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1. Contents, Vol. 94, 1991

Author

Graham S. LeGros, Hiroshi Yamakawa, K. Takatsu, Ratko Djukanovic, P.G. Holt, J. Bujanowski-Weber, P. Oehme, S. Bianchj, William Roche, I. Knöller, G. Delespesse, Toru Ando, Reinhold Penner, D. Macchia, R. Djukanovic, George W. Ward, Thomas Bieber, T. Furitsu, Makoto Dohi, Susan M. MacDonald, Martin D. Chapman, F. Chavarria, R. Robert Schellenberg, Michiko Haida, Makoto Nogami, John R. Brashler, J. Brom, Pascal Chanez, A. Ciccarelli, T.D. Whalley, M.J. Carmona, E. Saito, Mamoru Ito, H. Behrendt, W. Zachgo, Gabriele Zwadlo-Klarwasser, Philip J. Thompson, Sylvia Miescher, N.P. Siemensma, A. de Paulis, G. Schultze-Werninghaus, J.-P. Kinet, B.D. Gomperts, Takeo Juji, Ikuo Akutsu, Richard J. Simpson, S. Wilson, T.H. Lee, Suhad El-Lati, Bernhard Przybilla, J. Oliver, Sesha Reddigari, Monique Vogel, Koki Takahashi, Thomas Iff, L. Mugnai, E. Neher, Nathalie Paul-Eugène, Ph. Lassalle, Takeshi Fukuda, Dean D. Metcalfe, V. Lagente, C.E. O’Neil, Go Matsuzaki, C. McMenamin, Jordan N. Fink, G. Burow, Ch. Lemmermann, Ch. Schweiger, H. Wagner, K. Kurihara, D.R. Springall, Karin Pettenburger, A. Capron, H.Y.A. Lau, R. Wahl, G.J. Gleich, K. Rother, Shigeru Takafuji, W.R. Roche, Kurt Blaser, F. Gambassi, A. Pistelli, M. Bubak, Andrew F. Walls, Jeffrey M. Drazen, S.J. Lane, Johann-Christian Virchow, Akio Mori, J.M. Polak, Dietrich Kraft, Hans L. Spiegelberg, L. Lipponer, Friederike von zur Mühlen, R. zur Strassen, Rihoux Jean-Pierre, Susanne Spitzauer, Werner J. Pichler, Karen Britten, M. Schon-Hegrad, Barbara K. Stout, John Wilson, Hirokazu Okudaira, Otto Scheiner, Mitsuko Kondo, Akira Ishii, Richard Sporik, Daniel Weinreich, M. Keating, W. Dorsch, Manel Jordana, Ch.H. Heusser, Ingrid Enander, Massimo Triggiani, T. Ishizaka, Colin J. Sanderson, Dieter Vieluf, Stephanie A. Shore, J. Anrather, S. Terrados, Claus Bachert, Rosa M. Ten, E.W. Rauterberg, E. Masini, H. Rumpold, Jean Yves Lacoste, T.H.W. Lillie, K. Ohno, Alison M. Campbell, E. Gutierrez, F.L. Pearce, Stephan C. Bischoff, R. Suau, Miguel Blanca, P.H. Howarth, P.K. Jeffery, Robert L. Barker, E. Perez, M. Pfenning, Marshall Plaut, Piotr Kuna, T. Abe, H. Rotermund, Michael A. Lett-Brown, Herbert G. Johnson, Thomas Brunner, C. Ra, U. Ganzer, N. Hyslop, Kazuhiko Akiyoshi, Alain L. de Weck, J. Bews, A. Hartnell, J. Dry, K. Nosbüsch, Rafeul Alam, G. Le Gros, V. Brinkmann, Jacqueline M. Langdon, B. Thomas, P. Heap, Corinne Petit-Frère, A.G. Fernández, Wolfgang Schmutzler, Gianni Marone, Matsunobu Suko, R.W. Gristwood, D. Kraft, G.M. Walsh, A.G. Palma-Carlos, B. Bradley, N.S. Sakaguchi, J.M. Vega, O.-H. Wilhelms, R. Wiewrodt, A. Brini, Stephen R. Durham, M. Lupini, M.A. Reed, Thierry Maisonnet, A. Witzel, Peter J. Barnes, Ch. Brander, Lawrence M. Lichtenstein, A. Koffer, Y. Delneste, Laura Palma-Carlos, Jennifer Cairns, T. Brunnee, Elliott Homer, Diana J. Quint, F. Bettens, Monique Capron, Sohei Makino, Luanda Beck, T. Imai, Takayuki Ohtoshi, A. Akasawa, Lore Koller, Yoji Iikura, Naohiro Watanabe, Ahuva Nissim, J.W. Coleman, A. Ohgimi, D. Befus, J.R. Wilkinson, H. Küster, T. Katsunuma, Ch. Ebner, K.J. Turner, M.P. Piccinni, F. Ledermann, Michael Breitenbach, Bradley J. Undem, A.B. Kay, John E. Salvaggio, Carvalho de Sousa, S.T. Holgate, B. Girn, P. Berga, S. Bent, Gerald J. Gleich, Arnold S. Kirshenbaum, P.B. Boulos, Yoshitaka Ino, M. Breitenbach, R. Rathsack, May Azzawi, Sun Ying, Philippe Godard, J.H. Widdicombe, Rudolf Valenta, Christopher Corrigan, S. Romagnani, D.M. Kemeny, Bernard Dugas, Samuel B. Lehrer, Y. Churcher, John Gordon, C. Brom, F. Leynadier, Gert Kunkel, Gerard Cox, B.F. Weber, D. Diaz-Sanchez, Shinji Motojima, J.W. Wilson, Pieter L.B. Bruijnzeel, P.F. Mannaioni, K. Britten, Allen P. Kaplan, Yutaka Morita, K. Ishida, Erika Jensen-Jarolim, Jack Gauldie, Fiona R. Lake, S. Raspanti, Andrew Grant, R. Fadel, S. Dunnette, Jean Bousquet, Ivan Aebischer, Thomas A.E. Platts-Mills, T. Wyss, Richard D. O’Connor, Larry D. Ward, A.G. Morris, Clemens A. Dahinden, Toshifumi Yuuki, P. Parronchi, Hiroyuki Mochizuki, Gail M. McNutt, D.C. Reason, Martin Krieger, Lawrence E. Gelber, Naoki Inagaki, E. Kilchherr, Elisabeth Boichot, Qiu Gang, F. Gabl, Alec H. Sehon, J.V. Collins, Shiro Kasuya, J. Blomgren, Bernadette Pignol, Motohiro Ebisawa, N. Sakaguchi, Jacalyn H. Pierce, U. Blank, Fu-Tong Liu, Robert A. Seder, R. Hilger, Richard P. Bransford, M. Linssen, Jörg Kleine-Tebbe, P.D. Pare, Kazuhiko Yamamoto, Jean Michel Mencia-Huerta, Michael K. Bach, Pierre Braquet, J. Salvaggio, Reuben J.M. Falkoff, R. Merget, J. Hards, B.J. Holt, D. Strickland, P.E.R. Tatham, A.B. Tonnel, H. Saito, François-B. Michel, K. Akimoto, Jerry Dolovich, Brian M. Greenlee, Carl G. A. Persson, Anne Kagey-Sobotka, Tim R. Mosmann, Zelig Eshhar, N. Wallen, Maria Baeza, A.J. Wardlaw, Peter H. Howarth, Robin N. Poston, W. König, R.C. Benyon, M. Lopez, D. Mijic, E. Jarolim, William E. Paul, John P. Caulfield, B. Kunz, Milton A. Martins, Yasushi Okumura, J. Knöller, R. Ciriilo, K. Nieber, Geoffrey A. Stewart, Allen C. Myers, Zami Ben-Sasson, U. Hauser, M. G. Di Bello, Michael Duchêne, C. Baumgarten, C.J. Sanderson, Koji Ito, R. Valenta, M.-H. Jouvin, Menachem Rottem, F. Carswell, A. Miranda, K.R. Tainsh, Kimm J. Hamann, Judah A. Denburg, K. Wagner, Martin K. Church, Qutayba Hamid, O. Mejan, Johannes Ring, J. Fernandez, L. Juhlin, Kiyoshi Takatsu, Martin E. Sanders, Peter W. Heymann, C.E. Reed, P. Wentz-Murtha, Fred D. Finkelman, J. Llupiá, Helmut Rumpold, Stephen T. Holgate, Conceição B. Santos, G.M. Hänsch, W.L. Liu, Christoph Walker, M. Ricci, Ph. Gosset, E. Maggi, J. Wilson, R. Moqbel, and Beda M. Stadler

