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10 results on '"Sundqvist, Marie"'

1. Widespread horse-based mobility arose around 2200 bce in Eurasia

Author

Librado, Pablo, Tressières, Gaetan, Chauvey, Lorelei, Fages, Antoine, Khan, Naveed, Schiavinato, Stéphanie, Calvière-Tonasso, Laure, Kusliy, Mariya A., Gaunitz, Charleen, Liu, Xuexue, Wagner, Stefanie, Der Sarkissian, Clio, Seguin-Orlando, Andaine, Perdereau, Aude, Aury, Jean-Marc, Southon, John, Shapiro, Beth, Bouchez, Olivier, Donnadieu, Cécile, Collin, Yvette Running Horse, Gregersen, Kristian M., Jessen, Mads Dengsø, Christensen, Kirsten, Claudi-Hansen, Lone, Pruvost, Mélanie, Pucher, Erich, Vulic, Hrvoje, Novak, Mario, Rimpf, Andrea, Turk, Peter, Reiter, Simone, Brem, Gottfried, Schwall, Christoph, Barrey, Éric, Robert, Céline, Degueurce, Christophe, Horwitz, Liora Kolska, Klassen, Lutz, Rasmussen, Uffe, Kveiborg, Jacob, Johannsen, Niels Nørkjær, Makowiecki, Daniel, Makarowicz, Przemysław, Szeliga, Marcin, Ilchyshyn, Vasyl, Rud, Vitalii, Romaniszyn, Jan, Mullin, Victoria E., Verdugo, Marta, Bradley, Daniel G., Cardoso, João L., Valente, Maria J., Telles Antunes, Miguel, Ameen, Carly, Thomas, Richard, Ludwig, Arne, Marzullo, Matilde, Prato, Ornella, Bagnasco Gianni, Giovanna, Tecchiati, Umberto, Granado, José, Schlumbaum, Angela, Deschler-Erb, Sabine, Mráz, Monika Schernig, Boulbes, Nicolas, Gardeisen, Armelle, Mayer, Christian, Döhle, Hans-Jürgen, Vicze, Magdolna, Kosintsev, Pavel A., Kyselý, René, Peške, Lubomír, O’Connor, Terry, Ananyevskaya, Elina, Shevnina, Irina, Logvin, Andrey, Kovalev, Alexey A., Iderkhangai, Tumur-Ochir, Sablin, Mikhail V., Dashkovskiy, Petr K., Graphodatsky, Alexander S., Merts, Ilia, Merts, Viktor, Kasparov, Aleksei K., Pitulko, Vladimir V., Onar, Vedat, Öztan, Aliye, Arbuckle, Benjamin S., McColl, Hugh, Renaud, Gabriel, Khaskhanov, Ruslan, Demidenko, Sergey, Kadieva, Anna, Atabiev, Biyaslan, Sundqvist, Marie, Lindgren, Gabriella, López-Cachero, F. Javier, Albizuri, Silvia, Trbojević Vukičević, Tajana, Rapan Papeša, Anita, Burić, Marcel, Rajić Šikanjić, Petra, Weinstock, Jaco, Asensio Vilaró, David, Codina, Ferran, García Dalmau, Cristina, Morer de Llorens, Jordi, Pou, Josep, de Prado, Gabriel, Sanmartí, Joan, Kallala, Nabil, Torres, Joan Ramon, Maraoui-Telmini, Bouthéina, Belarte Franco, Maria-Carme, Valenzuela-Lamas, Silvia, Zazzo, Antoine, Lepetz, Sébastien, Duchesne, Sylvie, Alexeev, Anatoly, Bayarsaikhan, Jamsranjav, Houle, Jean-Luc, Bayarkhuu, Noost, Turbat, Tsagaan, Crubézy, Éric, Shingiray, Irina, Mashkour, Marjan, Berezina, Natalia Ya., Korobov, Dmitriy S., Belinskiy, Andrey, Kalmykov, Alexey, Demoule, Jean-Paul, Reinhold, Sabine, Hansen, Svend, Wallner, Barbara, Roslyakova, Natalia, Kuznetsov, Pavel F., Tishkin, Alexey A., Wincker, Patrick, Kanne, Katherine, Outram, Alan, and Orlando, Ludovic

Published
2024
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3. Molecular subtype and tumor characteristics of breast cancer metastases as assessed by gene expression significantly influence patient post-relapse survival

