu, Kazuo, Kawakami, Mamoru, and Taguchi, Toshihiko
- Published
- 2016
- Full Text
- View/download PDF
34. Relationship Between Kyphotic Posture and Falls in Community-Dwelling Men and Women: The Locomotive Syndrome and Health Outcome in Aizu Cohort Study.
- Author
-
Ryoji Tominaga, Shingo Fukuma, Shin Yamazaki, Miho Sekiguchi, Koji Otani, Shin-ichi Kikuchi, Sho Sasaki, Susumu Kobayashi, Shunichi Fukuhara, Shin-ichi Konno, Tominaga, Ryoji, Fukuma, Shingo, Yamazaki, Shin, Sekiguchi, Miho, Otani, Koji, Kikuchi, Shin-Ichi, Sasaki, Sho, Kobayashi, Susumu, Fukuhara, Shunichi, and Konno, Shin-Ichi
- Published
- 2016
- Full Text
- View/download PDF
35. Extensive Cervicothoracic Laminoplastic Decompression of the Spinal Cord: A New Method of Posterior Decompression for Thoracic Myelopathy Caused by Ossification of the Posterior Longitudinal Ligament
- Author
-
Yasuyoshi Wadano, Nobuyuki Tsuzuki, and Shin-ichi Kikuchi
- Subjects
medicine.medical_specialty ,business.industry ,Decompression ,Ossification of the posterior longitudinal ligament ,Anatomy ,Spinal cord ,Posterior decompression ,Surgery ,Thoracic myelopathy ,medicine.anatomical_structure ,Complete paraplegia ,medicine ,Spinal canal ,Anterior approach ,business - Abstract
Ossification of the posterior longitudinal ligament (OPLL) at the thoracic level tends to be multiple or extensive, depending on the degree and number of impingements on the spinal cord. In the case of thoracic myelopathy caused by OPLL, excision of OPLL is the most effective method of relieving pressure on the spinal cord, but the anterior approach for OPLL excision is technically demanding. Moreover, in the case of highly impinging OPLL, postoperative neurological deterioration resulting in complete paraplegia, although infrequent, has been reported [1-3]. So far, thoracic OPLL has remained a challenge to the spinal surgeon in Japan. Postoperative neurological catastrophes are thought to arise from inadvertent trauma of the spinal cord, resulting from the excision maneuvers in an OPLL-narrowed spinal canal. Moreover, the spinal cord has probably lost its vital resistance to trauma following severe and long-standing compression by OPLL.
- Published
- 1997
36. Pain, quality of life and activity in aged evacuees living in temporary housing after the Great East Japan earthquake of 11 March 2011: a cross-sectional study in Minamisoma City, Fukushima prefecture.
- Author
-
Shoji Yabuki, Kazuo Ouchi, Shin-ichi Kikuchi, Shin-ichi Konno, Yabuki, Shoji, Ouchi, Kazuo, Kikuchi, Shin-Ichi, and Konno, Shin-Ichi
- Subjects
QUALITY of life ,REFUGEES ,SENDAI Earthquake, Japan, 2011 ,NATURAL disasters ,CROSS-sectional method ,PAIN diagnosis ,PAIN & psychology ,MENTAL health ,HOUSING ,DISASTERS ,HEALTH surveys ,MOTOR ability ,PAIN ,QUESTIONNAIRES ,STANDARDS - Abstract
Background: The aim of this study was to clarify pain, quality of life and activity in the aged evacuees living in temporary housing after the Great East Japan Earthquake on 11 March 2011.Methods: The study was a cross-sectional study performed in Minamisoma City, Fukushima Prefecture 1 year and 6 months after the disaster. Inclusion criteria were the ability to walk independently and consent to answer questionnaires. Seventy-one evacuees who met the inclusion criteria were included in this study. There were 16 men and 55 women with a mean age of 75.9 years. Sixty evacuees were surveyed when they gathered at the assembly hall in the temporary housing (Assembled group) and 11 evacuees were surveyed through individual visits to their residences (Individual group). Evacuees in the Individual group agreed to participate in this study, but refused to visit the assembly hall to engage in exercise and recreation. Pain, quality of life (QOL) and level of activity were assessed with the