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15. Sculpting the tumour microenvironment by combining radiotherapy and ATR inhibition for curative-intent adjuvant immunotherapy

Author

Patin, Emmanuel C., Nenclares, Pablo, Chan Wah Hak, Charleen, Dillon, Magnus T., Patrikeev, Anton, McLaughlin, Martin, Grove, Lorna, Foo, Shane, Soliman, Heba, Barata, Joao P., Marsden, Joanna, Baldock, Holly, Gkantalis, Jim, Roulstone, Victoria, Kyula, Joan, Burley, Amy, Hubbard, Lisa, Pedersen, Malin, Smith, Simon A., Clancy-Thompson, Eleanor, Melcher, Alan A., Ono, Masahiro, Rullan, Antonio, and Harrington, Kevin J.

Published
2024
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18. Clinical Manifestations and Genomic Evaluation of Melioidosis Outbreak among Children after Sporting Event, Australia

Author

Smith, Simon, Marquardt, Tonia, Jennison, Amy V., D'Addona, Andrew, Stewart, James, Yarwood, Trent, Ho, Jennifer, Binotto, Enzo, Harris, Julian, Fahmy, Mark, Esmonde, Juliet, Richardson, Megan, Graham, Rikki M.A., Gair, Richard, Ariotti, Lawrence, Preston-Thomas, Annie, Rubenach, Sally, OSullivan, Siobhan, Allen, Darren, Ragh, Thomas, Grayson, Sachjuan, Manoy, Sophie, Warner, Jeffery M., Meumann, Ella M., Robson, Jennifer M., and Hanson, Josh

Subjects
Communicable diseases -- Complications and side effects -- Care and treatment, Pseudomonas infections -- Care and treatment -- Complications and side effects, Health
Abstract

Melioidosis, caused by the environmental gramnegative bacterium Burkholderia pseudomallei, is endemic in northern Australia (1). The most common clinical manifestation of the infection is pneumonia, with or without bacteremia, but [...]

Published
2023
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25. The Impact of Ferric Derisomaltose on Cardiovascular and Noncardiovascular Events in Patients With Anemia, Iron Deficiency, and Heart Failure With Reduced Ejection Fraction

Author

Kalra, Paul, Cowan, Elena, Howe, Serena, Turner, Charlotte, Austin, Rosalynn, Lane, Rebeca, Rogers, Paula, Foley, Paul, Chandrasekaran, Badri, Fraile, Eva, Kyeremeh, Lynsey, Ahmed, Fozia, Petrie, Mark, McGregor, Lorraine, Osmanska, Joanna, Graham, Fraser, Lang, Ninian, Meyer, Barbara, Ahmad, Faheem, Squire, Iain, Fisher, Jude, Kalra, Philip, Summersgill, Christina, Adeniji, Katarzyna, Chinnadurai, Rajkumar, Ludman, Andrew, Massimo, Lisa, Hardman, Clare, Sykes, Daisy, Cowburn, Peter, Frank, Sarah, Smith, Simon, Japp, Alan, Anwar, Mohamed, Whittington, Beth, Seed, Alison, Ray, Robin, Sookhoo, Vennessa, Al-Mohammad, Abdallah, Middle, Janet, Housley, Kay, Clark, Andrew, Bulemfu, Jeanne, Critoph, Christopher, Chong, Victor, Wood, Stephen, Szwejkowski, Benjamin, Lang, Chim, Duff, Jackie, MacDonald, Susan, Schiff, Rebekah, Donnelly, Patrick, Nageh, Thuraia, Kunhunny, Swapna, Gardner, Roy, McAdam, Marion, McPherson, Elizabeth, Banerjee, Prithwish, Sear, Eleanor, Edwards, Nigel, Glover, Jason, Pellicori, Pierpaolo, Murphy, Clare, Cooke, Justin, Spencer, Charles, Francis, Mark, Matthews, Iain, McKie, Hayley, Marshall, Andrew, Large, Janet, Stratford, Jenny, Clifford, Piers, Tavares, Sara, Boos, Christopher, Keeling, Philip, Hughes, Debbie, Wong, Aaron, Jones, Deborah, James, Alex, Williams, Rhys, Leslie, Stephen, Finlayson, Jim, Hannah, Andrew, Campbell, Philip, Walsh, John, Quinn, Jane, Chapman, Callum, Piper, Susan, Gupta, Preeti, Sim, Victor, Knibbs, Lucy, Lyons, Kristopher, Dixon, Lana, Petrie, Colin, Wong, Yuk-ki, Labinjoh, Catherine, Duckett, Simon, Massey, Ian, Savage, Henry, Matias, Sofia, Ramirez, Jonaifah, Manisty, Charlotte, Hussain, Ifza, Sankaranarayanan, Rajiv, Davis, Gershan, McClure, Samuel, Baxter, John, Wicks, Eleanor, Sobolewska, Jolanta, Murphy, Jerry, Elzayat, Ahmed, Cooke, Alastair, Wright, Jay, Williams, Simon, Muthumala, Amal, Chaggar, Parminder, Ellis, Gethin, Welch, Mandie, Bulugahapitiya, Sudantha, Jackson, Thomas, Pakrashi, Tapesh, Bakhai, Ameet, Gamma, Reto, Ellery, Susan, Jenkins, Geraint, Nightingale, Angus, Thomson, Elizabeth, Ford, Ian, Robertson, Michele, Greenlaw, Nicola, Wetherall, Kirsty, Clarke, Ross, Graham, Christopher, Kean, Sharon, Stevenson, Alan, Wilson, Robbie, Boyle, Sarah, McHugh, John, Hall, Lisa, Woollard, Joanne, Brunton, Claire, Dinnett, Eleanor, Reid, Amanda, Nicholls, Jill, Cunnington, Anna, Douglas, Elizabeth, Fegen, Margaret, Jones, Marc, McGowan, Sheila, Ross, Barbara, Sandu, Pamela, Surtees, Pamela, Stuart, Debra, Cleland, John G.F., Ahmed, Fozia Z., Cowburn, Peter J., Critoph, Chris, Kalra, Philip A., Lane, Rebecca E., Petrie, Mark C., Robertson, Michelle, and Kalra, Paul R.

