32 results on '"Stephen Contag"'
Search Results
2. Population based cohort study of fetal deaths, and neonatal and perinatal mortality at term within a Somali diaspora
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Stephen Contag, Rahel Nardos, Irina A. Buhimschi, and Jennifer Almanza
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Fetal ,Stillbirth ,Neonatal ,Death ,Perinatal ,Mortality ,Gynecology and obstetrics ,RG1-991 - Abstract
Abstract Background Somali women deliver at greater gestational age with limited information on the associated perinatal mortality. Our objective is to compare perinatal mortality among Somali women with the population rates. Methods This is a retrospective cohort study from all births that occurred in Minnesota between 2011 and 2017. Information was obtained from certificates of birth, and neonatal and fetal death. Data was abstracted from 470,550 non-anomalous births ≥37 and ≤ 42 weeks of gestation. The study population included U.S. born White, U.S. born Black, women born in Somalia or self-identified as Somali, and women who identified as Hispanic regardless of place of birth (377,426). We excluded births 42 weeks, > 1 fetus, age 45 years, or women of other ethnicities. The exposure was documented ethnicity or place of birth, and the outcomes were live birth, fetal death, neonatal death prior to 28 days, and perinatal mortality rates. These were calculated using binomial proportions with 95% confidence intervals and compared using odds ratios adjusted (aOR) for diabetes, hypertension and maternal body mass index. Results The aOR [95%CI] for stillbirth rate in the Somali cohort was greater than for U.S. born White (2.05 [1.49–2.83]) and Hispanic women (1.90 [1.30–2.79]), but similar to U.S. born Black women (0.88 [0.57–1.34]). Neonatal death rates were greater than for U.S. born White (1.84 [1.36–2.48], U.S. born Black women (1.47 [1.04–2.06]) and Hispanic women (1.47 [1.05–2.06]). This did not change after analysis was restricted to those with spontaneous onset of labor. When analyzed by week, at 42 weeks Somali aOR for neonatal death was the same as for U.S. born White women, but compared against U.S. born Black and Hispanic women, was significantly lower. Conclusions The later mean gestational age at delivery among women of Somali ethnicity is associated with greater overall risk for stillbirth and neonatal death rates at term, except compared against U.S. born Black women with whom stillbirth rates were not different. At 42 weeks, Somali neonatal mortality decreased and was comparable to that of the U.S. born White population and was lower than that of the other minorities. more...
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- 2021
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Catalog
3. Catecholaminergic polymorphic ventricular tachycardia in pregnancy: a case report
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Amy Schumer and Stephen Contag
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Inherited arrhythmia ,Cardiovascular disease in pregnancy ,High-risk obstetrics ,Medicine - Abstract
Abstract Introduction Catecholaminergic polymorphic ventricular tachycardia (CPVT) is a genetic disorder that can cause fatal tachyarrhythmias brought on by physical or emotional stress. There is little reported in the literature regarding management of CPVT in pregnancy much less during labor. Case presentation A gravida 2, para 1 presented to our high-risk clinic at 15 weeks gestation with known CPVT. The Caucasian female patient had been diagnosed after experiencing a cardiac arrest following a motor vehicle accident and found to have a pathogenic cardiac ryanodine receptor mutation. An implantable cardioverter defibrillator was placed at that time. Her pregnancy was uncomplicated, and she was medically managed with metoprolol, flecainide, and verapamil. Her labor course and successful vaginal delivery were uncomplicated and involved a multidisciplinary team comprising specialists in electrophysiology, maternal fetal medicine, anesthesiology, general obstetrics, lactation, and neonatology. Conclusions CPVT is likely underdiagnosed and, given that cardiovascular disease is a leading cause of death in pregnancy, it is important to bring further awareness to the diagnosis and management of this inherited arrhythmia syndrome in pregnancy. more...
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- 2020
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4. Influence of Birthweight on the Prospective Stillbirth Risk in the Third Trimester: A Cross-Sectional Cohort Study
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Stephen Contag, Clayton Brown, Sarah Crimmins, and Katherine Goetzinger
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third trimester ,birthweight ,stillbirth ,growth restriction ,prospective risk ,Gynecology and obstetrics ,RG1-991 - Abstract
Abstract Objective The objective of this study was to determine the effect of birthweight on prospective stillbirth risk. Methods Cross-sectional study of singleton births in the United States from 2010 to 2012 from 32 through 42 weeks was conducted. Stillbirth risk was stratified by birthweight and gestational age adjusted for time from death to delivery. The primary outcome was the prospective stillbirth risk for each birthweight category. Student t-test was used for continuous data, chi-square to compare categorical data. Binomial proportions were used to derive prospective and cumulative risks. Cox proportional hazards regression with log–rank test comparison for heterogeneity was used to compare birthweight categories and derive hazard ratios. Results There was an increase in the risk for stillbirth as birthweight diverged from the reference group. At 40 weeks adjusted gestational age, stillbirth rate per 10,000 births for the bottom (6.17, 95% CI: 7.47–4.87) and top (2.37, 95%CI: 3.1–1.65) 5th centiles of birthweight conveyed the highest risk. Hazard ratios (HR) after adjusting for covariates were: 1.55 (1.73–1.4) 95th centile (p more...