Subjects
business.industry, Immunology, Immunology and Allergy, Medicine, General Medicine, business
Published
1991
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2. Human mast cell progenitors in peripheral blood from atopic subjects with high IgE levels

Author

I, Nomura, T, Katsunuma, K, Matsumoto, M, Iida, H, Tomita, M, Tomikawa, H, Kawahara, A, Akasawa, R, Pawankar, and H, Saito

Subjects
Adult, Male, Adolescent, Interleukins, Stem Cells, Age Factors, Cell Count, Immunoglobulin E, Methylcellulose, Histamine Release, Antibodies, Dermatitis, Atopic, Japan, Case-Control Studies, Child, Preschool, Humans, Female, Mast Cells, Child, Cells, Cultured
Abstract

It remains unclear whether the number of circulating mast cell progenitors is increased in patients with atopic diseases. Distinct genotypes are reported to affect mast cell/basophil activation.We compared the number and function of mast cell progenitors present in the peripheral blood from donors with normal IgE (IgE400 U/mL) and those with atopic dermatitis accompanied by high serum IgE (IgE5000 U/mL).Purified peripheral blood cells were cultured in serum-free methylcellulose containing stem cell factor (SCF), IL-6 plus IL-3. Fresh methylcellulose containing the cytokines was layered over every 2 weeks. The cultured mast cells were retrieved from the methylcellulose and were functionally analysed.Mast cell colonies were distinguished at 6 weeks of culture as other colony types had been degenerated. The number of mast cell colony-forming cells varied depending on donors and was not significantly increased in peripheral blood from the hyper-IgE atopic patients. A significant inversed correlation was found between the number of mast cells per one colony and the ages of donors. The cultured mast cells derived from atopic patients and those from normal IgE donors equally expressed Fc epsilon RI and released histamine through Fc epsilon RI, although IL-4 priming in vitro markedly enhanced the function of mast cells regardless of donors.These results indicate that the number of circulating mast cell progenitors may be regulated by unknown individual factors unrelated to IgE levels. Mast cell function may be regulated largely by environmental factors, such as IL-4, but not determined by their progenitors' genotypes.