Numeric Rating Scale (NRS), the MOS Short-Form 36 item Health Survey (SF-36) and a pedometer, respectively. Student's t-test, Mann-Whitney U test, and Fisher's exact test were used for statistical analysis.Results: Forty-four (62.0 %) residents had chronic pain with a mean NRS of 2.74. Twenty-one (29.6 %) of these residents had relatively severe pain rated 5 or above on the NRS. QOL was significantly lower for the subscales of "physical functioning," "role physical", "general health", "social functioning", "role emotional" and "mental health", when compared with the national standard values. Values were also visibly lower for "physical component summary" in the summary score. On comparing the Assembled group and the Individual group, "physical function", "role physical", "social functioning" and "physical component summary" were found to be significantly lower in the Individual group. The mean daily number of steps was 1,892 in the Individual group and 4,579 in the Assembled group. The Individual group thus significantly took less mean daily number of steps compared with the Assembled group.Conclusions: This study quantified the state of pain, QOL and activity of aged evacuees living in temporary housing after the Great East Japan Earthquake. The evacuees frequently had chronic pain and lower physical and mental QOL scores compared to the national standard values. [ABSTRACT FROM AUTHOR]- Published
- 2015
- Full Text
- View/download PDF
37. 601 Mechanical Properties of Al-Al_2O_3-TiB_2 Composite Processed by Reactive Sintering and Hot-Rolling
- Author
-
Shin-ichi Kikuchi, Tohru Hayashi, Zhongchun Chen, and Takenobu Takeda
- Subjects
Materials science ,Composite number ,Metallurgy ,Sintering - Published
- 2005
38. 603 Formability of Al-Al_2O_3-TiC Composite Processed by Reactive Sintering and Hot Compression
- Author
-
Shin-ichi Kikuchi, Kazumasa Suzuki, Zhongchun Chen, and Takenobu Takeda
- Subjects
Materials science ,Composite number ,Formability ,Sintering ,Composite material ,Compression (physics) - Published
- 2005
39. 602 Development of Aluminum Matrix Composites by Reactive Sintering : Effect of Carbon Content of Al-TiC and Al-TiC-Al_2O_3 composites on Al_3Ti Phase
- Author
-
Shin-ichi Kikuchi, Zhongchun Chen, Naohiko Tsuda, and Takenobu Takeda
- Subjects
Materials science ,chemistry ,Aluminum matrix composites ,Phase (matter) ,chemistry.chemical_element ,Sintering ,Composite material ,Carbon - Published
- 2005
40. Melano-macrophage centre-like structure in the heart of the medaka, Oryzias latipes
- Author
-
Hiroaki Nakamura, Shin-ichi Kikuchi, and Atsumi Shimozawa
- Subjects
Male ,Kidney ,Cytoplasm ,biology ,Oryzias ,Phagocytosis ,Macrophages ,Myocardium ,Cell ,General Medicine ,Anatomy ,biology.organism_classification ,Cell biology ,Microscopy, Electron ,medicine.anatomical_structure ,Reticular cell ,medicine ,%22">Fish ,Macrophage ,Animals ,Female ,Developmental Biology - Abstract
Endocardial lining cells in the heart of certain teleosts are phagocytic against foreign materials. In the medaka Oryzias latipes, in addition to the endocardial lining cells, cells in the subendocardial spaces are also phagocytic. Most subendocardial cells contain yellowish-brown pigments and are often aggregated to form nodules resembling splenic and kidney melano-macrophage centres. Subendocardial cells are positive to PAS and Schmorl's reaction. Macrophages containing large heterogeneous inclusions together with lymphocytes, were observed with the TEM. The definitive characteristics of reticular cells, including the cell sheaths, were not observed. Because of these two characteristics they were regarded as more primitive aggregates of macrophages than the ordinary melano-macrophage centres. The possible analogy between these structures and MMCs is discussed.