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- 2016
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5. Impact of labor induction at 39 weeks gestation compared with expectant management on maternal and perinatal morbidity among a cohort of low-risk women
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Sabrina C. Burn, Ruofan Yao, Maria Diaz, Jordan Rossi, and Stephen Contag
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Risk ,Infant, Newborn ,Infant ,Obstetrics and Gynecology ,Gestational Age ,Stillbirth ,Infant, Newborn, Diseases ,Cohort Studies ,Pregnancy ,Seizures ,Pediatrics, Perinatology and Child Health ,Humans ,Female ,Labor, Induced ,Morbidity ,Watchful Waiting ,Retrospective Studies - Abstract
To determine maternal and perinatal outcomes after induction of labor (IOL) at 39 weeks compared with expectant management.This is a retrospective national cohort study from the National Center for Health Statistics birth database. The study included singleton, low-risk pregnancies with a non-anomalous fetus delivered at 39-42 weeks gestation between 2015 and 2018. Maternal outcomes available included chorioamnionitis (Triple I), blood transfusion, intensive care unit (ICU) admission, uterine rupture, cesarean delivery (CD), and cesarean hysterectomy. Fetal and infant outcomes included stillbirth, 5-min Apgar ≤3, prolonged ventilation, seizures, ICU admission, and death within 28 days. We compared women undergoing IOL at 39 weeks to those managed expectantly. Non-adjusted and adjusted relative risks (aRRs) were estimated using multivariate log-binomial regression analysis.There were 15,900,956 births available for review of which 5,017,524 met inclusion and exclusion criteria. For the maternal outcomes, the IOL group was less likely to require a CD (aRR 0.880; 95% CI [0.874-0.886];IOL at 39 weeks of gestation in a low-risk cohort is associated with a lower risk of CD and maternal infection, stillbirth, and lower neonatal morbidity. There was no effect on the risk for neonatal seizures or death. more...
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- 2021
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6. Obesity and maternal complication trends from 2015-2020
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Beverly C. Tse, Juliane Johnson, Stephen Contag, and Ruofan Yao
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Obstetrics and Gynecology - Published
- 2023
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7. Maternal ADHD and Perinatal Prescription Stimulant Use
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Meena N. Murugappan, Sarah M. Westberg, Stephen Contag, Tanya E. Melnik, Arun Kumar, Abhijeet Rajpurohit, Katie Thorsness, and Joel F. Farley
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Clinical Psychology ,Cross-Sectional Studies ,Prescriptions ,Attention Deficit Disorder with Hyperactivity ,Pregnancy ,Developmental and Educational Psychology ,Humans ,Central Nervous System Stimulants ,Female - Abstract
Objective: To describe patterns and predictors of perinatal prescription stimulant use. Methods: We used MarketScan® commercial claims data (2013–2018) and a repeated cross-sectional study design to assess perinatal use of prescription stimulants. Clinical/demographic characteristics were compared across cohorts of women who continued versus discontinued stimulant treatment at various stages of pregnancy. Associations were tested for significance using chi-square tests (categorical variables) and independent t-tests (continuous variables). Results: Out of 612,001 pregnancies, 15,413 involved pre-pregnancy stimulant use. Of these, stimulant treatment was discontinued prior to conception in 6,416 (42%), discontinued during trimester 1 in 5,977 (39%), and continued into later trimesters in 3,020 (19%). Compared with pregnancies involving stimulant discontinuation prior to conception, those that continued into pregnancy occurred in women who were older (29.9 vs. 28.9 years) and had more severe ADHD (3.1 vs. 1.8 ADHD-related billing claims). Conclusions: There is considerable heterogeneity in the management of ADHD during pregnancy. more...