Published
2001

3. Biographical Sketch of Dr. Alec H. Sehon

Author

Matsunobu Suko, R.W. Gristwood, A.G. Palma-Carlos, T.H.W. Lillie, K. Ohno, R. Wiewrodt, K. Nosbüsch, Jacqueline M. Langdon, A. Brini, Zelig Eshhar, E. Kilchherr, V. Lagente, C.E. O’Neil, T. Katsunuma, Jean Michel Mencia-Huerta, M. Lopez, Michael K. Bach, D. Mijic, E. Jarolim, F.L. Pearce, E. Perez, Beda M. Stadler, Pierre Braquet, E. Saito, Mamoru Ito, H. Behrendt, N. Wallen, Maria Baeza, A.J. Wardlaw, Ch. Lemmermann, Ch. Schweiger, Bernadette Pignol, A. de Paulis, J. Salvaggio, Reuben J.M. Falkoff, J. Hards, William E. Paul, B.J. Holt, P. Berga, R. Djukanovic, Philip J. Thompson, Sylvia Miescher, N.P. Siemensma, Graham S. LeGros, Hiroshi Yamakawa, Yoshitaka Ino, M. Breitenbach, D. Strickland, K. Wagner, Martin K. Church, B. Bradley, Gert Kunkel, Gerard Cox, John P. Caulfield, Milton A. Martins, Yasushi Okumura, Daniel Weinreich, C.E. Reed, M.A. Reed, Thierry Maisonnet, Sesha Reddigari, Monique Vogel, Philippe Godard, J.H. Widdicombe, Robert A. Seder, F. Gabl, Christopher Corrigan, S. Romagnani, J.V. Collins, Jacalyn H. Pierce, O. Mejan, J. Fernandez, Fred D. Finkelman, J. Llupiá, O.-H. Wilhelms, H. Saito, François-B. Michel, A. Witzel, Jean Bousquet, Ivan Aebischer, Lawrence E. Gelber, Naoki Inagaki, Fu-Tong Liu, Thomas A.E. Platts-Mills, T. Wyss, D.M. Kemeny, Elisabeth Boichot, T. Imai, Y. Delneste, Ch. Brander, Stephanie A. Shore, John R. Brashler, Wolfgang Schmutzler, Richard P. Bransford, Fiona R. Lake, Ingrid Enander, W. Zachgo, Gabriele Zwadlo-Klarwasser, S. Terrados, Jennifer Cairns, Rosa M. Ten, R.C. Benyon, J.W. Coleman, Bernard Dugas, Samuel B. Lehrer, Y. Churcher, Shiro Kasuya, Takayuki Ohtoshi, G. Le Gros, D. Diaz-Sanchez, A.B. Tonnel, J. Brom, Pascal Chanez, J. Blomgren, John Gordon, P. Heap, M. Linssen, Jörg Kleine-Tebbe, Manel Jordana, Ch.H. Heusser, K. Akimoto, Jerry Dolovich, T. Ishizaka, Ratko Djukanovic, I. Knöller, Thomas Bieber, Peter H. Howarth, Helmut Rumpold, H. Rumpold, Motohiro Ebisawa, Jean Yves Lacoste, Gianni Marone, P.G. Holt, Pieter L.B. Bruijnzeel, Massimo Triggiani, Karen Britten, D.C. Reason, N. Sakaguchi, N.S. Sakaguchi, Ikuo Akutsu, G. Schultze-Werninghaus, R. Valenta, U. Blank, J.M. Vega, F. Leynadier, C. Ra, Bernhard Przybilla, K. Takatsu, Robin N. Poston, Larry D. Ward, P.K. Jeffery, Stephen R. Durham, J. Bujanowski-Weber, Nathalie Paul-Eugène, J. Dry, E.W. Rauterberg, B. Kunz, Christoph Walker, Richard J. Simpson, S. Wilson, V. Brinkmann, Ph. Lassalle, G. Burow, P.D. Pare, P. Oehme, Rafeul Alam, J. Knöller, R. Ciriilo, Conceição B. Santos, W. König, S. Bianchj, Allen C. Myers, K.R. Tainsh, Thomas Iff, E. Maggi, A. Miranda, T.D. Whalley, William Roche, Kimm J. Hamann, Lawrence M. Lichtenstein, Herbert G. Johnson, Kazuhiko Akiyoshi, Allen P. Kaplan, G. Delespesse, M.J. Carmona, H.Y.A. Lau, Kazuhiko