Author

Hatschek, Thomas, Fernö, Mårten, Lindström, Linda Sofie, Hedenfalk, Ingrid, Brandberg, Yvonne, Carstensen, John, Egyhazy, Suzanne, Stolt, Marianne Frostvik, Skoog, Lambert, Hellström, Mats, Maliniemi, Maarit, Svensson, Helene, Åström, Gunnar, Bergh, Jonas, Bjöhle, Judith, Lidbrink, Elisabet, Rotstein, Sam, Wallberg, Birgitta, Einbeigi, Zakaria, Carlsson, Per, Linderholm, Barbro, Walz, Thomas, Loman, Niklas, Malmström, Per, Söderberg, Martin, Malmberg, Martin, Carlsson, Lena, Umeå, Lindh, Birgitta, Sundqvist, Marie, Malmberg, Lena, Tobin, N.P., Harrell, J.C., Lövrot, J., Egyhazi Brage, S., Frostvik Stolt, M., Carlsson, L., Einbeigi, Z., Linderholm, B., Loman, N., Malmberg, M., Walz, T., Fernö, M., Perou, C.M., Bergh, J., Hatschek, T., and Lindström, L.S.

Published
2015
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5. Impact of the first tumor response at eight weeks on overall survival in metastatic breast cancer patients treated with first-line combination chemotherapy

Author

Suzuki, Chikako, Blomqvist, Lennart, Hatschek, Thomas, Carlsson, Lena, Einbeigi, Zakaria, Linderholm, Barbro, Lindh, Birgitta, Loman, Niklas, Malmberg, Martin, Rotstein, Samuel, Söderberg, Martin, Sundqvist, Marie, Walz, Thomas M., Åström, Gunnar, Fujii, Hirofumi, Jacobsson, Hans, and Glimelius, Bengt

Published
2013
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6. Molecular subtype and tumor characteristics of breast cancer metastases as assessed by gene expression significantly influence patient post-relapse survival

Author

Tobin, N. P., Harrell, J. C., Lövrot, J., Egyhazi Brage, S., Frostvik Stolt, M., Carlsson, L., Einbeigi, Z., Linderholm, B., Loman, N., Malmberg, M., Walz, T., Fernö, M., Perou, C. M., Bergh, J., Hatschek, T., Lindström, L. S., Hatschek, Thomas, Fernö, Mårten, Lindström, Linda Sofie, Hedenfalk, Ingrid, Brandberg, Yvonne, Carstensen, John, Egyhazy, Suzanne, Stolt, Marianne Frostvik, Skoog, Lambert, Hellström, Mats, Maliniemi, Maarit, Svensson, Helene, Åström, Gunnar, Bergh, Jonas, Bjöhle, Judith, Lidbrink, Elisabet, Rotstein, Sam, Wallberg, Birgitta, Einbeigi, Zakaria, Carlsson, Per, Linderholm, Barbro, Walz, Thomas, Loman, Niklas, Malmström, Per, Söderberg, Martin, Malmberg, Martin, Carlsson, Lena, Umeå, Lindh, Birgitta, Sundqvist, Marie, and Malmberg, Lena

Published
2015
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7. Use of subcutaneous and intravenous trastuzumab: real-world experience from three hospitals in Sweden.

Author

Valachis, Antonis, Sundqvist, Marie, Carlsson, Lena, Li, Bing, Chiesa, Flaminia, Uhde, Milica, and Sanglier, Thibaut

Abstract

Aim: We aimed to describe the use of subcutaneous (sc.) trastuzumab use in a real-world setting. Patients & methods: This retrospective cohort study evaluated electronic medical records of patients with early breast cancer and trastuzumab use from January 2010 to February 2018 in three hospitals in Sweden. Results: In total, 363 patients received trastuzumab during study period. Of these, 217 (59.8%) patients started treatment with sc. trastuzumab and 146 (40.2%) with intravenous trastuzumab. After sc. trastuzumab approval, use of sc. trastuzumab increased from 70.2% in 2014 to 100% in 2017. Since 2013, 34 of 35 (97.4%) patients who started with intravenous trastuzumab switched to sc. formulation. Conclusion: Trastuzumab sc. quickly became the prevailing formulation for treatment in HER2-positive early breast cancer. [ABSTRACT FROM AUTHOR]

Published
2019
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8. Non-linear transformations of age at diagnosis, tumor size, and number of positive lymph nodes in prediction of clinical outcome in breast cancer.