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- 2022
8. Qualitative analysis of Doppler assessment in the management of isoimmunized women
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Christian Hannah, Stephen Contag, and Katelyn Tessier
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Obstetrics and Gynecology - Published
- 2022
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9. Combinations of risk factors that have equivalent or greater stillbirth risk compared with chronic hypertension
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Priya Chakrabarti, Stephen Contag, Stephanie Hur, and Ruofan Yao
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Obstetrics and Gynecology - Published
- 2022
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10. The effect of maternal age on fetal and neonatal mortality
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S Chaudhary and Stephen Contag
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Adult ,Male ,medicine.medical_specialty ,Adolescent ,Gestational Age ,Risk Assessment ,Young Adult ,03 medical and health sciences ,Age Distribution ,0302 clinical medicine ,Pregnancy ,Risk Factors ,Infant Mortality ,Humans ,Medicine ,030212 general & internal medicine ,Young adult ,Retrospective Studies ,030219 obstetrics & reproductive medicine ,business.industry ,Obstetrics ,Infant, Newborn ,Infant ,Obstetrics and Gynecology ,Gestational age ,Retrospective cohort study ,Odds ratio ,Middle Aged ,Stillbirth ,medicine.disease ,United States ,Infant mortality ,Relative risk ,Pediatrics, Perinatology and Child Health ,Regression Analysis ,Female ,business ,Risk assessment ,Maternal Age - Abstract
Determine the gestational age at which the risk of fetal or neonatal death associated with delaying delivery by 1 week exceeds the risk of neonatal death associated with immediate delivery, stratified by maternal age intervals. We conducted a retrospective cohort study of live births, stillbirths and neonatal deaths that occurred in the United States between 2010 and 2013 using birth data. Women were classified into six age categories. Singleton, non-anomalous pregnancies without hypertensive disease or diabetes were included. Relative risks were obtained using a generalized linear model comparing the rate of death associated with immediate delivery to those of expectant management. For all age groups with the exception of women 44 years and older, immediate delivery was associated with lower relative risk of death by 39 weeks. For more...
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- 2017
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11. Reference Values for Sonographically Estimated Fetal Weight in Twin Gestations Stratified by Chorionicity: A Single Center Study
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Stephen Contag, Sarah Crimmins, and Rinat Gabbay-Benziv
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Gynecology ,medicine.medical_specialty ,Fetus ,Pregnancy ,Percentile ,030219 obstetrics & reproductive medicine ,Radiological and Ultrasound Technology ,Obstetrics ,business.industry ,Gestational age ,Regression analysis ,Single Center ,medicine.disease ,Standard deviation ,03 medical and health sciences ,0302 clinical medicine ,medicine ,Gestation ,Radiology, Nuclear Medicine and imaging ,030212 general & internal medicine ,business - Abstract
Objectives To determine reference values for sonography-based estimated fetal weight (EFW) in twin gestations in one single tertiary medical center in the United States. Methods A retrospective longitudinal analysis of EFW evaluations of fetuses of twin gestations between November 2006 and June 2016. Fetuses with major congenital anomalies or chromosomal abnormalities were excluded. Estimated fetal weight was calculated using the Hadlock 1985 formula. Linear mixed models were used to allow for multiple but inconsistent observations among individuals, and to account for intertwin differences as well as for gender. Reference values were constructed using a best-fit regression model for estimation of mean and standard deviation at each gestational age after normalization of variables. Chorionicity-specific curves were constructed. Results A total of 5515 ultrasound examinations were performed in 2115 twin pregnancies between 24 and 38 weeks of gestation (2.6 ± 4.0 scans/pregnancy). Values corresponding to the 5th, 10th, 50th, 90th, and 95th percentiles for EFW are presented for every gestational age. At 28, 32, and 36 weeks, values were as follows: 855, 1109, and 1363 g; 1351, 1732, and 2294 g; and 1363, 2112, and 2881 g for the 10th, 50th, and 90th percentiles, respectively. Chorionicity-specific curves are presented for comparison with previously published references. Conclusions Reference values for sonographic-based fetal growth are presented for clinical and research use. more...