Yamamoto, C. McMenamin, J. Wilson, Peter J. Barnes, Laura Palma-Carlos, A. Akasawa, G.M. Walsh, A. Capron, Toru Ando, W.R. Roche, Qiu Gang, Andrew F. Walls, Monique Capron, Sohei Makino, M. Lupini, Luanda Beck, J. Oliver, C. Baumgarten, L. Mugnai, C.J. Sanderson, Naohiro Watanabe, L. Lipponer, Alec H. Sehon, T. Furitsu, A. Ohgimi, Makoto Dohi, T. Brunnee, Elliott Homer, Diana J. Quint, A. Koffer, Friederike von zur Mühlen, R. Moqbel, Bradley J. Undem, Barbara K. Stout, Arnold S. Kirshenbaum, P.B. Boulos, Judah A. Denburg, M.-H. Jouvin, Werner J. Pichler, Shigeru Takafuji, M. Schon-Hegrad, Michael Breitenbach, G.M. Hänsch, Johannes Ring, J. Anrather, Robert L. Barker, Reinhold Penner, Otto Scheiner, L. Juhlin, Johann-Christian Virchow, Hirokazu Okudaira, E. Masini, S. Dunnette, Gerald J. Gleich, E. Gutierrez, Marshall Plaut, K. Nieber, F. Carswell, Piotr Kuna, R. Hilger, H. Küster, Clemens A. Dahinden, D. Macchia, W.L. Liu, M.P. Piccinni, Colin J. Sanderson, F. Gambassi, Jeffrey M. Drazen, Geoffrey A. Stewart, R. Wahl, G.J. Gleich, R. zur Strassen, R. Merget, M. Ricci, Menachem Rottem, John E. Salvaggio, Qutayba Hamid, Go Matsuzaki, Peter W. Heymann, Martin D. Chapman, P.E.R. Tatham, F. Chavarria, P. Wentz-Murtha, H. Wagner, S.J. Lane, Ph. Gosset, Akio Mori, K. Rother, Dietrich Kraft, Hans L. Spiegelberg, Kurt Blaser, A. Pistelli, Koki Takahashi, Kiyoshi Takatsu, D. Kraft, Martin E. Sanders, R. Suau, Stephen T. Holgate, T. Abe, Thomas Brunner, John Wilson, N. Hyslop, Alain L. de Weck, A. Hartnell, Corinne Petit-Frère, Zami Ben-Sasson, F. Bettens, Lore Koller, Yoji Iikura, U. Hauser, May Azzawi, Yutaka Morita, K. Ishida, M. G. Di Bello, Michael Duchêne, Koji Ito, Martin Krieger, D.R. Springall, Karin Pettenburger, J.M. Polak, Ahuva Nissim, Susanne Spitzauer, D. Befus, J.R. Wilkinson, Ch. Ebner, K.J. Turner, M. Bubak, F. Ledermann, Akira Ishii, Richard Sporik, M. Keating, A.B. Kay, Carvalho de Sousa, S.T. Holgate, B. Girn, S. Bent, Dieter Vieluf, Rihoux Jean-Pierre, W. Dorsch, Mitsuko Kondo, Claus Bachert, T.H. Lee, Suhad El-Lati, George W. Ward, E. Neher, R. Robert Schellenberg, Michiko Haida, Makoto Nogami, Brian M. Greenlee, Carl G. A. Persson, Anne Kagey-Sobotka, M. Pfenning, Dean D. Metcalfe, B.F. Weber, H. Rotermund, Shinji Motojima, J.W. Wilson, Tim R. Mosmann, Michael A. Lett-Brown, K. Kurihara, P.F. Mannaioni, Erika Jensen-Jarolim, Jack Gauldie, S. Raspanti, Andrew Grant, U. Ganzer, R. Fadel, R. Rathsack, Susan M. MacDonald, Toshifumi Yuuki, Sun Ying, B. Thomas, Rudolf Valenta, P. Parronchi, A. Ciccarelli, J.-P. Kinet, B.D. Gomperts, Takeo Juji, C. Brom, Hiroyuki Mochizuki, Gail M. McNutt, Alison M. Campbell, Takeshi Fukuda, K. Britten, Jordan N. Fink, J. Bews, Richard D. O’Connor, Stephan C. Bischoff, Miguel Blanca, P.H. Howarth, A.G. Morris, and A.G. Fernández