Author

Forsare, Carina, Bak, Martin, Falck, Anna-Karin, Grabau, Dorthe, Killander, Fredrika, Malmström, Per, Rydén, Lisa, Stål, Olle, Sundqvist, Marie, Bendahl, Pär-Ola, and Fernö, Mårten

Subjects
HORMONE receptor positive breast cancer, CANCER patients, BREAST cancer, LYMPH nodes
Abstract

Background: Prognostic factors in breast cancer are often measured on a continuous scale, but categorized for clinical decision-making. The primary aim of this study was to evaluate if accounting for continuous non-linear effects of the three factors age at diagnosis, tumor size, and number of positive lymph nodes improves prognostication. These factors will most likely be included in the management of breast cancer patients also in the future, after an expected implementation of gene expression profiling for adjuvant treatment decision-making.Methods: Four thousand four hundred forty seven and 1132 women with primary breast cancer constituted the derivation and validation set, respectively. Potential non-linear effects on the log hazard of distant recurrences of the three factors were evaluated during 10 years of follow-up. Cox-models of successively increasing complexity: dichotomized predictors, predictors categorized into three or four groups, and predictors transformed using fractional polynomials (FPs) or restricted cubic splines (RCS), were used. Predictive performance was evaluated by Harrell's C-index.Results: Using FP-transformations, non-linear effects were detected for tumor size and number of positive lymph nodes in univariable analyses. For age, non-linear transformations did, however, not improve the model fit significantly compared to the linear identity transformation. As expected, the C-index increased with increasing model complexity for multivariable models including the three factors. By allowing more than one cut-point per factor, the C-index increased from 0.628 to 0.674. The additional gain, as measured by the C-index, when using FP- or RCS-transformations was modest (0.695 and 0.696, respectively). The corresponding C-indices for these four models in the validation set, based on the same transformations and parameter estimates from the derivation set, were 0.675, 0.700, 0.706, and 0.701.Conclusions: Categorization of each factor into three to four groups was found to improve prognostication compared to dichotomization. The additional gain by allowing continuous non-linear effects modeled by FPs or RCS was modest. However, the continuous nature of these transformations has the advantage of making it possible to form risk groups of any size. [ABSTRACT FROM AUTHOR]

Published
2018
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9. Using an Inbred Horse Breed in a High Density Genome-Wide Scan for Genetic Risk Factors of Insect Bite Hypersensitivity (IBH).

Author

Velie, Brandon D., Shrestha, Merina, Franҫois, Liesbeth, Schurink, Anouk, Tesfayonas, Yohannes G., Stinckens, Anneleen, Blott, Sarah, Ducro, Bart J., Mikko, Sofia, Thomas, Ruth, Swinburne, June E., Sundqvist, Marie, Eriksson, Susanne, Buys, Nadine, and Lindgren, Gabriella

Subjects
HORSE diseases, INSECT bites & stings, HORSE breeds, DISEASE susceptibility, ANIMAL species, SINGLE nucleotide polymorphisms, GENETICS
Abstract

While susceptibility to hypersensitive reactions is a common problem amongst humans and animals alike, the population structure of certain animal species and breeds provides a more advantageous route to better understanding the biology underpinning these conditions. The current study uses Exmoor ponies, a highly inbred breed of horse known to frequently suffer from insect bite hypersensitivity, to identify genomic regions associated with a type I and type IV hypersensitive reaction. A total of 110 cases and 170 controls were genotyped on the 670K Axiom Equine Genotyping Array. Quality control resulted in 452,457 SNPs and 268 individuals being tested for association. Genome-wide association analyses were performed using the GenABEL package in R and resulted in the identification of two regions of interest on Chromosome 8. The first region contained the most significant SNP identified, which was located in an intron of the DCC netrin 1 receptor gene. The second region identified contained multiple top SNPs and encompassed the PIGN, KIAA1468, TNFRSF11A, ZCCHC2, and PHLPP1 genes. Although additional studies will be needed to validate the importance of these regions in horses and the relevance of these regions in other species, the knowledge gained from the current study has the potential to be a step forward in unraveling the complex nature of hypersensitive reactions. [ABSTRACT FROM AUTHOR]

Published
2016
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10. Use of Superparamagnetic Iron Oxide (SPIO) Nanoparticles to Avoid Upfront Sentinel Node Dissection (SLND) in Patients with Ductal Cancer in Situ (DCIS): An Update of the Sentinot Study.

Author

Karakatsanis, Andreas, Hersi, Abdi, Pistolis, Lida, Olofsson-Bagge, Roger, Mohamed, Imad, Sundqvist, Marie, Nagy, Guyla, Kwong, Ava, Eriksson, Staffan, and Wärnberg, Fredrik

Subjects
SENTINEL lymph nodes, FERRIC oxide, CANCER patients, NANOPARTICLES, DISSECTION
Abstract

B Background: b SPIO is a SLN tracer that may reside in the tissue for several weeks after injection. B Conclusions b : Marking the SLN with SPIO seems to be an efficient technique to avoid upfront SLND for patients with a preoperative diagnosis of DCIS where SLND would be otherwise considered. [Extracted from the article]

Published
2020
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