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Your search keyword '"Snijders, Peter J. F."' showing total 213 results
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2. p16/Ki-67 dual-stained cytology for detecting cervical (pre)cancer in a HPV-positive gynecologic outpatient population

Author

Luttmer, Roosmarijn, Dijkstra, Maaike G, Snijders, Peter J F, Berkhof, Johannes, van Kemenade, Folkert J, Rozendaal, Lawrence, Helmerhorst, Theo J M, Verheijen, René H M, ter Harmsel, W Abraham, van Baal, W Marchien, Graziosi, Peppino G C M, Quint, Wim G V, Spruijt, Johan W M, van Dijken, Dorenda K E, Heideman, Daniëlle A M, and Meijer, Chris J L M

Published
2016
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4. Triage by methylation-marker testing versus cytology in women who test HPV-positive on self-collected cervicovaginal specimens (PROHTECT-3): a randomised controlled non-inferiority trial

Author

Verhoef, Viola M J, Bosgraaf, Remko P, van Kemenade, Folkert J, Rozendaal, Lawrence, Heideman, Daniëlle A M, Hesselink, Albertus T, Bekkers, Ruud L M, Steenbergen, Renske D M, Massuger, Leon F A G, Melchers, Willem J G, Bulten, Johan, Overbeek, Lucy I H, Berkhof, Johannes, Snijders, Peter J F, and Meijer, Chris J L M

Published
2014
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11. DNA hypermethylation analysis in sputum of asymptomatic subjects at risk for lung cancer participating in the NELSON trial: argument for maximum screening interval of 2 years

Author

Hubers, A Jasmijn, Heideman, Daniëlle A M, Duin, Sylvia, Witte, Birgit I, de Koning, Harry J, Groen, Harry J M, Prinsen, Clemens F M, Bolijn, Anne S, Wouters, Mandy, van der Meer, Susanne E, Steenbergen, Renske D M, Snijders, Peter J F, Uyterlinde, Anne, Berkhof, Hans, Smit, Egbert F, and Thunnissen, Erik

Published
2017
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34. DNA Copy Number Alterations in Endobronchial Squamous Metaplastic Lesions Predict Lung Cancer

Author

van Boerdonk, Robert A. A., Sutedja, Thomas G., Snijders, Peter J. F., Reinen, Emilie, Wilting, Saskia M., van de Wiel, Mark A., Thunnissen, (Erik) F. B. J. M., Duin, Sylvia, Kooi, Clarissa, Ylstra, Bauke, Meijer, Chris J. L. M., Meijer, Gerrit A., Grünberg, Katrien, Daniels, Johannes M. A., Postmus, Pieter E., Smit, Egbert F., and Heideman, Daniëlle A. M.

Published
2011
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41. Human Papillomavirus and Oral Cancer: The International Agency for Research on Cancer Multicenter Study

Author

Herrero, Rolando, Castellsagué, Xavier, Pawlita, Michael, Lissowska, Jolanta, Kee, Frank, Balaram, Prabda, Rajkumar, Thangarajan, Sridhar, Hema, Rose, Barbara, Pintos, Javier, Fernández, Leticia, Idris, Ali, Sánchez, María José, Nieto, Adoración, Talamini, Renato, Tavani, Alessandra, Bosch, F. Xavier, Reidel, Ulrich, Snijders, Peter J. F., Meijer, Chris J. L. M., Viscidi, Raphael, Muñoz, Nubia, and Franceschi, Silvia

Published
2003

44. Virological and Serological Predictors of Anal High-grade Squamous Intraepithelial Lesions Among Human Immunodeficiency Virus–positive Men Who Have Sex With Men.

Author

Marra, Elske, Heukelom, Matthijs L Siegenbeek van, Leeman, Annemiek, Waterboer, Tim, Meijer, Chris J L M, Snijders, Peter J F, King, Audrey J, Cairo, Irina, Eeden, Arne van, Brokking, Wilma, van der Weele, Pascal, Quint, Wim, Prins, Jan M, Vries, Henry J C de, and Loeff, Maarten F Schim van der

Subjects
BIOPSY, HIV-positive persons, LONGITUDINAL method, PAPILLOMAVIRUSES, RESEARCH funding, SEROLOGY, SQUAMOUS cell carcinoma, VIROLOGY, LOGISTIC regression analysis, VIRAL load, HIV seroconversion, MEN who have sex with men, DESCRIPTIVE statistics, GENOTYPES, ANAL intraepithelial neoplasia
Abstract

