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A case series is presented of five overweight or obese patients with confirmed coronavirus disease 2019 (COVID-19) in South Miami, Florida, United States. A multitude of coagulation parameters was suggestive of a hypercoagulable state among the hospitalized COVID-19 patients. This article reports various manifestations of hypercoagulable states in overweight and obese patients, such as overt bleeding consistent with disseminated intravascular coagulation, venous thromboembolism, gastrointestinal bleeding as well as retroperitoneal hematoma. All of the required admission to the intensive care unit and subsequently patients died. The characteristics of COVID-19-associated coagulopathy are atypical and warrant a further understanding of the pathophysiology to improve clinical outcomes, specifically in overweight or obese patients.

Perennial aromatic crops' production, yield, and quality are significantly impacted by seasonal variations. Cymbopogon martinii (Roxb.) (Poaceae) is a perennial aromatic grass that produces valuable essential oil from the leaves and inflorescence containing high concentrations of geraniol and geranyl acetate. The current study intends to determine how seasonal changes (autumn, winter, and summer) affect the production of geraniol, geraniol acetate, and essential oils from various plant components, (leaves and inflorescence). The field study was conducted at the experimental farm of India's CSIR-Central Institute of Medicinal and Aromatic Plants for two years (May 2018 to May 2020). Four varieties viz. cv. Tripta, Trishna, PRC1, and CIMAP Harsh were grown, and harvesting was done in three entirely different seasons, i.e., autumn, winter, and summer, for two consecutive years; thus, a total of six harvests (two in each season) were obtained. The research findings revealed that under the sub-tropical climatic conditions, cv. CIMAP Harsh performs better in yield and productivity with maximum essential oil yield obtained in the summer, followed by autumn. Maximum geraniol (89.9% and 51.26 kg ha-1) and geraniol acetate (3.0% and 1.73 kg ha-1) yields in leaves were reported during the summer season. In contrast, in inflorescence, geraniol (76.8% and 12.77 kg ha-1) yields were recorded maximum during the autumn season, irrespective of variety. In terms of essential oil yield and quality of oil, harvesting during the winter months did not make any significant difference. Nevertheless, it is intriguing to notice that the CIMAP Harsh variety placed top for the traits N2, N3, N5, N6, N7, N8, N13, N15, N21, and N22 and second for N1. In the traits N2 to N8, N13, and N14, Trishna was the variety that placed second. Therefore, it is advised that these two palmarosa cultivars be grown commercially on a wide basis. [ABSTRACT FROM AUTHOR]

Pb and Cd are ubiquitous heavy metals (HMs) in the environment and their accumulation in medicinal herbs poses a serious threat due to health hazards. The genetic selection of high-yielding and low Pb and Cd accumulating genotypes known as phtyoexclusion is a cost-effective and promising phytotechnology. In the present study, phtyoexclusion method was used for the selection of low Pb and Cd accumulating genotypes of Andrographis paniculata (Burm.F.) Nees with minimum alteration in their pharmacological important constituents in three application rates of Pb and Cd. The performance of genotypes of A. paniculata was evaluated by uptake and translocation of Pb and Cd, biomass yield, shoot-to-root ratio, metabolite content, oxidative enzymes, and mineral content for their safe production and commercial viability. The bio-concentration factor (BCF) and translocation factor (TF) of Pb among the genotypes ranged from 0.09-3.6 and 0.006–0.045, respectively. However, variations in BCF and TF of Cd were 0.05–3.36 and 0.001–0.150 respectively. The differential expression of the metal accumulation in genotypes of A. paniculata was majorly associated with ionomics and biomass. Four genotypes of A. paniculata were screened out and were divided in the three categories. One, genotypes that accumulated Pb and Cd below the prescribed limits with high productivity and tolerance could be used for safer herb production. In the second category, genotypes having high accumulation in roots and low translocation could be used for phytostabilization of the soil. The above-ground material of the plant can be used for the extraction of pure constituents. The third one is genotypes with high accumulators and low productivity. [Display omitted] • Fifteen genotypes of A. paniculata were screened for Pb and Cd accumulation. • Four genotypes demostrated the phytoexcluder potential for Pb and Cd. • Biomass and mineral contents were the main drivers for low accumulating genotypes. • Some high accumulating genotypes can be good candidate for phytostabilization. [ABSTRACT FROM AUTHOR]