- Published
- 1993
41. Association between hand-grip strength and depressive symptoms: Locomotive Syndrome and Health Outcomes in Aizu Cohort Study (LOHAS)
- Author
-
Norio Fukumori, Yosuke Yamamoto, Misa Takegami, Shin Yamazaki, Yoshihiro Onishi, Miho Sekiguchi, Koji Otani, Shin-Ichi Konno, Shin-Ichi Kikuchi, and Shunichi Fukuhara
- Abstract
Background: no study has examined the longitudinal association between hand-grip strength and mental health, such as depressive symptoms. Objective: we investigated the relationship between baseline hand-grip strength and the risk of depressive symptoms. Design: a prospective cohort study. Low hand-grip strength associates with depression Setting and Subjects: a prospective cohort study with a 1-year follow-up was conducted using 4,314 subjects from community-dwelling individuals aged 40--79 years in two Japanese municipalities, based on the Locomotive Syndrome and Health Outcomes in Aizu Cohort Study (LOHAS, 2008-10). Methods: we assessed baseline hand-grip strength standardised using national representative data classified by age and gender, and depressive symptoms at baseline and after the follow-up using the five-item version of the Mental Health Inventory (MHI-5). Results: the 4,314 subjects had a mean age of 66.3 years, 58.5% were women, and mean unadjusted hand-grip strength was 29.8 kg. Multivariable random-effect logistic regression analysis revealed that subjects with lower hand-grip strength (per 1SD decrease) had higher odds of having depressive symptoms at baseline [adjusted odds ratio (AOR) 1.15, 95% confidence interval (CI) 1.06--1.24; P = 0.001]. Further, lower hand-grip strength (per 1SD decrease) was associated with the longitudinal development of depressive symptoms after 1 year (AOR 1.13, 95% CI 1.01-1.27; P= 0.036). Conclusions: using a large population-based sample, our results suggest that lower hand-grip strength, standardised using age and gender, is both cross-sectionally and longitudinally associated with depressive symptoms. [ABSTRACT FROM AUTHOR]
- Published
- 2015
- Full Text
- View/download PDF
42. The Effect of a 5-HT2A Receptor Antagonist on Pain-Related Behavior, Endogenous 5-Hydroxytryptamine Production, and the Expression 5-HT2A Receptors in Dorsal Root Ganglia in a Rat Lumbar Disc Herniation Model.
- Author
-
Kinshi Kato, Miho Sekiguchi, Shin-ichi Kikuchi, and Shin-ichi Konno
- Published
- 2015
- Full Text
- View/download PDF
43. Preparation of Anode/Electrolyte Ceramic Composites by Coextrusion of Pastes
- Author
-
Keisuke Kikuchi, Shin-ichi Kikuchi, Takenobu Takeda, Keisuke Ikeda, and Zhongchun Chen
- Subjects
Materials science ,Nickel oxide ,Oxide ,Electrolyte ,Anode ,chemistry.chemical_compound ,chemistry ,visual_art ,Materials Chemistry ,Ceramics and Composites ,visual_art.visual_art_medium ,Cubic zirconia ,Extrusion ,Ceramic ,Composite material ,Yttria-stabilized zirconia - Abstract
Anode/electrolyte two-layer ceramic composites for tubular solid oxide fuel cells were prepared through coextrusion of multiple pastes containing a water-based binder (an aqueous solution of hydroxypropyl methylcellulose). The multibillet extrusion (MBE) technique was found to be effective in achieving the anode/electrolyte composite pipes. Furthermore, it is possible to reduce the wall thickness of both anode and electrolyte layers by raising the extrusion ratio of each layer. The extrusion pressure and binder content required to obtain sound extrudates decreased with an increase in the fraction of nickel oxide in an anode layer. It is feasible to decrease the difference in the sintering shrinkage between the anode and electrolyte layers by incorporating calcined coarse yttria-stabilized zirconia (YSZ) powder in the electrolyte layer. The incorporation of coarse YSZ powder in an anode is effective in forming a continuous NiO network within the YSZ matrix.