Published
2024
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30. Durable responses to ATR inhibition with ceralasertib in tumors with genomic defects and high inflammation

Author

Dillon, Magnus T., Guevara, Jeane, Mohammed, Kabir, Patin, Emmanuel C., Smith, Simon A., Dean, Emma, Jones, Gemma N., Willis, Sophie E., Petrone, Marcella, Silva, Carlos, Thway, Khin, Bunce, Catey, Roxanis, Ioannis, Nenclares, Pablo, Wilkins, Anna, McLaughlin, Martin, Jayme-Laiche, Adoracion, Benafif, Sarah, Nintos, Georgios, Kwatra, Vineet, Grove, Lorna, Mansfield, David, Proszek, Paula, Martin, Philip, Moore, Luiza, Swales, Karen E., Banerji, Udai, Saunders, Mark P., Spicer, James, Forster, Martin D., and Harrington, Kevin J.

Subjects
Tumors -- Drug therapy -- Genetic aspects, Inflammation -- Drug therapy -- Genetic aspects, Health care industry
Abstract

BACKGROUND. Phase 1 study of ATR inhibition alone or with radiation therapy (PATRIOT) was a first-in-human phase I study of the oral ATR (ataxia telangiectasia and Rad3-related) inhibitor ceralasertib (AZD6738) in advanced solid tumors. METHODS. The primary objective was safety. Secondary objectives included assessment of antitumor responses and pharmacokinetic (PK) and pharmacodynamic (PD) studies. Sixty-seven patients received 20-240 mg ceralasertib BD continuously or intermittently (14 of a 28-day cycle). RESULTS. Intermittent dosing was better tolerated than continuous, which was associated with dose-limiting hematological toxicity. The recommended phase 2 dose of ceralasertib was 160 mg twice daily for 2 weeks in a 4-weekly cycle. Modulation of target and increased DNA damage were identified in tumor and surrogate PD. There were 5 (8%) confirmed partial responses (PRs) (40-240 mg BD), 34 (52%) stable disease (SD), including 1 unconfirmed PR, and 27 (41%) progressive disease. Durable responses were seen in tumors with loss of AT-rich interactive domain-containing protein 1A (ARID1A) and DNA damageresponse defects. Treatment-modulated tumor and systemic immune markers and responding tumors were more immune inflamed than nonresponding. CONCLUSION. Ceralasertib monotherapy was tolerated at 160 mg BD intermittently and associated with antitumor activity. TRIAL REGISTRATION. Clinicaltrials.gov: NCT02223923, EudraCT: 2013-003994-84. FUNDING. Cancer Research UK, AstraZeneca, UK Department of Health (National Institute for Health Research), Rosetrees Trust, Experimental Cancer Medicine Centre., Introduction ATR (ataxia telangiectasia and Rad3-related) is a critical kinase in the DNA damage response (DDR) (1, 2). Preclinical data have identified multiple cancer-related phenotypes sensitizing tumor cells to monotherapy [...]