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- 2017
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12. 727: Neonatal morbidity and mortality associated with induction of labor at 39 weeks versus expectant management
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Sabrina C. Burn, Maria Diaz, Ruofan Yao, Jordan Rossi, and Stephen Contag
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Neonatal morbidity ,medicine.medical_specialty ,Obstetrics ,business.industry ,medicine ,Obstetrics and Gynecology ,Induction of labor ,business ,Expectant management - Published
- 2020
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13. EP19.08: Somali women have lower preterm birth rates than other ethnicities
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Stephen Contag
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Radiological and Ultrasound Technology ,business.industry ,Ethnic group ,Obstetrics and Gynecology ,General Medicine ,Somali ,language.human_language ,Birth rate ,Reproductive Medicine ,language ,Medicine ,Radiology, Nuclear Medicine and imaging ,business ,Demography - Published
- 2019
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14. OP18.04: Reference values for fetal cerebrorenal and cerebroplacental ratios
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Katherine Goetzinger, S. Visentin, E. V. Cosmi, S. Payton, and Stephen Contag
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Fetus ,medicine.medical_specialty ,Reproductive Medicine ,Radiological and Ultrasound Technology ,business.industry ,Obstetrics ,Reference values ,Obstetrics and Gynecology ,Medicine ,Radiology, Nuclear Medicine and imaging ,General Medicine ,business - Published
- 2017
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15. Developmental effect of antenatal exposure to betamethasone on renal angiotensin II activity in the young adult sheep
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Stephen Contag, Jianli Bi, Mark C. Chappell, and James C. Rose
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Male ,medicine.medical_specialty ,Angiotensin receptor ,Pyridines ,Renal Blood Flow, Effective ,Physiology ,medicine.drug_class ,Tetrazoles ,Blood Pressure ,Angiotensin II Type 2 Receptor Blockers ,Lithium ,Kidney ,Betamethasone ,Random Allocation ,Pregnancy ,Internal medicine ,medicine ,Animals ,Infusions, Intra-Arterial ,Glucocorticoids ,Sheep ,Translational Physiology ,Chemistry ,Angiotensin II ,Biphenyl Compounds ,Sodium ,Imidazoles ,Kidney metabolism ,Organ Size ,Endocrinology ,medicine.anatomical_structure ,Prenatal Exposure Delayed Effects ,Renal blood flow ,Corticosteroid ,Benzimidazoles ,Female ,Vascular Resistance ,Angiotensin II Type 1 Receptor Blockers ,hormones, hormone substitutes, and hormone antagonists ,Glomerular Filtration Rate ,medicine.drug - Abstract
Antenatal corticosteroids may have long-term effects on renal development which have not been clearly defined. Our objective was to compare the responses to intrarenal infusions of ANG II in two groups of year-old, male sheep: one group exposed to a clinically relevant dose of betamethasone before birth and one not exposed. We wished to test the hypothesis that antenatal steroid exposure would enhance renal responses to ANG II in adult life. Six pairs of male sheep underwent unilateral nephrectomy and renal artery catheter placement. The sheep were infused for 24 h with ANG II or with ANG II accompanied by blockade of the angiotensin type 1 (AT1) or type 2 (AT2) receptor. Baseline mean arterial blood pressure among betamethasone-exposed sheep was higher than in control animals (85.8 ± 2.2 and 78.3 ± 1.0 mmHg, respectively, P = 0.003). Intrarenal infusion of ANG II did not increase systemic blood pressure ( P ≥ 0.05) but significantly decreased effective renal plasma flow and increased renal artery resistance ( P < 0.05). The decrease in flow and increase in resistance were significantly greater in betamethasone- compared with vehicle-exposed sheep (betamethasone P < 0.05, vehicle P ≥ 0.05). This effect appeared to be mediated by a heightened sensitivity to the AT1 receptor among betamethasone-exposed sheep. Sodium excretion initially decreased in both groups during ANG II infusion; however, a rebound was observed after 24 h. AT1 blockade was followed by a significant rebound after 24 h in both groups. AT2 blockade blunted the 24-h rebound effect among the vehicle-exposed sheep compared with the betamethasone-exposed sheep. In conclusion, antenatal corticosteroid exposure appears to modify renal responsiveness to ANG II by increasing AT1- and decreasing AT2 receptor-mediated actions particularly as related to renal blood flow and sodium excretion. more...
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- 2010
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16. Neonatal Outcomes and Operative Vaginal Delivery Versus Cesarean Delivery
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Steve N. Caritis, John M. Thorp, Rebecca G. Clifton, Brian M. Mercer, Anthony Sciscione, Susan M. Ramin, Dwight J. Rouse, Steven L. Bloom, Marshall W. Carpenter, Jay D. Iams, Fergal D. Malone, Catherine Y. Spong, Michael W. Varner, Stephen Contag, Alan M. Peaceman, and Yoram Sorokin more...