- Published
- 2004
44. Diagnostic value of the lumbar extension-loading test in patients with lumbar spinal stenosis: a cross-sectional study.
- Author
-
Naoto Takahashi, Shin-ichi Kikuchi, Shoji Yabuki, Koji Otani, and Shin-ichi Konno
- Abstract
Background: The gait-loading test is a well known, important test with which to assess the involved spinal level in patients with lumbar spinal stenosis. The lumbar extension-loading test also functions as a diagnostic loading test in patients with lumbar spinal stenosis; however, its efficacy remains uncertain. The purpose of this study was to compare the diagnostic value of the lumbar extension-loading test with that of the gait-loading test in patients with lumbar spinal stenosis. Methods: A total of 116 consecutive patients (62 men and 54 women) diagnosed with lumbar spinal stenosis were included in this cross-sectional study of the lumbar extension-loading test. Subjective symptoms and objective neurological findings (motor, sensory, and reflex) were examined before and after the lumbar extension-loading and gait-loading tests. The efficacy of the lumbar extension-loading test for establishment of a correct diagnosis of the involved spinal level was assessed and compared with that of the gait-loading test. Results: There were no significant differences between the lumbar extension-loading test and the gait-loading test in terms of subjective symptoms, objective neurological findings, or changes in the involved spinal level before and after each loading test. Conclusions: The lumbar extension-loading test is useful for assessment of lumbar spinal stenosis pathology and is capable of accurately determining the involved spinal level. [ABSTRACT FROM AUTHOR]
- Published
- 2014
- Full Text
- View/download PDF
45. Unsymmetrical P-Chirogenic Bis(phosphane) Ligands: Their Preparation and Use in Rhodium-Catalyzed Asymmetric Hydrogenation
- Author
-
Masaya Yasutake, Shin-ichi Kikuchi, Tsuneo Imamoto, and Atsushi Ohashi
- Subjects
Chemistry ,Stereochemistry ,Organic Chemistry ,Asymmetric hydrogenation ,Enantioselective synthesis ,chemistry.chemical_element ,Substrate (chemistry) ,Physical and Theoretical Chemistry ,Isopropyl ,Adduct ,Rhodium ,Catalysis - Abstract
A series of bis(phosphanes) (SP,SP′)-R1(Me)PCH2CH2P′R2R3 (1a−k; R1, R2, and R3 = 1-adamantyl, tert-butyl, cyclohexyl, cyclopentyl, isopropyl, methyl, phenyl; abbreviated as unsymmetrical BisP*) has successfully been synthesized, by coupling of the (RP)-configured tosylates 5a−d or mesylates 6a−g with lithiated (SP)-R1(Me)PH−BH3 adducts. Asymmetric hydrogenations catalyzed by rhodium complexes of the unsymmetrical BisP* moieties as ligands revealed extremely high enantioselectivities − 99% (9b) and 98% (9e) − when the trisubstituted and tetrasubstituted dehydro-α-amino acid derivatives 8b and 8e, respectively, were used as substrates. It was found that unsymmetrical BisP* species tended to exhibit higher enantioselectivity than C2-symmetrical BisP* species in the Rh-catalyzed hydrogenation of (Z)-dehydro-β-amino acid and enamide derivatives. These results implied that the differentiation between the chiral environments at the two phosphorus atoms could effectively achieve higher enantioselectivity. For each substrate, moreover, it was possible to improve the enantioselectivity by changing the combination of substituents on the two phosphorus atoms. (© Wiley-VCH Verlag GmbH, 69451 Weinheim, Germany, 2002)