Published
2024
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34. Stimulus Business Writing: Using Case Studies and Reports in a Cross-Cultural Virtual Exchange

Author

Smith, Simon

Abstract

We evaluate the use of a Virtual Exchange (VE) writing task, Stimulus Writing, which we assigned to groups of UK and Finnish business students. There were two learner cohorts in the study: one in the UK (mainly Chinese students), the other in Finland (mainly Finns). The Finnish students wrote authentic case studies about Nordic businesses, while the students in the UK adopted our Stimulus Writing approach to write a report based on a case study given to them by the Finnish students. In Smith & Keng (2017) we reported on the experiences of the Finnish students in the collaboration. In this study, we examine the perceptions of the UK-based Chinese students. They found the approach motivating, and believed that through it their academic English skills improved, as did their understanding of business and culture.

Published
2022
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36. Chinese Segmentation and Collocation: A Platform for Blended Learning

Author

Smith, Simon

Abstract

Mandarin Chinese is an increasingly popular world language and object of study, and while there are numerous online character learning apps and flashcard systems, very little research has been done on inductive or autonomous learning in the realm of collocation acquisition. I propose a new Chinese implementation of a trusted corpus-based platform, currently available for English and several other languages, accompanied and enhanced by an adaptive approach to Chinese segmentation approach, whereby different ways of carving up a given sentence are selectively displayed to the learner. [For the complete volume, "Flipping the Blend through MOOCs, MALL and OIL--New Directions in CALL," see ED585277.]

Published
2018

37. Flipping the Blend through MOOCs, MALL and OIL--New Directions in CALL

Author

Research-publishing.net (France), Orsini-Jones, Marina, Smith, Simon, Orsini-Jones, Marina, Smith, Simon, and Research-publishing.net (France)

Abstract

This book presents a snapshot of innovative blended learning practices that either stem from the affordances of web 2.0 technologies--Mobile Assisted Language Learning (MALL) and Massive Open Online Courses (MOOCs)--or illustrate the re-purposing of 'older' ones, like the creation of tailor-made virtual learning environments, to set up telecollaborative projects or Online International Learning (OIL) projects. It is based on the papers presented at the Blending MOOCs into English Language Teacher Training (B-MELTT): Flipping the Blend through MALL, MOOCs, and (Blended) OIL?--?New Directions in CALL symposium held at Coventry University in June 2017. The symposium was supported by funding by a British Council English Language Teaching Research Award (ELTRA). The work presented in this volume can provide some ideas on pedagogically sound ways of blending technology into higher education curriculums to enhance both the digital literacy and the intercultural awareness of all stakeholders involved. Following notes on contributors, acknowledgments, the dedication and preface, this volume contains the following papers: (1) Mobile assistance for personal learning on a massive scale (Agnes Kukulska-Hulme); (2) MOOCs as a new technology: Approaches to normalising the MOOC experience for our learners (Stephen Bax); (3) What our MOOC did next: Embedding, exploiting, and extending an existing MOOC to fit strategic purposes and priorities (Kate Borthwick); (4) Integrating a MOOC into the MA curriculum: An 'expert' student's reflections on blended learning (Minh Tuan Phi); (5) Understanding learner autonomy through MOOC-supported blended learning environments: An investigation into Chinese MA ELT students' beliefs (Yan Jiao); (6) OIL for English for business: The intercultural product pitch (Andrew Preshous, An Ostyn, and Nicole Keng); (7) A role-reversal model of telecollaborative practice: The student-driven and student-managed FloCo (Elwyn Lloyd, Abraham Cerveró-Carrascosa, and Courtney Green); (8) Chinese segmentation and collocation: A platform for blended learning (Simon Smith); and (9) Student-teachers' beliefs concerning the usability of digital flashcards in ELT (Marwa Alnajjar and Billy Brick). An author index is included. Individual papers contain references.