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Male ,medicine.medical_specialty ,Vacuum Extraction, Obstetrical ,Forceps ,Gestational Age ,Umbilical cord ,Article ,Obstetrical Forceps ,Labor Stage, Second ,Pregnancy ,medicine ,Humans ,Gynecology ,Fetus ,Cesarean Section ,business.industry ,Vaginal delivery ,Infant, Newborn ,Pregnancy Outcome ,Obstetrics and Gynecology ,Gestational age ,medicine.disease ,medicine.anatomical_structure ,Pediatrics, Perinatology and Child Health ,Gestation ,Female ,Base excess ,business - Abstract
We compared outcomes for neonates with forceps-assisted, vacuum-assisted, or cesarean delivery in the second stage of labor. This is a secondary analysis of a randomized trial in laboring, low-risk, nulliparous women at >or=36 weeks' gestation. Neonatal outcomes after use of forceps, vacuum, and cesarean were compared among women in the second stage of labor at station +1 or below (thirds scale) for failure of descent or nonreassuring fetal status. Nine hundred ninety women were included in this analysis: 549 (55%) with an indication for delivery of failure of descent and 441 (45%) for a nonreassuring fetal status. Umbilical cord gases were available for 87% of neonates. We found no differences in the base excess (P = 0.35 and 0.78 for failure of descent and nonreassuring fetal status) or frequencies of pH below 7.0 (P = 0.73 and 0.34 for failure of descent and nonreassuring fetal status) among the three delivery methods. Birth outcomes and umbilical cord blood gas values were similar for those neonates with a forceps-assisted, vacuum-assisted, or cesarean delivery in the second stage of labor. The occurrence of significant fetal acidemia was not different among the three delivery methods regardless of the indication. more...
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- 2010
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17. Pregnancy Complicated by Triploidy: A Comparison of the Three Karyotypes
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Santiago Munné, Richard C. Miller, William Polzin, William J. Watson, Dennis McWeeney, N Cekleniak, Joseph R. Wax, and Stephen Contag
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Adult ,medicine.medical_specialty ,Placental Finding ,Prenatal diagnosis ,Preimplantation genetic diagnosis ,Risk Assessment ,Congenital Abnormalities ,Cohort Studies ,Polyploidy ,Young Adult ,Pregnancy ,XYY Karyotype ,medicine ,Humans ,Retrospective Studies ,Chromosome Aberrations ,Gynecology ,Chromosomes, Human, X ,Fetus ,Chromosomes, Human, Y ,Sex Chromosomes ,business.industry ,Obstetrics ,Incidence ,Pregnancy Outcome ,Obstetrics and Gynecology ,Ultrasonography, Doppler ,Karyotype ,medicine.disease ,Pregnancy Complications ,Karyotyping ,Pregnancy Trimester, Second ,Pediatrics, Perinatology and Child Health ,Gestation ,Female ,business - Abstract
We evaluated triploid pregnancy to determine whether there are clinically important differences between the three karyotypes: 69,XXX, 69,XXY, and 69,XYY. Prospectively maintained cytogenetic databases at five tertiary care centers were retrospectively reviewed over a 10-year period to identify all triploid pregnancies. Targeted ultrasounds were reviewed to identify fetal and placental findings. Sonographic findings were compared by karyotype. There was a total of 549 triploid gestations; preimplantation genetic diagnosis (PGD) detected 413 triploid embryos, and the cytogenetic databases provided 136 clinical pregnancies with triploidy. In triploid embryos with PGD, the frequency of the 69,XYY karyotype was 8.7% (36/413), compared with 0.74% (1/136) during the first trimester of clinical pregnancies (p = 0.002). In clinical pregnancies, 60% (36/60) of 69,XXY fetuses survived the first trimester of development compared with 69% (52/75) of 69,XXX fetuses (p = NS). No clinically important differences were observed between 69,XXX and 69,XXY karyotypes in terms of type, number, or severity of fetal or placental anomalies. Gestations with a 69,XYY karyotype are found less frequently compared with gestations with a 69,XXX or 69,XXY karyotype. The decline in fetal survival of the 69,XYY triploid karyotype needs further investigation. There are significant abnormalities detected during prenatal sonography in most all clinically recognized cases of triploidy. Sonography cannot reliably distinguish between the 69,XXY and 69,XXX karyotypes. more...