Subjects
Gerontology, media_common.quotation_subject, Immunology, Immunology and Allergy, Art history, General Medicine, Art, Biographical sketch, media_common
Published
1991
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4. Studies on rat liver argininosuccinate synthetase. Inhibition by various amino acids

Author

S, Takada, T, Saheki, Y, Igarashi, and T, Katsunuma

Subjects
Aspartic Acid, Kinetics, Structure-Activity Relationship, Liver, Protein Conformation, Circular Dichroism, Animals, Citrulline, Lyases, Histidine, Amino Acids, Argininosuccinate Lyase, Rats
Abstract

Inhibition studies of crystallized rat liver argininosuccinate synthetase [EC 6.3.4.5] are described. 1. L-Argininosuccinate, L-histidine, and L-tryptophan inhibited the enzyme activity at saturating amounts of the substrates. 2. L-Norvaline, L-argininosuccinate, L-arginine, L-isoleucine, and L-valine competitively inhibited the enzyme activity at a low concentration of L-citrulline, with Ki values of 1.3 x 10(4) M, 2.5 X 10(-4) M, 6.7 X 10(-4) M, 6.3 X 10(-4) M, and 6.0 x 10(-4) M, respectively. 3. L-Argininosuccinate and L-arginine competitively inhibited the enzyme activity at a low concentration of L-aspartate, with Ki values of 9.5 x 10(-4) M and 1.2 x 10(-3) M, respectively. 4. The modes of inhibition by L-histidine were mixed-noncompetitive, uncompetitive, and noncompetitive types with respect to L-citrulline, L-aspartate, and ATP, respectively. 5. When the enzyme was preincubated with L-citrulline, the enzyme activity was slightly increased in the presence of a low concentration of L-histidine in the assay mixture. 6. The conformation of the enzyme was markedly changed by the addition of L-histidine as judged from the CD spectrum. This change was partially reversed by incubation with L-citrulline.

Published
1979

6. Benefits of atomic-level processing by quasi-ALE and ALD technique.

Author

M Honda, T Katsunuma, M Tabata, A Tsuji, T Oishi, T Hisamatsu, S Ogawa, and Y Kihara

Subjects
*ATOMIC layer deposition, *SILICA, *THICKNESS measurement
Abstract

A new technology has been developed using the atomic layer etching (ALE) and atomic layer deposition (ALD) concepts. It has been applied to self-aligned contacts (SAC) and patterning processes, for the sub 7 nm technology generation. In the SAC process, ultra-high selectivity of SiO2 etching towards SiN is required, for which we have developed quasi-ALE technique for SiO2 etching. We were able to significantly improve the trade-off between the etching ability of SiO2 on the micro slit portions and SiN selectivity. Quasi-ALE precisely controls the reaction layer thickness of the surface, by controlling the radical flux and ion flux independently, and hence enables etching at lower ion energies (Ei  <  250 eV). On the other hand, in the patterning processes, the shrinking of critical dimensions (CD) without loading is mandatory. Therefore, we developed a new process flow that combines ALD technique and etching. With this method, we were able to achieve CD shrinking at atomic-layer level precision for various patterns, without causing CD loading. In addition, we were also able to uniformly control the CD shrinkage amount across the whole wafer. This is because this technique takes advantage of the deposition step which is independent of the pattern density and the location on the wafer by self-limited reactions. [ABSTRACT FROM AUTHOR]

Published
2017
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