Published
2018

43. Intravenous ferric derisomaltose in patients with heart failure and iron deficiency in the UK (IRONMAN): an investigator-initiated, prospective, randomised, open-label, blinded-endpoint trial

Author

Kalra, Paul R, Cleland, John GF, Petrie, Mark C, Thomson, Elizabeth A, Kalra, Philip A, Squire, Iain B, Ahmed, Fozia Z, Al-Mohammad, Abdallah, Cowburn, Peter J, Foley, Paul WX, Graham, Fraser J, Japp, Alan G, Lane, Rebecca E, Lang, Ninian N, Ludman, Andrew J, Macdougall, Iain C, Pellicori, Pierpaolo, Ray, Robin, Robertson, Michele, Seed, Alison, Ford, Ian, Boon, Nicholas, Amoils, Shannon, Chapman, Callum, Diness, Thomas G, McMurray, John, Mindham, Richard, Sandu, Pamela, Strom, Claes C, Travers, Maureen, Wilcox, Robert, Struthers, Allan, Mark, Patrick, Weir, Christopher, Cowan, Elena, Turner, Charlotte, Austin, Rosalynn, Rogers, Paula, Chandrasekaran, Badri, Fraile, Eva, Kyeremeh, Lynsey, McGregor, Lorraine, Osmanska, Joanna, Meyer, Barbara, Ahmad, Faheem, Fisher, Jude, Summersgill, Christina, Adeniji, Katarzyna, Chinnadurai, Rajkumar, Massimo, Lisa, Hardman, Clare, Sykes, Daisy, Frank, Sarah, Smith, Simon, Anwar, Mohamed, Whittington, Beth, Sookhoo, Vennessa, Lyons, Sinead, Middle, Janet, Housley, Kay, Clark, Andrew, Bulemfu, Jeanne, Critoph, Christopher, Chong, Victor, Wood, Stephen, Szwejkowski, Benjamin, Lang, Chim, Duff, Jackie, MacDonald, Susan, Schiff, Rebekah, Donnelly, Patrick, Nageh, Thuraia, Kunhunny, Swapna, Gardner, Roy, McAdam, Marion, McPherson, Elizabeth, Banerjee, Prithwish, Sear, Eleanor, Edwards, Nigel, Glover, Jason, Murphy, Clare, Cooke, Justin, Spencer, Charles, Francis, Mark, Matthews, Iain, McKie, Hayley, Marshall, Andrew, Large, Janet, Stratford, Jenny, Clifford, Piers, Boos, Christopher, Keeling, Philip, Hughes, Debbie, Wong, Aaron, Jones, Deborah, James, Alex, Williams, Rhys, Leslie, Stephen, Finlayson, Jim, Hannah, Andrew, Campbell, Philip, Walsh, John, Quinn, Jane, Piper, Susan, Patale, Sheetal, Gupta, Preeti, Sim, Victor, Knibbs, Lucy, Lyons, Kristopher, Dixon, Lana, Petrie, Colin, Wong, Yuk-ki, Labinjoh, Catherine, Duckett, Simon, Massey, Ian, Savage, Henry, Matias, Sofia, Ramirez, Jonaifah, Manisty, Charlotte, Hussain, Ifza, Sankaranarayanan, Rajiv, Davis, Gershan, McClure, Samuel, Baxter, John, Wicks, Eleanor, Sobolewska, Jolanta, Murphy, Jerry, Elzayat, Ahmed, Cooke, Alastair, Wright, Jay, Williams, Simon, Muthumala, Amal, Chaggar, Parminder, Webber, Sue, Ellis, Gethin, Welch, Mandie, Bulugahapitiya, Sudantha, Jackson, Thomas, Pakrashi, Tapesh, Bakhai, Ameet, Krishnamurthy, Vinodh, Gamma, Reto, Ellery, Susan, Jenkins, Geraint, Thomas, Gladdys, Nightingale, Angus, Greenlaw, Nicola, Wetherall, Kirsty, Clarke, Ross, Graham, Christopher, Kean, Sharon, Stevenson, Alan, Wilson, Robbie, Boyle, Sarah, McHugh, John, Hall, Lisa, Woollard, Joanne, Brunton, Claire, Dinnett, Eleanor, Reid, Amanda, Howe, Serena, Nicholls, Jill, Cunnington, Anna, Douglas, Elizabeth, Fegen, Margaret, Jones, Marc, McGowan, Sheila, Ross, Barbara, Surtees, Pamela, Stuart, Debra, Cleland, John G F, and Foley, Paul W X

Published
2022
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45. HER2-enriched subtype and novel molecular subgroups drive aromatase inhibitor resistance and an increased risk of relapse in early ER+/HER2+ breast cancer