Background Our objective was to identify virological and serological predictors of anal high-grade squamous intraepithelial lesions (HSIL) in human immunodeficiency virus (HIV)-positive men who have sex with men (MSM). Methods HIV-positive MSM were recruited from a longitudinal study during which anal self-swabs and serum were collected at up to 5 bi-annual visits. Swabs were human papillomavirus (HPV) genotyped, and the type-specific HPV viral load in the anal swabs was determined. Serum antibodies to the E6, E7, E1, E2, and L1 proteins of 7 high-risk HPV (hrHPV) types and HPV6 and 11 were analyzed. The participants who had a high-resolution anoscopy after the last study visit were included in the current analysis. Anal HSIL was diagnosed by histopathological examinations of anal biopsies. The causative HPV type of anal HSIL was determined in whole tissue sections (WTS) and by laser capture micro-dissection if more than one HPV-type was found in WTS. Multivariable logistic regression was used to study whether persistent anal HPV infections, HPV viral loads, and seropositivity for HPV were predictors of anal HSIL, either in general or caused by the concordant HPV type. Results Of 193 HIV-positive MSM, 50 (26%) were diagnosed with anal HSIL. HrHPV persistence in anal swabs was common, varying by hrHPV type between 3–21%. Anal HPV persistence was the only determinant independently associated with anal HSIL, both in general and by concordant, causative HPV type. Conclusions Persistent HPV infections were strongly associated with anal HSIL, in general as well as for the concordant HPV type. [ABSTRACT FROM AUTHOR]

Published
2019
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45. Three-tiered score for Ki-67 and p16ink4a improves accuracy and reproducibility of grading CIN lesions.

Author

van Zummeren, Marjolein, Leeman, Annemiek, Kremer, Wieke W., Bleeker, Maaike C. G., Jenkins, David, de Sandt, Miekel van, Heideman, Daniëlle A. M., Steenbergen, Renske, Snijders, Peter J. F., Quint, Wim G. V., Berkhof, Johannes, and Meijer, Chris J. L. M.

Subjects
CERVICAL intraepithelial neoplasia, CERVIX uteri diseases, IMMUNOHISTOCHEMISTRY, IMMUNOCHEMISTRY, IMMUNOSTAINING
Published
2018
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46. Cervical cancer risk in HPV‐positive women after a negative FAM19A4/mir124‐2 methylation test: A post hoc analysis in the POBASCAM trial with 14 year follow‐up.

Author

De Strooper, Lise M. A., Berkhof, Johannes, Steenbergen, Renske D. M., Lissenberg‐Witte, Birgit I., Snijders, Peter J. F., Meijer, Chris J. L. M., and Heideman, Daniëlle A. M.

Abstract

DNA methylation analysis of cervical scrapes using FAM19A4 and mir124‐2 genes has shown a good clinical performance in detecting cervical cancer and advanced CIN lesions in need of treatment in HPV‐positive women. To date, longitudinal data on the cancer risk of methylation test‐negative women are lacking. In our study, we assessed the longitudinal outcome of FAM19A4/mir124‐2 methylation analysis in an HPV‐positive screening cohort with 14 years of follow‐up. Archived HPV‐positive cervical scrapes of 1,040 women (age 29–61 years), who were enrolled in the POBASCAM screening trial (ISRCTN20781131) were tested for FAM19A4/mir124‐2 methylation. By linkage with the nationwide network and registry of histo‐ and cytopathology in the Netherlands (PALGA), 35 cervical cancers were identified during 14 years of follow‐up comprising three screens (baseline, and after 5 and 10 years). The baseline scrape of 36.1% (n = 375) women tested positive for FAM19A4/mir124‐2 methylation, including 24 women with cervical cancer in follow‐up, and 30.6% (n = 318) had abnormal cytology (threshold borderline dyskaryosis or ASCUS), including 14 women with cervical cancer in follow‐up. Within screening round capability of FAM19A4/mir124‐2 methylation to detect cervical cancer was 100% (11/11, 95% CI: 71.5–100). Kaplan–Meier estimate of 14‐year cumulative cervical cancer incidence was 1.7% (95% CI: 0.66–3.0) among baseline methylation‐negative and 2.4% (95% CI: 1.4–3.6) among baseline cytology‐negative women (risk difference: 0.71% [95% CI: 0.16–1.4]). In conclusion, a negative FAM19A4/mir124‐2 methylation test provides a low cervical cancer risk in HPV‐positive women of 30 years and older. FAM19A4/mir124‐2 methylation testing merits consideration as an objective triage test in HPV‐based cervical screening programs. [ABSTRACT FROM AUTHOR]

Published
2018
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47. Molecular heterogeneity in human papillomavirus‐dependent and ‐independent vulvar carcinogenesis.