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- 2009
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18. 263: Reference values for sonographic estimated fetal weight in twin gestations stratified by chorionicity - a single center study
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Sarah Crimmins, Rinat Gabbay-Benziv, and Stephen Contag
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medicine.medical_specialty ,Obstetrics ,business.industry ,Reference values ,medicine ,Obstetrics and Gynecology ,Gestation ,Fetal weight ,Single Center ,business - Published
- 2017
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19. Comparison of gene expression in squamous cell carcinoma and adenocarcinoma of the uterine cervix
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Stephen Contag, Renee M. McGovern, Amy C. Clayton, Melanie H. Dixon, Bobbie S. Gostout, and Eric S. Calhoun
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Pathology ,medicine.medical_specialty ,DNA, Complementary ,Uterine Cervical Neoplasms ,Adenocarcinoma ,Polymerase Chain Reaction ,Gene expression ,medicine ,Humans ,Cervix ,Cervical cancer ,biology ,Gene Expression Profiling ,Obstetrics and Gynecology ,Middle Aged ,medicine.disease ,Phenotype ,Epithelium ,Gene expression profiling ,stomatognathic diseases ,medicine.anatomical_structure ,Oncology ,Keratin 4 ,Carcinoma, Squamous Cell ,biology.protein ,Female - Abstract
Objectives. Microarray expression analysis of cervical tumors has revealed differential expression of genes that may be useful as markers or targets for treatment. We question the application of array findings across the major categories of cervical cancer. We sought to identify differences between normal squamous epithelium (NSQ) and glandular epithelium (NGL) of the uterine cervix and their malignant variants: squamous cell cancer (SCC) and adenocarcinoma (ACA). Methods. Eight genes were selected: 12-lipoxygenase (12-LOX), keratin 4, trypsinogen 2 (TRY2), Rh glycoprotein C (RhGC), collagen type V alpha 2, integrin alpha 5, integrin alpha 6, and c- myc . Ten cases each of SCC and ACA of the cervix were selected from our tumor bank. NSQ and NGL epithelia were obtained from consecutive patients undergoing surgery for benign disease. RNA extraction, cDNA synthesis, and DNA amplification of all samples were performed according to an established protocol. Electrophoresis of the multiplexed polymerase chain reaction (PCR) products was performed under standard conditions, followed by digital image capture. A ratio of target to control gene (β-actin) was obtained for each sample. Analysis of variance was applied to the mean ratios for each tissue to establish significant differences. Individual pairwise comparisons were made by Student t tests and verified with the Tukey-Kramer test. Results. Clinically valid comparisons are NSQ to NGL, NSQ to SCC, NGL to ACA, and SCC to ACA. Various expression patterns were observed between the epithelia and their malignant phenotypes. Significant differences in gene expression were observed between benign squamous and glandular epithelium in four of the eight genes and between malignant squamous and glandular epithelium in three of the eight genes. Significant differences in gene expression between benign and malignant tissues were demonstrated in four of the eight genes. Conclusions. We have defined significant differential expression changes between the two principal cervical tumor types. Differences in genes are demonstrated and must be considered if array technology is applied to the study of the biologic behavior of these tumors as well as their screening and management. The observed differential expression should be a compelling argument to perform type-specific expression analysis for other tumors with histological variants. more...
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- 2004
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20. Cumulative first live birth after elective cryopreservation of all embryos due to ovarian hyperresponsiveness
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Stephen Contag, Alan R. Thornhill, Donna R. Session, Daniel A. Dumesic, Ian S. Tummon, and Mark A Damario
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Adult ,medicine.medical_specialty ,Time Factors ,Ovarian hyperstimulation syndrome ,Context (language use) ,Fertilization in Vitro ,Biology ,Chorionic Gonadotropin ,Cryopreservation ,Ovarian Hyperstimulation Syndrome ,Pregnancy ,medicine ,Humans ,Longitudinal Studies ,Retrospective Studies ,Gynecology ,Intention-to-treat analysis ,Estradiol ,Obstetrics ,Infant, Newborn ,Pregnancy Outcome ,Obstetrics and Gynecology ,Retrospective cohort study ,Embryo Transfer ,Embryo, Mammalian ,medicine.disease ,Embryo transfer ,Reproductive Medicine ,embryonic structures ,Oocytes ,Female ,Live birth ,Follow-Up Studies - Abstract
Objective To estimate cumulative chance for first live birth after elective pronuclear stage cryopreservation of all embryos due to ovarian hyperresponsiveness. Design Retrospective analysis with longitudinal follow-up. Setting Academic hospital. Patient(s) Thirty subjects with elective cryopreservation of all embryos due to ovarian hyperresponsiveness. Intervention(s) Elective cryopreservation of all embryos at the pronuclear stage (n = 30) and subsequent cryopreserved–thawed ET (n = 51). Main outcome measure(s) Cumulative chance for first live birth. Result(s) Cumulative chance for first live birth was 77% when analyzed by intention to treat and 82% by treatment with ET. Nearly 40% of live births were multiple. Conclusion(s) Cumulative first live birth increased with repetitive ET after elective pronuclear stage cryopreservation of all embryos due to ovarian hyperresponsiveness. Multiple births, however, were frequent. In the context of initial ET attempts in young women, transfer of no more than two cryopreserved–thawed embryos is advised. more...