Author

Evans, Abigail, Ball, Adrian, Johri, Akhil, Nejim, Ali, Jones, Alison, Corder, Allan, Thorne, Amanda, Anand, Ambika, Chakrabarti, Amitabha, Robinson, Anne, Skene, Anthony, Modi, Anupam, Patel, Ashraf, Kothari, Ashutosh, McFall, Brendan, Mortimer, Caroline, Lee, Caroline, Chan, Charlie, Abson, Charlotte, Holcombe, Christopher, Hinton, Christopher, Hollywood, Ciaran, Murphy, Claire, Crowley, Clare, Harding-Mackean, Claudia, Griffith, Clive, Lewanski, Conrad, Rea, Daniel, Hwang, David, Crawford, Derek, Thekkinkattil, Dinesh, Ferguson, Douglas, Adamson, Douglas, Wheatley, Duncan, Ravichandran, Duraisamy, Babu, Ed, Hyett, Elaine, Ashkanani, Fawzia, Hoar, Fiona, Kenny, Frances, Dyke, Gary, Sparrow, Geoffrey, Gilbert, Cunnick, Giles, Algurafi, Hafiz, Sweetland, Helen, Prof, Highes-Davies, Hamed, Hisham, Smith, Ian, Laidlaw, Ian, Khattak, Ilyas, Newby, Jacqueline, Rees-Lee, Jacqueline, Kokan, Jalal, Barrett, Jane, Naik, Jay Dolatrai, Vaidya, Jayant, Forrest, Jennifer, Parmar, Jitendra, Adams, Jocelyn, Fox, John, Roberts, Jonathan, Dawson, Jonathan, Doughty, Julie, Donnelly, Jull, Dunn, Kathleen, Chin, Kian, Horgan, Kieran, Thakur, Kislaya, Barthelmes, Ludger, Wyld, Lynda, Bhattacharyya, Madhumita, Hadaki, Maher, Kishore, Makam, Ornstein, Marcus, Bramley, Maria, Bews-Hair, Maria, Parton, Marina, Sibbering, Mark, Kissin, Mark, Churn, Mark, Hogg, Martin, Quigley, Mary, Hatton, Matthew, Winter, Matthew, Adelekan, Matthew, Shere, Michael, Carr, Michael, Williams, Michael, Absar, Mohammed, Sharif, Muhammad, Kelleher, Muireann, Walji, Nawaz, Williams, Nicholas, Gallegos, Nicholas, Bundred, Nigel, Hatcher, Olivia, Crellin, Perric, Crane, Peter, Donnelly, Peter, Kneeshaw, Peter, Walker, Philip, Sinha, Prakash, Bhaskar, Pudhupalayam, Soulsby, Racheal, Todd, Radha, Vidya, Raghavan, Mehra, Rakesh, Prasad, Ramachandran, Cutress, Ramsay, Sharma, Ravi, Roylance, Rebecca, Goranova, Rebecca, Salman, Reem Ramzi, Bonom, Riccardo, Johnson, Richard, Sutton, Richard, Linforth, Rick, Coleman, Rob, Grieve, Robert, Leonard, Robert, Reichert, Robert, Kennedy, Robert, Agarwal, Roshan, Allerton, Rozenn, Burcombe, Russell, Davis, Ruth, Narayanan, Sankaran, Chandrasekharan, Sankaran, Vesty, Sarah, Seetharam, Seema, Ledwidge, Serena, Iqbal, Shabana, Wahee, Shamaela, Silva, Shobha, Pain, Simon, Holt, Simon, Thomson, Simon, Smith, Simon, Ellenbogen, Simon, Laws, Siobhan, Chan, Stephen, Johnston, Stephen, Holt, Steve, Thrush, Steven, McIntosh, Stuart, Chatterjee, Sumohan, Cleator, Susan, Usman, Tamoor, Johnson, Tayo, Kovacs, Tibor, Irvine, Tracey, Barthkur, Urmila, Pope, Vanessa, Brown, Victoria Alexandra, Muralikrishna, Vummiti, Samra, Walid, Maxwell, William, Winters, Zoe, Bergamino, Milana A., López-Knowles, Elena, Morani, Gabriele, Tovey, Holly, Kilburn, Lucy, Schuster, Eugene F., Alataki, Anastasia, Hills, Margaret, Xiao, Hui, Holcombe, Chris, Robertson, John F., Smith, Ian E., Bliss, Judith M., Dowsett, Mitch, and Cheang, Maggie C.U.

Published
2022
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