Author

Swarts, Dorian R. A., Voorham, Quirinus J. M., van Splunter, Annina P., Wilting, Saskia M., Sie, Daoud, Pronk, Divera, van Beurden, Marc, Heideman, Daniëlle A. M., Snijders, Peter J. F., Meijer, Chris J. L. M., Steenbergen, Renske D. M., and Bleeker, Maaike C. G.

Subjects
VULVAR cancer, SQUAMOUS cell carcinoma, PAPILLOMAVIRUSES, CARCINOGENESIS, DNA copy number variations, CLINICAL pathology
Abstract

Abstract: Vulvar squamous cell carcinoma (VSCC) and precancerous vulvar intraepithelial neoplasia (VIN) can develop through human papillomavirus (HPV)‐dependent and ‐independent pathways, indicating a heterogeneous disease. Only a minority of VIN progress, but current clinicopathological classifications are insufficient to predict the cancer risk. Here we analyzed copy number alterations (CNA) to assess the molecular heterogeneity of vulvar lesions in relation to HPV and cancer risk. HPV‐status and CNA by means of whole‐genome next‐generation shallow‐sequencing were assessed in VSCC and VIN. The latter included VIN of women with associated VSCC (VINVSCC) and women who did not develop VSCC during follow‐up (VINnoVSCC). HPV‐testing resulted in 41 HPV‐positive (16 VINVSCC, 14 VINnoVSCC, and 11 VSCC) and 24 HPV‐negative (11 VINVSCC and 13 VSCC) lesions. HPV‐positive and ‐negative VSCC showed a partially overlapping pattern of recurrent CNA, including frequent gains of 3q and 8q. In contrast, amplification of 11q13/cyclinD1 was exclusively found in HPV‐negative lesions. HPV‐negative VINVSCC had less CNA than HPV‐negative VSCC (P = .009), but shared chromosome 8 alterations. HPV‐positive VINnoVSCC had less CNA than VINVSCC (P = .022). Interestingly, 1pq gain was detected in 81% of HPV‐positive VINVSCC and only in 21% of VINnoVSCC (P = .001). In conclusion, HPV‐dependent and ‐independent vulvar carcinogenesis is characterized by distinct CNA patterns at the VIN stage, while more comparable patterns are present at the cancer stage. Cancer risk in VIN seems to be reflected by the extent of CNA, in particular chromosome 1 gain in HPV‐positive cases. [ABSTRACT FROM AUTHOR]

Published
2018
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48. Detection of hypermethylated genes as markers for cervical screening in women living with HIV.

Author

Kremer, Wieke W., Van Zummeren, Marjolein, Novianti, Putri W., Richter, Karin L., Verlaat, Wina, Snijders, Peter J. F., Heideman, Daniëlle A. M., Steenbergen, Renske D. M., Dreyer, Greta, and Meijer, Chris J. L. M.

Subjects
CERVICAL cancer diagnosis, CERVICAL cancer, CERVICAL intraepithelial neoplasia, HIV-positive women, MEDICAL virology
Abstract

Abstract: Introduction: To evaluate the performance of hypermethylation analysis of ASCL1, LHX8 and ST6GALNAC5 in physician‐taken cervical scrapes for detection of cervical cancer and cervical intraepithelial neoplasia (CIN) grade 3 in women living with HIV (WLHIV) in South Africa. Methods: Samples from a prospective observational cohort study were used for these analyses. Two cohorts were included: a cohort of WLHIV who were invited for cervical screening (n = 321) and a gynaecologic outpatient cohort of women referred for evaluation of abnormal cytology or biopsy proven cervical cancer (n = 108, 60% HIV seropositive). Cervical scrapes collected from all subjects were analysed for hypermethylation of ASCL1, LHX8 and ST6GALNAC5 by multiplex quantitative methylation specific PCR (qMSP). Histology endpoints were available for all study subjects. Results: Hypermethylation levels of ASCL1, LHX8 and ST6GALNAC5 increased with severity of cervical disease. The performance for detection of CIN3 or worse (CIN3+) as assessed by the area under the receiver operating characteristic (ROC) curves (AUC) was good for ASCL1 and LHX8 (AUC 0.79 and 0.81 respectively), and moderate for ST6GALNAC5 (AUC 0.71). At a threshold corresponding to 75% specificity, CIN3+ sensitivity was 72.1% for ASCL1 and 73.8% for LHX8 and all samples from women with cervical cancer scored positive for these two markers. Conclusions: Hypermethylation analysis of ASCL1 or LHX8 in cervical scrape material of WLHIV detects all cervical carcinomas with an acceptable sensitivity and good specificity for CIN3+, warranting further exploration of these methylation markers as a stand‐alone test for cervical screening in low‐resource settings. [ABSTRACT FROM AUTHOR]