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- 2004
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21. 509: The association between fetal growth trajectories and adverse neonatal outcomes in a preterm population
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Stephen Contag, Amanda Mahle, Sarah Crimmins, and Katherine Goetzinger
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education.field_of_study ,medicine.medical_specialty ,Neonatal outcomes ,business.industry ,Obstetrics ,Population ,Fetal growth ,Obstetrics and Gynecology ,Medicine ,Association (psychology) ,education ,business - Published
- 2018
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22. OP01.01: Abnormal cerebroplacental (CPR) and cerebrorenal (CRR) Doppler indices in fetuses with small abdominal circumference
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Stephen Contag, Sarah Crimmins, Katherine Goetzinger, and S. Payton
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medicine.medical_specialty ,Fetus ,Radiological and Ultrasound Technology ,business.industry ,Abdominal circumference ,Obstetrics and Gynecology ,General Medicine ,symbols.namesake ,Reproductive Medicine ,Internal medicine ,symbols ,medicine ,Cardiology ,Radiology, Nuclear Medicine and imaging ,business ,Doppler effect - Published
- 2017
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23. EP14.03: Fetal renal artery Doppler in a healthy population
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Katherine Goetzinger, Sarah Crimmins, Stephen Contag, and S. Payton
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medicine.medical_specialty ,Fetus ,Radiological and Ultrasound Technology ,business.industry ,Healthy population ,Obstetrics and Gynecology ,General Medicine ,symbols.namesake ,Reproductive Medicine ,medicine.artery ,Internal medicine ,symbols ,Cardiology ,medicine ,Radiology, Nuclear Medicine and imaging ,Renal artery ,business ,Doppler effect - Published
- 2017
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24. EP14.42: Fetal cerebrorenal ratio and cerebroplacental ratio to evaluate the small fetus
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Katherine Goetzinger, Sarah Crimmins, S. Payton, and Stephen Contag
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medicine.medical_specialty ,Fetus ,Reproductive Medicine ,Radiological and Ultrasound Technology ,business.industry ,Obstetrics ,Small fetus ,Obstetrics and Gynecology ,Medicine ,Radiology, Nuclear Medicine and imaging ,General Medicine ,business - Published
- 2017
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25. Sex-specific effect of antenatal betamethasone exposure on renal oxidative stress induced by angiotensins in adult sheep
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Jianli Bi, Yixin Su, Stephen Contag, Kai Chen, Mark C. Chappell, James C. Rose, and Jorge P. Figueroa
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Male ,medicine.medical_specialty ,Angiotensins ,Physiology ,Renal cortex ,Renal function ,Nephron ,Biology ,medicine.disease_cause ,Dinoprost ,Kidney ,Betamethasone ,Excretion ,Sex Factors ,Pregnancy ,Internal medicine ,medicine ,Animals ,Glucocorticoids ,Sheep ,Superoxide Dismutase ,NADPH Oxidases ,Peptide Fragments ,Oxidative Stress ,Proteinuria ,medicine.anatomical_structure ,Endocrinology ,Prenatal Exposure Delayed Effects ,Call for Papers ,Female ,Angiotensin I ,Oxidative stress ,Glucocorticoid ,medicine.drug - Abstract
Prenatal glucocorticoid administration in clinically relevant doses reduces nephron number and renal function in adulthood and is associated with hypertension. Nephron loss in early life may predispose the kidney to other insults later but whether sex influences increases in renal susceptibility is unclear. Therefore, we determined, in male and female adult sheep, whether antenatal glucocorticoid (betamethasone) exposure increased 8-isoprostane (marker of oxidative stress) and protein excretion after acute nephron reduction and intrarenal infusions of angiotensin peptides. We also examined whether renal proximal tubule cells (PTCs) could contribute to alterations in 8-isoprostane excretion in a sex-specific fashion. In vivo, ANG II significantly increased 8-isoprostane excretion by 49% and protein excretion by 44% in male betamethasone- but not in female betamethasone- or vehicle-treated sheep. ANG-(1-7) decreased 8-isoprostane excretion but did not affect protein excretion in either group. In vitro, ANG II stimulated 8-isoprostane release from PTCs of male but not female betamethasone-treated sheep. Male betamethasone-exposed sheep had increased p47 phox abundance in the renal cortex while superoxide dismutase (SOD) activity was increased only in females. We conclude that antenatal glucocorticoid exposure enhances the susceptibility of the kidney to oxidative stress induced by ANG II in a sex-specific fashion and the renal proximal tubule is one target of the sex-specific effects of antenatal steroids. ANG-(1-7) may mitigate the impact of prenatal glucocorticoids on the kidney. P47 phox activation may be responsible for the increased oxidative stress and proteinuria in males. The protection from renal oxidative stress in females is associated with increased SOD activity. more...
