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2. Exploitation of the Ugi 5-Center-4-Component Reaction (U-5C-4CR) for the Generation of Diverse Libraries of Polycyclic (Spiro)Compounds

Author

Lisa Moni, Fabio De Moliner, Silvia Garbarino, Jörn Saupe, Christian Mang, and Andrea Basso

Subjects
multicomponent reactions, diversity oriented synthesis, scaffold diversity, combinatorial libraries, isocyanides, Chemistry, QD1-999
Abstract

An Ugi multicomponent reaction with chiral cyclic amino acids, benzyl isocyanide and cyclic ketones (or acetone) has been exploited as key step for the generation of peptidomimetics. After a straightforward set of elaborations, the peptidomimetics were converted into polycyclic scaffolds displaying two orthogonally protected secondary amines. Libraries of compounds were obtained decorating the molecules through acylation/reductive amination reactions on these functional groups.

Published
2018
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