Published
2018
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49. Host-cell DNA methylation patterns during high-risk HPV-induced carcinogenesis reveal a heterogeneous nature of cervical pre-cancer.

Author

Verlaat, Wina, Van Leeuwen, Robert W., Novianti, Putri W., Schuuring, Ed, Meijer, Chris J. L. M., Van Der Zee, Ate G. J., Snijders, Peter J. F., Heideman, Daniëlle A. M., Steenbergen, Renske D. M., and Wisman, G. Bea A.

Abstract

Cervical cancer development following a persistent infection with high-risk human papillomavirus (hrHPV) is driven by additional host-cell changes, such as altered DNA methylation. In previous studies, we have identified 12 methylated host genes associated with cervical cancer and pre-cancer (CIN2/3). This study systematically analyzed the onset and DNA methylation pattern of these genes during hrHPV-induced carcinogenesis using a longitudinal in vitro model of hrHPV-transformed cell lines (n = 14) and hrHPV-positive cervical scrapings (n = 113) covering various stages of cervical carcinogenesis. DNA methylation analysis was performed by quantitative methylation-specific PCR (qMSP) and relative qMSP values were used to analyze the data. The majority of genes displayed a comparable DNA methylation pattern in both cell lines and clinical specimens. DNA methylation onset occurred at early or late immortal passage, and DNA methylation levels gradually increased towards tumorigenic cells. Subsequently, we defined a so-called cancer-like methylation-high pattern based on the DNA methylation levels observed in cervical scrapings from women with cervical cancer. This cancer-like methylation-high pattern was observed in 72% (38/53) of CIN3 and 55% (11/20) of CIN2, whereas it was virtually absent in hrHPV-positive controls (1/26). In conclusion, hrHPV-induced carcinogenesis is characterized by early onset of DNA methylation, typically occurring at the pre-tumorigenic stage and with highest DNA methylation levels at the cancer stage. Host-cell DNA methylation patterns in cervical scrapings from women with CIN2 and CIN3 are heterogeneous, with a subset displaying a cancer-like methylation-high pattern, suggestive for a higher cancer risk. [ABSTRACT FROM AUTHOR]

Published
2018
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50. HPV-positive women with normal cytology remain at increased risk of CIN3 after a negative repeat HPV test.

Author

Polman, Nicole J, Veldhuijzen, Nienke J, Heideman, Daniëlle A M, Snijders, Peter J F, Meijer, Chris J L M, Berkhof, Johannes, and Heideman, Daniëlle A M

Abstract

Background: In human papillomavirus (HPV)-based screening, a repeat HPV test is often recommended for HPV-positive women with normal cytology (HPV-pos/cyt-neg), but its absolute risk of cervical precancer (CIN3+) over two screening rounds needs to be assessed.Methods: We compared the 5-year risk of HPV infection and CIN3+ in HPV-pos/cyt-neg women with a negative repeat HPV test to the risk in HPV-negative women with normal cytology (double negatives) in the POBASCAM cohort. We obtained histology data from the Dutch pathology registry (PALGA).Results: Human papillomavirus infection risk was 20.4% (19 of 93) in HPV-pos/cyt-neg, repeat HPV-negative women and 3.2% (294 of 9186; P<0.001) in double negatives. Corresponding CIN3+ risks were 2.0% (4 of 199) and 0.2% (41 of 18 562; P<0.001). Infection risks were also increased in type-specific analyses of HPV16, 31, 33, 39, 52, 56 and 58.Conclusions: HPV-pos/cyt-neg women continue to have an increased CIN3+ risk, also when the repeat HPV test is negative. Therefore, intervals in primary HPV screening should be determined separately for HPV-positive and -negative women. [ABSTRACT FROM AUTHOR]

Published
2017
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