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- 2014
26. Maternal preeclampsia and risk for cardiovascular disease in offspring
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Guadalupe Herrera-Garcia and Stephen Contag
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Gestational hypertension ,medicine.medical_specialty ,Offspring ,Blood Pressure ,Global Health ,Preeclampsia ,Coronary artery disease ,Pre-Eclampsia ,Pregnancy ,Risk Factors ,Internal medicine ,Diabetes mellitus ,Internal Medicine ,medicine ,Humans ,business.industry ,Incidence ,Infant, Newborn ,medicine.disease ,Prognosis ,Blood pressure ,Cardiovascular Diseases ,Hypertensive disease of pregnancy ,Cardiology ,Female ,Metabolic syndrome ,business - Abstract
Hypertensive disease of pregnancy (HDP) has been associated with elevated lifetime cardiovascular risk, including stroke, myocardial disease, coronary artery disease, and peripheral arterial disease. These two entities share common risk factors such as obesity, insulin resistance, diabetes, and hypertension. This article will evaluate the current literature on the maternal and fetal cardiovascular risks posed by HDP. The landmark study by Barker et al. demonstrated increased cardiovascular risk in growth-restricted infants, which may also be associated with HDP. Research has demonstrated the effects that HDP may have on the vascular and nephron development in offspring, particularly with respect to endothelial and inflammatory markers. In order to control for confounding variables and better understand the relationship between HDP and lifetime cardiovascular risk, future research will require following blood pressure and metabolic profiles of the parturients and their offspring. more...
- Published
- 2014
27. 448: The effect of maternal age on fetal and neonatal mortality
- Author
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Stephen Contag and Ruofan Yao
- Subjects
medicine.medical_specialty ,Fetus ,business.industry ,Obstetrics ,Neonatal mortality ,Obstetrics and Gynecology ,Medicine ,business - Published
- 2016
- Full Text
- View/download PDF
28. 862: External cephalic version and complication rates according to maternal body mass index
- Author
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Ruofan Yao, Shahrukh Chaudhary, and Stephen Contag
- Subjects
medicine.medical_specialty ,business.industry ,Obstetrics ,External cephalic version ,medicine.medical_treatment ,Obstetrics and Gynecology ,Medicine ,Mass index ,Complication ,business ,Maternal body - Published
- 2017
- Full Text
- View/download PDF
29. 515: The effects of obesity on complications associated with uterine rupture
- Author
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Stephen Contag and Ruofan Yao
- Subjects
medicine.medical_specialty ,business.industry ,Obstetrics ,Obstetrics and Gynecology ,Medicine ,business ,medicine.disease ,Obesity ,Uterine rupture - Published
- 2017
- Full Text
- View/download PDF
30. P15.06: Measurement of the fetal anterior cerebral artery pulsatility index in normal pregnancy
- Author
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Gabriele Filip, Stephen Contag, E. Vogrig, Alberto Rossi, Diego Marchesoni, and Ayuna Angarkhayeva
- Subjects
Fetus ,medicine.medical_specialty ,Radiological and Ultrasound Technology ,business.industry ,Obstetrics and Gynecology ,General Medicine ,Normal pregnancy ,Pulsatility index ,Reproductive Medicine ,medicine.artery ,Internal medicine ,Cardiology ,Anterior cerebral artery ,Medicine ,Radiology, Nuclear Medicine and imaging ,business - Published
- 2014
- Full Text
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31. Effect of prenatal exposure to Betamethasone on responses to intrarenal infusion of Angiotensin‐(1–7) (Ang 1–7) and its antagonist in male sheep
- Author
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Mark C. Chappell, James C. Rose, Jorge P. Figueroa, Stephen Contag, and Jianli Bi
- Subjects
medicine.medical_specialty ,Angiotensin 1 ,business.industry ,Antagonist ,Biochemistry ,Endocrinology ,Internal medicine ,Genetics ,Medicine ,Betamethasone ,business ,Molecular Biology ,Prenatal exposure ,Biotechnology ,medicine.drug - Published
- 2008
- Full Text
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32. The cumulative chance for a liveborn delivery following elective pronuclear stage cryopreservation in patients with high response cycles
- Author
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Alan R. Thornhill, Stephen Contag, Ian S. Tummon, and Mark A. Damario
- Subjects
medicine.medical_specialty ,Reproductive Medicine ,medicine ,Obstetrics and Gynecology ,In patient ,Biology ,Stage (cooking) ,Cryopreservation ,Surgery - Published
- 2002
- Full Text
- View/download PDF
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