- Published
- 2002
46. Minimally Invasive Surgery for Osteoid Osteoma of the Cervical Spine Using Microendoscopic Discectomy System.
- Author
-
Yukako Nakamura, Shoji Yabuki, Shin-Ichi Kikuchi, and Shin-Ichi Konno
- Subjects
ENDOSCOPY ,OSTEOMALACIA ,BONE diseases ,CERVICAL vertebrae injuries ,VERTEBRAE injuries ,SPINE - Abstract
We report herein the case of an 18-year-old man who underwent endoscopic resection for an osteoid osteoma in the seventh cervical facet joint. The patient had experienced right neck pain for approximately one year, but no neurological abnormalities were noted. Cervical magnetic resonance imaging suggested an osteoid osteoma in the superior articular process of the seventh cervical vertebra. The tumor was resected microendoscopically. Operative time was 1 hour 29 minutes, and blood loss was 5 mL. During the two years since surgery, the patient has remained pain free with no cervical spine instability. We thus propose microendoscopic surgery for osteoid osteoma developing in a posterior element of the cervical spine is a potentially effective operative procedure. [ABSTRACT FROM AUTHOR]
- Published
- 2013
- Full Text
- View/download PDF
47. In Memoriam
- Author
-
Shin-ichi Kikuchi
- Subjects
General Chemistry ,Atomic and Molecular Physics, and Optics ,Computer Science Applications ,Electronic, Optical and Magnetic Materials - Published
- 1997
48. Mesothelial stomata of the transverse septa of the medaka, Oryzias latipes
- Author
-
Emiko Furuta, Shin-ichi Kikuchi, Hiroaki Nakamura, and Keiichiro Yamaguchi
- Subjects
biology ,Oryzias ,Immunology ,biology.organism_classification ,Developmental Biology ,Cell biology - Published
- 1997
49. Most surprising cells among epithelial cells of the body wall from terrestrial slug, Incilaria fruhstorferi
- Author
-
Shin-ichi Kikuchi, Keiichiro Yamaguchi, Emiko Furuta, and Hiroaki Nakamura
- Subjects
biology ,Slug ,Immunology ,Anatomy ,biology.organism_classification ,Incilaria fruhstorferi ,Developmental Biology - Published
- 1997
50. Insertion of lateral mass screw of the atlas via the posterior arch: anatomical study of screw insertion using dry bone samples of the atlas from Japanese cadavers.
- Author
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Yoshitaka Kobayashi, Shin-Ichi Kikuchi, Shin-Ichi Konno, and Miho Sekiguchi
- Subjects
- *
BONE screws , *VERTEBRAL artery , *SPINAL canal , *TOMOGRAPHY , *MEDICAL technology , *MEDICAL radiography , *DISEASES - Abstract
Abstract Background A new technique involving screw fixation of the atlas via the posterior arch and lateral mass has recently been reported for atlantoaxial instability. Because the posterior arch is thin, lateral mass screws risk penetrating the upper part of the posterior arch and damaging the vertebral artery running along the upper part of the posterior arch. Methods A total of 50 dry bone samples of the atlas from Japanese cadavers were used. We manually measured the shortest distance from the vertebral canal to the transverse foramen and the thickness at the thinnest part of the groove using calipers and investigated the frequency of dorsal ponticuli at the posterior arch. Results The area from the vertebral canal to the transverse foramen was thick enough to allow screw insertion, but the thickness of the posterior arch at the thinnest part of the groove was less than the screw diameter (3.5 mm) in 22% of vertebrae and Conclusions The size and shape of the posterior arch must be evaluated using radiography and computed tomography before inserting a lateral mass screw of the atlas via the posterior arch. [ABSTRACT FROM AUTHOR]
- Published
- 2008
- Full Text
- View/download PDF
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