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134 results on '"Siu, Victoria"'

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1. Evaluation of the diagnostic accuracy of exome sequencing and its impact on diagnostic thinking for patients with rare disease in a publicly funded health care system: A prospective cohort study

2. Clinico-biological refinement of BCL11B-related disorder and identification of an episignature: A series of 20 unreported individuals

3. Characterization of a novel heterozygous variant in the histidyl‐tRNA synthetase gene associated with Charcot–Marie–Tooth disease type 2W.

4. Novel diagnostic DNA methylation episignatures expand and refine the epigenetic landscapes of Mendelian disorders

5. Haploinsufficiency of PRR12 causes a spectrum of neurodevelopmental, eye, and multisystem abnormalities

6. Clinical epigenomics: genome-wide DNA methylation analysis for the diagnosis of Mendelian disorders

7. Defining the genotypic and phenotypic spectrum of X-linked MSL3-related disorder

10. Phenotypic spectrum and transcriptomic profile associated with germline variants in TRAF7

11. Evaluation of DNA Methylation Episignatures for Diagnosis and Phenotype Correlations in 42 Mendelian Neurodevelopmental Disorders

12. Diagnostic Utility of Genome-wide DNA Methylation Testing in Genetically Unsolved Individuals with Suspected Hereditary Conditions

13. De novo variants predicting haploinsufficiency for DIP2C are associated with expressive speech delay.

14. A Unique Comprehensive Model to Screen Newborns for Severe Combined Immunodeficiency—An Ontario Single-Centre Experience Spanning 2013–2023.

18. Molecular characterization of NRXN1 deletions from 19,263 clinical microarray cases identifies exons important for neurodevelopmental disease expression

19. Frameshift mutations at the C-terminus of HIST1H1E result in a specific DNA hypomethylation signature

21. Dual diagnosis of trisomy 21 and lethal perinatal Gaucher disease as a cause of non‐immune hydrops fetalis in a twin pregnancy for a consanguineous couple.

22. The clinical and genetic spectrum of autosomal-recessive TOR1A-related disorders.

23. BAFopathies’ DNA methylation epi-signatures demonstrate diagnostic utility and functional continuum of Coffin–Siris and Nicolaides–Baraitser syndromes

25. Identification of a novel synaptic protein, TMTC3, involved in periventricular nodular heterotopia with intellectual disability and epilepsy

26. Copy-Number Gains of HUWE1 Due to Replication- and Recombination-Based Rearrangements

31. Mutations in SPINT2 Cause a Syndromic Form of Congenital Sodium Diarrhea

36. Loss-of-function HDAC8 mutations cause a phenotypic spectrum of Cornelia de Lange syndrome-like features, ocular hypertelorism, large fontanelle and X-linked inheritance

37. Evidence-based work up and management of non-specific neck pain in the emergency department.

38. Mutations in cohesin complex members SMC3 and SMC1A cause a mild variant of Cornelia de Lange syndrome with predominant mental retardation

41. Moyamoya Syndrome in an Infant with Aicardi–Goutières and Williams Syndromes: A Case Report.

42. HDAC8 mutations in Cornelia de Lange syndrome affect the cohesin acetylation cycle

49. Symptomatic mosaicism for a novel FBN1 splice site variant in a parent causing inherited neonatal Marfan syndrome.

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